CN107041907A - A kind of compound preparation of Urtica macrorrhiza Hand.-Mazz extract and fevervine extract - Google Patents
A kind of compound preparation of Urtica macrorrhiza Hand.-Mazz extract and fevervine extract Download PDFInfo
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- CN107041907A CN107041907A CN201710190688.8A CN201710190688A CN107041907A CN 107041907 A CN107041907 A CN 107041907A CN 201710190688 A CN201710190688 A CN 201710190688A CN 107041907 A CN107041907 A CN 107041907A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
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Abstract
The present invention provides the compound preparation of a kind of Urtica macrorrhiza Hand.-Mazz extract and fevervine extract, and it is made up of Urtica macrorrhiza Hand.-Mazz extract, fevervine extract, when percentage by weight is：Urtica macrorrhiza Hand.-Mazz extract 10 90%, fevervine extract 10 90%, the content of polysaccharide is more than 50% wherein in Urtica macrorrhiza Hand.-Mazz extract, the content of polysaccharide is more than 50% in fevervine extract, with obvious immunological enhancement, particularly when Urtica macrorrhiza Hand.-Mazz extract accounts for 40%, fevervine extract and accounts for 40%, preparation can be produced and to strengthen immune effect preferable.The compound preparation of a kind of Urtica macrorrhiza Hand.-Mazz extract that the present invention is provided and fevervine extract, simple with preparing compared with prior art, curative effect is reliable, and toxic side effect is low, and with low cost, therefore, and the present invention has very high application value, suitable for popularization and application.
Description
Technical field
The present invention relates to a kind of Urtica macrorrhiza Hand.-Mazz extract and the compound preparation of fevervine extract, exempt from for repairing, improving
Epidemic disease function.
Background technology
Polysaccharide (Polysaccharide, also known as polysaccharide) refer to by more than 10 identical or different monosaccharide molecules and
Uronic acid connects the carbohydrate of condensation by glycosidic bond.Polysaccharide is extremely wide in distributed in nature, and rich content is deposited extensively
It is in plant, microorganism, algae, mushroom and animal body.Polysaccharide is the important biological information macromolecular of another class in organism,
4 most basic class living matters are constituted with protein, nucleic acid, lipid, it is closely related with human lives, to the work that sustains life
It is dynamic to play vital effect[1].And plant polyose is a kind of bioactive ingredients being prevalent in plant cell wall,
As extremely important nutriment in plant, the vital movements such as cell recognition, substance transportation, Organism immunoregulation are being participated in
It is middle to play irreplaceable effect.Plant polyose is the new drug research resources bank for having important application prospect, and numerous studies show,
Plant polyose has unique biological activity, is the main active substances composition of many Chinese herbal medicines, in immunological regulation, resists and swells
Extensive pharmacological action is played in terms of knurl, antibacterial, antiviral, anti-oxidant, anti-aging, hypoglycemic, reducing blood lipid, with good
Application prospect, and its, cytotoxicity smaller to the toxic side effect of body while pharmacological action is played is low, is to compare
Preferable medicine and Material for Health Food.
Urtica (Urtica L.) plant is annual or herbaceos perennial, all herbal medicine.Plant resources enriches,
The whole world there are about 35 kinds, in domestic 23 kinds, and distributed more widely, wherein Urtica macrorrhiza Hand.-Mazz is the peculiar kind in Yunnan.Nettle platymiscium is
Conventional ethnic drug and Folk medicine, its medicinal history first recorded in《Bencao Tujing》、《Compendium of Materia Medica》Deng ancient books and records, it has wind-dispelling
The effects such as dredging collateral, promoting blood circulation and stopping pain, soothing the liver are calmed the frightened.Cure mainly the diseases such as hyperplasia of prostate, rheumatalgia pain, postpartum exhausting, postpartum infantile convulsion.
In nettle platymiscium containing flavonoids, lignin, organic acid, volatile oil, terpene, phenols, Phenylpropanoid Glycosides class, protein,
Polysaccharide and other class compounds.
Fevervine is Rubiaceae chicken droppings Calamus herbaceous perennial vine, with aerial part and root people's medicine, is distributed mainly on print
The ground, the Shaanxi, Gansu, Shandong, Jiangsu, Anhui, lake of China such as degree, western mute, Malaysian, the Japanese, Korea of India Buddhist nun, China
The provinces and regions such as north, Hunan, Guizhou are distributed.Chinese Fevervine Herb complete stool is used as existing thousands of years of the history of conventional herbal medicine among the people, history tree
It is on the books, once recorded in the drug standards of the province such as Chinese Pharmacopoeia and Sichuan, Shanghai, Henan, with expelling wind and activating blood flow, analgesic
The effects such as removing toxic substances, promoting digestion, dehumidification swelling, swollen and ache for treating arthralgia pain due to rheumatism, diarrhoea, dysentery, epigastric pain and sore wound
Disease.Containing a variety of chemical compositions, mainly have flavonoids, iridoids, volatile oil (including monoterpene, fatty alcohol, aliphatic acid,
Compound containing S etc.), sterols, triterpenes etc., in addition also a small amount of phenol hydroxyl acid compounds and some trace elements.
There is the immune medicine of many enhancings in the market, but had no that Urtica macrorrhiza Hand.-Mazz extract is extracted with fevervine
Thing composition preparation, and the combination preparation have it is cheap, safely and effectively act on.
The content of the invention
It is an object of the invention to provide a kind of Urtica macrorrhiza Hand.-Mazz extract and the compound preparation of fevervine extract, for repairing
Multiple, raising immunologic function.
The compound preparation of a kind of Urtica macrorrhiza Hand.-Mazz extract and fevervine extract, it is by Urtica macrorrhiza Hand.-Mazz extract, fevervine
Extract is constituted, and its percentage by weight is：Urtica macrorrhiza Hand.-Mazz extract 10-90%, fevervine extract 10-90%, wherein thick root
The content of polysaccharide is more than the content of polysaccharide in 50%, fevervine extract more than 50% in nettle extract.
The preparation technology of Urtica macrorrhiza Hand.-Mazz extract and fevervine extract is：（1）By wash clean and dried fevervine
Powder 1000g, is put into decoction kettle, adds deionized water, big fire decocts 30min, then is cooked by slow fire 2h, filters decocting liquid, collects filter
Liquid, is concentrated into dense fluids, and adding ethanol makes concentration of alcohol reach 80%, stands overnight, incline supernatant, sediment spend from
After sub- water just dissolves, adding ethanol makes concentration of alcohol reach 80%, stands overnight, and collects drying precipitate, obtains extract, carry
The polyoses content of thing is taken to be more than 50%.（2）By wash clean and dried Urtica macrorrhiza Hand.-Mazz powder 1000g, it is put into decoction kettle, adds
Deionized water, big fire decocts 30min, then is cooked by slow fire 2h, filters decocting liquid, collects filtrate, be concentrated into dense fluids, adds second
Alcohol makes concentration of alcohol reach 80%, stands overnight, and incline supernatant, after sediment deionized water just dissolves, and adding ethanol makes
Concentration of alcohol reaches 80%, stands overnight, and collects drying precipitate, obtains extract, and the polyoses content of extract is more than 50%.
The present invention provides the preparation that Urtica macrorrhiza Hand.-Mazz extract and fevervine extract are constituted, compared with prior art with
Lower effect：Prepare simply, curative effect is reliable, and toxic side effect is small, and with low cost, therefore, the present invention has very high application value,
Suitable for popularization and application.
Embodiment
Embodiment one
The compound preparation of a kind of Urtica macrorrhiza Hand.-Mazz extract and fevervine extract, its percentage by weight is：Urtica macrorrhiza Hand.-Mazz extract
40%th, fevervine extract 40%, remaining is auxiliary material, so as to preparation of preparation.
Embodiment two
The compound preparation of a kind of Urtica macrorrhiza Hand.-Mazz extract and fevervine extract, its percentage by weight is：Urtica macrorrhiza Hand.-Mazz extract
60%th, fevervine extract 20%, remaining is auxiliary material, so as to preparation of preparation.
Embodiment three
The compound preparation of a kind of Urtica macrorrhiza Hand.-Mazz extract and fevervine extract, its percentage by weight is：Urtica macrorrhiza Hand.-Mazz extract
20%th, fevervine extract 60%, remaining is auxiliary material, so as to preparation of preparation.
Example IV immunization experiment
After mouse adaptability is raised 3~5 days, 4 are randomly divided into by body weight by SPF grades of ICR male mices 48,20 ± 2g of body weight
Group：Blank group, model group, ferment cordyceps sinensis D-mannitol group (referred to as positive group), Urtica macrorrhiza Hand.-Mazz extract and fevervine extract
Compound preparation group, respectively containing 40%, remaining 20% be auxiliary material（Abbreviation preparation group）, every group 12.Preparation group gives 1.0 g/kg daily
Gavage, positive group gives the g/kg gavages of ferment cordyceps sinensis D-mannitol 1.0 daily, is administered 8 days altogether, blank group, model group are given daily
With 0.9% sodium chloride injection（NS）Gavage（About 0.3ml）, weigh daily and record mouse weight, calculated and be administered according to body weight
Amount, while observing mouse active situation.Model group, positive controls, preparation group are in experiment the 1st, 3,5,7 days intraperitoneal injection ring phosphorus
Acid amides 50mg/kg, the isometric sterile NS of blank control group injection.After the h of final injection endoxan 24 at cervical dislocation
Dead mouse, materials carry out intestinal mucosa sIgA, IFN-γ, the detection of IL-4 secretory volumes.As a result preparation group and positive group are apparently higher than mould
Type group, close to blank group, shows preparation group and positive effect of the group with Immune-enhancing effect, preparation group is better than positive group.It is shown in Table 1.
The intestinal mucosa sIgA of table 1, IFN-γ, IL-4 secretory volumes (`x±S, n=12)
| Group | sIgA(ng/mL) | IFN-γ(pg/mL) | IL-4(pg/mL) | ||
| Blank group | 42.06±3.22 | 75.48±5.98 | 233.12±18.12 | ||
| Model group | 27.36±6.24 | 33.51±6.45 | 164.32±7.21 | ||
| Positive group | 36.22±3.98 | 61.66±6.02 | 186.34±13.68 | ||
| Preparation group | 37.52±3.98 | 63.10±4.36 | 198.71±15.52 |
Claims (2)
1. the compound preparation of a kind of Urtica macrorrhiza Hand.-Mazz extract and fevervine extract, it is characterised in that it is extracted by Urtica macrorrhiza Hand.-Mazz
Thing, fevervine extract are constituted, and its percentage by weight is：Urtica macrorrhiza Hand.-Mazz polyoses extract 10-90%, fevervine Polyose extraction
Thing 10-90%.
2. the compound preparation of Urtica macrorrhiza Hand.-Mazz extract according to claim 1 and fevervine extract, it is characterised in that：
The polyoses content of the Urtica macrorrhiza Hand.-Mazz extract is more than 50%, and the polyoses content of fevervine extract is more than 50%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710190688.8A CN107041907A (en) | 2017-03-28 | 2017-03-28 | A kind of compound preparation of Urtica macrorrhiza Hand.-Mazz extract and fevervine extract |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710190688.8A CN107041907A (en) | 2017-03-28 | 2017-03-28 | A kind of compound preparation of Urtica macrorrhiza Hand.-Mazz extract and fevervine extract |
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| CN107041907A true CN107041907A (en) | 2017-08-15 |
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| CN201710190688.8A Pending CN107041907A (en) | 2017-03-28 | 2017-03-28 | A kind of compound preparation of Urtica macrorrhiza Hand.-Mazz extract and fevervine extract |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112898445A (en) * | 2021-03-10 | 2021-06-04 | 昆明市延安医院 | Separation and extraction method and application of urtica macrorrhiza polysaccharide |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1865289A (en) * | 2005-05-16 | 2006-11-22 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | Preparation and uses of polysaccharide from urtica fissa |
-
2017
- 2017-03-28 CN CN201710190688.8A patent/CN107041907A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1865289A (en) * | 2005-05-16 | 2006-11-22 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | Preparation and uses of polysaccharide from urtica fissa |
Non-Patent Citations (3)
| Title |
|---|
| 冉靓等: "鸡矢藤多糖的分离纯化及体内抗菌活性", 《中国实验方剂学杂志》 * |
| 李仲昆等: "粗根荨麻提取物对环磷酰胺所致小鼠免疫功能低下保护作用的实验观察", 《中成药》 * |
| 王鑫杰等: "鸡矢藤的研究进展", 《世界临床药物》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112898445A (en) * | 2021-03-10 | 2021-06-04 | 昆明市延安医院 | Separation and extraction method and application of urtica macrorrhiza polysaccharide |
| CN112898445B (en) * | 2021-03-10 | 2022-06-21 | 昆明市延安医院 | Separation and extraction method and application of urtica macrorrhiza polysaccharide |
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