CN107029283A - The method that a kind of graphene and BNNT cooperate with Strengthening and Toughening akermanite bone support - Google Patents
The method that a kind of graphene and BNNT cooperate with Strengthening and Toughening akermanite bone support Download PDFInfo
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- CN107029283A CN107029283A CN201510408494.1A CN201510408494A CN107029283A CN 107029283 A CN107029283 A CN 107029283A CN 201510408494 A CN201510408494 A CN 201510408494A CN 107029283 A CN107029283 A CN 107029283A
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Abstract
The invention provides the synergy of a kind of utilization graphene and boron nitride nano-tube, promote its dispersed and Strengthening and Toughening akermanite bone support method in the base, the advantage is that：It is mutually scattered by cooperateing with support to promote using two-dimensional graphene and the one-dimensional boron nitride Nanotube composite formation phase of three-dimensional manometer second, solve exclusive use graphene or the problem of boron nitride nano-tube is easy to reunite；Using the excellent mechanical property of graphene and boron nitride nano-tube and huge specific surface area, the strength and toughness of akermanite bone support is improved by extracting the mechanism such as effect, crack deflection；The characteristics of can inducing stem cell Osteoblast Differentiation using graphene and boron nitride nano-tube, further improves the osteogenic ability of akermanite bone support.
Description
Technical field
The present invention relates to the synergy of a kind of utilization graphene and boron nitride nano-tube, promote its dispersed and tough
Change the method for akermanite bone support, belong to biological manufacture field.
Background technology
It is used as a kind of silicate bioactive ceramics, akermanite (Ca2MgSi2O7) there is moderate stability to degradation
And the ability of induction apatite formation, compared to traditional calcium phosphate ceramic, akermanite ceramics have also been shown more
Good cell compatibility, cytoactive and external osteoinductive, can support adhesion, propagation, the differentiation of various kinds of cell
And gene expression, the propagation of a variety of stem cells of ion product energy obvious stimulation containing Ca, Si, Mg of release and into
Bone breaks up.Further study show that, akermanite ceramics can not only induce the growth of new bone, but also can promote
The formation of body vessel.But mechanics low intensity of akermanite ceramics, toughness itself is also not up to compact bone requirement, limitation
Its application as bone support in bone defect healing.
Low-dimension nano material such as two-dimensional graphene, one-dimensional boron nitride nanotube (BNNT) etc., because with excellent power
Learn performance, high thermal conductivity and huge specific surface area, it has also become most potential second phase material.Consider
To its intrinsic biocompatibility and good osteogenic induction ability, graphene and BNNT are in Strengthening and Toughening akermanite bone
Great expectations is sent in terms of support.But a series of research shows, graphene or the enhanced akermanites of BNNT are compound
Bone support does not reach desired high intensity and high tenacity, and this is mainly due between graphene, between BNNT
There is strong Van der Waals force, along with its surface lacks functional site so that graphene and BNNT are easily rolled into a ball
It is poly- and be difficult it is uniform and stable be dispersed in ceramic matrix, cause the interface cohesion of low-dimension nano material and ceramic matrix compared with
It is weak or even bring defect therefore very limited to the improvement of bone support mechanical property.
In order to further develop graphene, BNNT Strengthening and Toughening potentiality, some scholars are modified in its table by covalent bond
Face adds functional site to improve its dispersity and interface fine structure in the base, but covalent bond modification
In strong acid or strong alkali environment also serious structure can be brought to destroy to low-dimension nano material so that it is original excellent to reduce its
Different in nature energy.In view of graphene and two unique peacekeeping one-dimentional structures of BNNT, if the two combination is formed into three wieners
The second phase of rice：Long and straight BNNT forms " sandwich " structure between being clipped in adjacent graphene layer, is expected to play association
With the effect of support, promote the dispersed of low-dimension nano material, so that it is strong in Composite Bone support to give full play to it
Toughening potentiality.
In summary, during selective laser sintering prepares akermanite bone support, by two-dimensional graphene and one
Dimension boron nitride nano-tube combines to form the phase of three-dimensional manometer second, is expected to promote the dispersed of them by acting synergistically,
And the mechanical property of bone support is greatly improved, so as to extend its application in osteanagenesis reparation.
The content of the invention
The problem of being easy to reunite in mutually applying second for graphene, BNNT, the present invention is proposed the two combination shape
Into the phase of three-dimensional manometer second, by acting synergistically, promotion is dispersed, and is compound to magnesium Huang using selective laser sintering
The method that its mechanical property is improved in feldspar bone support.
The key step of the present invention includes：
(1) powder disperses：Graphene, BNNT and akermanite powder are weighed in proportion, are surpassed in absolute ethyl alcohol
Graphene suspension, BNNT suspension and akermanite suspension are obtained after sound stirring；
(2) powder is mixed：Graphene suspension is poured slowly into BNNT suspension, continues ultrasonic agitation and obtains
Akermanite suspension, is then slowly added into graphene/BNNT suspension by graphene/BNNT suspension, then
Secondary ultrasonic agitation obtains graphene/BNNT/ akermanite suspension, obtains dispersed after filtering, vacuum drying
Mixed-powder；
(3) prepared by bone support：Graphene/BNNT/ akermanites powder to mix utilizes selectivity as raw material
Laser sintering process, prepares graphene/BNNT/ akermanite Composite Bone supports.
The mass ratio of described graphene, BNNT and akermanite powder is 0.5: 1.5: 98.
It is 30~60 minutes that described powder, which disperseed with the ultrasonic agitation time in mixed process,.
Using high pure nitrogen (99.999%) protection during described selective laser sintering, spot diameter is 0.8mm,
Laser power is 8W, and sweep speed is 150mm/min.
Advantage of the present invention is as follows：
(1) combine to form common support net structure using two-dimensional graphene and one-dimensional BNNT, by cooperateing with support to promote
Enter mutually scattered, solve graphene or the problem of BNNT is easy to reunite；
(2) utilize graphene and the excellent mechanical properties of BNNT and huge specific surface area, by extract effect,
The mechanism such as crack deflection, crackle bridging improve the strength and toughness of akermanite bone support；
(3) the characteristics of can inducing stem cell Osteoblast Differentiation using graphene and BNNT, further improves magnesium Huang long
The osteogenic ability of stone bone support, accelerates the Regeneration and Repair of Cranial defect.
Embodiment
With reference to one embodiment to the present invention embodiment be further described, but the present invention content simultaneously
It is not limited to this.
(1) powder disperses：0.002g graphenes, 0.006g BNNT and 0.392g are weighed by 0.5: 1.5: 98 mass ratio
Akermanite powder, is respectively placed in three different 200ml beakers, is slowly added to 50ml absolute ethyl alcohols, ultrasound
Stirring obtains graphene suspension, BNNT suspension and akermanite suspension after 40 minutes；
(2) powder is mixed：Graphene suspension is poured slowly into BNNT suspension, continues ultrasonic agitation 40
Minute, graphene/BNNT suspension is obtained, akermanite suspension is then slowly added into graphene/BNNT
In suspension, then ultrasonic agitation obtains graphene/BNNT/ akermanite suspension after 40 minutes, through miillpore filter mistake
Filter, vacuum drying 24 hours after, obtain dispersed mixed-powder；
(3) prepared by bone support：Graphene/BNNT/ akermanites powder to mix utilizes selectivity as raw material
Laser sintering process, is protected using high pure nitrogen (99.999%), is 0.8mm in spot diameter, laser power is
8W, sweep speed be 150mm/min under conditions of prepare graphene/BNNT/ akermanite Composite Bone supports.
Claims (4)
1. one kind is in akermanite bone stent procedures are prepared using selective laser sintering, by two-dimensional graphene and one-dimensional nitridation
The boron Nanotube composite formation phase of three-dimensional manometer second, it is dispersed by cooperateing with support to promote, and greatly improve bone branch
The method of frame mechanical property, key step includes：
(1) powder disperses：Graphene, BNNT and akermanite powder are weighed in proportion, it is ultrasonic in absolute ethyl alcohol
Graphene suspension, BNNT suspension and akermanite suspension are obtained after stirring；
(2) powder is mixed：Graphene suspension is poured slowly into BNNT suspension, continues ultrasonic agitation and obtains stone
Akermanite suspension, is then slowly added into graphene/BNNT suspension by black alkene/BNNT suspension,
Ultrasonic agitation obtains graphene/BNNT/ akermanite suspension again, is uniformly divided after filtering, vacuum drying
Scattered mixed-powder；
(3) prepared by bone support：Graphene/BNNT/ akermanites powder to mix is swashed as raw material using selectivity
Light sintering process, prepares graphene/BNNT/ akermanite Composite Bone supports.
2. according to the method described in claim 1, it is characterised in that：Described graphene, BNNT and akermanite powder
The mass ratio at end is 0.5: 1.5: 98.
3. according to the method described in claim 1, it is characterised in that：Described powder is scattered to be stirred with ultrasound in mixed process
The time is mixed for 30~60 minutes.
4. according to the method described in claim 1, it is characterised in that：High Purity Nitrogen is used during described selective laser sintering
Gas (99.999%) is protected, and spot diameter is 0.8mm, and laser power is 8W, and sweep speed is 150mm/min.
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| CN201510408494.1A CN107029283A (en) | 2015-07-13 | 2015-07-13 | The method that a kind of graphene and BNNT cooperate with Strengthening and Toughening akermanite bone support |
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| CN201510408494.1A CN107029283A (en) | 2015-07-13 | 2015-07-13 | The method that a kind of graphene and BNNT cooperate with Strengthening and Toughening akermanite bone support |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108530104A (en) * | 2018-05-07 | 2018-09-14 | 北京航空航天大学 | PIP combinations growth in situ graphene/boron nitride nano-tube ceramic matric composite densifying method |
| CN110327496A (en) * | 2019-07-15 | 2019-10-15 | 江西理工大学 | A kind of Sr-GO/PCL Composite Bone bracket and preparation method thereof |
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| CN103145411A (en) * | 2013-03-08 | 2013-06-12 | 山东大学 | Two-phase calcium phosphate composite material adopting graphene and carbon nano-tube as synergistic toughening phases and preparation method of composite material |
| CN104276826A (en) * | 2013-07-08 | 2015-01-14 | 中南大学 | Optical fiber laser three dimensional printer for preparation of nano-ceramic bone tissue engineering scaffold |
| CN104744022A (en) * | 2013-12-26 | 2015-07-01 | 中南大学 | Laser preparation method for strengthening and toughening ceramic bone scaffold with silicon carbide fibers |
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| CN103145411A (en) * | 2013-03-08 | 2013-06-12 | 山东大学 | Two-phase calcium phosphate composite material adopting graphene and carbon nano-tube as synergistic toughening phases and preparation method of composite material |
| CN104276826A (en) * | 2013-07-08 | 2015-01-14 | 中南大学 | Optical fiber laser three dimensional printer for preparation of nano-ceramic bone tissue engineering scaffold |
| CN104744022A (en) * | 2013-12-26 | 2015-07-01 | 中南大学 | Laser preparation method for strengthening and toughening ceramic bone scaffold with silicon carbide fibers |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108530104A (en) * | 2018-05-07 | 2018-09-14 | 北京航空航天大学 | PIP combinations growth in situ graphene/boron nitride nano-tube ceramic matric composite densifying method |
| CN110327496A (en) * | 2019-07-15 | 2019-10-15 | 江西理工大学 | A kind of Sr-GO/PCL Composite Bone bracket and preparation method thereof |
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