CN106693061A - Preparation method of polyvinylidene fluoride-based nano-composite bone scaffold - Google Patents
Preparation method of polyvinylidene fluoride-based nano-composite bone scaffold Download PDFInfo
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- CN106693061A CN106693061A CN201510408457.0A CN201510408457A CN106693061A CN 106693061 A CN106693061 A CN 106693061A CN 201510408457 A CN201510408457 A CN 201510408457A CN 106693061 A CN106693061 A CN 106693061A
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- polyvinylidene fluoride
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- kynoar
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Abstract
The invention belongs to the technical field of composite bone scaffold preparation and provides a selective laser sintering preparation method by the utilization of nanometer 1393 bioglass and nano-diamond reinforced polyvinylidene fluoride. By the short degradation period of the 1393 bioglass, degradation of a polyvinylidene fluoride scaffold is promoted and the degradation speed is accelerated. By the high hardness and low granularity of nano-diamond, hardness and rigidity of the polyvinylidene fluoride scaffold are enhanced. Meanwhile, by excellent biological properties, bone inductivity of the polyvinylidene fluoride scaffold is enhanced. By the method, the nano-composite bone scaffold with good biological properties, controllable degradability and good mechanical property is prepared. The product is low-cost, has strong practicality, and has strong promotion and practical value.
Description
Art
The present invention relates to the biology that a kind of bio-vitric of utilization nanometer 1393 and Nano diamond are respectively increased polyvinylidene fluoride material
Performance and mechanical property, and the method that high-performance nano Composite Bone support is prepared using selective laser sintering technique, belong to machinery
Engineering, organizational project, the field that life science is intersected.
Background technology
Autologous bone transplanting is considered as the golden standard of bone collection, but presence materials are limited, easily cause the defects such as confession area's complication,
Therefore developing preferable artificial bone repairing bone defect turns into the research emphasis of current biological manufacture, and bone support is in artificial bone graft
Play important role.Kynoar (Polyvinylidene fluoride) is that repeat unit is-CH2-CF2- hemicrystalline
The excellent macromolecular material of energy, abbreviation PVDF, its easy to process, good mechanical performance, good heat endurance and biology
Compatibility, makes it be widely used in biomedical sector.
Bone support is directed to for the demand of biomaterial, is come with some shortcomings again, such as Kynoar does not have bioactivity,
Can not induce the formation of bone like apatite layer, and biological degradability is poor, rigidity and hardness are not enough, greatly limit
Its application in vivo.1393 bio-vitric (53wt%SiO2, 6wt%Na2O, 12wt%K2O, 5wt%MgO,
20wt%CaO, 4wt%P2O5) have good bioactivity, bone binding affinity and biodegradability, and catabolite is to people
Body nonhazardous is acted on, therefore is widely used in bone tissue engineer field as matrix material or additive.
Nano diamond (5-10nm), because its hardness is high, granularity is small, specific surface area is big, can be filled as nano material
It is used for improving its mechanical property in polymer.Additionally, a large amount of free electron number (originals more than number on Nano diamond surface
Sub- donor), substantial amounts of oxygen-containing functional group, the water-wet behavior on surface on plane of crystal, it is had in biomedical sector widely
Application prospect.
In sum, the deficiency that the present invention exists for Kynoar bone support, by adding the bio-vitric of nanometer 1393 and receiving
Rice diamond produces the bone support of tri compound using selective laser sintering, to produce in Kynoar matrix
Composite Bone support with good biological activity, biodegradability and mechanical performance.
The content of the invention
The bioactivity that exists present invention aim to address Kynoar bone support is weak, degradability is poor, hardness and insufficient rigidity
The problems such as, the bio-vitric of nanometer 1393 and Nano diamond are compound in Kynoar, prepared using selective laser sintering
Go out the Composite Bone support with good biological performance and mechanical property.
Embodiment of the present invention includes：
1) by 18: 1: 1 mass percent, accurate measuring Kynoar, the bio-vitric of nanometer 1993, nanometer Buddha's warrior attendant
Stone, carries out mechanical dispersion；
2) by step 1) in scattered composite be dissolved in absolute ethyl alcohol and be made into the scattered turbid liquid of tri compound, first pass through ultrasound point
Dissipate 30 minutes, then by magnetic stirrer 1 hour, finally ultrasonic disperse obtained well mixed solution in 30 minutes again；
3) the solution filtering that will be obtained in step 2, composite powder after drying obtains well mixed answering by ball mill grinding
Close powder；
4) well mixed composite powder is filled into the automatic auxiliary powder device of selective laser sintering machine, is entered under argon atmosphere
Row is laser sintered, and the technological parameter of sintering is as follows：Spot diameter 0.8mm, sweep span 3mm, powder layer thickness 0.1-0.2mm,
Laser power 2.6W, sweep speed 600mm/min.
Described drying is carried out under vacuum conditions, and drying temperature is 50-60 DEG C, and the time is 9-10 hours.
Advantage of the present invention is as follows：
1) it is binding affinity using the excellent bone of the bio-vitric of nanometer 1393, the formation of polyvinylidene fluoride surface bone like apatite layer is induced,
Its bioactivity is improved, osteoinductive is made it have.
2) using the performance that 1393 bio-vitric degradation cycles are short, the degraded of Kynoar is promoted, so as to accelerate polyvinylidene fluoride
The degradation speed of alkene bone support.
3) using the mechanical performance that Nano diamond is extraordinary, the hardness and rigidity of Kynoar bone support are improved.
Specific embodiment
Specific embodiment of the invention is further described with reference to one embodiment, but the content of the present invention is not limited to
In this.
1) accurate measuring 90g Kynoar, 5g nanometer of 1993 bio-vitric, 5g Nano diamonds, carries out mechanical dispersion.
2) by step 1) in scattered composite be dissolved in absolute ethyl alcohol and be made into the scattered suspension of tri compound, first pass through ultrasound
Dispersion 30 minutes, by magnetic stirrer 1 hour, is finally obtaining well mixed molten for 30 minutes with ultrasonic disperse
Liquid.
3) the solution filtering that will be obtained in step 2, dries 10 hours, by dried composite powder in the environment of 60 DEG C
Well mixed composite powder is obtained by ball mill grinding.
4) well mixed composite powder is filled into the automatic auxiliary powder device of selective laser sintering machine, is entered under argon atmosphere
Row is laser sintered, and the technological parameter of sintering is as follows：Spot diameter 0.8mm, sweep span 3mm, powder layer thickness 0.1-0.2mm,
Laser power 2.6W, sweep speed 600mm/min.
Claims (2)
1. wood invention is related to one kind to mix Kynoar, the bio-vitric of nanometer 1393, three kinds of materials of Nano diamond by a certain percentage
Close, Kynoar support is promoted with reference to the bio-vitric of nanometer 1393 and the respective advantage of both materials of Nano diamond
Degraded, while the method for improving its biology performance and mechanical property, its preparation technology is：
1) by 18: 1: 1 mass percent, accurate measuring Kynoar, the bio-vitric of nanometer 1993, Nano diamond,
Carry out mechanical dispersion；
2) by step 1) in scattered composite be dissolved in absolute ethyl alcohol and be made into the scattered turbid liquid of tri compound, first pass through ultrasonic disperse 30
Minute, then by magnetic stirrer 1 hour, finally obtaining well mixed solution within 30 minutes with ultrasonic disperse；
3) the solution filtering that will be obtained in step 2, composite powder after drying obtains well mixed composite powder by ball mill grinding
End；
4) well mixed composite powder is filled into the automatic auxiliary powder device of selective laser sintering machine, is swashed under argon atmosphere
Light is sintered, and the technological parameter of sintering is as follows：Spot diameter 0.8mm, sweep span 3mm, powder layer thickness 0.1-0.2mm,
Laser power 2.6W, sweep speed 600mm/min.
2. according to the method described in claim 1, it is characterised in that：Described drying is carried out under vacuum conditions, dries temperature
It is 50-60 DEG C to spend, and the time is 9-10 hours.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510408457.0A CN106693061A (en) | 2015-07-13 | 2015-07-13 | Preparation method of polyvinylidene fluoride-based nano-composite bone scaffold |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510408457.0A CN106693061A (en) | 2015-07-13 | 2015-07-13 | Preparation method of polyvinylidene fluoride-based nano-composite bone scaffold |
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| CN106693061A true CN106693061A (en) | 2017-05-24 |
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| CN201510408457.0A Pending CN106693061A (en) | 2015-07-13 | 2015-07-13 | Preparation method of polyvinylidene fluoride-based nano-composite bone scaffold |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110302429A (en) * | 2019-07-15 | 2019-10-08 | 江西理工大学 | A kind of Ag-DBT/PVDF Composite Bone bracket and preparation method thereof |
| CN110314250A (en) * | 2019-07-15 | 2019-10-11 | 江西理工大学 | A kind of preparation method of PVDF/DBT Composite Bone bracket |
| CN112076345A (en) * | 2020-09-07 | 2020-12-15 | 江西理工大学 | CoFe2O4PVDF composite bone scaffold and preparation method thereof |
| CN115569239A (en) * | 2022-09-16 | 2023-01-06 | 张皓轩 | Preparation method of vancomycin-carrying material |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103656752A (en) * | 2012-09-25 | 2014-03-26 | 中南大学 | Method for strengthening and toughening biological ceramic material by use of graphene and preparing artificial bone prepared from material |
| CN104108928A (en) * | 2013-04-22 | 2014-10-22 | 中南大学 | Method for preparing ceramic bone scaffold by introducing continuous liquid phase during selective laser sintering |
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2015
- 2015-07-13 CN CN201510408457.0A patent/CN106693061A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103656752A (en) * | 2012-09-25 | 2014-03-26 | 中南大学 | Method for strengthening and toughening biological ceramic material by use of graphene and preparing artificial bone prepared from material |
| CN104108928A (en) * | 2013-04-22 | 2014-10-22 | 中南大学 | Method for preparing ceramic bone scaffold by introducing continuous liquid phase during selective laser sintering |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110302429A (en) * | 2019-07-15 | 2019-10-08 | 江西理工大学 | A kind of Ag-DBT/PVDF Composite Bone bracket and preparation method thereof |
| CN110314250A (en) * | 2019-07-15 | 2019-10-11 | 江西理工大学 | A kind of preparation method of PVDF/DBT Composite Bone bracket |
| CN110302429B (en) * | 2019-07-15 | 2021-11-26 | 江西理工大学 | Ag-DBT/PVDF composite bone scaffold and preparation method thereof |
| CN112076345A (en) * | 2020-09-07 | 2020-12-15 | 江西理工大学 | CoFe2O4PVDF composite bone scaffold and preparation method thereof |
| CN115569239A (en) * | 2022-09-16 | 2023-01-06 | 张皓轩 | Preparation method of vancomycin-carrying material |
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Application publication date: 20170524 |