CN109806438A - A kind of orthopaedics adhesive and preparation method with promotion bone uptake function - Google Patents
A kind of orthopaedics adhesive and preparation method with promotion bone uptake function Download PDFInfo
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- CN109806438A CN109806438A CN201910191728.XA CN201910191728A CN109806438A CN 109806438 A CN109806438 A CN 109806438A CN 201910191728 A CN201910191728 A CN 201910191728A CN 109806438 A CN109806438 A CN 109806438A
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Abstract
The invention discloses a kind of with the orthopaedics adhesive and preparation method that promote bone uptake function, and described adhesive includes the raw material of following parts by weight: 40-60 parts of modified phosphate magnesium bone cement, 10-20 parts of nanometer calcium carbonate, 10-20 parts of sodium alginate, 1-3 parts of sodium selenite, 3-5 parts of pearl powder, 3-5 parts of medical stone, 5-10 parts of Sodium Polyacrylate, 1-3 parts of calcium lignosulfonate, 1-3 parts of glycerol, 3-5 parts of chitosan, 3-5 parts of lecithin, 1-3 parts of sapindoside, 5-10 parts of Arabic gum and 10-15 parts of collagen.Adhesive provided by the invention have caking property it is good, without secondary toxic action, good biocompatibility, antibiotic property is good, can promote growth of spur, the advantages that accelerating bone healing, anti-good water solubility, it is able to satisfy clinical application requirement, is suitble in orthopaedics, spinal surgery, the treatment of osteoporosis and the fixation of fracture and treatment.
Description
Technical field
The present invention relates to medical material tech field, it is specifically a kind of have promote bone uptake function orthopaedics adhesive and
Preparation method.
Background technique
The mankind are long using medical adhesive material history, are in recent decades the complexity for reducing operation, medical adhesive dressing
Agent obtains rapid development and extensive use.In surgical operation, medical adhesive is viscous for the part of certain organs and tissue
It closes and repairs, the prevention of capilary oozing of blood at postoperative adhesions；Gynaecology is used to viscous stifled fallopian tubal and completes ligation；Gear division is used for tooth
Repairing；The combination and positioning of bone, joint in bone surgery.Bone adhesive requires have good biocompatibility.It can
Degradability, no dysentery and cytotoxicity, without carcinogenic teratogenesis, and may be implemented quick-binding, not shadow at normal temperatures and pressures
Growth of spur is rung, it is degradable within a certain period of time, have good adhesive strength and persistence to guarantee union.
Adhesive type used at present is mainly a- cyanoacrylate vinegar class, bone cement class etc..A- cyanoacrylate vinegar
Class is a kind of instantaneous glue bull agent, and normal temperature solidified, with preferable histocompatbility, curing rate is fast, intensity is high, and is had certain
Bacteriostasis, easy to use, be applied to many medical fields mainly as hemostat and tissue bonding agent, achieve significant
Clinical effectiveness.Under compressive loading, pass through the mechanics to a- alpha-cyanoacrylate n-octyl glue sticking people's middle tibia butterfly fracture
Analytical proof, incompressible intensity can be significantly improved by being bonded shin bone fragment with it.The compressive load that can be born before colloid fracture can
To meet Human Physiology and the clinical fixed requirement of fragment of fracturing.Although a- cyanoacrylate vinegar class adhesive is in adhering speed
Fastly, this big two aspect of adhesive strength is splendid, but its solidification process is an exothermic reaction, and the heat of generation is to adjacent tissue around
There is thermal burn effect；Solidfied material is really up to the mark, and the rough surface of bonding agent polymer wears surrounding soft tissue repeatedly can cause machinery
Damage；Surface of a wound hemostasis is incomplete, and the formaldehyde that the hydrolysis of cured polymer generates has the shortcomings that toxicity, to a certain extent
It is limited in the application of orthopaedics.
Bone cement class orthopaedics adhesive is broadly divided into poly- methyl-prop as a kind of novel bone tissue reparation and alternative materials
E pioic acid methyl ester, calcium phosphate bone cement (CPC) and magnesium phosphate cement (MPC).CPC and MPC have good biocompatibility and
Osteoconductive, biological safety, energy random-shaping, isothermal in the curing process, it has also become clinical tissue is repaired field and ground
Study carefully and one of the hot spot applied.But be conventionally present brittleness is big, water resistant dissolubility (blood dissolubility) is poor, mechanical property is insufficient, degradation slowly
The disadvantages of, its extensive use clinically is limited, and compound bone cement is beneficial to improve its performance.
Currently used jointing material respectively has its advantage and disadvantage, though chemically jointing material bonding force is stronger, and it is extremely difficult in vivo
It absorbs, there is certain toxic side effect more；Proteinaceous jointing material may cause strong allergy and immune response or virus infection,
Bonding force is too small to be difficult to the bone block that is adhesively fixed, for bone tissue complexity structure merely a kind of material hardly consistent with bone tissue reparation
It needs.
The disclosure of background above technology contents is only used for auxiliary and understands inventive concept and technical solution of the invention, not
The prior art for necessarily belonging to present patent application shows above content in the applying date of present patent application in no tangible proof
In the case where having disclosed, above-mentioned background technique should not be taken to the novelty and creativeness of evaluation the application.
Summary of the invention
The present invention in view of the problems of the existing technology, provide it is a kind of with promote bone uptake function orthopaedics adhesive and
Preparation method.Adhesive provided by the invention have caking property it is good, without secondary toxic action, good biocompatibility, antibiotic property is good, can promote
Into growth of spur, the advantages that accelerating bone healing, anti-good water solubility.
In order to achieve the goal above, The technical solution adopted by the invention is as follows:
A kind of orthopaedics adhesive with promotion bone uptake function, the raw material including following parts by weight: modified phosphate magnesium
40-60 parts of bone cement, 10-20 parts of nanometer calcium carbonate, 10-20 parts of sodium alginate, 1-3 parts of sodium selenite, 3-5 parts of pearl powder, wheat
3-5 parts of meal stone, 5-10 parts of Sodium Polyacrylate, 1-3 parts of calcium lignosulfonate, 1-3 parts of glycerol, 3-5 parts of chitosan, lecithin 3-5
Part, 1-3 parts of sapindoside, 5-10 parts of Arabic gum and 10-15 parts of collagen.
Preferably, the modified phosphate magnesium bone cement is by magnesium phosphate cement by redispersible latex powder and polyoxy
Propylene glycerin ether is modified.
Preferably, the modifying agent usage amount is the 2-4% of magnesium phosphate cement weight.
Preferably, the mass ratio of redispersible latex powder and polypropylene glycerol aether is 1-3:1 in the modifying agent.
Preferably, the redispersible latex powder is ethylene-vinyl acetate copolymer, vinylacetate-ethylene-
Methylmethacrylate copolymer, vinylacetate-ethylene-acrylate copolymer and vinyl acetate-acrylate-uncle
One of ethylene carbonate ester copolymer or multiple combinations.
The preparation method with the orthopaedics adhesive for promoting bone uptake function of the present invention, includes the following steps:
(1) redispersible latex powder and polypropylene glycerol aether are added in magnesium phosphate cement base-material, stirs evenly,
Obtain modified phosphate magnesium bone cement；
(2) modified phosphate magnesium bone cement, nanometer calcium carbonate, sodium alginate, sodium selenite, pearl powder, medical stone are added
Ball mill is crushed to 100-250 mesh, obtains mixed powder；
(3) Sodium Polyacrylate, calcium lignosulfonate, glycerol, chitosan, lecithin, soapberry are added in mixed powder
Saponin(e, Arabic gum and collagen are added water and stir into paste, and microwave drying is cooled to room temperature, and both obtains orthopaedics adhesive.
Preferably, the microwave drying be temperature be at 80-120 DEG C it is dry.
Compared with prior art, it advantages of the present invention and has the beneficial effect that
1, the present invention is with modified phosphate magnesium bone cement, nanometer calcium carbonate, sodium alginate, sodium selenite, pearl powder, medical stone
Equal raw materials are prepared, orthopaedics jointing material obtained have caking property it is good, without secondary toxic action, good biocompatibility, antibiotic property
Well, the advantages that growth of spur, accelerating bone healing can be promoted, market prospects are extensive.
2, the magnesium phosphate cement that the present invention uses passes through changes by redispersible latex powder and polypropylene glycerol aether
Property, improves the adhesiveness, flexural strength, plasticity, toughness of bone cement, while improving the compatible of bone cement and other components
Property.
3, the sodium selenite that the present invention is added, can be improved the immunity of patient's body, the growth of quick bone tissue.It is added
Pearl powder be rich in a variety of amino acid and microelement, can not only promote growth of spur, accelerating bone healing, also there is sterilization
Disinfection.The medical stone main component of addition includes SiO2、Al2O3、Fe2O3、 FeO、MgO、CaO、K2O、Na2O、TiO2、
P2O5, MnO etc., also containing whole macroelements needed for animal, such as: K, Na, Ca, Mg, Cu, Mo microelement and rare earth member
Element；Medical stone can not only adjustable body metabolism, accelerate osteoblastic proliferation accelerate its atomization, with promote
The formation of new bone and growth of spur, and osteoblast can be promoted to secrete vascular endothelial growth factor, and then bone is promoted to repair, also to thin
Bacterium has very strong bactericidal effect.
4, the Sodium Polyacrylate and sodium alginate that the present invention is added can form the alginic acid magnesium being not soluted in water with magnesium ion
Hydrogel, and then effectively prevent temper defeated and dispersed by water erosion, improve the water resistant dissolubility of magnesium phosphate cement.
5, calcium lignosulfonate, glycerol, chitosan, lecithin, sapindoside, Arabic gum and glue that the present invention is added
Former albumen has good biocompatibility, biodegradable and bioactivity, can promote the life of bone surrounding tissue
It is long, accelerating bone healing.
Specific embodiment
Invention is further described in detail With reference to embodiment.It is emphasized that following the description is only
It is merely exemplary, the range and its application being not intended to be limiting of the invention.
Embodiment 1
A kind of orthopaedics adhesive with promotion bone uptake function, the raw material including following parts by weight: modified phosphate magnesium
55 parts of bone cement, 15 parts of nanometer calcium carbonate, 18 parts of sodium alginate, 1.5 parts of sodium selenite, 4 parts of pearl powder, 4 parts of medical stone, poly- third
8 parts of olefin(e) acid sodium, 1.5 parts of calcium lignosulfonate, 2.5 parts of glycerol, 4 parts of chitosan, 3 parts of lecithin, 2 parts of sapindoside, I
8 parts and 15 parts of collagen of primary glue.
The modified phosphate magnesium bone cement be by magnesium phosphate cement by mass ratio be 2:1 redispersible latex powder and
Polypropylene glycerol aether is modified.Redispersible latex powder is ethylene-vinyl acetate copolymer, and modifying agent usage amount is phosphoric acid
The 3% of magnesium bone cement weight.
Preparation method includes the following steps:
(1) redispersible latex powder and polypropylene glycerol aether are added in magnesium phosphate cement base-material, stirs evenly,
Obtain modified phosphate magnesium bone cement；
(2) modified phosphate magnesium bone cement, nanometer calcium carbonate, sodium alginate, sodium selenite, pearl powder, medical stone are added
Ball mill is crushed to 200 mesh, obtains mixed powder；
(3) Sodium Polyacrylate, calcium lignosulfonate, glycerol, chitosan, lecithin, soapberry are added in mixed powder
Saponin(e, Arabic gum and collagen are added water and stir into paste, and microwave drying is cooled to room temperature, and both obtains orthopaedics adhesive.
Embodiment 2
A kind of orthopaedics adhesive with promotion bone uptake function, the raw material including following parts by weight: modified phosphate magnesium
60 parts of bone cement, 15 parts of sodium alginate, 2.5 parts of sodium selenite, 3.5 parts of pearl powder, 3 parts of medical stone, gathers at 10 parts of nanometer calcium carbonate
6 parts of sodium acrylate, 2.5 parts of calcium lignosulfonate, 2 parts of glycerol, 3 parts of chitosan, 5 parts of lecithin, 1.5 parts of sapindoside, Ah
Draw 6 parts and 12 parts of collagen of primary glue.
The modified phosphate magnesium bone cement be by magnesium phosphate cement by mass ratio be 3:1 redispersible latex powder and
Polypropylene glycerol aether is modified.Redispersible latex powder is vinylacetate-ethylene-methylmethacrylate copolymer,
Modifying agent usage amount is the 2% of magnesium phosphate cement weight.
Preparation method includes the following steps:
(1) redispersible latex powder and polypropylene glycerol aether are added in magnesium phosphate cement base-material, stirs evenly,
Obtain modified phosphate magnesium bone cement；
(2) modified phosphate magnesium bone cement, nanometer calcium carbonate, sodium alginate, sodium selenite, pearl powder, medical stone are added
Ball mill is crushed to 200 mesh, obtains mixed powder；
(3) Sodium Polyacrylate, calcium lignosulfonate, glycerol, chitosan, lecithin, soapberry are added in mixed powder
Saponin(e, Arabic gum and collagen are added water and stir into paste, and microwave drying is cooled to room temperature, and both obtains orthopaedics adhesive.
Embodiment 3
A kind of orthopaedics adhesive with promotion bone uptake function, the raw material including following parts by weight: modified phosphate magnesium
45 parts of bone cement, 15 parts of nanometer calcium carbonate, 12 parts of sodium alginate, 2 parts of sodium selenite, 4 parts of pearl powder, 5 parts of medical stone, poly- third
8 parts of olefin(e) acid sodium, 3 parts of calcium lignosulfonate, 1.5 parts of glycerol, 4 parts of chitosan, 4 parts of lecithin, 2 parts of sapindoside, Arab
8 parts and 15 parts of collagen of glue.
The modified phosphate magnesium bone cement be by magnesium phosphate cement by mass ratio be 1:1 redispersible latex powder and
Polypropylene glycerol aether is modified.Redispersible latex powder is vinylacetate-ethylene-methylmethacrylate copolymer,
Modifying agent usage amount is the 3% of magnesium phosphate cement weight.
Preparation method includes the following steps:
(1) redispersible latex powder and polypropylene glycerol aether are added in magnesium phosphate cement base-material, stirs evenly,
Obtain modified phosphate magnesium bone cement；
(2) modified phosphate magnesium bone cement, nanometer calcium carbonate, sodium alginate, sodium selenite, pearl powder, medical stone are added
Ball mill is crushed to 250 mesh, obtains mixed powder；
(3) Sodium Polyacrylate, calcium lignosulfonate, glycerol, chitosan, lecithin, soapberry are added in mixed powder
Saponin(e, Arabic gum and collagen are added water and stir into paste, and microwave drying is cooled to room temperature, and both obtains orthopaedics adhesive.
Embodiment 4
A kind of orthopaedics adhesive with promotion bone uptake function, the raw material including following parts by weight: modified phosphate magnesium
40 parts of bone cement, 20 parts of nanometer calcium carbonate, 18 parts of sodium alginate, 1.5 parts of sodium selenite, 5 parts of pearl powder, 3 parts of medical stone, poly- third
10 parts of olefin(e) acid sodium, 1.5 parts of calcium lignosulfonate, 1 part of glycerol, 5 parts of chitosan, 3 parts of lecithin, 1.5 parts of sapindoside, I
10 parts and 10 parts of collagen of primary glue.
The modified phosphate magnesium bone cement be by magnesium phosphate cement by mass ratio be 3:1 redispersible latex powder and
Polypropylene glycerol aether is modified.Redispersible latex powder is vinylacetate-ethylene-acrylate copolymer, and modifying agent makes
Dosage is the 4% of magnesium phosphate cement weight.
Preparation method includes the following steps:
(1) redispersible latex powder and polypropylene glycerol aether are added in magnesium phosphate cement base-material, stirs evenly,
Obtain modified phosphate magnesium bone cement；
(2) modified phosphate magnesium bone cement, nanometer calcium carbonate, sodium alginate, sodium selenite, pearl powder, medical stone are added
Ball mill is crushed to 160 mesh, obtains mixed powder；
(3) Sodium Polyacrylate, calcium lignosulfonate, glycerol, chitosan, lecithin, soapberry are added in mixed powder
Saponin(e, Arabic gum and collagen are added water and stir into paste, and microwave drying is cooled to room temperature, and both obtains orthopaedics adhesive.
Embodiment 5
A kind of orthopaedics adhesive with promotion bone uptake function, the raw material including following parts by weight: modified phosphate magnesium
50 parts of bone cement, 12 parts of nanometer calcium carbonate, 20 parts of sodium alginate, 1.5 parts of sodium selenite, 4 parts of pearl powder, 5 parts of medical stone, poly- third
8 parts of olefin(e) acid sodium, 2 parts of calcium lignosulfonate, 1.5 parts of glycerol, 5 parts of chitosan, 4 parts of lecithin, 2.5 parts of sapindoside, I
8 parts and 10 parts of collagen of primary glue.
The modified phosphate magnesium bone cement be by magnesium phosphate cement by mass ratio be 2:1 redispersible latex powder and
Polypropylene glycerol aether is modified.Redispersible latex powder is vinyl acetate-acrylate-vinyl versatate copolymer,
Modifying agent usage amount is the 3.5% of magnesium phosphate cement weight.
Preparation method includes the following steps:
(1) redispersible latex powder and polypropylene glycerol aether are added in magnesium phosphate cement base-material, stirs evenly,
Obtain modified phosphate magnesium bone cement；
(2) modified phosphate magnesium bone cement, nanometer calcium carbonate, sodium alginate, sodium selenite, pearl powder, medical stone are added
Ball mill is crushed to 120 mesh, obtains mixed powder；
(3) Sodium Polyacrylate, calcium lignosulfonate, glycerol, chitosan, lecithin, soapberry are added in mixed powder
Saponin(e, Arabic gum and collagen are added water and stir into paste, and microwave drying is cooled to room temperature, and both obtains orthopaedics adhesive.
Comparative example
This comparative example difference from Example 5 is: magnesium phosphate cement used is without any modification.
Orthopaedics adhesive made from embodiment 1-5 and comparative example is conventionally tested for the property, test result
As shown in the table.
Table 1: the performance test results of jointing material produced by the present invention
Learnt from above-mentioned test result, orthopaedics adhesive produced by the present invention have caking property it is good, without secondary toxic action, antibacterial
Effect is strong.
The above content is combine it is specific/further detailed description of the invention for preferred embodiment, cannot
Assert that specific implementation of the invention is only limited to these instructions.General technical staff of the technical field of the invention is come
It says, without departing from the inventive concept of the premise, some replacements or modifications can also be made to the embodiment that these have been described,
And these substitutions or variant are regarded as belonging to the scope of protection of the present invention.
Claims (7)
1. a kind of with the orthopaedics adhesive for promoting bone uptake function, it is characterised in that: the raw material including following parts by weight: change
Property 40-60 parts of magnesium phosphate cement, 10-20 parts of nanometer calcium carbonate, 10-20 parts of sodium alginate, 1-3 parts of sodium selenite, pearl powder
3-5 parts, 3-5 parts of medical stone, 5-10 parts of Sodium Polyacrylate, 1-3 parts of calcium lignosulfonate, 1-3 parts of glycerol, 3-5 parts of chitosan, ovum
- 5 parts of phosphatidase 3,1-3 parts of sapindoside, 5-10 parts of Arabic gum and 10-15 parts of collagen.
2. having the orthopaedics adhesive for promoting bone uptake function according to claim 1, it is characterised in that: the modified phosphate
Magnesium bone cement is that magnesium phosphate cement is modified by redispersible latex powder and polypropylene glycerol aether.
3. having the orthopaedics adhesive for promoting bone uptake function according to claim 2, it is characterised in that: the modifying agent makes
Dosage is the 2-4% of magnesium phosphate cement weight.
4. according to right want 2 described in have promote bone uptake function orthopaedics adhesive, it is characterised in that: can in the modifying agent
The mass ratio of redispersibility latex powder and polypropylene glycerol aether is 1-3:1.
5. having the orthopaedics adhesive for promoting bone uptake function according to claim 4, it is characterised in that: described redispersible
Property latex powder be ethylene-vinyl acetate copolymer, vinylacetate-ethylene-methylmethacrylate copolymer, acetic acid second
One of enester-vinyl-acrylate copolymer and vinyl acetate-acrylate-vinyl versatate copolymer are more
Kind combination.
6. having the preparation method for the orthopaedics adhesive for promoting bone uptake function according to claim 1, it is characterised in that: packet
Include following steps:
(1) redispersible latex powder and polypropylene glycerol aether are added in magnesium phosphate cement base-material, stirs evenly, must change
Property magnesium phosphate cement；
(2) ball milling is added in modified phosphate magnesium bone cement, nanometer calcium carbonate, sodium alginate, sodium selenite, pearl powder, medical stone
Machine is crushed to 100-250 mesh, obtains mixed powder；
(3) in mixed powder be added Sodium Polyacrylate, calcium lignosulfonate, glycerol, chitosan, lecithin, sapindoside,
Arabic gum and collagen are added water and stir into paste, and microwave drying is cooled to room temperature, and both obtains orthopaedics adhesive.
7. having the preparation method for the orthopaedics adhesive for promoting bone uptake function according to claim 5, it is characterised in that: institute
State microwave drying be temperature be at 80-120 DEG C it is dry.
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Cited By (3)
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| CN111388746A (en) * | 2020-03-24 | 2020-07-10 | 刘涛 | Pain-relieving medical orthopedic adhesive containing turpentine |
| CN114377213A (en) * | 2022-02-25 | 2022-04-22 | 苏州大学附属第一医院 | Novel selenium-enhanced bioactive bone cement and preparation method thereof |
| CN114470307A (en) * | 2022-04-06 | 2022-05-13 | 天新福（北京）医疗器材股份有限公司 | Degradable hemostatic plugging adhesive and preparation method thereof |
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| CN114377213A (en) * | 2022-02-25 | 2022-04-22 | 苏州大学附属第一医院 | Novel selenium-enhanced bioactive bone cement and preparation method thereof |
| CN114470307A (en) * | 2022-04-06 | 2022-05-13 | 天新福（北京）医疗器材股份有限公司 | Degradable hemostatic plugging adhesive and preparation method thereof |
| CN114470307B (en) * | 2022-04-06 | 2022-06-24 | 天新福（北京）医疗器材股份有限公司 | Degradable hemostatic plugging adhesive and preparation method thereof |
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