CN107027901A - A kind of sesame oil with anti-inflammatory and repair of neuron damage effect and preparation method thereof - Google Patents
A kind of sesame oil with anti-inflammatory and repair of neuron damage effect and preparation method thereof Download PDFInfo
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- A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
- A23D9/007—Other edible oils or fats, e.g. shortenings, cooking oils characterised by ingredients other than fatty acid triglycerides
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The present invention relates to edible oil and fat technical field, and in particular to a kind of sesame oil with anti-inflammatory and repair of neuron damage effect and preparation method thereof oil and preparation method thereof, composed of the following components：Sesame, almond, Chinese ephedra, the root of kudzu vine, radix glycyrrhizae, fibert and vegetable seed；The sesame oil that the present invention makes is by promoting the increase and expression of BDNF after Hypoxia and ischemia to strengthen, expression of brain-derived neurotrophic factor enhancing can not only mitigate the degree of injury of Affected neurons, the neuron of damage is repaired in induction, injury of lungs coefficient can also substantially be reduced, neutrophil accumulation is reduced, the peroxidating of lipid is reduced；In addition, the generation by suppressing oxygen radical, scorching medium, TNF, increases the content of glutathione peroxidase, so as to reach effect of anti-inflammatory；The present invention is higher than traditional handicraft using the technique such as biofermentation and the concentration of three-level film, the purity of the ephedrine of extraction, and the highest recovery rate of ephedrine is 98.53%.
Description
Technical field
The present invention relates to edible oil and fat technical field, and in particular to a kind of with anti-inflammatory and repair of neuron damage effect
Sesame oil and preparation method thereof oil and preparation method thereof.
Background technology
Sesame oil, the north sesame oil sesame oil that are referred to as are extract more from sesame, with special fragrance, therefore referred to as sesame oil.
Milling process, filter press technique and water substitution are generally divided into by extracting process, ground sesameseed oil is the sesame oil that traditional handicraft water substitution makes.Its
Middle Nanyang scented oil fragrance is genuine, comes from the sesame that Nanyang Basin local climate is grown, and Nanyang Basin is located at the Henan Province west and south,
It is located between Qinling Mountains mountain range and Tongbai mountain range, has a moderate climate, environment is pleasant, soil property is fertile, is particularly suitable for the growth of sesame, it is true
Stand as Chinese Academy of Sciences's sesame science and technology plantation Demonstration Base, the genuine famous product in Oleum Sesami meaning Nanyang；Sesame oil colours such as amber, it is orange micro-
Red, crystal clear, giving off a strong fragrance is mellow, prolonged not dissipate.Available for cool Hot dishes meat and fish dishes is modulated, go urine smell and give birth to fragrance；Soup is added on, is increased fresh
It is agreeable to the taste；For cooking, frying, taste is pure and color just, be the treasure in edible oil.Sesame oil contains unrighted acid needed by human
And amino acid, occupy first of each vegetable oil.Also containing the trace element such as abundant vitamin and iron, zinc, copper needed by human, its
Cholesterol level is loved by people well below animal tallow.
Sesame oil prepared by prior art typically all only focuses on its use value, often ignores its medical value.
The content of the invention
For above-mentioned problem, a kind of sesame oil with anti-inflammatory and repair of neuron damage effect prepared by the present invention
With anti-inflammatory and repair of neuron damage effect.
To achieve the above object, the present invention uses following technical scheme：
A kind of sesame oil with anti-inflammatory and repair of neuron damage effect, its composition is by weight:Sesame 70~90
Part, 30~38 parts of almond, 8~15 parts of Chinese ephedra, 6~10 parts of the root of kudzu vine, 12~16 parts of radix glycyrrhizae, 8~12 parts of fibert and vegetable seed 16~25
Part.
It is preferred that, a kind of sesame oil with anti-inflammatory and repair of neuron damage effect, its preparation method comprises the following steps：
A, cleaning and drying：Respectively by sesame, almond, Chinese ephedra, the root of kudzu vine, radix glycyrrhizae, fibert, vegetable seed as in clear water, with sieve
Net filters out shrivelled component, and then each group is placed in baking oven respectively, under conditions of 40~55 DEG C, and baking 15~
20min, after baking is finished, each component is taken out from baking oven, and places respectively；
B, crushing and milling：Chinese ephedra, the root of kudzu vine, almond and radix glycyrrhizae are respectively placed in pulverizer and crushed, and will be crushed
Each component afterwards is individually deposited, and then different component is individually placed in material grinder and carries out abrasive material, by each component list after abrasive material
Solely deposit in standby in dry environment；
C, almond processing：Almond powder is handled by sieving, water is added thereto, 74~86 DEG C are warming up to, decoct 25~
30min, is then heated up with 2 DEG C/min speed, when temperature rises to 96 DEG C, is dried, is obtained after stopping heating, 15~20min of insulation
To component A；
D, ephedrine extraction and enrichment：
1) extraction of ephedrine：By the Chinese ephedra powder obtained after step b processing, biology is sent out under conditions of 28~38 DEG C
18~26h of ferment, adds then and thereto the water of 6~9 times of quality, is warming up to 55~65 DEG C, 120~150min is extracted with water,
60~90min is incubated, component B is obtained；
2) component B is subjected to pre-filtering with filter, removes the fine particles on liquid level, then by the concentration of three-level film,
After being concentrated into the 30~38% of total amount, stop concentration, obtain concentrate；
3) it is the sodium hydroxide that the 4~8% of concentrate quality, mass fraction is 7~15% that quality is added into concentrate,
Flushed three times after being warming up to 20~30 DEG C, 70~100min of immersion with the clear water that quality is three times concentrate, obtain component C；
4) ethyl acetate that quality is twice of component C is added into component C and shakes 15~20min and then adds quality and is
Component C 3~7% oxalic acid solution, fully shaking, shake up after, stand 25~35min after, dry chlorination is passed through thereto
Hydrogen, by the solid of precipitation by filtering, drying, produces ephedrine；
E, the kudzu-vine root powder and hay powder in step b be respectively placed in 50% ethanol, 25~36 DEG C be warming up to, in heating
Stop stirring after stirring, 30~40min, obtain component D；
F, sesame, fibert, component A and vegetable seed are respectively put into pot carry out frying, each component after frying is sent respectively
Remove bushel iron to magnetic room, be then fed into oil press, crude oil of squeezing out, then crude oil refined, is decolourized, separating treatment, obtain not
With the expressed oil of component；
G, ephedrine, component D mixed while stirring with each component expressed oil obtained in step f, then thereto plus
Enter the ethanol that twice of concentration that quality is component D is 80~90%, be warming up to boiling, keep 30~40min of boiling, heated
Bi Hou, produces sesame oil finished product.
It is preferred that, the step 4 in the extraction and enrichment of the ephedrine) in be passed through hydrogen chloride gas speed be 40mL/
min。
It is preferred that, the mesh number of the screen cloth in the step a is 20 mesh.
It is preferred that, the heating rate in the step g is 5 DEG C/min, and stir speed (S.S.) is 30r/min.
It is preferred that, the step 4 in the extraction and enrichment of the ephedrine) select oxalic acid solution concentration be 0.9mol/
L。
Using above-mentioned technical scheme, the beneficial effect that the present invention reaches is：
1st, the Puerarin in the ephedrine and the root of kudzu vine in Chinese ephedra is compatible, to hippocampus after neonates with HIBD
Somatic nerves cell has protective effect, by promoting the increase and expression of BDNF after Hypoxia and ischemia to strengthen,
Expression of brain-derived neurotrophic factor enhancing can not only mitigate the degree of injury of Affected neurons, moreover it is possible to which damage is repaired in induction
Neuron.
2nd, almond and the mutual compatibility of Chinese ephedra, can be by directly acting on target cell or indirectly the reduction oxygen of regulation inflammatory factor
The generation of free radical, adjusts the generation of inflammatory mediator, it can in addition contain substantially reduction injury of lungs coefficient, reduces neutrophil leucocyte and gathers
Collection, reduces the peroxidating of lipid, is improved ALI histologic lesion, therefore, ephedrine and almond in Chinese ephedra
In almond glycosides cooperate have good antiinflammatory action.
3rd, hay and active ingredient both during Chinese ephedra compatibility are by suppressing oxygen radical, scorching medium, TNF
Generation, increase glutathione peroxidase content, so as to reach effect of anti-inflammatory.
4th, the present invention is using the technique such as biofermentation and the concentration of three-level film, and the purity of the ephedrine of extraction is higher than traditional work
Skill, then ephedrine cell is lost activity by sodium hydroxide so that the cell liquid outflow in ephedrine cell, then pass through acetic acid
Ethyl ester is extracted, and the highest recovery rate for obtaining ephedrine is 98.53%.
Embodiment
To make the purpose, technical scheme and advantage of the embodiment of the present invention clearer, below in conjunction with the embodiment of the present invention,
Technical scheme in the embodiment of the present invention is clearly and completely described.Based on embodiments of the invention, the common skill in this area
The every other embodiment that art personnel are obtained under the premise of creative work is not made, belongs to the model that the present invention is protected
Enclose.
Embodiment 1：
A kind of sesame oil with anti-inflammatory and repair of neuron damage effect, its composition is by weight:70 parts of sesame, almond
18 parts of 32 parts, 10 parts of Chinese ephedra, 7 parts of the root of kudzu vine, 12 parts of radix glycyrrhizae, 9 parts of fibert and vegetable seed.
It is preferred that, a kind of described sesame oil with anti-inflammatory and repair of neuron damage effect, its preparation method include with
Lower step：
A, cleaning and drying：Respectively by sesame, almond, Chinese ephedra, the root of kudzu vine, radix glycyrrhizae, fibert, vegetable seed as in clear water, with sieve
Net filters out shrivelled component, and then each group is placed in baking oven respectively, under conditions of 40 DEG C, toasts 15min, has toasted
Bi Hou, each component is taken out from baking oven, and places respectively；
B, crushing and milling：Chinese ephedra, the root of kudzu vine, almond and radix glycyrrhizae are respectively placed in pulverizer and crushed, and will be crushed
Each component afterwards is individually deposited, and then different component is individually placed in material grinder and carries out abrasive material, by each component list after abrasive material
Solely deposit in standby in dry environment；
C, almond processing：Almond powder is handled by sieving, water is added thereto, 74 DEG C are warming up to, 25min is decocted, so
Heated up afterwards with 2 DEG C/min speed, when temperature rises to 96 DEG C, dried after stopping heating, insulation 15min, obtain component A；
D, ephedrine extraction and enrichment：
1) extraction of ephedrine：By the obtained Chinese ephedra powder biofermentation under conditions of 28 DEG C after step b processing
18h, adds then and thereto the water of 6~9 times of quality, is warming up to 55 DEG C, 120min is extracted with water, be incubated 60min, obtain component
B；
2) component B is subjected to pre-filtering with filter, removes the fine particles on liquid level, then by the concentration of three-level film,
After being concentrated into the 30% of total amount, stop concentration, obtain concentrate；
3) it is the sodium hydroxide that the 4% of concentrate quality, mass fraction is 7% quality to be added into concentrate, is warming up to
20 DEG C, flushed three times after soaking 70min with the clear water that quality is three times concentrate, obtain component C；
4) it is component C that ethyl acetate concussion 15min that quality is twice of component C is added into component C and then quality is added
3% oxalic acid solution, fully shaking, shake up after, stand 25min after, dry hydrogen chloride gas is passed through thereto, will be separated out
Solid by filtering, dry, produce ephedrine；
E, the kudzu-vine root powder and hay powder in step b be respectively placed in 50% ethanol, be warming up to 25 DEG C, stirred in heating
Mix, stop stirring after 30min, obtain component D；
F, sesame, fibert, component A and vegetable seed are respectively put into pot carry out frying, each component after frying is sent respectively
Remove bushel iron to magnetic room, be then fed into oil press, crude oil of squeezing out, then crude oil refined, is decolourized, separating treatment, obtain not
With the expressed oil of component；
G, ephedrine, component D mixed while stirring with each component expressed oil obtained in step f, then thereto plus
Enter the ethanol that twice of concentration that quality is component D is 80%, be warming up to boiling, keep boiling 30min, after heating is finished, i.e.,
Obtain sesame oil finished product.
Embodiment 2：
A kind of sesame oil with anti-inflammatory and repair of neuron damage effect, its composition is by weight:78 parts of sesame, almond
16 parts of 30 parts, 8 parts of Chinese ephedra, 6 parts of the root of kudzu vine, 13 parts of radix glycyrrhizae, 8 parts of fibert and vegetable seed.
It is preferred that, a kind of described sesame oil with anti-inflammatory and repair of neuron damage effect, its preparation method include with
Lower step：
A, cleaning and drying：Respectively by sesame, almond, Chinese ephedra, the root of kudzu vine, radix glycyrrhizae, fibert, vegetable seed as in clear water, with sieve
Net filters out shrivelled component, and then each group is placed in baking oven respectively, under conditions of 45 DEG C, toasts 16min, has toasted
Bi Hou, each component is taken out from baking oven, and places respectively；
B, crushing and milling：Chinese ephedra, the root of kudzu vine, almond and radix glycyrrhizae are respectively placed in pulverizer and crushed, and will be crushed
Each component afterwards is individually deposited, and then different component is individually placed in material grinder and carries out abrasive material, by each component list after abrasive material
Solely deposit in standby in dry environment；
C, almond processing：Almond powder is handled by sieving, water is added thereto, 76 DEG C are warming up to, 26min is decocted, so
Heated up afterwards with 2 DEG C/min speed, when temperature rises to 96 DEG C, dried after stopping heating, insulation 16min, obtain component A；
D, ephedrine extraction and enrichment：
1) extraction of ephedrine：By the obtained Chinese ephedra powder biofermentation under conditions of 30 DEG C after step b processing
20h, adds then and thereto the water of 7 times of quality, is warming up to 57 DEG C, 128min is extracted with water, be incubated 68min, obtain component B；
2) component B is subjected to pre-filtering with filter, removes the fine particles on liquid level, then by the concentration of three-level film,
After being concentrated into the 32% of total amount, stop concentration, obtain concentrate；
3) it is the sodium hydroxide that the 5% of concentrate quality, mass fraction is 10% quality to be added into concentrate, is warming up to
25 DEG C, flushed three times after soaking 82min with the clear water that quality is three times concentrate, obtain component C；
4) it is component C that ethyl acetate concussion 16min that quality is twice of component C is added into component C and then quality is added
4% oxalic acid solution, fully shaking, shake up after, stand 27min after, dry hydrogen chloride gas is passed through thereto, will be separated out
Solid by filtering, dry, produce ephedrine；
E, the kudzu-vine root powder and hay powder in step b be respectively placed in 50% ethanol, be warming up to 28 DEG C, heat while stirring
Stop stirring after 33min, obtain component D；
F, sesame, fibert, component A and vegetable seed are respectively put into pot carry out frying, each component after frying is sent respectively
Remove bushel iron to magnetic room, be then fed into oil press, crude oil of squeezing out, then crude oil refined, is decolourized, separating treatment, obtain not
With the expressed oil of component；
G, ephedrine, component D mixed while stirring with each component expressed oil obtained in step f, then thereto plus
Enter the ethanol that twice of concentration that quality is component D is 83%, be warming up to boiling, keep boiling 33min, after heating is finished, i.e.,
Obtain sesame oil finished product.
Embodiment 3：
A kind of sesame oil with anti-inflammatory and repair of neuron damage effect, its composition is by weight:90 parts of sesame, almond
23 parts of 36 parts, 15 parts of Chinese ephedra, 10 parts of the root of kudzu vine, 16 parts of radix glycyrrhizae, 10 parts of fibert and vegetable seed.
It is preferred that, a kind of described sesame oil with anti-inflammatory and repair of neuron damage effect, its preparation method include with
Lower step：
A, cleaning and drying：Respectively by sesame, almond, Chinese ephedra, the root of kudzu vine, radix glycyrrhizae, fibert, vegetable seed as in clear water, with sieve
Net filters out shrivelled component, and then each group is placed in baking oven respectively, under conditions of 53 DEG C, toasts 19min, has toasted
Bi Hou, each component is taken out from baking oven, and places respectively；
B, crushing and milling：Chinese ephedra, the root of kudzu vine, almond and radix glycyrrhizae are respectively placed in pulverizer and crushed, and will be crushed
Each component afterwards is individually deposited, and then different component is individually placed in material grinder and carries out abrasive material, by each component list after abrasive material
Solely deposit in standby in dry environment；
C, almond processing：Almond powder is handled by sieving, water is added thereto, 84 DEG C are warming up to, 28min is decocted, so
Heated up afterwards with 2 DEG C/min speed, when temperature rises to 96 DEG C, dried after stopping heating, insulation 18min, obtain component A；
D, ephedrine extraction and enrichment：
1) extraction of ephedrine：By the obtained Chinese ephedra powder biofermentation under conditions of 36 DEG C after step b processing
24h, adds then and thereto the water of 8 times of quality, is warming up to 63 DEG C, 145min is extracted with water, be incubated 85min, obtain component B；
2) component B is subjected to pre-filtering with filter, removes the fine particles on liquid level, then by the concentration of three-level film,
After being concentrated into the 36% of total amount, stop concentration, obtain concentrate；
3) it is the sodium hydroxide that the 7% of concentrate quality, mass fraction is 13% quality to be added into concentrate, is warming up to
28 DEG C, flushed three times after soaking 92min with the clear water that quality is three times concentrate, obtain component C；
4) it is component C that ethyl acetate concussion 18min that quality is twice of component C is added into component C and then quality is added
6% oxalic acid solution, fully shaking, shake up after, stand 33min after, dry hydrogen chloride gas is passed through thereto, will be separated out
Solid by filtering, dry, produce ephedrine；
E, the kudzu-vine root powder and hay powder in step b be respectively placed in 50% ethanol, be warming up to 34 DEG C, stirred in heating
Mix, stop stirring after 38min, obtain component D；
F, sesame, fibert, component A and vegetable seed are respectively put into pot carry out frying, each component after frying is sent respectively
Remove bushel iron to magnetic room, be then fed into oil press, crude oil of squeezing out, then crude oil refined, is decolourized, separating treatment, obtain not
With the expressed oil of component；
G, ephedrine, component D mixed while stirring with each component expressed oil obtained in step f, then thereto plus
Enter the ethanol that twice of concentration that quality is component D is 86%, be warming up to boiling, keep boiling 37min, after heating is finished, i.e.,
Obtain sesame oil finished product.
Embodiment 4：
A kind of sesame oil with anti-inflammatory and repair of neuron damage effect, its composition is by weight:86 parts of sesame, almond
25 parts of 38 parts, 13 parts of Chinese ephedra, 9 parts of the root of kudzu vine, 15 parts of radix glycyrrhizae, 12 parts of fibert and vegetable seed.
It is preferred that, a kind of described sesame oil with anti-inflammatory and repair of neuron damage effect, its preparation method include with
Lower step：
A, cleaning and drying：Respectively by sesame, almond, Chinese ephedra, the root of kudzu vine, radix glycyrrhizae, fibert, vegetable seed as in clear water, with sieve
Net filters out shrivelled component, and then each group is placed in baking oven respectively, under conditions of 55 DEG C, toasts 20min, has toasted
Bi Hou, each component is taken out from baking oven, and places respectively；
B, crushing and milling：Chinese ephedra, the root of kudzu vine, almond and radix glycyrrhizae are respectively placed in pulverizer and crushed, and will be crushed
Each component afterwards is individually deposited, and then different component is individually placed in material grinder and carries out abrasive material, by each component list after abrasive material
Solely deposit in standby in dry environment；
C, almond processing：Almond powder is handled by sieving, water is added thereto, 86 DEG C are warming up to, 30min is decocted, so
Heated up afterwards with 2 DEG C/min speed, when temperature rises to 96 DEG C, dried after stopping heating, insulation 20min, obtain component A；
D, ephedrine extraction and enrichment：
1) extraction of ephedrine：By the obtained Chinese ephedra powder biofermentation under conditions of 38 DEG C after step b processing
26h, adds then and thereto the water of 9 times of quality, is warming up to 65 DEG C, 150min is extracted with water, be incubated 90min, obtain component B；
2) component B is subjected to pre-filtering with filter, removes the fine particles on liquid level, then by the concentration of three-level film,
After being concentrated into the 38% of total amount, stop concentration, obtain concentrate；
3) it is the sodium hydroxide that the 8% of concentrate quality, mass fraction is 15% quality to be added into concentrate, is warming up to
30 DEG C, flushed three times after soaking 100min with the clear water that quality is three times concentrate, obtain component C；
4) it is component C that ethyl acetate concussion 20min that quality is twice of component C is added into component C and then quality is added
7% oxalic acid solution, fully shaking, shake up after, stand 35min after, dry hydrogen chloride gas is passed through thereto, will be separated out
Solid by filtering, dry, produce ephedrine；
E, the kudzu-vine root powder and hay powder in step b be respectively placed in 50% ethanol, be warming up to 36 DEG C, stirred in heating
Mix, stop stirring after 40min, obtain component D；
F, sesame, fibert, component A and vegetable seed are respectively put into pot carry out frying, each component after frying is sent respectively
Remove bushel iron to magnetic room, be then fed into oil press, crude oil of squeezing out, then crude oil refined, is decolourized, separating treatment, obtain not
With the expressed oil of component；
G, ephedrine, component D mixed while stirring with each component expressed oil obtained in step f, then thereto plus
Enter the ethanol that twice of concentration that quality is component D is 90%, be warming up to boiling, keep boiling 40min, after heating is finished, i.e.,
Obtain sesame oil finished product.
50 white mouse are divided into 5 groups at random, by one of which as a control group, remaining four groups are used as experimental group, control
Group feeds commercially available sesame oil three times daily, and experimental group feeds the sesame oil that embodiment 1,2,3 and 4 is prepared in three present invention daily,
The amount of feeding of control group and experimental group every time is equal.Contrast under the same conditions, obtain the brain source property god in hippocampus in mouse
Expression and paddy through trophic factors, the related X protein of B cell lymphoma and Caspase -3
The content of the sweet peptide peroxidase of Guang obtains following data：
The data in table, are higher than traditional handicraft using the recovery rate of the ephedrine prepared by the present invention.White mouse is in clothes
The sesame oil produced with the present invention is above taking city in BDNF and glutathione peroxidase content
Sell the white mouse of sesame oil；The expression of B cell lymphoma correlation X protein and Caspase -3 is equal
Less than the white mouse for taking commercially available sesame oil.Show that preparation technology of the present invention is more perfect, product overall performance than control group more preferably, is worth
Promote.
The above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although with reference to the foregoing embodiments
The present invention is described in detail, it will be understood by those within the art that：It still can be to foregoing each implementation
Technical scheme described in example is modified, or carries out equivalent substitution to which part technical characteristic；And these modification or
Replace, the essence of appropriate technical solution is departed from the spirit and scope of various embodiments of the present invention technical scheme.
Claims (6)
1. a kind of sesame oil with anti-inflammatory and repair of neuron damage effect, it is characterised in that its composition is by weight:Sesame
70~90 parts, 30~38 parts of almond, 8~15 parts of Chinese ephedra, 6~10 parts of the root of kudzu vine, 12~16 parts of radix glycyrrhizae, 8~12 parts of fibert and vegetable seed
16~25 parts.
2. a kind of sesame oil with anti-inflammatory and repair of neuron damage effect according to claim 1, its preparation method bag
Include following steps：
A, cleaning and drying：Sesame, almond, Chinese ephedra, the root of kudzu vine, radix glycyrrhizae, fibert, vegetable seed are incited somebody to action as in clear water with screen cloth respectively
Shrivelled component is filtered out, and then each group is placed in baking oven respectively, under conditions of 40~55 DEG C, toasts 15~20min, is dried
Bake after finishing, each component is taken out from baking oven, and places respectively；
B, crushing and milling：Chinese ephedra, the root of kudzu vine, almond and radix glycyrrhizae are respectively placed in pulverizer and crushed, and by after crushing
Each component is individually deposited, and then different component is individually placed in material grinder and carries out abrasive material, each component after abrasive material is individually deposited
It is put in standby in dry environment；
C, almond processing：Almond powder is handled by sieving, water is added thereto, 74~86 DEG C are warming up to, decoct 25~
30min, is then heated up with 2 DEG C/min speed, when temperature rises to 96 DEG C, is dried, is obtained after stopping heating, 15~20min of insulation
To component A；
D, ephedrine extraction and enrichment：
1) extraction of ephedrine：By the obtained Chinese ephedra powder biofermentation 18 under conditions of 28~38 DEG C after step b processing
~26h, adds then and thereto the water of 6~9 times of quality, is warming up to 55~65 DEG C, 120~150min, insulation are extracted with water
60~90min, obtains component B；
2) component B is subjected to pre-filtering with filter, removes the fine particles on liquid level, then by the concentration of three-level film, concentration
To the 30~38% of total amount, stop concentration, obtain concentrate；
3) it is the sodium hydroxide that the 4~8% of concentrate quality, mass fraction is 7~15%, heating that quality is added into concentrate
To 20~30 DEG C, flushed three times after 70~100min of immersion with the clear water that quality is three times concentrate, obtain component C；
4) it is component C that the ethyl acetate that quality is twice of component C is added into component C and shakes 15~20min and then adds quality
3~7% oxalic acid solution, fully shaking, shake up after, stand 25~35min after, dry hydrogen chloride gas are passed through thereto
Body, by the solid of precipitation by filtering, drying, produces ephedrine；
E, the kudzu-vine root powder and hay powder in step b be respectively placed in 50% ethanol, be warming up to 25~36 DEG C, stirred in heating
Mix, stop stirring after 30~40min, obtain component D；
F, sesame, fibert, component A and vegetable seed are respectively put into pot carry out frying, each component after frying is delivered into magnetic respectively
Room removes bushel iron, is then fed into oil press, crude oil of squeezing out, then crude oil refined, is decolourized, separating treatment, obtain different groups
The expressed oil divided；
G, ephedrine, component D mixed while stirring with each component expressed oil obtained in step f, matter is then added thereto
The ethanol that twice of the concentration that amount is component D is 80~90%, is warming up to boiling, keeps 30~40min of boiling, and heating is finished
Afterwards, sesame oil finished product is produced.
3. a kind of preparation method with anti-inflammatory and repair of neuron damage effect sesame oil according to claim 2, it is special
Levy and be：Step 4 in the extraction and enrichment of the ephedrine) in be passed through hydrogen chloride gas speed be 40mL/min.
4. a kind of preparation method with anti-inflammatory and repair of neuron damage effect sesame oil according to claim 2, it is special
Levy and be：The mesh number of screen cloth in the step a is 20 mesh.
5. a kind of preparation method with anti-inflammatory and repair of neuron damage effect sesame oil according to claim 2, it is special
Levy and be：Heating rate in the step g is 5 DEG C/min, and stir speed (S.S.) is 30r/min.
6. a kind of preparation method with anti-inflammatory and repair of neuron damage effect sesame oil according to claim 2, it is special
Levy and be：Step 4 in the extraction and enrichment of the ephedrine) select oxalic acid solution concentration be 0.9mol/L.
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Application publication date: 20170811 |