CN1070188C - 一种从l型取代苯丝氨酸酯制备d-(一)苏式-2-噁唑啉衍生物的方法 - Google Patents
一种从l型取代苯丝氨酸酯制备d-(一)苏式-2-噁唑啉衍生物的方法 Download PDFInfo
- Publication number
- CN1070188C CN1070188C CN97106492A CN97106492A CN1070188C CN 1070188 C CN1070188 C CN 1070188C CN 97106492 A CN97106492 A CN 97106492A CN 97106492 A CN97106492 A CN 97106492A CN 1070188 C CN1070188 C CN 1070188C
- Authority
- CN
- China
- Prior art keywords
- aryl
- substituted
- oxazoline
- phenyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
化合物 | R1 | R2 | R3 | 产率% | 物理常数1H-MNR | 元素公析理论值 分析值 |
2h C16H14N2O4 | NO2 | Ph | CH2OH | 81.2 | 3.5-3.9(m,2H)4.00-4.2(m,1H)5.10(t,J=6Hz,OH)5.70(d,J=6.3Hz,1H)7.6-8.00(M,5H) | C:64.42 64.50H:4.73 4.75N:9.39 9.32 |
2i C16H13FN2O3 | NO2 | Ph | CH2F | 84 | 4.3-4.5(m,1H)4.6-4.9(m,2H)5.8(d,1H,J=6Hz)7.5-8.00(m,9H) | C:64.00 64.01H:4.36 4.41F:6.33 6.29N:9.33 9.28 |
2j C17H17NO2S | CH3S | Ph | CH2OH | 83.1 | 2.48(s,3H)3.5-3.65(m,1H)5.52(d,1H,J=6Hz)7.30(s,4H)7.45-7.65(m,3H)7.94(d,2H,J=9Hz) | C:68.19 68.15H:5.72 5.73N:4.68 4.65S:10.71 10.74 |
2k C17H16FNOS | CH3S- | Ph | CH2F | 85 | 2.46(s,3H)3.62(m,1H)3.79(m,1H)4.13(m,1H)5.79(d,1H,J=6.4Hz)7.30(s,4H)7.45-7.98(m,5H) | C:67.77 67.68H:5.32 5.36N:4.65 4.61S:10.63 10.62 |
化合物 | R1 | R2 | R3 | 产率% | 物理常数1H-MNR | 元素公析理论值 分析值 |
21 C19H16N2O3(320.35) | CN | COOEt | C6H5 | 82.1 | 1.27(t,J=7.0Hz,3H)4.25(q,J=7.0Hz,2H)4.36(d,J=7.5Hz,1H)6.05(d,J=7.5Hz,1H)7.60(M,5H)7.98(m,4H) | C:71.24 71.20H:5.04 5.08N:8.74 8.71 |
2m C20H18F3NO3(377.37) | CF3 | COOEt | CH3C6H4 | 83.6 | 1.25(t,J=6.9Hz,3H)2.36(s,3H)4.25(q,J=6.9Hz,2H)4.85(d,J=7.3Hz,1H)6.05(d,J=7.3Hz,1H)7.6-8.10(m,8H) | C:63.66 63.60H:4.81 4.90N:3.71 3.70 |
2n C19H9NO3(309.37) | CF3 | COOEt | CH2OH | 84.1 | 1.27(t,J=7.0Hz,3H)2.35(s,3H)4.2 5(q,J=7.0Hz,2H)4.86(d,J=7.3Hz,1H)6.05(d,J=7.3Hz,1H)7.62(m,5H)8.00(m,4H) | C:73.77 73.71H:6.19 6.22N:4.53 4.50 |
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN97106492A CN1070188C (zh) | 1997-06-27 | 1997-06-27 | 一种从l型取代苯丝氨酸酯制备d-(一)苏式-2-噁唑啉衍生物的方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN97106492A CN1070188C (zh) | 1997-06-27 | 1997-06-27 | 一种从l型取代苯丝氨酸酯制备d-(一)苏式-2-噁唑啉衍生物的方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1179420A CN1179420A (zh) | 1998-04-22 |
CN1070188C true CN1070188C (zh) | 2001-08-29 |
Family
ID=5168730
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN97106492A Expired - Fee Related CN1070188C (zh) | 1997-06-27 | 1997-06-27 | 一种从l型取代苯丝氨酸酯制备d-(一)苏式-2-噁唑啉衍生物的方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1070188C (zh) |
-
1997
- 1997-06-27 CN CN97106492A patent/CN1070188C/zh not_active Expired - Fee Related
Non-Patent Citations (4)
Title |
---|
SYNTHESIS 10 1991.1.1 CLAR JON E ET * |
SYNTHESIS 10 1991.1.1 CLAR JON E ET;TETRAHEDRON 44(17) 1988.1.1 ITO YOSHIHIKO ET;中国医药杂志20(5) 1989.1.1 JIN YUNHUA ET * |
TETRAHEDRON 44(17) 1988.1.1 ITO YOSHIHIKO ET * |
中国医药杂志20(5) 1989.1.1 JIN YUNHUA ET * |
Also Published As
Publication number | Publication date |
---|---|
CN1179420A (zh) | 1998-04-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104356160A (zh) | L-α-甘油磷酰胆碱的纯化工艺 | |
CN111875612B (zh) | 色满酮拼接吡咯螺环氧化吲哚骨架与三氟甲基类化合物及其制备方法及应用 | |
JPH01180894A (ja) | アミノ糖誘導体の新規な製造法 | |
CN1265092A (zh) | 制备l-肉碱的方法 | |
CN1070188C (zh) | 一种从l型取代苯丝氨酸酯制备d-(一)苏式-2-噁唑啉衍生物的方法 | |
CN110092793B (zh) | 山酮素骨架和异噁唑螺环氧化吲哚拼接衍生物及其制备方法及应用 | |
CN1173933C (zh) | 一种从l型取代苯丝氨酸酯制备d-(-)-苏式1-r-取代苯基-2-二氯乙酰氨基-3-氟-1-丙醇的方法 | |
EP1063232B1 (en) | Process for producing erythro-3-amino-2-hydroxybutyric acid derivatives | |
CN1915982A (zh) | 一种雷诺嗪合成方法 | |
EP0239122B1 (en) | Process for the enzymatic resolution of racemic 2-amino-1-alkanols | |
CN1070850C (zh) | 含有氨基硫羰基的新颖的氨基甲酸酯化合物及其制备方法 | |
US6639095B1 (en) | Process for preparing optically active α-hydroxy acids and derivatives thereof | |
CN86108424A (zh) | 硝噻烯啶的合成方法 | |
CN115772107B (zh) | 一种硫亚胺酯\酰胺的制备方法 | |
CN111018869B (zh) | 手性稠环吡喃并二氢吡咯类化合物的制备方法 | |
CN118005538A (zh) | 一种合成4,5-二羟基亮氨酸衍生物的方法 | |
CN109503674B (zh) | 2-氟代洋地黄毒糖及其制备方法和应用 | |
CN109503681B (zh) | 2-Fluoro-L-ristosamine化合物及其合成方法和应用 | |
RU2051900C1 (ru) | 5-амино-1-гидроксиметилциклопентан-1,2,3,4-тетраол, 2-амино-4-гидроксиметил-3a,5,6,6a-тетрагидро-4н-циклопент-[d]-оксазол-4,5,6-триол, их фармацевтически приемлемые соли и способы их получения | |
CN1070851C (zh) | 新颖的有n-取代的硫代氨基甲酰基的氨基甲酸酯化合物及其制备方法 | |
JP2560250B2 (ja) | 天然型スフィンゴシン類の製造方法とその合成中間体 | |
KR100400885B1 (ko) | 라세미체의 케토로락을 단일이성체로 분리하는 방법 | |
CN117105888A (zh) | 一种mpla酰基链中间体的合成方法 | |
CN118221754A (zh) | 一种5-氟尿嘧啶三磷酸脱氧核苷中间体及其制备方法 | |
JPH02235828A (ja) | 光学活性な2―フルオロ―2―メチル―1―アルカノール類及びその製造方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C06 | Publication | ||
PB01 | Publication | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Zhangjiagang Hengsheng Pharmaceutical Co., Ltd. Assignor: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences Contract fulfillment period: 2008.5.6 to 2017.6.17 contract change Contract record no.: 2008310000005 Denomination of invention: A substituted phenyl serine ester from L type D- (a) -2- each method Su quinazoline derivatives Granted publication date: 20010829 License type: Exclusive license Record date: 2008.7.24 |
|
LIC | Patent licence contract for exploitation submitted for record |
Free format text: EXCLUSIVE LICENCE; TIME LIMIT OF IMPLEMENTING CONTACT: 2008.5.6 TO 2017.6.17 Name of requester: ZHANGJIAGANG CITY HENGSHENG MEDICINAL CHEMISTRY C Effective date: 20080724 |
|
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20010829 Termination date: 20140627 |
|
EXPY | Termination of patent right or utility model |