CN107007884A - Carry the purposes of the pure titanium implant material of cerium oxide nano particle functional film layer - Google Patents
Carry the purposes of the pure titanium implant material of cerium oxide nano particle functional film layer Download PDFInfo
- Publication number
- CN107007884A CN107007884A CN201710136295.9A CN201710136295A CN107007884A CN 107007884 A CN107007884 A CN 107007884A CN 201710136295 A CN201710136295 A CN 201710136295A CN 107007884 A CN107007884 A CN 107007884A
- Authority
- CN
- China
- Prior art keywords
- cerium oxide
- pure titanium
- oxide nano
- diabetes
- nano particle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/06—Titanium or titanium alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/12—Materials or treatment for tissue regeneration for dental implants or prostheses
Abstract
The invention discloses carry purposes of the pure titanium implant material of cerium oxide nano particle functional film layer in the plantation repair materials of diabetes agomphosis patient are prepared.The planting body material that the present invention carries CNPs can promote the Bone Defect Repari of diabetes model, used as the dental prosthetic material of diabetes patient, can effectively repair the tooth defect or missing of diabetes patient, excellent effect, potential applicability in clinical practice is good.
Description
Technical field
It is especially load cerium oxide nano particle the present invention relates to a kind of planting body material for diabetes agomphosis patient
The purposes of the pure titanium implant material of functional film layer.
Background technology
Optimal tooth defect or the repair mode of missing have been turned into based on the theoretical oral implant rehabilitation of Integrated implant.Both
Show toward document, 5 years success rates of the fixed or movable artificial tooth that tooth-planting is supported up to 90%-100%, for without oral cavity simultaneously
10 years success rates of patient of disease and whole body health are sent out up to more than 95%.However, the whole body system such as diabetes disease can influence
The generation of implant osseointegration, is all the relative contraindication that plantation is repaired all the time.According to statistics, diabetic's titanium kind
Implant mortality is up to 10%-20%, far above general population (1%-3%), significantly limit pushing away for plantation recovery technique
Wide application.
Diabetes (Diabetes Mellitus, DM) are that a kind of endocrine metabolism being characterized with chronic hyperglycemia is integrated
Levy.The number of global diabetic in 2012 is more than 3.7 hundred million, it is contemplated that the year two thousand thirty will increase to 5.52 hundred million.Wherein Chinese sugar
Urinate patient's number to occupy first of the whole world, investigation statisticses number in 2013 is 1.14 hundred million.Under diabetes pathological conditions, the small blood of whole body
Pipe and microangiopathies etc. can influence knitting and Bone m etabolism, so as to cause the poor primary stability of planting body and relatively low bone
Integration rate.It is immature that diabetes also result in bone regeneration around implant bone tissue formation reduction, healing time length, area of new bone；Enable
Part Integrated implant is being partially formed, feature reparation can not be but carried out, success rate at a specified future date is substantially reduced.Although actively controlling blood
Sugar, topical application insulin, calcitonin etc., which are intervened, can improve bone regeneration around implant bon e formation, but implant osseointegration rate is not
Have be improved significantly.Therefore the plantation reparation of diabetes agomphosis patient is always clinical treatment difficult point, how to improve diabetes
Patient plants Integrated implant, and the success rate for improving plantation reparation is tooth-planting research field problem urgently to be resolved hurrily.
At present generally by controlling the blood sugar level and infection control of diabetes patient to improve diabetic's planting body
Success rate, also has been reported that by handling implant surface, such as ultraviolet irradiation, chitosan coating mode, or induction
The mode of relevant growth factors height expression improves diabetic's planting body success rate.But, improve diabetic's plantation
The problem of Integrated implant, success rate for improving plantation reparation, does not still solve.
The content of the invention
In order to solve the above problems, the invention provides the pure titanium implant material for carrying cerium oxide nano particle functional film layer
Purposes in the plantation repair materials of diabetes agomphosis patient are prepared.
The pure titanium implant material that the present invention carries cerium oxide nano particle functional film layer is preparing diabetes agomphosis patient's
Plant the purposes in repair materials.
The pure titanium implant material of described load cerium oxide nano particle functional film layer, it is by pure titanium and contains cerium oxide
The suspension of nano-particle and gelatin is prepared from.
Preferably, the suspension of the pure compound 1uL-5uL in every square millimeter of titanium surface.It is further preferred that the pure titanium
The compound 4uL-5uL in every square millimeter of surface suspension.
Preferably, the suspension contains 5nmol~15nmol cerium oxide nano particles per 1L and concentration is 0.2% (m/v)
Gelatin.
Present invention also offers the preparation method of previous materials, step is as follows：
(1) pure titanium and cerium oxide nano particle are taken；
(2) differential arc oxidation processing, the pure titanium after must handling are carried out to pure titanium surface；
(3) cerium oxide nano particle is dispersed in gelatin solution, suspension is made；
(4) suspension of step (3) is added dropwise in the pure titanium surface after step (2) processing, oscillator processing, you can.
In step (1), the cerium oxide nano particle is prepared as follows：Cerous nitrate solution is taken to be added to oxalic acid two
In methyl ester solution, carbon black is added, is stirred, heating response, by products therefrom through filtering, washing, dry, is placed in roasting in crucible
Burn, produce cerium oxide nano particle.
In step (2), the running parameter of the differential arc oxidation processing is：Electrolyte be containing 0.2mol/L calcium acetates and
The solution of 0.04mol/L sodium glycero-phosphates, operating voltage 350V-450V, frequency 500-700Hz, dutycycle 8%, processing time
5min。
In step (3), the suspension contains 5nmol~15nmol cerium oxide nano particles per 1L and concentration is 0.2% (m/
V) gelatin.
In step (4), the suspension of the pure compound 1uL-5uL in every square millimeter of titanium surface.It is further preferred that described pure
The compound 4uL-5uL in every square millimeter of surface of titanium suspension.
In step (4), oscillator processing is that frequency of oscillation is 50~80 turns using the processing of rotary oscillator/
Min, processing time is 10min.
Reported according to existing literature, cerium oxide nano particle has the function of removing free radical, should in biomedical sector
With widely, but have not yet to see the report that CNPs is applied to oral implant rehabilitation field.And the present invention will plant body surface
Surface by micro-arc oxidation film layer load C NPs can promote the new strategy of diabetes Osseointegrated implants, lack to prevent and reducing diabetes
Tooth patient plantation repairing failure rate, improvement clinical therapeutic efficacy provide new approaches.
The planting body material that the present invention carries CNPs can promote the Integrated implant of diabetes patient, be used as diabetes agomphosis patient's
Plantation repair materials are used, and excellent effect, potential applicability in clinical practice is good.
Obviously, according to the above of the present invention, according to the ordinary technical knowledge and customary means of this area, do not departing from
Under the premise of the above-mentioned basic fundamental thought of the present invention, the modification of other diversified forms can also be made, replaces or changes.
The embodiment of form, remakes further specifically to the above of the invention by the following examples
It is bright.But the scope that this should not be interpreted as to above-mentioned theme of the invention is only limitted to following example.It is all to be based on the above of the present invention
The technology realized belongs to the scope of the present invention.
Brief description of the drawings
Fig. 1 CNPs high-resolution-ration transmission electric-lens observation
The visually observing of Fig. 2 porous ceramics film surface patterns (a) and SEM observations (b)
Embodiment
The present invention of embodiment 1 carries preparation and its nature examination of CNPs planting body material
1st, preparation method
(1) prepared by CNPs (cerium oxide nano particle)
5mL0.2mol/L cerous nitrate solution is added in 10mL 0.2mol/L dimethyl oxalate solution at room temperature,
0.05g-1g carbon black is added simultaneously, is stirred.This solution is heated to 60 DEG C, 20h is reacted.By products therefrom through filtering,
Wash, dry, be placed in crucible, through 700 DEG C of roasting 2h in air atmosphere, produce CeO2Nano-powder (i.e. cerium oxide nano
Particle).
Obtained nano-cerium oxide particle is as shown in Figure 1.
(2) preparation of the pure titanium sample of CNPs functional film layers is carried
Using the medical pure titaniums of TA2 of business, Φ=14mm is processed into, thickness is 1mm circular disc test specimen (experiment in vitro) and Φ
3.75mm*8mm column planting body (experiment in vivo), carries out MAO (differential arc oxidation) processing and prepares porous ceramics film layer.MAO works
Make parameter：Electrolyte is the solution containing 0.2mol/L calcium acetates and 0.04mol/L sodium glycero-phosphates, operating voltage 350V-
450V, frequency 500-700Hz, dutycycle 8%, processing time 5min.Surface after processing is as shown in Figure 2.
Then CNPs is dispersed in 0.2% (CNPs concentration can be 5-15nmol/L) (w/v) gelatin solution
Suspension is made, and (in 1L suspensions, CNPs concentration is 5nmol/L-15nmol/L, and the concentration of gelatin is 0.2%), to be added dropwise successively
100 μ L, 200 μ L, 300 μ L, 400 μ L, 500 μ L in porous membrane layer specimen surface, (fix, and is diameter 4mm, length by sample size
8mm, surface area of sample 100mm2), rotary oscillator processing (frequency of oscillation is 50~80 turns/min) 10min is placed in, is obtained
Carry the planting body material of CNPs functional film layers.
2nd, biological assessment
Take prepared by the present invention
Cytotoxicity, thermal source and sensitization test (STT) have been carried out, it is as a result as follows：
0 grade of cytotoxicity, no cytotoxicity；
Sensitization test (STT) result finds that test group animal skin is identical with physiological saline group without erythema, oedema, positive control
There is significant erythema and oedema in group animal, excites rear 24h hydrodermas significantly, erythema moderate or severe.Test group animal
Score as 0, negative control group animal is scored as 0, and positive controls animal is scored more than 1, test group and negative control group animal
Compare indifference in sensitization scoring statistics, the sensitization test (STT) reaction for showing material is feminine gender；
Pyrogen testing result finds that the body temperature rise of three rabbits every in experiment is less than 0.6 DEG C, and three rabbit bodies
Temperature rise sum is below 1.2 DEG C.
Experimental result illustrates that the present invention carries CNPs planting body material no cytotoxicity, no sensitization and apyrogenetity.
Hereinafter beneficial effects of the present invention are verified with the mode of experimental example：
The present invention of experimental example 1 carries the repairing effect for diabetes model of CNPs planting body material
Diabetic rabbit model is set up, and takes 6 monthly age Male New Zealand rabbits, after the sodium intravenous anesthesia of amobarbital, slow note
Penetrate alloxan.50g/L glucose solutions are subcutaneously injected in a few hours after injection, prevent hypoglycemia, and provided in 24h
100g/L glucose is drunk water.1 blood glucose is detected during modeling per 24h.It is normal after modeling to raise 6 weeks, blood glucose and body are measured weekly
Quality.Modeled successfully with stable be considered as in more than 13.9mmol/L of fasting blood-glucose.
Control group：
Control group 1：The medical pure titaniums of TA2, Φ 4mm*8mm column planting body
Control group 2：The medical pure titaniums of TA2 after MAO processing, Φ 4mm*8mm column planting body (experiment in vivo) carries out MAO
Processing prepares porous membrane layer.MAO running parameters：Electrolyte is 0.2mol/L calcium acetates and 0.04mol/L sodium glycero-phosphates, work
Voltage 400V, frequency 600Hz, dutycycle 8%, processing time 5min.
Test group：CNPs suspensions are added dropwise for 50 μ L, 100 μ L, 200 μ L, 300 in the medical pure titanium samples of TA2 respectively after MAO processing
μL、400μL、500μL。
Implantation experiment：Experimental animal Diabetic Rabbits give Su Mian Xin intramuscular injection anesthesia, in outside, shin bone knot under bilateral condyle of femur
Otch is done in inner side on section, and electric drill is for hole (at bilateral 4mm*8mm Cranial defect, every side two), and side is implanted into two pieces of planting bodies.Layering
Suture, closing wound.Bone volume fraction and ratio of bone contact analysis are carried out after 12 weeks.
As a result it is as shown in table 1.It can be seen that, 50uL samples and control sample without significant difference, 500uL and 400uL without significant difference,
Show, when CNPs amount is in 100-500uL, there is obvious facilitation to Diabetic Rabbits skeletonization.
The skeletonization analysis result of the different samples of table 1
Compared with three control groups, the diaphysis fraction of material 1,2,3,4,5 of the present invention has with ratio of bone contact significantly to be carried
It is high.
Experimental result illustrates that the planting body material that the present invention carries CNPs can promote the Bone Defect Repari of diabetes model, can be with
Use, and compare with pure titanium and the material phase after two methods processing in addition as the dental prosthetic material of diabetes patient
Than the present invention carries the excellent effect of CNPs planting body material, and the plantation that volume is 400~500 μ L is added dropwise in preferably CNPs suspensions
Body material.
To sum up, present invention load CNPs planting body material can promote the Bone Defect Repari of diabetes model, be used as diabetes patient
Dental prosthetic material use, can effectively repair the tooth defect or missing of diabetes patient, excellent effect, potential applicability in clinical practice
Well.
Claims (5)
1. the pure titanium implant material for carrying cerium oxide nano particle functional film layer is preparing the plantation reparation of diabetes agomphosis patient
Purposes in material.
2. purposes according to claim 1, it is characterised in that：The pure titanium kind for carrying cerium oxide nano particle functional film layer
Implant material is to be prepared from by pure titanium with the suspension containing cerium oxide nano particle and gelatin.
3. purposes according to claim 2, it is characterised in that：The compound 1uL-5uL in every square millimeter of surface of the pure titanium
Suspension.
4. purposes according to claim 2, it is characterised in that：The compound 4uL-5uL in every square millimeter of surface of the pure titanium
Suspension.
5. the purposes according to claim 2~4 any one, it is characterised in that：The suspension per 1L contain 5nmol~
15nmol cerium oxide nano particles and the gelatin that concentration is 0.2% (m/v).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710136295.9A CN107007884A (en) | 2017-03-09 | 2017-03-09 | Carry the purposes of the pure titanium implant material of cerium oxide nano particle functional film layer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710136295.9A CN107007884A (en) | 2017-03-09 | 2017-03-09 | Carry the purposes of the pure titanium implant material of cerium oxide nano particle functional film layer |
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| Publication Number | Publication Date |
|---|---|
| CN107007884A true CN107007884A (en) | 2017-08-04 |
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| CN201710136295.9A Pending CN107007884A (en) | 2017-03-09 | 2017-03-09 | Carry the purposes of the pure titanium implant material of cerium oxide nano particle functional film layer |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110859997A (en) * | 2018-12-20 | 2020-03-06 | 四川大学 | Dental implant with osteogenesis-anti-inflammatory-blood sugar three-dimensional response structure and preparation method thereof |
| CN113318272A (en) * | 2021-04-22 | 2021-08-31 | 南京大学 | Bone implantation material based on nano enzyme drug modification and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104523341A (en) * | 2014-12-18 | 2015-04-22 | 中国人民解放军第四军医大学 | Method for manufacturing immediately implanted tooth with periodontal bioactivity |
| CN104744026A (en) * | 2015-03-31 | 2015-07-01 | 苏州维泰生物技术有限公司 | Rear-earth doped hydroxyapatite bioactive ceramic and preparation method thereof |
-
2017
- 2017-03-09 CN CN201710136295.9A patent/CN107007884A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104523341A (en) * | 2014-12-18 | 2015-04-22 | 中国人民解放军第四军医大学 | Method for manufacturing immediately implanted tooth with periodontal bioactivity |
| CN104744026A (en) * | 2015-03-31 | 2015-07-01 | 苏州维泰生物技术有限公司 | Rear-earth doped hydroxyapatite bioactive ceramic and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110859997A (en) * | 2018-12-20 | 2020-03-06 | 四川大学 | Dental implant with osteogenesis-anti-inflammatory-blood sugar three-dimensional response structure and preparation method thereof |
| CN110859997B (en) * | 2018-12-20 | 2020-06-23 | 四川大学 | Dental implant with osteogenesis-anti-inflammatory-blood sugar three-dimensional response structure and preparation method thereof |
| CN113318272A (en) * | 2021-04-22 | 2021-08-31 | 南京大学 | Bone implantation material based on nano enzyme drug modification and preparation method and application thereof |
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Application publication date: 20170804 |