CN107007820A - It is a kind of to be used to treat dry and cracked water-soluble lipstick of lip and preparation method thereof - Google Patents
It is a kind of to be used to treat dry and cracked water-soluble lipstick of lip and preparation method thereof Download PDFInfo
- Publication number
- CN107007820A CN107007820A CN201710317204.1A CN201710317204A CN107007820A CN 107007820 A CN107007820 A CN 107007820A CN 201710317204 A CN201710317204 A CN 201710317204A CN 107007820 A CN107007820 A CN 107007820A
- Authority
- CN
- China
- Prior art keywords
- lipstick
- soluble
- stirring
- water
- mixed liquor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1808—Epidermal growth factor [EGF] urogastrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention provides a kind of for treating moderate and the dry and cracked water-soluble lipstick of severe lip and preparation method thereof, and water-soluble lipstick includes following component described in per 100ml：100 ~ 10000 IU recombinant human epidermal growth factor, 100 ~ 1000mg medical chitose, 100 ~ 1000mg Sodium Hyaluronate, 10 ~ 200mg poly-D-lysine, by solution ph adjust to 7.0 ~ 7.5 concentration for 0.1mol/L sodium hydroxide solution, the mixture of said components is settled to 100ml phosphate buffer.Water-soluble lipstick prepared by the present invention is with medical chitose and recombinant human epidermal growth factor（hEGF）For primary raw material, traditional solid lipstick and lipid lipstick is different from, moderate and the dry and cracked external application lipstick of severe lip can be effectively treated, and without grease, non-stimulated, absorbable water-soluble lipstick.
Description
Technical field
The present invention relates to biomedicine technical field, and in particular to it is a kind of be used for treat the dry and cracked water-soluble lipstick of lip and
Its preparation method.
Background technology
It is the common disease in winter in spring and autumn that lip is dry and cracked, and this is mainly due to winter in spring and autumn dry weather, temperature Change be big, people
The reason that body resistance declines.The dry and cracked bleeding of lip, has really suffered from angular stomatitis, is a kind of common mouth disease, spring and autumn
Winter is the season occurred frequently for suffering from angular stomatitis, and serious patient dehisces easy bleeding, have a meal, speak it is all impacted.
The lip dry and cracked healing cycle is general at one week or so, in this week age, patient except replenishing vitamins with
Beyond moisture, most common method is exactly that lip is smeared using lip gloss.But, sent out by market survey and research
Existing, the lipstick often sold on the market at present is solid lipstick more than 95%, containing substantial amounts of lipid material, and patient is using this class
During lipstick, protective effect is not had not only, on the contrary can because smear lipstick caused by wound deterioration, particularly during smearing easily
Extruding is formed to affected part and is torn.In addition, largely using lipid lipstick, make lip formation very heavy oil soapy feeling, hinder skin of lip
Eupnea, cause angular stomatitis to be difficult rehabilitation.
The lip gloss that is used for of the liquid lipstick of market sale almost without exception is made up, not with controlling treatment functions, and
It is expensive.
Medical chitose is a star for being active in biomedicine field at present, and modern medicine and life science think several
Tetrose is a kind of important substance of human body, is also described as " the 6th vital principle ".The superiority that medical chitose has has：
（1）Promotion organization regeneration, suppression cicatrization（With promotion epithelial cell, vascular endothelial cell growth, and suppress into fiber finer
The biological characteristics of intracellular growth）；（2）Reduce wound fluid；（3）The invisible film of moistening can be formed, accelerates wound healing；（4）
With pain easing and hemostasis effect；（5）With antiinflammation.At present, medical chitose is anti-sticking in the treatment of skin burn, Post operation
The field such as company, eyes postoperative rehabilitation, eye drops, new pattern compress is widely used.
Recombinant human epidermal growth factor（hEGF）It is a kind of small peptide, is made up of 53 amino acid residues, is class EGF extended familys
A member, be a kind of multi-functional growth factor.HEGF can stimulate the propagation of various kinds of cell, mainly epidermal cell, interior
Chrotoplast, good curative effect is achieved in terms of the reparation and healing of the surface of a wound such as corneal injury, burn and scald and operation.In medical science
On, hEGF is widely used in treating the disease of burn and scald, ulcer, all kinds of wounds and corneal injury etc..HEGF can also promote just
The metabolism of normal epidermal cell, tender skin, whitening, crease-resistant, anti-aging effect can be reached by being added in cosmetics and skincare product.
The content of the invention
It is used to treat the dry and cracked water-soluble lipstick of lip and its preparation the technical problem to be solved in the present invention is to provide a kind of
Method, can form the invisible film of moistening, and protection affected part reduces infection, can promote the generation of affected part epidermal cell, accelerates wound
Mouth healing, with analgesia, hemostasis and anti-inflammatory effect, mitigates patient suffering.
In order to solve the above technical problems, embodiments of the invention provide a kind of for treating the dry and cracked water-soluble lip of lip
Cream, water-soluble lipstick includes following component described in per 100ml：100 ~ 10000 IU recombinant human epidermal growth factor, 100 ~
1000mg medical chitose, 100 ~ 1000mg Sodium Hyaluronate, 10 ~ 200mg poly-D-lysine, solution ph adjusted
Concentration to 7.0 ~ 7.5 is settled to 100ml phosphate for 0.1mol/L sodium hydroxide solution, by the mixture of said components
Buffer solution.
Further, water-soluble lipstick described in every 100ml includes following component：1000 ~ 5000 IU recombinant human epidermal growth
The factor, 300 ~ 700mg medical chitose, 300 ~ 700mg Sodium Hyaluronate, 50 ~ 120mg poly-D-lysine, by solution
PH value adjusts to 7.2 concentration the phosphorus that 100ml is settled to for 0.1mol/L sodium hydroxide solution, by the mixture of said components
Phthalate buffer.
Preferably, water-soluble lipstick described in every 100ml includes following component：3000 IU recombinant human epidermal growth factor,
500mg medical chitose, 550mg Sodium Hyaluronate, 100mg poly-D-lysine, by solution ph adjust to 7.2 it is dense
Spend the sodium hydroxide solution for 0.1mol/L, the mixture of said components is settled to 100ml phosphate buffer.
Wherein, the pH value of the phosphate buffer is 7.2, and its phosphate concentration is 0.01mol/L.
Further, the phosphate buffer is by potassium dihydrogen phosphate, AMSP and ten sodium dihydrogen phosphate dihydrates
In one or more mixtures, sodium chloride, distilled water is formulated.
Preferably, phosphate buffer described in every 1000ml is by 0.38g potassium dihydrogen phosphates, 1.02g AMSPs
After being mixed with any of sodium dihydrogen phosphate dihydrates of 2.58g ten with 8g sodium chloride, 1000ml is settled to by distilled water.
The embodiment of the present invention also provides a kind of above-mentioned preparation method for being used to treat the dry and cracked water-soluble lipstick of lip, bag
Include following steps：
（1）Phosphate buffer is taken, is placed in sterile chamber；
（2）Recombinant human epidermal growth factor is taken, step is added to（1）Phosphate buffer in, stirring, dissolving；
（3）Medical chitose is taken, step is added to（2）Mixed liquor in, stirring, dissolving；
（4）Poly-D-lysine is taken, step is added to（3）Mixed liquor in, stirring, dissolving；
（5）Sodium Hyaluronate is taken, step is added to（4）Mixed liquor in, stirring, dissolving；
（6）To step（5）Mixed liquor in add sodium hydroxide solution, stirring, mix, the pH value to mixed liquor is 7.0 ~ 7.5；
（7）With phosphate solution, by step（6）Gained mixed liquor constant volume, stirring, mixing；
（8）By step（7）Obtained aqueous solution is dispensed into sterile glass vials, sealing, produces water-soluble lipstick.
Wherein, the step of configuration 100ml water-soluble lipstick is as follows：
(1) ' and 50ml phosphate buffers are taken, it is placed in sterile chamber；
(2) ' take 100 ~ 10000 IU recombinant human epidermal growth factor, be added to step (1) ' phosphate buffer in, stir
Mix, dissolve；
(3) ' take 100 ~ 1000mg medical chitose, be added to step (2) ' mixed liquor in, stirring, dissolving；
(4) ' take 10 ~ 200mg poly-D-lysine, be added to step (3) ' mixed liquor in, stirring, dissolving；
(5) ' take 100 ~ 1000mg Sodium Hyaluronate, be added to step (4) ' mixed liquor in, stirring, dissolving；
(6) ' to step (5) ' mixed liquor in add concentration be 0.1mol/L sodium hydroxide solution, stirring, mix, to mix
The pH value of liquid is 7.0 ~ 7.5；
(7) ' and phosphate solution is used, step (6) ' gained mixed liquor is settled to 100ml, stirring, mixing；
(8) ' step (7) ' obtained aqueous solution is dispensed into sterile glass vials, seal, produce water-soluble lipstick.
Preferably, the step of configuration 100ml water-soluble lipstick is as follows：
(1) 50ml phosphate buffers " are taken, are placed in sterile chamber；
(2) " take 3000 IU recombinant human epidermal growth factor, be added to step (1) " phosphate buffer in, stirring, it is molten
Solution；
(3) " take 500mg medical chitose, be added to step (2) " mixed liquor in, stirring, dissolving；
(4) " take 100mg poly-D-lysine, be added to step (3) " mixed liquor in, stirring, dissolving；
(5) " take 550mg Sodium Hyaluronate, be added to step (4) " mixed liquor in, stirring, dissolving；
(6) sodium hydroxide solution that concentration is 0.1mol/L is added in the mixed liquor " to step (5) ", stirring, mixing are extremely mixed
The pH value of liquid is 7.2；
(7) " phosphate solution being used, by step (6), " gained mixed liquor is settled to 100ml, stirring, mixing；
(8) " by step (7) ", obtained aqueous solution is dispensed into sterile glass vials, sealing, produces water-soluble lipstick.
The above-mentioned technical proposal of the present invention has the beneficial effect that：
1st, the active drug composition in the present invention can form the invisible film of moistening, and infection is reduced in protection affected part.
2nd, the drug ingedient in the present invention can promote the generation of affected part epidermal cell, accelerating wound healing.
3rd, the drug ingedient in the present invention has analgesia, hemostasis and inflammation-diminishing function, mitigates patient suffering.
4th, the present invention is water-soluble liquid, using soft, will not cause secondary injury to affected part.
5th, the present invention is water-soluble liquid, without grease type material, does not result in greasy feeling, exhaling for epidermal cell is not influenceed
Inhale.
6th, the invention belongs to therapeutic medical class product, there is more preferable therapeutic effect and wider array of than toiletries lipstick
The crowd of being applicable.
Embodiment
To make the technical problem to be solved in the present invention, technical scheme and advantage clearer, below in conjunction with specific implementation
Example is described in detail.
The present invention provides a kind of for treating the dry and cracked water-soluble lipstick of lip, and water-soluble lipstick includes described in per 100ml
Following component：100 ~ 10000 IU recombinant human epidermal growth factor, 100 ~ 1000mg medical chitose, 100 ~ 1000mg
Sodium Hyaluronate, 10 ~ 200mg poly-D-lysine, the hydrogen-oxygen for being 0.1mol/L by the concentration that solution ph is adjusted to 7.0 ~ 7.5
Change sodium solution, the mixture of said components is settled to 100ml phosphate buffer.
The above-mentioned preparation method for being used to treat the dry and cracked water-soluble lipstick of lip comprises the following steps：
（1）Phosphate buffer is taken, is placed in sterile chamber；
（2）Recombinant human epidermal growth factor is taken, step is added to（1）Phosphate buffer in, stirring, dissolving；
（3）Medical chitose is taken, step is added to（2）Mixed liquor in, stirring, dissolving；
（4）Poly-D-lysine is taken, step is added to（3）Mixed liquor in, stirring, dissolving；
（5）Sodium Hyaluronate is taken, step is added to（4）Mixed liquor in, stirring, dissolving；
（6）To step（5）Mixed liquor in add sodium hydroxide solution, stirring, mix, the pH value to mixed liquor is 7.0 ~ 7.5；
（7）With phosphate solution, by step（6）Gained mixed liquor constant volume, stirring, mixing；
（8）By step（7）Obtained aqueous solution is dispensed into sterile glass vials, sealing, produces water-soluble lipstick.
Below by several samples and its effect contrast prepared using above-mentioned preparation method, technical solution of the present invention is verified
Effective effect.
Embodiment 1：
S101,50ml phosphate buffers are taken, be placed in sterile chamber；
In S102, the recombinant human epidermal growth factor for taking 3000 IU, the phosphate buffer for being added to step S101, stirring, it is molten
Solution；
In S103, the medical chitose for taking 500mg, the mixed liquor for being added to step S102, stirring, dissolving；
In S104, the poly-D-lysine for taking 100mg, the mixed liquor for being added to step S103, stirring, dissolving；
In S105, the Sodium Hyaluronate for taking 550mg, the mixed liquor for being added to step S104, stirring, dissolving；
S106, the sodium hydroxide solution that addition concentration is 0.1mol/L into step S105 mixed liquor, stirring, mixing are extremely mixed
The pH value for closing liquid is 7.2；
S107, with phosphate solution, mixed liquor obtained by step S106 is settled to 100ml, stirring, mixed；
S108, step S107 obtained aqueous solutions are dispensed into sterile glass vials, seal, produce water-soluble lipstick sample G1.
Embodiment 2：
According to the preparation technology and flow of embodiment 1, sample G2 and G3 are prepared.Wherein, G2 and G3 component and proportioning see the table below
One.
Table one：Prepare G2 and G3 formula
Embodiment 3：
Take according to embodiment 1 and embodiment 2 gained sample G1, G2 and G3 is prepared, selection is with moderate with the dry and cracked patient of upper lip
45 people, patient shows as：Upper lower lip is dry and cracked, bleeding, and lip turns up, corners of the mouth inflammation, and dead skin occurs in lip, and influence is fed and said
Words, ill more than 2 days cycle, patient's medicine-less allergy history and diabetes.
The people of patient 45 is divided into five groups, wherein the people of control group 9, without using external application lipstick class medicine, only takes doctor formula
Drug therapy；The people of lipstick group 9, it is daily to smear three times using solid lipstick auxiliary treatment in addition to doctor formula medicine is taken, Gu
Body lipstick mainly turns into vegetable oil, honey, vaseline and essential oil；The people of G1 groups 9, in addition to doctor formula medicine is taken, uses this hair
G1 prepared by bright embodiment 1, it is daily to smear three times；G2 groups and each 9 people of G3 groups, in addition to doctor formula medicine is taken, use this hair
G2 and G3 prepared by bright embodiment 2, it is daily to smear three times.Tracking daily to patient is accessed, statistics Cure and effect.Completely
Healing is shown as：Lip is without turning up, and no bleeding and inflammation, no dead skin come off, and lip is smooth, normally can speak and feed, control
More result such as table three.
The Cure of the different therapeutic scheme lip-syncing cheilosis of table three
| Group | Test patient's number | Healing time |
| Control group | 9 people | 6.2 ± 2.3 days |
| Lipstick group | 9 people | 5.8 ± 2.1 days |
| G1 groups | 9 people | 2.8 ± 1.5 days |
| G2 groups | 9 people | 3.6 ± 2.0 days |
| G3 groups | 9 people | 3.3 ± 1.9 days |
Suffer from moderate it can be seen from upper table data with the dry and cracked patient of upper lip in the case of identical drug therapy, make
With G1, G2 and G3, more untapped patient, healing time substantially shortens, and wherein G1 effect is better than G2 and G3.
Described above is the preferred embodiment of the present invention, it is noted that for those skilled in the art
For, on the premise of principle of the present invention is not departed from, some improvements and modifications can also be made, these improvements and modifications
It should be regarded as protection scope of the present invention.
Claims (9)
1. a kind of be used to treat the dry and cracked water-soluble lipstick of lip, it is characterised in that water-soluble lipstick is included such as described in per 100ml
Lower component：100 ~ 10000 IU recombinant human epidermal growth factor, 100 ~ 1000mg medical chitose, 100 ~ 1000mg it is saturating
The sour sodium of bright matter, 10 ~ 200mg poly-D-lysine, the hydroxide for being 0.1mol/L by the concentration that solution ph is adjusted to 7.0 ~ 7.5
Sodium solution, the phosphate buffer that the mixture of said components is settled to 100ml.
2. according to claim 1 be used to treat the dry and cracked water-soluble lipstick of lip, it is characterised in that described in per 100ml
Water-soluble lipstick includes following component：1000 ~ 5000 IU recombinant human epidermal growth factor, 300 ~ 700mg medical chitin
Sugar, 300 ~ 700mg Sodium Hyaluronate, 50 ~ 120mg poly-D-lysine, by the concentration that solution ph is adjusted to 7.2 it is
0.1mol/L sodium hydroxide solution, the phosphate buffer that the mixture of said components is settled to 100ml.
3. according to claim 1 be used to treat the dry and cracked water-soluble lipstick of lip, it is characterised in that described in per 100ml
Water-soluble lipstick includes following component：3000 IU recombinant human epidermal growth factor, 500mg medical chitose, 550mg
Sodium Hyaluronate, 100mg poly-D-lysine, by solution ph adjust to 7.2 concentration for 0.1mol/L sodium hydroxide it is molten
Liquid, the phosphate buffer that the mixture of said components is settled to 100ml.
4. being used for according to any one of claim 1 ~ 3 treats the dry and cracked water-soluble lipstick of lip, it is characterised in that institute
The pH value for stating phosphate buffer is 7.2, and its phosphate concentration is 0.01mol/L.
5. according to claim 4 be used to treat the dry and cracked water-soluble lipstick of lip, it is characterised in that the phosphate delays
Fliud flushing by one or more mixtures in potassium dihydrogen phosphate, AMSP and ten sodium dihydrogen phosphate dihydrates, sodium chloride,
Distilled water is formulated.
6. according to claim 5 be used to treat the dry and cracked water-soluble lipstick of lip, it is characterised in that described in per 1000ml
Phosphate buffer is in 0.38g potassium dihydrogen phosphates, 1.02g AMSPs and the sodium dihydrogen phosphate dihydrates of 2.58g ten
It is any mixed with 8g sodium chloride after, 1000ml is settled to by distilled water.
7. a kind of being used for as any one of claim 1 ~ 6 treats the preparation method of the dry and cracked water-soluble lipstick of lip,
It is characterised in that it includes following steps：
（1）Phosphate buffer is taken, is placed in sterile chamber；
（2）Recombinant human epidermal growth factor is taken, step is added to（1）Phosphate buffer in, stirring, dissolving；
（3）Medical chitose is taken, step is added to（2）Mixed liquor in, stirring, dissolving；
（4）Poly-D-lysine is taken, step is added to（3）Mixed liquor in, stirring, dissolving；
（5）Sodium Hyaluronate is taken, step is added to（4）Mixed liquor in, stirring, dissolving；
（6）To step（5）Mixed liquor in add sodium hydroxide solution, stirring, mix, the pH value to mixed liquor is 7.0 ~ 7.5；
（7）With phosphate solution, by step（6）Gained mixed liquor constant volume, stirring, mixing；
（8）By step（7）Obtained aqueous solution is dispensed into sterile glass vials, sealing, produces water-soluble lipstick.
8. preparation method according to claim 7, it is characterised in that the step of configuring 100ml water-soluble lipstick is as follows：
(1) ' and 50ml phosphate buffers are taken, it is placed in sterile chamber；
(2) ' take 100 ~ 10000 IU recombinant human epidermal growth factor, be added to step (1) ' phosphate buffer in, stir
Mix, dissolve；
(3) ' take 100 ~ 1000mg medical chitose, be added to step (2) ' mixed liquor in, stirring, dissolving；
(4) ' take 10 ~ 200mg poly-D-lysine, be added to step (3) ' mixed liquor in, stirring, dissolving；
(5) ' take 100 ~ 1000mg Sodium Hyaluronate, be added to step (4) ' mixed liquor in, stirring, dissolving；
(6) ' to step (5) ' mixed liquor in add concentration be 0.1mol/L sodium hydroxide solution, stirring, mix, to mix
The pH value of liquid is 7.0 ~ 7.5；
(7) ' and phosphate solution is used, step (6) ' gained mixed liquor is settled to 100ml, stirring, mixing；
(8) ' step (7) ' obtained aqueous solution is dispensed into sterile glass vials, seal, produce water-soluble lipstick.
9. the preparation method according to claim 7 or 8, it is characterised in that the step of configuring 100ml water-soluble lipstick is such as
Under：
(1) 50ml phosphate buffers " are taken, are placed in sterile chamber；
(2) " take 3000 IU recombinant human epidermal growth factor, be added to step (1) " phosphate buffer in, stirring, it is molten
Solution；
(3) " take 500mg medical chitose, be added to step (2) " mixed liquor in, stirring, dissolving；
(4) " take 100mg poly-D-lysine, be added to step (3) " mixed liquor in, stirring, dissolving；
(5) " take 550mg Sodium Hyaluronate, be added to step (4) " mixed liquor in, stirring, dissolving；
(6) sodium hydroxide solution that concentration is 0.1mol/L is added in the mixed liquor " to step (5) ", stirring, mixing are extremely mixed
The pH value of liquid is 7.2；
(7) " phosphate solution being used, by step (6), " gained mixed liquor is settled to 100ml, stirring, mixing；
(8) " by step (7) ", obtained aqueous solution is dispensed into sterile glass vials, sealing, produces water-soluble lipstick.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710317204.1A CN107007820A (en) | 2017-05-08 | 2017-05-08 | It is a kind of to be used to treat dry and cracked water-soluble lipstick of lip and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710317204.1A CN107007820A (en) | 2017-05-08 | 2017-05-08 | It is a kind of to be used to treat dry and cracked water-soluble lipstick of lip and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107007820A true CN107007820A (en) | 2017-08-04 |
Family
ID=59448784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710317204.1A Pending CN107007820A (en) | 2017-05-08 | 2017-05-08 | It is a kind of to be used to treat dry and cracked water-soluble lipstick of lip and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107007820A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105056286A (en) * | 2015-07-15 | 2015-11-18 | 军事医学科学院华南干细胞与再生医学研究中心 | Liquid band-aid and preparing method thereof |
| CN106176688A (en) * | 2016-08-16 | 2016-12-07 | 深圳市华生元基因工程发展有限公司 | A kind of wound repair liquid and preparation method thereof |
-
2017
- 2017-05-08 CN CN201710317204.1A patent/CN107007820A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105056286A (en) * | 2015-07-15 | 2015-11-18 | 军事医学科学院华南干细胞与再生医学研究中心 | Liquid band-aid and preparing method thereof |
| CN106176688A (en) * | 2016-08-16 | 2016-12-07 | 深圳市华生元基因工程发展有限公司 | A kind of wound repair liquid and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| NAJMEH KHANBANHA等: "Healing Efficacy of an EGF Impregnated Triple Gel Based Wound Dressing: In Vitro and In Vivo Studies", 《BIOMED RESEARCH INTERNATIONAL》 * |
| 陈榕等: "壳聚糖与生长因子复合贴剂对创面愈合的疗效观察", 《广东药学》 * |
| 高合意等: "生物防腐技术在化妆品中的应用", 《化工管理》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105107007B (en) | A kind of medical protective dressing of cation and preparation method thereof | |
| KR20160064410A (en) | Composition comprising spicules for skin care | |
| CN108578747A (en) | A kind of gradient hyaluronic acid dressing and preparation method thereof | |
| CN107303253A (en) | It is a kind of to be used to be damaged renovation agent of skin and preparation method thereof | |
| CN113332162B (en) | protamine-PDRN compound, composition and application in preparation of skin care product | |
| CN104921983A (en) | Medical biological repairing dressing for pregnant woman striae gravidarum and preparation method thereof | |
| CN108686255A (en) | It is a kind of to prevent the biological dressing and preparation method thereof that scar is formed | |
| RU2289417C1 (en) | Method for biological skin rejuvenation | |
| KR102613845B1 (en) | Cosmetic composition for improvement of skin derived from natural products | |
| CN105726366B (en) | Sebum film remediation composition | |
| KR20160069158A (en) | Sericite carbonate beauty pack and the manufacturing method | |
| WO2018224099A1 (en) | Silicone pad having active ingredients for skin care and against skin aging | |
| CN109222534A (en) | A kind of pillowcase | |
| Hao et al. | Dermlin and silver nanoparticles combined antibacterial dressing for skin wound repair | |
| KR20080068077A (en) | Fibroblast activator, method for activation of fibroblast, collagen synthesis promoter, method for promotion of collagen synthesis, skin aging-preventing agent, and method for prevention of aging of the skin | |
| KR20200030022A (en) | Composition for for treating wound or scar comprising hydrogel patches | |
| CN107007820A (en) | It is a kind of to be used to treat dry and cracked water-soluble lipstick of lip and preparation method thereof | |
| CN105411973A (en) | Preparation method of nano pearl powder and sodium hyaluronate composite moisturizing particles | |
| US11759479B2 (en) | Compositions comprising a manganese mineral and methods of use | |
| RU2481834C2 (en) | Antimicrobial composition for treatment of wounds and burns | |
| CN108578297A (en) | A kind of compounding moisturizing sun cream and preparation method thereof | |
| RU2577950C1 (en) | Method of stimulating healing dermal burns | |
| CN109646359B (en) | Rose-agaric mud membrane paste with effects of cleaning, purifying, maintaining beauty and keeping young and preparation method thereof | |
| CN111743812A (en) | Vaginal repair nutrient solution and preparation method thereof | |
| CN113473963A (en) | Cosmetic/dermatological composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170804 |
|
| RJ01 | Rejection of invention patent application after publication |