CN107003320B - 慢性肾脏疾病的快速进展的生物标志物 - Google Patents

慢性肾脏疾病的快速进展的生物标志物 Download PDF

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CN107003320B
CN107003320B CN201580062658.8A CN201580062658A CN107003320B CN 107003320 B CN107003320 B CN 107003320B CN 201580062658 A CN201580062658 A CN 201580062658A CN 107003320 B CN107003320 B CN 107003320B
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CN107003320A (zh
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梅拉妮·布鲁耶尔
穆尔迪·穆奥拉哈
法比奥拉·特尔西
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French National Institute Of Health Medicine
F Hoffmann La Roche AG
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/485—Epidermal growth factor [EGF] (urogastrone)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/495—Transforming growth factor [TGF]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/521—Chemokines
    • G01N2333/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1or LDCF-2
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/34—Genitourinary disorders
    • G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
CN201580062658.8A 2014-11-25 2015-11-24 慢性肾脏疾病的快速进展的生物标志物 Active CN107003320B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14306879 2014-11-25
EP14306879.9 2014-11-25
PCT/EP2015/077504 WO2016083374A1 (en) 2014-11-25 2015-11-24 Biomarkers of fast progression of chronic kidney disease

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CN107003320A CN107003320A (zh) 2017-08-01
CN107003320B true CN107003320B (zh) 2021-08-17

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US (3) US20170328914A1 (enExample)
EP (1) EP3224625B1 (enExample)
JP (1) JP6753861B2 (enExample)
CN (1) CN107003320B (enExample)
WO (1) WO2016083374A1 (enExample)

Families Citing this family (11)

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Publication number Priority date Publication date Assignee Title
WO2016083374A1 (en) 2014-11-25 2016-06-02 F. Hoffmann-La Roche Ag Biomarkers of fast progression of chronic kidney disease
US12057228B1 (en) 2015-12-30 2024-08-06 Cerner Innovation, Inc. Predicting newly incident chronic kidney disease
US11026625B2 (en) * 2017-08-08 2021-06-08 Fresenius Medical Care Holdings, Inc. Systems and methods for treating and estimating progression of chronic kidney disease
KR20210014109A (ko) * 2018-05-10 2021-02-08 더 메서디스트 하스피틀 질환의 예후와 관리 방법
ES2745352B2 (es) * 2018-08-28 2023-08-10 Fundacion Instituto De Investig Sanitaria Fundacion Jimenez Diaz GDF15 en orina como biomarcador de enfermedad renal crónica
EP3864407A4 (en) * 2018-10-11 2022-07-13 Northwestern University BIOMARKERS OF CHRONIC KIDNEY DISEASE IN LIVER TRANSPLANT RECIPIENTS
CN113667713A (zh) * 2020-05-14 2021-11-19 深圳市长卿医学研究院 一种肾功能损害风险降低的方法及应用
BR112023004441A2 (pt) * 2020-09-23 2023-04-11 Baxter Int Sistema, métodos e aparelho de aprendizado de máquina de previsão de doença renal crônica (ckd)
EP4320445A1 (en) * 2021-04-08 2024-02-14 Joslin Diabetes Center, Inc. Methods of diagnosing and predicting renal decline
CN116042809B (zh) * 2022-12-12 2025-07-15 山西省人民医院 X连锁凋亡抑制蛋白在慢性肾脏病诊断中的应用
CN118707104A (zh) * 2024-05-08 2024-09-27 杭州珞米医疗科技有限公司 蛋白标志物联合用于制备诊断区分糖尿病肾病进展者与非进展者的试剂盒的用途

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Publication number Priority date Publication date Assignee Title
US9476880B2 (en) 2008-11-21 2016-10-25 Future Medical Diagnostics Co., Ltd. Methods, devices and kits for detecting or monitoring acute kidney injury
JP5735922B2 (ja) * 2008-11-22 2015-06-17 アスチュート メディカル，インコーポレイテッド 腎損傷および腎不全の診断および予後のための方法
EP3112871B1 (en) 2009-12-20 2020-07-29 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
MX2013000220A (es) * 2010-06-23 2013-03-22 Astute Medical Inc Metodos y composiciones para diagnóstico y pronóstico de lesión renal e insuficiencia renal.
US20140079769A1 (en) * 2010-10-01 2014-03-20 Fabiola Terzi Methods for predicting the progression and treating a chronic kidney disease in a patient
CN102854306B (zh) * 2011-12-23 2013-08-07 中国人民解放军第三〇九医院 用于预警肾移植后排斥反应的试剂盒及其使用方法
WO2016083374A1 (en) 2014-11-25 2016-06-02 F. Hoffmann-La Roche Ag Biomarkers of fast progression of chronic kidney disease
EP3864407A4 (en) 2018-10-11 2022-07-13 Northwestern University BIOMARKERS OF CHRONIC KIDNEY DISEASE IN LIVER TRANSPLANT RECIPIENTS

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
体液MCP-1水平与系统性红斑狼疮相关性分析;王鹏等;《包头医学院学报》;20071231;摘要，结论 *

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JP6753861B2 (ja) 2020-09-09
US12203943B2 (en) 2025-01-21
JP2017536558A (ja) 2017-12-07
EP3224625A1 (en) 2017-10-04
US20200096523A1 (en) 2020-03-26
EP3224625B1 (en) 2020-07-29
US20170328914A1 (en) 2017-11-16
WO2016083374A1 (en) 2016-06-02
US20220252617A1 (en) 2022-08-11
CN107003320A (zh) 2017-08-01

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