CN106994135B - Sea grape extract with function of inhibiting allergy, preparation method and application - Google Patents

Sea grape extract with function of inhibiting allergy, preparation method and application Download PDF

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CN106994135B
CN106994135B CN201610043924.9A CN201610043924A CN106994135B CN 106994135 B CN106994135 B CN 106994135B CN 201610043924 A CN201610043924 A CN 201610043924A CN 106994135 B CN106994135 B CN 106994135B
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extract
sea grape
sea
allergy
grape extract
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CN106994135A (en
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黄钰林
賴惠敏
李宗翰
谢威永
沈绣慈
李增澎
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Teh Fong Min International Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A61K36/05—Chlorophycota or chlorophyta (green algae), e.g. Chlorella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02—Preparations containing skin colorants, e.g. pigments
    • A61Q1/04—Preparations containing skin colorants, e.g. pigments for lips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02—Preparations containing skin colorants, e.g. pigments
    • A61Q1/10—Preparations containing skin colorants, e.g. pigments for eyes, e.g. eyeliner, mascara
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/12—Face or body powders for grooming, adorning or absorbing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/14—Preparations for removing make-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/005—Preparations for sensitive skin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The invention relates to a sea grape extract with an allergy inhibiting function, a preparation method and application thereof, and relates to a sea grape extract, in particular to a sea grape extract capable of inhibiting allergy and not causing allergy, a preparation method and application thereof. The preparation method of the sea grape extract comprises the following steps: the weight ratio of the sea grape to the pure water is 1: 1-20, pulping and uniformly mixing, stirring for 30-120 minutes at the temperature of 20-100 ℃, filtering the obtained liquid for the first time to obtain a sea grape extract, further filtering the sea grape extract for the second time, filtering the sea grape extract by using EW (electron beam radiation), PW (pseudo wire) and DK (dark yellow) membranes, and drying to obtain a sea grape refined extract; the invention has excellent effect of inhibiting allergy, does not cause allergy per se, and can be used for cosmetics and foods.

Description

Sea grape extract with function of inhibiting allergy, preparation method and application
Technical Field
The invention relates to a sea grape extract, in particular to a sea grape extract capable of inhibiting allergy and not causing allergy, a preparation method and application thereof.
Background
Allergy is a phenomenon of excessive reaction to environmental substances (also called allergens) due to the abnormality of the immune system of the human body, and the allergens entering the body bind to IgE antibodies. At this time, the mast cells are stimulated to release inflammatory substances such as histamine, which causes inflammatory reaction of body tissues, and allergic symptoms vary depending on the body part releasing histamine, including symptoms of nasal discharge, lacrimation, itching, shortness of breath, dry skin, and the like, and serious patients may suffer from shock and thus be threatened. Allergy in people with allergic constitution is usually relieved by using anti-histamines and other drugs, and the allergic drugs generally have certain side effects, so that the inhibition of the allergic activity by using natural plants or extracting components with the function of inhibiting allergy from the plants is also an issue of public concern.
The ampelopsis belongs to green algae, is rich in algal polysaccharides, has zero fat and low calorie, has fresh and crisp mouthfeel, is the best natural health food in the minds of Japanese people and many experts like the caviar, and is also a high-grade food material in Japanese food shops. Since the sea grape contains a large amount of trace elements and has an anti-aging effect, the sea grape extract has been legally used as a cosmetic raw material by the world cosmetic society.
Most of the existing sea grape extraction technologies are extraction with alcohol or other organic solvents, taiwan patent I484966, which is an extraction method of sea grape extract, comprising the steps of performing crude extraction on sea grape powder with alcohol, and sequentially separating effective substances from the sea grape powder with n-hexane and ethyl acetate, wherein the effective substances have the effect of inhibiting cancers; korean patent KR101252149 uses water and C1-C4 alcohol to prepare a sea grape extract having antioxidant, anti-inflammatory, moisturizing, etc. effects. The extract of the sea grape in the prior art has no effect of inhibiting allergy, and the sea grape is extracted by an organic solvent, so that the sea grape can cause harm to human bodies even if a small amount of the organic solvent is remained.
The present invention relates to a method for extracting a vitis amurensis extract, and more particularly to a method for extracting a vitis amurensis extract from a vitis amurensis extract, which is an important subject to be solved by the present invention.
Disclosure of Invention
In order to overcome the defects of the prior art, the inventor provides a sea grape extract, which does not use organic solvent for extraction, uses water for extracting the sea grape at a specific temperature and time and further uses a membrane for filtration to obtain an active substance with the function of inhibiting allergy in the sea grape.
The invention provides a preparation method of a sea grape extract, which comprises the following steps:
step 1: pulping the sea grapes and pure water, wherein the weight ratio of the sea grapes to the pure water is 1: 1-20 parts of pure water, and uniformly mixing to obtain sea grape pulp;
step 2: continuously stirring the sea grape pulp, wherein the stirring temperature is 20-100 ℃, and the stirring time is 30-120 minutes;
and step 3: and (4) carrying out primary filtration, and obtaining liquid obtained by primary filtration to obtain the sea grape extract.
Optionally, in step 1, the sea grape may be fresh sea grape, dried sea grape, or sea grape powder.
Optionally, in the step 2, the stirring temperature is 60-90 ℃; preferably, the stirring temperature is 85 ℃; the stirring temperature is 60-105 minutes; preferably, the stirring temperature is 90 minutes.
Optionally, in step 3, the conditions of the first filtration are 5 microns and 1 micron.
Optionally, a second filtration may be further performed after the first filtration, wherein the second filtration is a membrane filtration; the 1 st film of the film filtration treatment is an EW film of GE company, the 2 nd film is a PW film of GE company, and the 3 rd film is a DK film of GE company.
Another object of the present invention is a Vitis amurensis extract with an allergy-suppressing effect, which is obtained by the above-mentioned method for preparing a Vitis amurensis extract.
The invention provides a composition, which comprises an effective amount of an anti-allergic ampelopsis extract and a cosmetically, dietetically or pharmaceutically acceptable excipient, wherein the composition is a cosmetic composition or a pharmaceutical composition.
Optionally, the effective amount of the vitis amurensis extract is more than 1 mg/ml; preferably, the effective amount of the sea grape extract is 4 mg/ml.
Optionally, wherein the cosmetic composition is a blend consisting of one or more of the following: creams, multiple emulsions, anhydrous compositions, aqueous dispersions, oils, emulsions, balms, foams, lotions, gels, latexes, aqueous ethanolic solutions, aqueous glycol solutions (hydroalcoholic solutions), hydrogels, paints, serums, soaps, shampoos, conditioners, serum, ointments, mousses, pomades, powders, sticks, pens, sprays, aerosols, capsules, gelatin capsules, soft capsules, hard capsules, lozenges, dragees, granules, chewing gums, solutions, suspensions, emulsions, syrups, polysaccharide films, jellies, and gelatins.
Optionally, wherein the cosmetic composition may be incorporated into a product selected from the group consisting of an eye-finishing cream, a foundation, a makeup-removing lotion, a makeup-removing cream, an eye shadow, a lipstick, a lip gloss, a lip balm, and a honeydew.
Optionally, the shampoo component comprises 10-50% of a surfactant, 0.3-2% of an emollient, 0.01-0.1% of a vitis amurensis extract, 0-2% of a thickener, 0.1-1% of an essence, 0.3-1% of a preservative and the balance of water.
Drawings
FIG. 1 is a schematic diagram showing the effect of sea grape extract on the release amount of beta-hexosaminidase in response to allergy induction, wherein calcium ionophore A23187 stimulates degranulation of cells to release beta-hexosaminidase;
FIG. 2 is a schematic diagram showing the effect of the extract of Vitis amurensis on suppressing allergy;
FIG. 3 is a schematic diagram showing the effect of the extract of Vitis amurensis on suppressing allergy.
Detailed Description
All technical and scientific terms used herein are, unless otherwise defined, common general knowledge to those skilled in the art.
The following examples are provided by way of illustration only, and the present invention is not limited to the following examples.
Example 1
Preparation method of vitis amurensis extract (I)
Taking 80g of sea grape dry powder and 1600g of pure water, using sea grape as Caulerpa lentillifera, beating and mixing uniformly (the temperature is about 85 ℃, the time is about 90 minutes), and then filtering by using a filter screen with the size of 5 mu m and a filter screen with the size of 1 mu m to obtain liquid sea grape extract (I); and then performing membrane filtration, wherein the 1 st membrane is an EW membrane of GE (General Electric) company, the Microfiltration (Microfiltration) removes impurities with larger volume, the 2 nd membrane is a PW membrane of the GE company, the Ultrafiltration (Ultrafiltration) removes impurities with fine volume, the 3 rd membrane is a DK membrane of the GE company, the Nanofiltration (nanofiltation) removes salt, and the freeze drying is performed after the membrane filtration to obtain the sea grape refined extract (I). The above Caulerpa lentillifera can also be replaced by other strains of Styrax amurensis (Caulerpa taxifolia) such as Caulerpa yezoensis.
The extract (I) of Vitis amurensis does not cause allergy
Cells were observed for release of the allergic medium beta-hexosaminidase (hexosaminidase) without using a stimulant (A23187(-)) added only to the extract (I) of Vitis heyneana and the extract (I) of Vitis heyneana alone as shown in FIG. 1, and the release of beta-hexosaminidase was not increased by the extract (I) of Vitis heyneana and the extract (I) of Vitis heyneana alone as compared with the control group, indicating that the extract (I) of Vitis heyneana and the extract (I) of Vitis heyneana alone did not themselves provoke allergy.
Third, allergy Induction experiment
Calcium ionophore a23187 stimulates degranulation of cells to release the allergen mediator β -hexosaminidase (β hexosaminidase), and the β -hexosaminidase concentration was detected by enzyme-linked immunosorbent assay (ELISA), as shown in fig. 1, indicating that a23187 stimulation induces β -hexosaminidase release.
Sichuan grape extract (I) for suppressing allergy
According to the results of fig. 2, the vitis amurensis extract (I) inhibited the release of β -hexosaminidase induced by a23187 stimulation (group a23187(+), the release of β -hexosaminidase was reduced by 8% by 2 mg/ml for vitis amurensis extract (I), and the release of β -hexosaminidase was reduced by 25% by 4mg/ml for vitis amurensis extract (I); the inhibitory effect of the vitis amurensis extract (I) on the release of the beta-hexosaminidase is more obvious than that of the vitis amurensis extract, the release of the beta-hexosaminidase is inhibited by 45% at 1mg/ml of the vitis amurensis extract (I), the release of the beta-hexosaminidase is inhibited by 82% at 4mg/ml of the vitis amurensis extract (I), and the cell survival rate is not affected (as shown in fig. 1).
Application of Vitis amurensis extract (I) in cosmetics
Heating quantitative pure water to 50-60 ℃, sequentially adding the surfactant, and stirring and mixing uniformly. Then adding the emollient in sequence, stirring and mixing uniformly. Stopping heating, cooling to 30 deg.C, adding Vitis heyneana extract (I), fructus Citri sinensis essential oil, and sodium anisate, stirring, and mixing to obtain mousse shampoo containing Vitis heyneana extract (I), with the formula ratio shown in Table 1.
TABLE 1 Muscovy shampoo formula proportions containing Hai grape extract (I)
Figure GDA0003016058770000051
Human body experiment of cosmetic prepared from extract of Vitis heyneana (I)
The united states Food and Drug Administration (FDA) certification laboratory AMA Laboratories inc. was entrusted with a human experiment of whether mousse shampoo (formula ratio, for example, table 1) containing a grape essence (I) produced skin irritation and sensitivity test, the number of subjects in this human experiment was 52, the number of subjects completing the study was 50, the subjects were in the age range of 20-68 years, and the gender and race are shown in table 2.
TABLE 2 Calculations of Subjects in Musco shampoo human experiments with Hai grape extract (I)
Figure GDA0003016058770000061
The human body experiment procedure was to dilute 10 times the mousse shampoo shown in table 1 with water, place 0.2ml of the diluted mousse shampoo on a semi-closed hypoallergenic patch, attach it to the back side of the skin of the subscapular region of the subject, the left side or the right side of the midline, and indicate that the subject area is not to be moistened or directly irradiated with the sun, remove the patch at home after 24 hours, repeat the attachment procedure until a series of 9 contacts were completed, each monday, wednesday and friday, for three consecutive weeks, and if an adverse reaction occurs, determine the region of erythema and edema, as shown in table 3, the shampooing of 50 subjects who completed the study did not have an allergic reaction to the mousse shampoo of the sea grape essence extract (I), indicating that the mousse shampoo containing the sea grape essence extract (I) is not skin-irritating and does not cause allergy.
TABLE 3 Muscovy shampoo human body test results of Hai grape extract (I)
Figure GDA0003016058770000071
Figure GDA0003016058770000081
Wherein, C is white, H is Hispanic, A is Asian, F is female, M is male, 0 is non-responsive, Dc is withdrawn from the experiment in the middle
Example 2
Taking 1.5 kg of fresh sea grape and 1.5 kg of pure water, wherein the used sea grape is Caulerpa lentillifera, pulping and mixing uniformly (the temperature is about 85 ℃/time is about 30 minutes), and then filtering by using a filter screen with the size of 5 mu m and a filter screen with the size of 1 mu m to obtain liquid which is sea grape extract (II); and then performing membrane filtration, wherein the 1 st membrane is an EW membrane of GE company, Microfiltration (Microfiltration) is used for removing large impurities, the 2 nd membrane is a PW membrane of GE company, Ultrafiltration (Ultrafiltration) is used for removing fine impurities, the 3 rd membrane is a DK membrane of GE company, Nanofiltration (nanofiltation) is used for removing salt, and freeze drying is performed after membrane filtration to obtain the sea grape refined extract (II). The Caulerpa lentillifera can be replaced by other strains of Styrax japonicus (Caulerpa taxifolia) and the like.
According to the results shown in FIG. 3, the Vitis amurensis extract (II) inhibited the release of β -hexosaminidase induced by stimulation with A23187 (group A23187(+), whereas the Vitis amurensis extract (II) inhibited the release of β -hexosaminidase by 40% at a concentration of 1mg/ml, by 60% at a concentration of 2 mg/ml and by 80% at a concentration of 4 mg/ml.
Example 3
Taking 1.5 kg of fresh sea grape and 1.5 kg of pure water, wherein the used sea grape is Caulerpa lentillifera, pulping and mixing uniformly (the temperature is about 25 ℃/time is about 60 minutes), and then filtering by a filter screen with the size of 5 mu m and the size of 1 mu m to obtain liquid which is sea grape extract (III); and then performing membrane filtration, wherein the 1 st membrane is an EW membrane of GE company, Microfiltration (Microfiltration) is used for removing large impurities, the 2 nd membrane is a PW membrane of GE company, Ultrafiltration (Ultrafiltration) is used for removing fine impurities, the 3 rd membrane is a DK membrane of GE company, Nanofiltration (nanofiltation) is used for removing salt, and freeze drying is performed after membrane filtration to obtain the sea grape refined extract (III). The Caulerpa lentillifera can be replaced by other strains of Styrax japonicus (Caulerpa taxifolia) and the like.
According to the results of FIG. 3, the Sedum amurensis extract (III) inhibited the release of β -hexosaminidase induced by stimulation with A23187 (group A23187 (+); the Vitis amurensis extract (III) can inhibit the release of the beta-hexosaminidase by 33% at the concentration of 1mg/ml, 56% at the concentration of 2 mg/ml and 75% at the concentration of 4 mg/ml.
The above detailed description is specific to possible embodiments of the present invention and is not intended to limit the scope of the present invention, and all equivalent modifications or substitutions that do not depart from the spirit of the present invention should be construed as within the scope of the present invention.
The above-mentioned several functions are fully met the requirements for novelty and creativity of patent law, and according to the law, the application is made, and the patent office is solicited to approve the patent application of said invention, so as to encourage innovation.

Claims (13)

1. A preparation method of a sea grape extract with an allergy inhibiting function is characterized by comprising the following steps:
step 1: pulping the sea grapes and pure water, wherein the weight ratio of the sea grapes to the pure water is 1: 1-20 parts of pure water, and uniformly mixing to obtain sea grape pulp;
step 2: continuously stirring the sea grape pulp, wherein the stirring temperature is 20-100 ℃, and the stirring time is 30-120 minutes;
and step 3: filtering with a filter screen;
and 4, step 4: performing membrane filtration treatment, wherein the liquid obtained by the membrane filtration treatment is the sea grape extract;
the film filtration treatment layer 1 is an EW film of GE company, the layer 2 is a PW film of GE company, and the layer 3 is a DK film of GE company.
2. The method of preparing a sea grape extract according to claim 1, wherein the sea grapes are fresh sea grapes, dried sea grapes, or sea grape powder in step 1.
3. The method according to claim 1, wherein the stirring temperature in step 2 is 60 to 90 ℃.
4. The method of preparing a sea grape extract according to claim 1, wherein the stirring temperature in the step 2 is 85 ℃.
5. The method according to claim 1, wherein the stirring time in step 2 is 60 to 105 minutes.
6. The method of preparing a sea grape extract according to claim 1, wherein the stirring time in step 2 is 90 minutes.
7. A Vitis heyneana extract having an inhibitory effect on allergy, which is obtained by the method for producing a Vitis heyneana extract according to any one of claims 1 to 6.
8. A composition comprising an effective amount of the allergy-suppressing sea grape extract of claim 7 and a cosmetically, dietetically, or pharmaceutically acceptable excipient, wherein the composition is a cosmetic composition or a pharmaceutical composition.
9. The composition of claim 8, wherein the effective amount of the extract of Vitis heyneana is 1mg/ml or more.
10. The composition of claim 8, wherein the effective amount of the extract of Vitis heyneana is 4 mg/ml.
11. The composition of claim 8, wherein said cosmetic composition is incorporated into the following products: eye-finishing cream, foundation make-up, makeup-removing lotion, makeup-removing cream, eye shadow, lipstick, lip gloss, lip balm, shampoo, and honey powder.
12. The composition according to claim 11, wherein the shampoo component comprises 10 to 50% of a surfactant, 0.3 to 2% of an emollient, 0.01 to 0.1% of a Vitis heyneana extract, 0 to 2% of a thickener, 0.1 to 1% of an essence, 0.3 to 1% of a preservative, and the balance of water.
13. Use of a sea grape extract for the preparation of a medicament for inhibiting allergy, wherein the sea grape extract is the sea grape extract according to claim 7.
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CN108158884A (en) * 2018-02-01 2018-06-15 百朗德生物化学(海门)有限公司 With the cosmetic material composition and its application in cosmetics for inhibiting allergy, function of delaying senility
CN109400743B (en) * 2018-11-14 2021-06-18 浙江海洋大学 Method for extracting sulfated galactan from sea grapes
CN109833334A (en) * 2018-12-13 2019-06-04 香港科技大学 The preparation method and application of long shoot grape caulerpa extract
TWI725715B (en) * 2020-01-20 2021-04-21 國立屏東科技大學 Caulerpa microphysa extract and product containing extract thereof
CN113244136A (en) * 2020-02-11 2021-08-13 台湾海洋大学 Pteridium aquilinum extract and additive product thereof
US11672754B2 (en) 2020-06-16 2023-06-13 Mary Kay Inc. Cosmetic composition
CN112370404B (en) * 2020-11-25 2022-09-16 桂林理工大学 Moisturizing and whitening composition, and preparation method and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105146641A (en) * 2015-10-30 2015-12-16 王永妍 Sea grape beverage and making method thereof

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JP2011012040A (en) * 2009-06-30 2011-01-20 Toshihiko Endo Preparation produced by using sea grape, especially sea grape originated in sea around cebu island and bohol island of philippine, and use thereof as medicine, cosmetic, food and food additive

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105146641A (en) * 2015-10-30 2015-12-16 王永妍 Sea grape beverage and making method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"海葡萄蕨藻多糖ASE提取工艺研究";王小兵等;《广东农业科学》;20131231(第16期);第104－106页 *

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