CN106986824A - A kind of 8 oxyquinoline preparation facilities - Google Patents
A kind of 8 oxyquinoline preparation facilities Download PDFInfo
- Publication number
- CN106986824A CN106986824A CN201710315148.8A CN201710315148A CN106986824A CN 106986824 A CN106986824 A CN 106986824A CN 201710315148 A CN201710315148 A CN 201710315148A CN 106986824 A CN106986824 A CN 106986824A
- Authority
- CN
- China
- Prior art keywords
- kettle
- synthesis reactor
- import
- discharging opening
- storage tank
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- MCJGNVYPOGVAJF-UHFFFAOYSA-N quinolin-8-ol Chemical compound C1=CN=C2C(O)=CC=CC2=C1 MCJGNVYPOGVAJF-UHFFFAOYSA-N 0.000 title claims abstract description 18
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 27
- 238000003786 synthesis reaction Methods 0.000 claims abstract description 27
- 238000006386 neutralization reaction Methods 0.000 claims abstract description 17
- 238000004065 wastewater treatment Methods 0.000 claims abstract description 12
- 239000012043 crude product Substances 0.000 claims abstract description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 51
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 36
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 34
- 230000008676 import Effects 0.000 claims description 29
- 238000007599 discharging Methods 0.000 claims description 22
- 238000003860 storage Methods 0.000 claims description 21
- 239000007788 liquid Substances 0.000 claims description 19
- 235000011187 glycerol Nutrition 0.000 claims description 17
- 235000011121 sodium hydroxide Nutrition 0.000 claims description 17
- 239000005725 8-Hydroxyquinoline Substances 0.000 claims description 16
- 229960003540 oxyquinoline Drugs 0.000 claims description 16
- 239000000945 filler Substances 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 235000009508 confectionery Nutrition 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 238000005119 centrifugation Methods 0.000 abstract description 4
- 206010020852 Hypertonia Diseases 0.000 abstract description 2
- 238000004140 cleaning Methods 0.000 abstract description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 239000000463 material Substances 0.000 abstract description 2
- 239000002351 wastewater Substances 0.000 abstract description 2
- CDAWCLOXVUBKRW-UHFFFAOYSA-N 2-aminophenol Chemical compound NC1=CC=CC=C1O CDAWCLOXVUBKRW-UHFFFAOYSA-N 0.000 description 2
- IQUPABOKLQSFBK-UHFFFAOYSA-N 2-nitrophenol Chemical compound OC1=CC=CC=C1[N+]([O-])=O IQUPABOKLQSFBK-UHFFFAOYSA-N 0.000 description 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 description 2
- 230000003472 neutralizing effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000003513 alkali Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A kind of 8 oxyquinoline preparation facilities, including synthesis reactor, neutralize kettle, centrifuge, rectifying still, receive kettle, slicer, wastewater treatment kettle and control warning system, the present apparatus is from synthesis, neutralize, centrifugation, crude product essence is steamed, section has special independent equipment, scientific structure design is reasonable, synthesis reactor completes after complex functionality that solution is evacuated into neutralization kettle by hydraulic vacuum pump, synthesis reactor can be carried out the preparation of the second batch materials after over cleaning, whole device can be produced continuously, substantially increase production efficiency and yield, temperature monitor is installed on each key equipment simultaneously, pressure gauge and timer and all with control warning system be connected, when discovering device temperature is too high or hypertonia or timer time to situations such as being capable of automatic alarm, in addition the present apparatus is additionally provided with wastewater treatment kettle, waste water progress processing is reached and discharged again after discharge standard.
Description
Technical field
8-hydroxyquinoline preparation facilities is prepared the present invention relates to chemicals preparation field, more particularly to one kind.
Background technology
8-hydroxyquinoline is after the quantitative concentrated sulfuric acid is slowly added into glycerine quantitative in synthesis reactor at normal temperatures,
O-aminophenol, o-nitrophenol, water are separately added under normal temperature, 130 DEG C or so are to slowly warm up to, continues to be slowly added to quantitative
The concentrated sulfuric acid, and be incubated.After end, add water, unnecessary o-nitrophenol is steamed.After cooling, viscous liquid is pumped into and neutralized
Kettle is neutralized to neutrality with liquid caustic soda, centrifugation.Crude product steams through rectifying still essence, cut into slices, packaging, obtains finished product 8-hydroxyquinoline.
In the preparation process of whole 8-hydroxyquinoline, chemicals is chemically reacted in each equipment, to chemistry
Time, temperature control and the Stress control of reaction have strict requirements, and major part 8-hydroxyquinoline preparation facilities is present at present
Problems with：（1）The equipment division of labor is indefinite, causes some equipment to be used repeatedly in a preparation process so that 8- hydroxyls
The preparation of quinoline can not be carried out continuously, it is necessary to after the completion of a collection of, then be started new a collection of；（2）Current majority 8-hydroxyquinoline systems
Temperature monitor, pressure gauge and the timer set on synthesis reactor, neutralization kettle, rectifying still and reception kettle in standby device is only
Vertical unit, temperature control, Stress control and timing controlled are intended to manually observe.
The content of the invention
It is an object of the invention to provide a kind of scientific structure design rationally, each equipment division of labor is clear and definite, being capable of Realtime Alerts company
The continuous device for preparing 8-hydroxyquinoline.
The technical solution adopted by the present invention is：A kind of 8-hydroxyquinoline preparation facilities, including synthesis reactor, neutralization kettle, centrifugation
Machine, rectifying still, receive at the top of kettle, slicer, wastewater treatment kettle and control warning system, the synthesis reactor provided with glycerine import and
Sulfuric acid import, the glycerine import connects glycerine storage tank, and the sulfuric acid import connects sulfuric acid storage tank, and synthesis reactor bottom is provided with discharging
Mouthful, the discharging opening is connected with neutralizing kettle；Liquid caustic soda import is provided with the top of the neutralization kettle, the liquid caustic soda import connects with liquid caustic soda storage tank
Connect, neutralization bottom portion is provided with discharging opening, the discharging opening is connected with centrifuge；The centrifuge provided with centrifugate outlet and
Crude product is exported, centrifugate outlet connection wastewater treatment kettle, and the crude product outlet connection rectifying still, the rectifying still connects conduction oil
System, rectifying still bottom is provided with discharging opening, and the discharging opening connection receives kettle, receives the discharging opening connection slicer of kettle, described
Synthesis reactor, neutralize kettle, rectifying still and receive and be equipped with temperature monitor, pressure gauge and timer on kettle, the temperature monitor,
Pressure gauge and timer are all connected with controlling warning system.
Preferably, the glycerine import and glycerine storage tank, sulfuric acid import and sulfuric acid storage tank, liquid caustic soda import and liquid caustic soda storage tank
Between be equipped with measuring tank.
Preferably, being provided with hydraulic vacuum pump between the synthesis reactor and neutralization kettle.
Preferably, the control warning system includes PLC and alarm.
Preferably, being equipped with manhole and visor on the synthesis reactor, neutralization kettle, rectifying still and reception kettle.
Preferably, being provided with filler in the wastewater treatment kettle.
Beneficial effects of the present invention：The present apparatus is from synthesis, neutralization, and centrifugation, crude product essence are steamed, section has specially independent set
Standby, solution rationally, neutralization kettle, synthesis reactor warp is evacuated to after synthesis reactor completion complex functionality by scientific structure design by hydraulic vacuum pump
The preparation of the second batch materials is can be carried out after over cleaning, such whole device can be produced continuously, substantially increase production effect
Rate and yield, while installing temperature monitor, pressure gauge and timer on each key equipment and being with control alarm
System connection, when discovering device temperature is too high or hypertonia or timer time to situations such as being capable of automatic alarm, in addition this dress
Put and be additionally provided with wastewater treatment kettle, waste water progress processing is reached and discharged again after discharge standard.
Brief description of the drawings
Fig. 1 is schematic structural view of the invention.
In figure：1 be synthesis reactor, 1.1 be glycerine import, 1.2 be glycerine storage tank, 1.3 be sulfuric acid import, 1.4 be sulfuric acid storage
Groove, 2 be neutralize kettle, 2.1 be liquid caustic soda import, 2.2 be liquid caustic soda storage tank, 3 be centrifuge, 3.1 be centrifugate outlet, 3.2 be crude product
Outlet, 4 be rectifying still, 5 be receive kettle, 6 be wastewater treatment kettle, 6.1 be filler, 7 be measuring tank, 8 be heat-conducting oil system, 9 be
Hydraulic vacuum pump, 10 be slicer, 11 be control warning system, 11.1 be temperature monitor, 11.2 be pressure gauge, 11.3 be fixed
When device, 12 be discharging opening.
Specific embodiment
A kind of 8-hydroxyquinoline preparation facilities, including synthesis reactor 1, neutralize kettle 2, centrifuge 3, rectifying still 4, receive kettle 5, cut
Piece machine 10, wastewater treatment kettle 6 and control warning system 11, the top of synthesis reactor 1 are provided with glycerine import 1.1 and sulfuric acid import
1.3, the connection glycerine of glycerine import 1.1 storage tank 1.2, the connection sulfuric acid of sulfuric acid import 1.3 storage tank 1.4, the bottom of synthesis reactor 1
Provided with discharging opening 12, the discharging opening 12 is connected with neutralizing kettle 2；The top of neutralization kettle 2 is provided with liquid caustic soda import 2.1, the liquid
Alkali import 2.1 is connected with liquid caustic soda storage tank 2.2, and neutralization kettle 2 bottom is provided with discharging opening 12, the discharging opening 12 and centrifuge 3
Connection；The centrifuge 3 connects wastewater treatment kettle 6 provided with centrifugate outlet 3.1 and crude product outlet 3.2, centrifugate outlet 3.1,
The crude product outlet 3.2 connects rectifying still 4, and the rectifying still 4 connects heat-conducting oil system 8, and the bottom of rectifying still 4 is provided with discharging opening
12, the discharging opening 12 connection receives kettle 5, receives the connection slicer 10 of discharging opening 12 of kettle 5, the synthesis reactor 1, neutralize kettle 2,
Temperature monitor 11.1, pressure gauge 11.2 and timer 11.3, the temperature monitor are equipped with rectifying still 4 and reception kettle 5
11.1st, pressure gauge 11.2 and timer 11.3 are all connected with controlling warning system 11；The glycerine import 1.1 and glycerine storage tank 1.2,
Measuring tank 7, the synthesis reactor are equipped between sulfuric acid import 1.3 and sulfuric acid storage tank 1.4, liquid caustic soda import 2.1 and liquid caustic soda storage tank 2.2
Hydraulic vacuum pump 9 is provided between 1 and neutralization kettle 2；The control warning system 11 includes PLC and alarm；It is described to close
Manhole and visor are equipped with into kettle 1, neutralization kettle 2, rectifying still 4 and reception kettle 5；Filler is provided with the wastewater treatment kettle 6
6.1。
Claims (6)
1. a kind of 8-hydroxyquinoline preparation facilities, including synthesis reactor, neutralize kettle, centrifuge, rectifying still, receive kettle, it is slicer, useless
Water process kettle and control warning system, it is characterised in that：Glycerine import and sulfuric acid import are provided with the top of the synthesis reactor, it is described sweet
Oil inlet connects glycerine storage tank, and the sulfuric acid import connects sulfuric acid storage tank, and synthesis reactor bottom is provided with discharging opening, the discharging opening with
Neutralize kettle connection；Liquid caustic soda import is provided with the top of the neutralization kettle, the liquid caustic soda import is connected with liquid caustic soda storage tank, the neutralization bottom
Portion is provided with discharging opening, and the discharging opening is connected with centrifuge；The centrifuge is provided with centrifugate outlet and crude product outlet, centrifugate
Outlet connection wastewater treatment kettle, the crude product outlet connection rectifying still, the rectifying still connects heat-conducting oil system, rectifying still bottom
Provided with discharging opening, the discharging opening connection receives kettle, receives the discharging opening connection slicer of kettle, the synthesis reactor, neutralization kettle, essence
Evaporate kettle and receive and be equipped with temperature monitor, pressure gauge and timer on kettle, the temperature monitor, pressure gauge and timer are equal
Connection control warning system.
2. a kind of 8-hydroxyquinoline preparation facilities according to claim 1, it is characterised in that：The glycerine import and glycerine
Measuring tank is equipped between storage tank, sulfuric acid import and sulfuric acid storage tank, liquid caustic soda import and liquid caustic soda storage tank.
3. a kind of 8-hydroxyquinoline preparation facilities according to claim 1, it is characterised in that：The synthesis reactor and neutralization kettle
Between be provided with hydraulic vacuum pump.
4. a kind of 8-hydroxyquinoline preparation facilities according to claim 1, it is characterised in that：The control warning system bag
Include PLC and alarm.
5. a kind of 8-hydroxyquinoline preparation facilities according to claim 1, it is characterised in that：The synthesis reactor, neutralize kettle,
Manhole and visor are equipped with rectifying still and reception kettle.
6. a kind of 8-hydroxyquinoline preparation facilities according to claim 1, it is characterised in that：Set in the wastewater treatment kettle
There is filler.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710315148.8A CN106986824A (en) | 2017-05-08 | 2017-05-08 | A kind of 8 oxyquinoline preparation facilities |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710315148.8A CN106986824A (en) | 2017-05-08 | 2017-05-08 | A kind of 8 oxyquinoline preparation facilities |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106986824A true CN106986824A (en) | 2017-07-28 |
Family
ID=59417463
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710315148.8A Pending CN106986824A (en) | 2017-05-08 | 2017-05-08 | A kind of 8 oxyquinoline preparation facilities |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106986824A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107954929A (en) * | 2017-12-24 | 2018-04-24 | 抚州市萨弗隆化工有限公司 | A kind of process units of 8-hydroxyquinoline halides |
| CN109485603A (en) * | 2018-10-31 | 2019-03-19 | 梁敏华 | A kind of preparation method of the 8-hydroxyquinoline of no solid waste output |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101591290A (en) * | 2009-06-19 | 2009-12-02 | 夏士朋 | The back-end production process of synthesis of quinoline and derivative thereof |
| CN102267943A (en) * | 2011-07-29 | 2011-12-07 | 江苏力达宁化工有限公司 | Method for preparing 5-chloro-8-hydroxyquinoline |
-
2017
- 2017-05-08 CN CN201710315148.8A patent/CN106986824A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101591290A (en) * | 2009-06-19 | 2009-12-02 | 夏士朋 | The back-end production process of synthesis of quinoline and derivative thereof |
| CN102267943A (en) * | 2011-07-29 | 2011-12-07 | 江苏力达宁化工有限公司 | Method for preparing 5-chloro-8-hydroxyquinoline |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107954929A (en) * | 2017-12-24 | 2018-04-24 | 抚州市萨弗隆化工有限公司 | A kind of process units of 8-hydroxyquinoline halides |
| CN109485603A (en) * | 2018-10-31 | 2019-03-19 | 梁敏华 | A kind of preparation method of the 8-hydroxyquinoline of no solid waste output |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170728 |
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| RJ01 | Rejection of invention patent application after publication |