CN205420245U - A lun sodium phosphate preparation in -process and salify equipment - Google Patents
A lun sodium phosphate preparation in -process and salify equipment Download PDFInfo
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- CN205420245U CN205420245U CN201620252467.XU CN201620252467U CN205420245U CN 205420245 U CN205420245 U CN 205420245U CN 201620252467 U CN201620252467 U CN 201620252467U CN 205420245 U CN205420245 U CN 205420245U
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- cauldron
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Abstract
The utility model relates to a lun sodium phosphate preparation in -process and salify equipment, in including and the cauldron, in with the import of cauldron ligation liquid cauldron respectively, the ware is put in to water tank and alkali piece, in with the cauldron in be equipped with the coil pipe, refrigerating unit is connected to the coil pipe, in be equipped with heating device with the periphery of cauldron, in with the exit linkage centrifuge of cauldron, vacuum suction filter's import is connected to centrifuge's solid delivery outlet, the export of ethanol jar is still connected in vacuum suction filter's import, the recovery cauldron is connected to vacuum suction filter's liquid outlet, retrieve the exit linkage ethanol jar of cauldron, the exit linkage vacuum suction filter's of ethanol jar import. The utility model discloses the refining process of A lun sodium phosphate preparation in -process and salify can be improved, the yield is improved.
Description
Technical field
This utility model belongs to chemical field, in specifically a kind of alendronate preparation process with become salt equipment.
Background technology
Alendronate preparation process, during neutralizing salification process, technique is the most rough, and items of equipment is used alone, and lacks and directly coordinates, and product yield is relatively low.
Utility model content
This utility model provide in a kind of alendronate preparation process with become salt equipment, in order to solve defect of the prior art.
This utility model is achieved by the following technical programs:
In alendronate preparation process with become salt equipment, including neutralizing still, neutralize import coupled reaction liquid still, water tank and the alkali sheet dispenser respectively of still, it is provided with coil pipe in neutralizing still, coil pipe connects refrigeration unit, the periphery neutralizing still is provided with heater, the outlet neutralizing still connects centrifuge, the solids outlet of centrifuge connects the import of vacuum filter, the import of vacuum filter is also connected with the outlet of Ethanol tank, the liquid outlet of vacuum filter connects recovery still, and the outlet reclaiming still connects Ethanol tank, and the outlet of Ethanol tank connects the import of vacuum filter.
In alendronate preparation process as above with become salt equipment, described heater is steam jacket.
In alendronate preparation process as above and becomes salt equipment, the described outlet connection distillation column reclaiming still, the outlet connection Ethanol tank of distillation column.
nullThe utility model has the advantages that: in this utility model，Quantitative water is added to neutralizing in still，Water is added by water tank，It is cooled to 10～20 DEG C by refrigeration unit，Stirring adds condensation reaction solution，Condensation reaction solution is added by reactant liquor still，Then it is warming up to 95～105 DEG C of insulation backflows 2～3 hours by steam jacket，Backflow terminates，It is cooled to less than 80 DEG C，PH=5～5.3 is regulated by alkali sheet dispenser sheet alkali，Then cool to 5～10 DEG C，It is discharged to centrifuge，Alendronate dry product is added and rinses to vacuum filter，First pass through Ethanol tank addition ethanol rinse centrifugal solids and obtain alendronate wet product，Rinsing liquid is concentrated and is gone to reclaim still recovery，Reclaim and retortable in still reclaim ethanol by distillation column，Intensification atmospheric distillation，Control to reclaim still temperature at 120～140 DEG C，Tower top temperature 76～80 DEG C，The fraction collected is that ethanol is to Ethanol tank.This utility model can improve in alendronate preparation process with the subtractive process becoming salt, improve yield.
Accompanying drawing explanation
In order to be illustrated more clearly that this utility model embodiment or technical scheme of the prior art, the accompanying drawing used required in embodiment or description of the prior art will be briefly described below, apparently, accompanying drawing in describing below is embodiments more of the present utility model, for those of ordinary skill in the art, on the premise of not paying creative work, it is also possible to obtain other accompanying drawing according to these accompanying drawings.
Fig. 1 is structural representation of the present utility model.
Figure number marks: 1 refrigeration unit, 2 steam jackets, and in 3 and still, 4 reactant liquor stills, 5 water tanks, 6 alkali sheet dispensers, 7 centrifuges, 8 vacuum filters, 9 reclaim stills, 10 distillation column, 11 Ethanol tank.
Detailed description of the invention
For making the purpose of this utility model embodiment, technical scheme and advantage clearer, below in conjunction with the accompanying drawing in this utility model embodiment, technical scheme in this utility model embodiment is clearly and completely described, obviously, described embodiment is a part of embodiment of this utility model rather than whole embodiments.Based on the embodiment in this utility model, the every other embodiment that those of ordinary skill in the art are obtained under not making creative work premise, broadly fall into the scope of this utility model protection.
In alendronate preparation process with become salt equipment, as shown in the figure, including neutralizing still 3, neutralize the import coupled reaction liquid still 4 respectively of still 3, water tank 5 and alkali sheet dispenser 6, it is provided with coil pipe in neutralizing still 3, coil pipe connects refrigeration unit 1, the periphery neutralizing still 3 is provided with heater, the outlet neutralizing still 3 connects centrifuge 7, the solids outlet of centrifuge 7 connects the import of vacuum filter 8, the import of vacuum filter 8 is also connected with the outlet of Ethanol tank 11, the liquid outlet of vacuum filter 8 connects recovery still 9, the outlet reclaiming still 9 connects Ethanol tank 11, the outlet of Ethanol tank 11 connects the import of vacuum filter 8.nullIn this utility model，Quantitative water is added to neutralizing in still 2，Water is added by water tank 5，It is cooled to 10～20 DEG C by refrigeration unit 1，Stirring adds condensation reaction solution，Condensation reaction solution is added by reactant liquor still 4，Then it is warming up to 95～105 DEG C of insulation backflows 2～3 hours by steam jacket 2，Backflow terminates，It is cooled to less than 80 DEG C，PH=5～5.3 is regulated by alkali sheet dispenser 6 sheet alkali，Then cool to 5～10 DEG C，It is discharged to centrifuge 7 be centrifuged，Alendronate dry product is added to vacuum filter 8 rinsing，First pass through Ethanol tank 11 to add ethanol rinse centrifugal solids and obtain alendronate wet product，Rinsing liquid is concentrated and is gone recovery still 9 to reclaim，Reclaim and retortable in still 9 reclaim ethanol by distillation column 10，Intensification atmospheric distillation，Control to reclaim still temperature at 120～140 DEG C，Tower top temperature 76～80 DEG C，The fraction collected is that ethanol is to Ethanol tank 11.This utility model can improve in alendronate preparation process with the subtractive process becoming salt, improve yield.
Specifically, heater can be electrically heated rod, it is possible to use following structure, and the heater described in the present embodiment is steam jacket 2.Steam jacket 2 is safe to use, it is possible to use the steam that other production process produces, and saves the energy.
Concrete, for the most effective purifying ethanol, the outlet reclaiming still 9 described in the present embodiment connects distillation column 10, and the outlet of distillation column 10 connects Ethanol tank 11.Ethanol can effectively purify after distillation column 10, directly uses after purification, reduces the impurity of product.
Last it is noted that above example is only in order to illustrate the technical solution of the utility model, it is not intended to limit；Although this utility model being described in detail with reference to previous embodiment, it will be understood by those within the art that: the technical scheme described in foregoing embodiments still can be modified by it, or wherein portion of techniques feature is carried out equivalent；And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of this utility model each embodiment technical scheme.
Claims (3)
1. in alendronate preparation process with become salt equipment, it is characterized in that: include neutralizing still (3), neutralize import coupled reaction liquid still (4) respectively of still (3), water tank (5) and alkali sheet dispenser (6), it is provided with coil pipe in neutralizing still (3), coil pipe connects refrigeration unit (1), the periphery neutralizing still (3) is provided with heater, the outlet neutralizing still (3) connects centrifuge (7), the solids outlet of centrifuge (7) connects the import of vacuum filter (8), the import of vacuum filter (8) is also connected with the outlet of Ethanol tank (11), the liquid outlet of vacuum filter (8) connects recovery still (9), the outlet reclaiming still (9) connects Ethanol tank (11), the outlet of Ethanol tank (11) connects the import of vacuum filter (8).
In alendronate preparation process the most according to claim 1 with become salt equipment, it is characterised in that: described heater is steam jacket (2).
In alendronate preparation process the most according to claim 1 with become salt equipment, it is characterized in that: the outlet of described recovery still (9) connects distillation column (10), the outlet of distillation column (10) connects Ethanol tank (11).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620252467.XU CN205420245U (en) | 2016-03-29 | 2016-03-29 | A lun sodium phosphate preparation in -process and salify equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620252467.XU CN205420245U (en) | 2016-03-29 | 2016-03-29 | A lun sodium phosphate preparation in -process and salify equipment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN205420245U true CN205420245U (en) | 2016-08-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201620252467.XU Expired - Fee Related CN205420245U (en) | 2016-03-29 | 2016-03-29 | A lun sodium phosphate preparation in -process and salify equipment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN205420245U (en) |
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2016
- 2016-03-29 CN CN201620252467.XU patent/CN205420245U/en not_active Expired - Fee Related
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| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160803 Termination date: 20170329 |
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| CF01 | Termination of patent right due to non-payment of annual fee |