CN106974838A - A kind of biological collagen face mask substrate material and its application - Google Patents

A kind of biological collagen face mask substrate material and its application Download PDF

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Publication number
CN106974838A
CN106974838A CN201710241239.1A CN201710241239A CN106974838A CN 106974838 A CN106974838 A CN 106974838A CN 201710241239 A CN201710241239 A CN 201710241239A CN 106974838 A CN106974838 A CN 106974838A
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CN
China
Prior art keywords
mask substrate
face mask
parts
substrate material
face
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Pending
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CN201710241239.1A
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Chinese (zh)
Inventor
周亚仙
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WUZHOU SHENGUAN PROTEIN CASING CO Ltd
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WUZHOU SHENGUAN PROTEIN CASING CO Ltd
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Priority to CN201710241239.1A priority Critical patent/CN106974838A/en
Publication of CN106974838A publication Critical patent/CN106974838A/en
Priority to SG11201902245T priority patent/SG11201902245TA/en
Priority to PCT/CN2017/116213 priority patent/WO2018188366A1/en
Priority to PH12018550147A priority patent/PH12018550147A1/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0212Face masks
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35Ketones, e.g. benzophenone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35Ketones, e.g. benzophenone
    • A61K8/355Quinones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/39Derivatives containing from 2 to 10 oxyalkylene groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/58Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
    • A61K8/585Organosilicon compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86Polyethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/005Preparations for sensitive skin

Abstract

The present invention relates to a kind of biological collagen face mask substrate material and its application.The face mask substrate material natural no stimulation, using safety, prevents infringement of the industrial chemicals to skin, all kinds of skin can be safe to use including anaphylaxis skin;The face mask substrate material is a softer and smoother touch, especially such as human body second layer skin, and the usage experience of high-quality is provided to consumer.

Description

A kind of biological collagen face mask substrate material and its application
Technical field
The present invention relates to a kind of biological collagen face mask substrate material and its application, belong to biomaterial applied technical field.
Background technology
The native protein that collagen is made up of 19 kinds of amino acid such as glycine, alanine, proline.Its is main It is present in the skin of animal, cartilage, ligament, tendon and other connective tissues, plays support, protection etc., is connective tissue weight The structural proteins wanted.
Over nearly 20 years, with the development of molecular biology, people are more and more deep to the understanding of collagen property, there is research Show:Collagen it is antigenic low, with good biocompatibility and biodegradability.Therefore, as natural life Physical resources, collagen becomes increasingly conspicuous in the importance and economic status of the commercial Applications such as food, biomedicine, cosmetics, Research of the collagen film being made with collagen in above-mentioned field also day animando.
Mask product is numerous in the market, but wherein most all contains industrial chemicals.Adopted even if portioned product is claimed With natural material, but still it can not accomplish really pure natural.Therefore, for anaphylaxis skin consumer, particularly serious mistake , really can be few with facial mask safe to use for the consumer of quick constitution.
The content of the invention
It is an object of the invention to provide a kind of biological collagen face mask substrate material and its application.The natural nothing of face mask substrate material Stimulate, using safety, prevent infringement of the industrial chemicals to skin, all kinds of skin can be safe to use including anaphylaxis skin;Should Face mask substrate material is a softer and smoother touch, especially such as human body second layer skin, is used in combination with the facial mask liquid of special formulation, can bring consumer The usage experience of high-quality.
The present invention adopts the following technical scheme that realization:
A kind of biological collagen face mask substrate material, is prepared by the following method:
S1:Biological collagen is inserted into extruder, tubulose biological collagen film is obtained, to tubulose biological collagen Film is cut, and is flattened;
S2:The collagen film extension of pressing is stretched on the roller of facial mask shaping slicer, the mould of customization is used It is pressed on roller, the minimum range of mould and roller is adjusted with handwheel, driven mold cutting knife pressure is rotated collagen using motor Protein film is cut off, and obtains collagen diaphragm;
Wherein, in step (1), the biological collagen is extracted from Animal Skin and obtained, and specific method is:
(1) Animal Skin is cleaned, split;
(2) after the Animal Skin alkali process of segmentation, by Animal Skin and water weight ratio 1:1 adds water, is carried out with protease at enzyme Reason, the protease addition is the 0.5-2% of Animal Skin weight, is handled 3-6 hours at 25-35 DEG C, and acid is carried out after cleaning Processing;
(3) Animal Skin after acid treatment is cooled to less than 10 DEG C, using pelletizing, tabletting, cut mix, lapping mode or its combine Mode is shredded, and rolls in flakes, silk quality fiber is extracted by high-pressure filteration;
(4) dietary fiber element or the derivative element of dietary fiber element, fat liquor are added while stirring, control ph and aqueous Amount, is mixed evenly, obtains biological collagen.
Wherein, in the step (1), by Animal Skin segmentation preferably into 5-20mm2.The Animal Skin be ox-hide, pigskin or Other Animal Skins.
In the step (2), the protease is pepsin, papain or pancreatin.
In the step (2), the alkali process is preferably that milk of lime is pickled after 1-2 days and rinsed well with water;Acid treatment is excellent From 0.1-0.5M hydrochloric acid or lactic acid solution, immersion makes Animal Skin be changed into translucent expansion shape, venting acid with lactic acid again after 4 hours Liquid, is washed 3-4 times with clear water.
In the step (4), fat liquor is made as follows:Edible oil and fat are heated into it is liquid, by edible oil Fat and water weight ratio 1:1 adds water, reheats, colloid mill emulsification;The edible oil and fat are hydrogenated oil and fat, margarine or shortening Oil.
In the step (4), the consumption of the derivative element of the dietary fiber element or dietary fiber element is the 1- of Animal Skin weight 3%, fat liquor is the 1-5% of Animal Skin weight, controls pH2.5-3.5, water content is 88-94%.
The shape of face mask substrate material of the present invention can be cut according to actual use demand.For example, being directly cut into mesh Preceding commercially available whole the most frequently used facial mask shape, and in eye, nose, mouth corresponding site perforate;Or, face mask substrate material is cut into multiple flat Face part formed segmented face mask substrate material, such as up and down two parts, left and right two parts, or more part;Or it is cut into three-dimensional 3D Structure, to facilitate different face users to carry out more targeted facial-care according to face's diverse location.
As one of preferred embodiment for the present invention, the face mask substrate material be segmented face mask substrate material, using nose bottom as Line of demarcation, is divided into top half and the latter half by face, and mold shape is adjusted according to the top half of face and the latter half, Each several part face mask substrate material is made in preparation method according still further to above-mentioned face mask substrate material.Specifically as Figure 1-4.
The specific size of segmented face mask substrate material is as follows:Facial top half face mask substrate material length is 230 ± 5mm, wide Spend for 102 ± 5mm;Wherein, eyelet is provided with the facial top half face mask substrate material in eye relevant position, eyelet is ellipse Shape, major axis is 50 ± 2mm, and short axle is 20 ± 2mm;It is open in the lower edge of facial top half face mask substrate material provided with six, its In, two openings are located at lower edge two close end, 190 ± 5mm of distance;Remaining four openings are located at face mask substrate material nose areas Both sides, make its more docile face with convenient use person's adjustment face mask substrate material;Wherein it is located at the both sides of face mask substrate material nose areas Opening be arranged symmetrically, farthest two extended distances are 60 ± 2mm, and middle two extended distances are 40 ± 2mm.
Facial the latter half face mask substrate material length is 230 ± 5mm, and width is 100 ± 5mm;Nose areas is wherein corresponded to set One breach, width is 45 ± 2mm, it is to avoid facial mask liquid influence user's breathing;Lip perforate in facial the latter half face mask substrate material For ellipse, major axis is 63 ± 2mm, and short axle is 20 ± 2mm, and nose areas whose lower end is 13 apart from lip perforate upper end distance ±2mm;Equally, the lower end of facial the latter half face mask substrate material also is provided with four openings, by axis of facial axis in symmetrical Arrangement, most two, two ends extended distance is 125 ± 2mm, and middle two extended distances are 63 ± 2mm.
As one of preferred embodiment for the present invention, the face mask substrate material is 3D face mask substrate materials, then can be according to left face, right face And mouth and nose triangle portion adjustment mold shape, each several part facial mask is made according still further to the above method, the special bonding of collagen is utilized Each several part facial mask is glued together by agent, 3D round faces is made using mold shape cutting surrounding, so as to obtain 3D collagen protein faces Base material.Specifically as shown in Figure 5-10.
As one of preferred embodiment of the present invention, the 3D face mask substrate materials are divided into left face part, right face part and mouth The part of nose triangular portions three;Wherein, the left face part length of the 3D face mask substrate materials be 203 ± 5mm, upper end width be 88 ± 5mm, lower end width is 106 ± 5mm;Eye perforate is ellipse, and major axis is 46 ± 2mm, and short axle is 19 ± 2mm;Right face part It is divided into mirror-image structure with left face;
And the mouth and nose triangular portions of the 3D face mask substrate materials are in the low stereochemical structure in middle high both sides, middle edge length is 109 ± 5mm, the distance of left and right ends to middle edge is 48 ± 2mm;In the mouth and nose triangular portions pair of the 3D face mask substrate materials Answer at nose and lip position be provided with nostril and lip hole, middle edge is divided into five sections, be followed successively by 20 ± 2mm, 13 ± 2mm, 13 ± 2mm, 20 ± 2mm, 43 ± 2mm;The distalmost end in nostril apart from 26 ± 2mm of middle edge, the distalmost end in lip hole apart from middle edge 35 ± 2mm.
The present invention also provides a kind of facial mask, is made up of above-mentioned biological collagen face mask substrate material and facial mask liquid.
The facial mask liquid is made up of the component of following parts by weight:80.0-90.0 parts of water, 1.0-5.0 parts of 1,3-PD is sweet It is oily 1.0-5.0 parts, 0.05-3.0 parts of methyl-monosilane alcohol hydroxyproline ester aspartate, hydrolysis Jojoba esters 0.01-1.0 Part, 0.1-2.0 parts of Sodium Hyaluronate, 0.1-2.0 parts of german chamomile (CHAMOMILLARECUTITA) extract, glycoprotein 0.1-1.0 Part, 0.2-3.0 parts of aloe barbadensis Miller (ALOEBARBADENSIS) leaf extract, centella (CENTELLAASIATICA) is extracted 0.1-1.0 parts of thing, 0.1-1.0 parts of Fourstamen Stephania Root (STEPHANIATETRANDRA) extract, 0.1-0.8 parts of ubiquinone, Queensland nut (MACADAMIATERNIFOLIA) 0.1-0.8 parts of seed oil, 0.1-1.0 parts of -8/5/3 glycerine of PEG/PPG/ polytetramethylene glycols, to hydroxyl 0.3-0.6 parts of acetophenone, 0.1-3.0 parts of butanediol, 1,2- 0.4-2.0 parts of hexylene glycol, 0.1-1.0 parts of xanthans, rose (ROSARUGOSA) caul-fat 0.01-0.05 parts, 0.5-0.8 parts of Cremophor RH40, PPG-26- butylol polyethers -260.5- 0.8 part.
As one of preferred embodiment of the present invention, the facial mask liquid is made up of the component of following parts by weight:Water 85-88 Part, 4-5 part of 1,3-PD, 3-5 parts of glycerine, 0.1-0.2 parts of methyl-monosilane alcohol hydroxyproline ester aspartate, hydrolyze flash 0.01-0.02 parts of bar esters, 0.1-0.15 parts of Sodium Hyaluronate, german chamomile (CHAMOMILLARECUTITA) extract 0.1-0.15 Part, 0.1-0.15 parts of glycoprotein, 0.2-0.25 parts of aloe barbadensis Miller (ALOEBARBADENSIS) leaf extract, centella (CENTELLAASIATICA) extract 0.1-0.15 parts, Fourstamen Stephania Root (STEPHANIATETRANDRA) extract 0.1-0.15 Part, 0.1-0.15 parts of ubiquinone, 0.1-0.15 parts of Queensland nut (MACADAMIATERNIFOLIA) seed oil, PEG/PPG/ polybutadienes 0.4-0.6 parts of the glycerine of alcohol -8/5/3,0.5-0.6 parts of parahydroxyacet-ophenone, 0.1-0.15 parts of butanediol, 1,2- hexylene glycol 0.4- 0.5 part, 0.5-0.7 parts of xanthans, 0.01-0.02 parts of rose (ROSARUGOSA) caul-fat, Cremophor RH40 0.7-0.8 Part, 0.7-0.8 parts of PPG-26- butylol polyethers -26.
The beneficial effect of technical scheme of the present invention:
The present invention is using biological collagen as raw material, and originality is made into face mask substrate material, successfully replaces existing non-woven fabrics The problems such as allergy that class face mask substrate material is present.Using face mask substrate material of the present invention, good penetrability, natural no stimulation is utilized Its unique design feature and perfectly fit ability, Essence can be preferably penetrated into skin, not back suction is received, nothing with skin Residual, efficient moisture-retention makes facial mask facial treatment essence ingredient draws more thorough.
Brief description of the drawings
Fig. 1 is the collagen diaphragm overall schematic of embodiment 1.
Fig. 2 is the collagen diaphragm overall dimensions figure of embodiment 1.
Fig. 3 is upper shape of face collagen diaphragm size figure in embodiment 1.
Fig. 4 is lower shape of face collagen diaphragm size figure in embodiment 1.
Fig. 5 is 3D collagen films piece facial mask stereogram described in embodiment 2.
Fig. 6 is the whole face collagen diaphragm plane figure of facial mask described in embodiment 2
Fig. 7 is the upper face position collagen diaphragm figure of facial mask described in embodiment 2.
Fig. 8 is the mouth and nose triangle portion collagen diaphragm figure of facial mask described in embodiment 2.
Fig. 9 is the left face collagen diaphragm figure of facial mask described in embodiment 2.
Figure 10 is the right face collagen diaphragm figure of facial mask described in embodiment 2.
Embodiment
Following examples are used to illustrate the present invention, but are not limited to the scope of the present invention.
Embodiment 1:Segmented facial mask
Comprise the following steps:
(1) preparation of facial mask liquid:
Water 15.7212g, 1,3-PD 0.9g, glycerine 0.54g, methyl-monosilane alcohol hydroxyproline ester aspartate 0.018g, hydrolyzes Jojoba esters 0.0018g, Sodium Hyaluronate 0.0252g, german chamomile extract 0.018g, glycoprotein 0.018g, Aloe barbadensis Miller leaf extract 0.036g, Gotu Kola P.E 0.018g, stephania tetrandra extract 0.018g, ubiquinone 0.018g, Australia Continent nut seed oil 0.018g, PEG/PPG/ polytetramethylene glycols -8/5/3 glycerine 0.09g, parahydroxyacet-ophenone 0.09g, butanediol 0.018g, 1,2- hexylene glycol 0.072g, 0.108 part of xanthans, rose oil 0.0018g, Cremophor RH40 0.135g, PPG-26- butylol polyethers 0.135g.
(2) preparation of segmented face mask substrate material
Operating environment requirements:In 100,000 grades of GMP clean rooms
Temperature requirement:Control is at 22-26 DEG C
Relative humidity requirement:Control is in 45%-55%
1st, on long 230mm × wide 102mm shape of face collagen diaphragm preparation process:
1) biological collagen, is obtained according to the method described in CN100548127C, biological collagen is inserted crowded Press, obtains tubulose biological collagen film, and diameter 52-54mm tubulose collagen films are placed on to the fixation of tubulose edge opener It is fixed on the pulley spindle of support.
2), tubulose collagen film is cut open side with cutter machine, flattening shaft device by fold flattens.
3), the collagen film extension of pressing is stretched on the roller of facial mask shaping slicer, the upper face of customization is used Mould be pressed on roller, the mould of upper face and the minimum range of roller are adjusted with handwheel, is cut using motor rotation driven mold Knife pressure cuts off collagen film, obtains face collagen diaphragm.
2nd, under long 230mm × wide 100mm shape of face collagen diaphragm preparation process:
4), diameter 52-54mm tubulose collagen films are placed on the support bracket fastened pulley spindle of tubulose edge opener solid It is fixed.
5), tubulose collagen film is cut open side with cutter machine, flattening shaft device by fold flattens.
6), the collagen film extension of pressing is stretched on the roller of facial mask shaping slicer, the lower face of customization is used Mould be pressed on roller, the mould of lower face and the minimum range of roller are adjusted with handwheel, is cut using motor rotation driven mold Knife pressure cuts off collagen film, obtains lower face collagen diaphragm.
Upper face, lower face are each a piece of to be a set of when the 3rd, producing, and apply into shape of face when using respectively.
Gained facial mask is as Figure 1-Figure 4.
Embodiment 2:3D collagen protein faces
Comprise the following steps:
(1) preparation of facial mask liquid:Facial mask formula of liquid described in be the same as Example 1.
(2) 3D collagen protein faces making step:
Operating environment requirements:In 100,000 grades of GMP clean rooms
Temperature requirement:Control is at 22-26 DEG C
Relative humidity requirement:Control is in 45%-55%
1st, biological collagen is obtained according to the method described in CN100548127C, biological collagen is inserted into extruding Machine, obtains tubulose biological collagen film, and diameter 52-54mm tubulose collagen films are placed on to the fixed branch of tubulose edge opener It is fixed on the pulley spindle of frame.
2nd, tubulose collagen film is cut open side with cutter machine, flattening shaft device by fold flattens.
3rd, the collagen film extension of pressing is stretched on the roller of facial mask shaping slicer, uses the left face mould of customization Tool is pressed on roller, and the collagen wound membrane held side successfully and flattened is clipped in the middle, and the mould and roller of upper face are adjusted with handwheel Minimum range, using motor rotation driven mold cutting knife pressure collagen film is cut off, obtain left face collagen diaphragm.
4th, the mould of right face is changed using the above method, right face collagen diaphragm is obtained.
5th, mouth and nose triangle portion mould is changed using the above method, obtains mouth and nose triangle portion collagen diaphragm.
6th, by left face collagen diaphragm, mouth and nose triangle portion collagen diaphragm, right face collagen diaphragm, collagen is used Albumen adhesive specially is glued together, and makes 3D round faces using mold shape cutting surrounding, obtains 3D collagen protein faces.
Gained 3D face mask substrate materials are as shown in Figure 5-10.
Although above the present invention is described in detail with a general description of the specific embodiments, On the basis of the present invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Cause This, these modifications or improvements, belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.

Claims (10)

1. a kind of biological collagen face mask substrate material, it is characterised in that prepare by the following method:
S1:Biological collagen is inserted into extruder, tubulose biological collagen film is obtained, tubulose biological collagen film is cut Cut, flatten;
S2:The collagen film extension of pressing is stretched on the roller of facial mask shaping slicer, is pressed in using the mould of customization On roller, the minimum range of mould and roller is adjusted with handwheel, driven mold cutting knife pressure is rotated collagen using motor Film is cut off, and obtains collagen diaphragm;
Wherein, in step (1), the biological collagen is extracted from Animal Skin and obtained, and specific method is:
(1) Animal Skin is cleaned, split;
(2) after the Animal Skin alkali process of segmentation, by Animal Skin and water weight ratio 1:1 adds water, and ferment treatment, institute are carried out with protease The 0.5-2% that protease addition is Animal Skin weight is stated, is handled 3-6 hours at 25-35 DEG C, acid treatment is carried out after cleaning;
(3) Animal Skin after acid treatment is cooled to less than 10 DEG C, using pelletizing, tabletting, cut mix, lapping mode or its combination Chopping, rolls in flakes, silk quality fiber is extracted by high-pressure filteration;
(4) dietary fiber element or the derivative element of dietary fiber element, fat liquor, control ph and water content are added while stirring, are mixed Conjunction stirs, and obtains biological collagen.
2. biological collagen face mask substrate material according to claim 1, it is characterised in that in the step (2), the egg White enzyme is pepsin, papain or pancreatin.
3. biological collagen face mask substrate material according to claim 1, it is characterised in that in the step (2), the alkali It is processed as milk of lime and pickles after 1-2 days to be rinsed well with water;Acid treatment 0.1-0.5M hydrochloric acid or lactic acid solution, soak 4 hours Make Animal Skin that translucent expansion shape is presented with lactic acid again afterwards, venting acid solution is washed 3-4 times with clear water.
4. biological collagen face mask substrate material according to claim 1, it is characterised in that in the step (4), it is described can The consumption of edible cellulose or the derivative element of dietary fiber element is the 1-3% of Animal Skin weight, and fat liquor is the 1- of Animal Skin weight 5%, pH2.5-3.5 is controlled, water content is 88-94%.
5. biological collagen face mask substrate material according to claim 1, it is characterised in that the face mask substrate material is shaped as Whole face mask substrate material of plane, segmented face mask substrate material, solid 3D structure face mask substrate materials.
6. biological collagen face mask substrate material according to claim 5, it is characterised in that the face mask substrate material is segmented Face mask substrate material, its concrete structure is:Face is divided into top half and the latter half using nose bottom as line of demarcation;The face Top half length is 230 ± 5mm, and width is 102 ± 5mm;The facial the latter half face mask substrate material length is 230 ± 5mm, Width is 100 ± 5mm.
7. biological collagen face mask substrate material according to claim 6, it is characterised in that the facial top half facial mask Oval eyelet is provided with base material in eye relevant position, its major axis is 50 ± 2mm, and short axle is 20 ± 2mm;
Facial top half face mask substrate material lower edge provided with six opening, two of which opening close to face mask substrate material two ends, Spacing is 190 ± 5mm, and remaining four openings are located at face mask substrate material nose both sides, and are arranged symmetrically, farthest two extended distances For 60 ± 2mm, middle two extended distances are 40 ± 2mm;
A breach is set in the facial the latter half face mask substrate material at correspondence nose, width is 45 ± 2mm;In the facial lower half Partial face mask base material lip correspondence position opens an oval lip hole, and major axis is 63 ± 2mm, and short axle is 20 ± 2mm, and nose areas lacks Mouth lower end is apart from lip hole 13 ± 2mm of upper end;
Four openings being arranged symmetrically using facial axis as axis are provided with the lower end of facial the latter half face mask substrate material, its In most both ends open spacing be 125 ± 2mm, middle two openings spacing are 63 ± 2mm.
8. biological collagen face mask substrate material according to claim 5, it is characterised in that the face mask substrate material is 3D facial masks Base material, is divided into left face part, right face part and the part of mouth and nose triangular portions three;
Wherein, the left face part length of the 3D face mask substrate materials is 203 ± 5mm, and upper end width is 88 ± 5mm, and lower end width is 106±5mm;Eye perforate is ellipse, and major axis is 46 ± 2mm, and short axle is 19 ± 2mm;Right face part is divided into mirror with left face As structure;
The mouth and nose triangular portions of the 3D face mask substrate materials in the low stereochemical structure in middle high both sides, middle edge length is 109 ± 5mm, the distance of left and right ends to middle edge is 48 ± 2mm;At the mouth and nose triangular portions correspondence nose of the 3D face mask substrate materials With lip position be provided with nostril and lip hole, middle edge is divided into five sections, be followed successively by 20 ± 2mm, 13 ± 2mm, 13 ± 2mm, 20 ± 2mm, 43 ± 2mm;The distalmost end in nostril is apart from 26 ± 2mm of middle edge, and the distalmost end in lip hole is apart from 35 ± 2mm of middle edge.
9. a kind of facial mask, it is characterised in that by any biological collagen face mask substrate materials of claim 1-8 and facial mask liquid group Into.
10. facial mask according to claim 9, it is characterised in that the facial mask liquid is made up of the component of following parts by weight:Water 80.0-90.0 parts, 1.0-5.0 parts of 1,3-PD, 1.0-5.0 parts of glycerine, methyl-monosilane alcohol hydroxyproline ester aspartate 0.05-3.0 parts, 0.01-1.0 parts of Jojoba esters of hydrolysis, 0.1-2.0 parts of Sodium Hyaluronate, 0.1-2.0 parts of german chamomile extract, 0.1-1.0 parts of glycoprotein, 0.2-3.0 parts of aloe barbadensis Miller leaf extract, 0.1-1.0 parts of Gotu Kola P.E, Fourstamen Stephania Root is extracted 0.1-1.0 parts of thing, 0.1-0.8 parts of ubiquinone, 0.1-0.8 parts of Queensland nut seed oil, the glycerine of PEG/PPG/ polytetramethylene glycols -8/5/3 0.1-1.0 parts, 0.3-0.6 parts of parahydroxyacet-ophenone, 0.1-3.0 parts of butanediol, 1,2- 0.4-2.0 parts of hexylene glycol, xanthans 0.1-1.0 parts, 0.01-0.05 parts of rose oil, 0.5-0.8 parts of Cremophor RH40, PPG-26- butylol polyethers -26 0.5-0.8 parts.
CN201710241239.1A 2017-04-13 2017-04-13 A kind of biological collagen face mask substrate material and its application Pending CN106974838A (en)

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PCT/CN2017/116213 WO2018188366A1 (en) 2017-04-13 2017-12-14 Biologic collagen mask base material and application thereof
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CN110507548A (en) * 2019-09-28 2019-11-29 广州香枝化妆品有限公司 A kind of macromolecule 3D is seamless super to be impregnated with compact facial mask and preparation method thereof
CN110664633A (en) * 2019-11-16 2020-01-10 烟台东方化学有限公司 Anticorrosion synergistic composition and application thereof

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