CN1069535C - Clinical medicinal prepns. contg. flavongly coside extracted for persimmon leaves, and process for preparing same - Google Patents
Clinical medicinal prepns. contg. flavongly coside extracted for persimmon leaves, and process for preparing same Download PDFInfo
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- CN1069535C CN1069535C CN98113018A CN98113018A CN1069535C CN 1069535 C CN1069535 C CN 1069535C CN 98113018 A CN98113018 A CN 98113018A CN 98113018 A CN98113018 A CN 98113018A CN 1069535 C CN1069535 C CN 1069535C
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- persimmon leaves
- diospyros kaki
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Abstract
The present invention relates to a pharmaceutical preparation of flavonoid glycoside of persimmon leaves in clinic and a preparation process thereof. After the impurities of the collected persimmon leaves are removed, water is added; after secondary decoction is carried out, filter liquid is merged and is concentrated into extractum; etanol is added to make the extractum precipitated; after refrigerated storage is carried out, supernatant liquid is collected and taken, and the etanol is recovered simultaneously; the pharmaceutical preparation of flavonoid glycoside of persimmon leaves in clinic called by the present invention is obtained. When the pharmaceutical preparation of the present invention is used for doing a pharmacological and bacteriostasis test, a result shows that the function of the present invention is basically consistent with the functions of penicillin and metronidazole, and the medicinal ingredients in the pharmaceutical preparation have an obvious function of expanding blood vessels; meanwhile, the present invention has certain curative effects on platelet reduction and neurogenic insomnia.
Description
The present invention relates to a kind of technology of extracting the leaf of Diospyros kaki L.f. active substance.
Persimmon grows in each province to the north of China the Changjiang river more, extensively distributes in China Shan south Qin crust mountain area.According to one's analysis, the chemical analysis of leaf of Diospyros kaki L.f. mainly contains: flavonoid glycoside, phenols, resin, coumarin overseas Chinese chemical compound, the fat of mixing, reducing sugar, polysaccharide, volatile oil, organic acid (betulic acid, oleanolic acid, the acid of Bears state) etc.Astragalin (Astragalin) is wherein arranged in the flavonoid glycoside, and myricitrin (Myr-icitrin) contains abundant vitamin C and carotene in addition.Extract flavonoid glycoside and make pharmacology and bacteriostatic test from leaf of Diospyros kaki L.f.: the result shows that it is with penicillin and metronidazole effect basically identical.Medicinal composition has the effect of tangible blood vessel dilating in the glycoside, and simultaneously, it has certain curative effect to hematoblastic minimizing and nerve insomnia.Chinese patent literature invention disclosed name is called: the production method of leaves flavone plant growth accelerating agent (publication number: 1134225 applyings date: 96.01.05), it is its correlation technique, it is characterized in that, use water extraction, add alkaloids as cosolvent, with the active ingredient of adsorbent resin adsorption and enrichment, but its purpose (it is to be used for plant) and preparation method and the present invention are essentially different.
The objective of the invention is to propose a kind of technology of extracting the leaf of Diospyros kaki L.f. active substance.
The technical scheme that realizes the object of the invention is as follows, and it is,
Gather leaf of Diospyros kaki L.f., remove impurity, the water that the 5-7 of adding leaf of Diospyros kaki L.f. weight doubly measures boiled 30-50 minute, filter,
Add water logging again and do not have the above-mentioned leaf of Diospyros kaki L.f. that had boiled, decocted once more 20-40 minute, filter it,
Merging filtrate, and filtrate is condensed into extractum, add 96% ethanol precipitation, after cold preservation, collect supernatant, reclaim ethanol simultaneously, promptly get the alleged leaf of Diospyros kaki L.f. extract of the present invention.
Good effect of the present invention is as follows:
The leaf of Diospyros kaki L.f. extract that alleged technology is extracted according to the present invention, further make medicine after, it is right: pneumonia, acute and chronic tracheitis, infantile pneumonia, pertussis, urinary system infection, pyelonephritis, cystitis, urethritis, diseases such as mastitis have curative effect preferably.The present invention also can be used for the hypertensive patient, with blood vessel dilating, strengthens the blood flow of its tremulous pulse, makes blood pressure drops, and can improve symptoms such as patient's headache, giddy.In addition, this leaf of Diospyros kaki L.f. extract also has hemostasis, analgesic, cooling effect, and hematoblastic minimizing of purpura and the gynaecopathia that caused by anaerobe, mycete are had therapeutical effect.Its medicine of further making is not in use found untoward reaction such as allergy and toxicity.
Observation of curative effect: with the alleged leaf of Diospyros kaki L.f. extract of the present invention and after further making preparation, 178 routine patients have been carried out clinical observation treatment,
Wherein: cure rate is 72.4%,
Obvious effective rate 12%,
Improvement rate 9.2%,
Inefficiency 6.4%, total effective rate are 93.6%.
Clinical using method: with the leaf of Diospyros kaki L.f. extract, make injection, make every milliliter to contain 2mg leaf of Diospyros kaki L.f. extract, every 2ml.According to the state of an illness: each intramuscular injection 2-4ml, every 4-8 hour once, is weekly a course of treatment, need not use other antibacterials in the treatment phase.
The invention will be further described below in conjunction with embodiment,
Embodiment:
Gather the leaf of Diospyros kaki L.f. in autumn, clean,
Choose above-mentioned leaf of Diospyros kaki L.f., and add the water of six times of amounts of leaves weight, boiled 40 minutes, filter.
Add water logging again and do not have the above-mentioned leaf of Diospyros kaki L.f. that had boiled, decocted once more 30 minutes, filter it,
Merge filtrate twice, filtrate is condensed into extractum, and add 96% ethanol and make it precipitation, after 24 hours, collect supernatant, reclaim ethanol simultaneously, and adjust concentration, make every milliliter to contain leaf of Diospyros kaki L.f. extract 2mg in cold preservation.
The leaf of Diospyros kaki L.f. extract that the present invention is alleged also can further be processed into tablet, capsule, electuary and gynecological external use irrigation etc., with convenient clinical use.
Claims (1)
1, a kind of extraction process of leaf of Diospyros kaki L.f. extract is characterized in that, it is the leaf of Diospyros kaki L.f. that will gather, after removing impurity, the water that the 5-7 of adding leaf of Diospyros kaki L.f. weight doubly measures boiled 30-50 minute, filter, add water logging again and do not have the above-mentioned leaf of Diospyros kaki L.f. that had boiled, decocted once more 20-40 minute, filter it, merging filtrate, and filtrate is condensed into extractum, add 96% ethanol precipitation, after cold preservation, collect supernatant, reclaim ethanol simultaneously, promptly get the alleged leaf of Diospyros kaki L.f. extract of the present invention.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98113018A CN1069535C (en) | 1998-11-20 | 1998-11-20 | Clinical medicinal prepns. contg. flavongly coside extracted for persimmon leaves, and process for preparing same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98113018A CN1069535C (en) | 1998-11-20 | 1998-11-20 | Clinical medicinal prepns. contg. flavongly coside extracted for persimmon leaves, and process for preparing same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1225268A CN1225268A (en) | 1999-08-11 |
| CN1069535C true CN1069535C (en) | 2001-08-15 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98113018A Expired - Fee Related CN1069535C (en) | 1998-11-20 | 1998-11-20 | Clinical medicinal prepns. contg. flavongly coside extracted for persimmon leaves, and process for preparing same |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1069535C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2298349C (en) * | 1999-02-16 | 2008-11-18 | Sunstar Inc. | Antiallergic composition and antipruritic composition |
| CN101152223B (en) * | 2007-08-31 | 2010-04-14 | 哈尔滨医科大学 | Use of poplar leaf phenols extract in preparation of medicine for treating cardiovascular disease |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1134225A (en) * | 1996-01-05 | 1996-10-30 | 浙江省农业科学院 | Producing method for persimmon leaf flavone plant growth accelerating agent |
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1998
- 1998-11-20 CN CN98113018A patent/CN1069535C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1134225A (en) * | 1996-01-05 | 1996-10-30 | 浙江省农业科学院 | Producing method for persimmon leaf flavone plant growth accelerating agent |
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| Publication number | Publication date |
|---|---|
| CN1225268A (en) | 1999-08-11 |
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