CN1225268A - Clinical medicinal prepns. contg. flavongly coside extracted for persimmon leaves, and process for preparing same - Google Patents
Clinical medicinal prepns. contg. flavongly coside extracted for persimmon leaves, and process for preparing same Download PDFInfo
- Publication number
- CN1225268A CN1225268A CN 98113018 CN98113018A CN1225268A CN 1225268 A CN1225268 A CN 1225268A CN 98113018 CN98113018 CN 98113018 CN 98113018 A CN98113018 A CN 98113018A CN 1225268 A CN1225268 A CN 1225268A
- Authority
- CN
- China
- Prior art keywords
- leaf
- clinical
- diospyros kaki
- glycoside
- flavongly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a clinical use preparation made from persimmon tree leaf flavone glycoside and its preparation technology. The collected persimmon tree leaves after removal of impurities are added with water through decocting twice, combining and filtrating, concentrating to paste or extract, adding ethanol and precipitating, refrigerating, collecting supernatant, and at the same time, recovering ethanol, the invented perimmon tree leaf flavone glycoside clinical-use preparation is obtained. Clinical experiments show its action is basicall same as penicillin and metronidazole. The medical composition in the glycoside possess apparent action of dilate blood vessel, in addition , it also can decrease of has a certain curative effect on thrombocyte and neurotic insomnia.
Description
The present invention relates to a kind of clinical pharmaceutical formulation, specifically be meant clinical pharmaceutical formulation of leaf of Diospyros kaki L.f. flavonoid glycoside and preparation technology thereof.
Persimmon grows in each province to the north of China the Changjiang river more, extensively distributes in China Shan south Qin crust mountain area.According to one's analysis, the chemical analysis of leaf of Diospyros kaki L.f. mainly contains: flavonoid glycoside, phenols, resin, coumarin chemical compound, the fat of mixing, reducing sugar, polysaccharide, volatile oil, organic acid (betulic acid, oleanolic acid, the acid of Bears state) etc.Astragalin (Astraga1in) is wherein arranged in the flavonoid glycoside, and myricitrin (Myr-icitrin) contains abundant vitamin C and carotene in addition.Extract flavonoid glycoside and make pharmacology and bacteriostatic test from leaf of Diospyros kaki L.f.: the result shows that it is with Armeniaca mume Sieb. element and metronidazole effect basically identical.Medicinal composition has the effect of tangible blood vessel dilating in the glycoside, and simultaneously, it has certain curative effect to hematoblastic minimizing and nerve insomnia.Chinese patent literature invention disclosed name is called: the production method of persimmon leaf flavone plant growth accelerating agent (notification number: 1134225 applyings date: 96.01.05), it is its correlation technique, it is characterized in that, use water extraction, add alkaloids as cosolvent, with adsorbent resin adsorption and enrichment effective ingredient, but its purpose (it is to be used for plant) and preparation method and the present invention are essentially different.
The objective of the invention is to propose clinical pharmaceutical formulation of a kind of leaf of Diospyros kaki L.f. flavonoid glycoside and preparation technology thereof.
The technical scheme that realizes the object of the invention is as follows, and it is,
Gather leaf of Diospyros kaki L.f., remove impurity, the water that the 5-7 of adding leaf of Diospyros kaki L.f. weight doubly measures boiled 30-50 minute, filter,
Add water logging again and do not have the above-mentioned leaf of Diospyros kaki L.f. that had boiled, decocted once more 20-40 minute, filter it,
Merge filtering, and filtrate is condensed into extractum, add ethanol precipitation, after cold preservation, collect supernatant, reclaim ethanol simultaneously, promptly get the alleged clinical pharmaceutical formulation of leaf of Diospyros kaki L.f. flavonoid glycoside of the present invention.
Good effect of the present invention is as follows:
Use the alleged preparation of the present invention right: pneumonia, acute and chronic tracheitis, infantile pneumonia, pertussis, urinary system infection, nephropyelitis, cystitis, urethritis, diseases such as mastitis have curative effect preferably.The present invention also can be used for the hypertensive patient, with blood vessel dilating, strengthens the blood flow of its tremulous pulse, makes blood pressure drops, and can improve symptoms such as patient's headache, giddy.In addition, the clinical pharmaceutical formulation of this leaf of Diospyros kaki L.f. flavonoid glycoside also has hemostasis, analgesic, cooling effect, and hematoblastic minimizing of purpura and the gynaecopathia that caused by anaerobe, mycete are had therapeutical effect.Above-mentioned preparation is not in use found untoward reaction such as allergy and toxicity.
Observation of curative effect: use the alleged preparation of the present invention, 178 routine patients have been carried out clinical observation treatment,
Wherein: cure rate is 72.4%,
Obvious effective rate 12%,
Improvement rate 9.2%,
Inefficiency 6.4%, total effective rate are 93.6%.
Clinical using method: with the extract flavone glycoside, make injection, make every milliliter to contain the 2mg flavonoid glycoside, every 2ml.According to the state of an illness: each intramuscular injection 2-4ml, every 4-8 hour once, is weekly a course of treatment, need not use other antibacterials in the treatment phase.
The invention will be further described below in conjunction with embodiment,
Embodiment:
Gather the leaf of Diospyros kaki L.f. in autumn, clean,
Choose above-mentioned leaf of Diospyros kaki L.f., and add the water of six times of amounts of leaves weight, boiled 40 minutes, filter.
Add water logging again and do not have the above-mentioned leaf of Diospyros kaki L.f. that had boiled, decocted once more 30 minutes, filter it,
Merge filtrate twice, filtrate is condensed into extractum, and add 96% ethanol and make it precipitation, after 24 hours, collect supernatant, reclaim ethanol simultaneously, and adjust formulation concentrations, make every ml of formulation contain flavonoid glycoside 2mg in cold preservation.
The pharmaceutical formulation that the present invention is alleged also can further be processed into tablet, capsule, electuary and gynecological external use towards Xian's agent etc., with convenient clinical use.
Claims (1)
1, clinical pharmaceutical formulation of a kind of leaf of Diospyros kaki L.f. flavonoid glycoside and preparation technology thereof is characterized in that,
It is the leaf of Diospyros kaki L.f. that will gather, remove impurity after, add the water that the 5-7 of leaf of Diospyros kaki L.f. weight doubly measures, boiled 30-50 minute, filter,
Add water logging again and do not have the above-mentioned leaf of Diospyros kaki L.f. that had boiled, decocted once more 20-40 minute, filter it,
Merging filtrate, and filtrate is condensed into extractum, add ethanol precipitation, after cold preservation, collect supernatant, reclaim ethanol simultaneously, promptly get the alleged clinical pharmaceutical formulation of leaf of Diospyros kaki L.f. flavonoid glycoside of the present invention.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98113018A CN1069535C (en) | 1998-11-20 | 1998-11-20 | Clinical medicinal prepns. contg. flavongly coside extracted for persimmon leaves, and process for preparing same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98113018A CN1069535C (en) | 1998-11-20 | 1998-11-20 | Clinical medicinal prepns. contg. flavongly coside extracted for persimmon leaves, and process for preparing same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1225268A true CN1225268A (en) | 1999-08-11 |
| CN1069535C CN1069535C (en) | 2001-08-15 |
Family
ID=5222803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98113018A Expired - Fee Related CN1069535C (en) | 1998-11-20 | 1998-11-20 | Clinical medicinal prepns. contg. flavongly coside extracted for persimmon leaves, and process for preparing same |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1069535C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6863907B2 (en) * | 1999-02-16 | 2005-03-08 | Sunstar, Inc. | Antiallergic composition and antipruritic composition |
| CN101152223B (en) * | 2007-08-31 | 2010-04-14 | 哈尔滨医科大学 | Use of poplar leaf phenols extract in preparation of medicine for treating cardiovascular disease |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1134225A (en) * | 1996-01-05 | 1996-10-30 | 浙江省农业科学院 | Producing method for persimmon leaf flavone plant growth accelerating agent |
-
1998
- 1998-11-20 CN CN98113018A patent/CN1069535C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6863907B2 (en) * | 1999-02-16 | 2005-03-08 | Sunstar, Inc. | Antiallergic composition and antipruritic composition |
| CN101152223B (en) * | 2007-08-31 | 2010-04-14 | 哈尔滨医科大学 | Use of poplar leaf phenols extract in preparation of medicine for treating cardiovascular disease |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1069535C (en) | 2001-08-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101112458B (en) | Process for extracting effective component of sweet tea | |
| CN1813802A (en) | Bufonid skin extract production process | |
| CN110101728B (en) | Combined extraction method of purslane polysaccharide and total flavonoids based on micelle medium treatment | |
| CN103735633B (en) | A kind of preparation method of instant gardenia powder | |
| CN1875786A (en) | A face beautifying tea drink and preparation method thereof | |
| CN102718817A (en) | Method for preparing anthocyanin extract from black bean peel | |
| CN101709094A (en) | Method for separating sweet tea polysaccharide by ultrafiltration membranes | |
| CN1733793A (en) | Method for preparing holothurin from waste solution of sea cucumber processing | |
| CN111374247B (en) | Fracture setting raspberry concentrated juice and preparation method thereof | |
| CN105412209A (en) | Astragalus extract and preparation method thereof and application | |
| CN1069535C (en) | Clinical medicinal prepns. contg. flavongly coside extracted for persimmon leaves, and process for preparing same | |
| CN112675278A (en) | Composition for moistening lung to arrest cough and inhibiting lung inflammatory reaction and preparation method and application thereof | |
| CN111803531A (en) | Preparation method and application of dandelion leaf water-soluble crude extract | |
| CN102477105A (en) | Method for combined preparation of polysaccharide and flavone by using pumpkin stems and leaves as raw material | |
| CN110218262A (en) | Application of the low sulphated heteroglycan rich in glucuronic acid in brown alga source in preparation treatment diabetes B drug | |
| CN105192820A (en) | Blood-fat-reducing cordyceps militaris polysaccharide beverage and preparing method thereof | |
| KR20050041802A (en) | Polysaccharides of plants belonging to panax having effect on treatment and prevention of obesity | |
| KR100857687B1 (en) | A method for isolation of high concentration of magnesium lithospermate b from salviae miltiorrhizae | |
| CN104523851A (en) | Method for extracting polygonum orientale pericarp general flavone extract product | |
| CN108440477B (en) | A method of preparing Quercetin from tungoiltree juvenile leaf | |
| CN111557406A (en) | Kudzuvine flower extract rich in pueraria flower isoflavone and preparation method and application thereof | |
| CN1094291A (en) | Houttuynia oral administration liquid | |
| CN1943647A (en) | The method for preparing triterpenic acid extract from the loquat leaves | |
| CN101721450B (en) | Application of oriental cocklebur root chloroform extract used for treating peritonitis | |
| CN114369026B (en) | Method for extracting chlorogenic acid and rutin from ficus pumila leaves |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |