CN106943581A - 泥炙及其制备方法 - Google Patents
泥炙及其制备方法 Download PDFInfo
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Abstract
本发明涉及一种泥炙及其制备方法,其中,按重量份数计,其原料包括,井底泥23~29份,蜂蜡17~21份,明胶5~9份,海藻糖13~17份,中药混合物24~30份;其制备方法中通过明胶搭接具有活性成分的中药药材以及海藻糖,使制备得到的泥炙具有显著的祛风散痛,温热补体的效果,同时保护皮肤不受损伤。
Description
技术领域
本发明涉及养生保健领域,更具体的说,它涉及一种泥炙及其制备方法。
背景技术
泥灸作为现代人在传统蜡灸疗法、温敷疗法延伸出来的一种新型实用的高效疗法,创新发展了祖国温灸技术,它以经络学说为原理,现代医学为依据,根据分子医学理论、生物医学全息理论以及内病外治、异病同治等中医理论,通过刺激穴位、疏通脉络和药力热传导,安全高效祛除体内的风、寒、湿、热、毒,达到扶本固元,促进新陈代谢,增强肌体免疫力的功效。
在泥炙的使用过程中,由于泥炙的生物活性较高,通常需要在皮肤涂覆有泥炙的区域包覆一层保鲜膜,防止泥炙中的活性成分与外界空气发生反应,保证大部分的活性成分被皮肤吸收。但是皮肤长时间处于一个高温、不透气,且营养浓度高的环境中,皮肤的表皮细胞很容易受到损伤。
发明内容
本发明的目的在于提供一种泥炙及其制备方法,通过该种方法制备得到具有不破坏中药混合物中活性成分,同时保护皮肤不受损伤的泥炙。
本发明的上述目的是通过以下技术方案得以实现的,一种泥炙,按重量份数计,其原料包括,井底泥23~29份,蜂蜡17~21份,明胶5~9份,海藻糖13~17份,中药混合物24~30份。
通过采用上述技术方案,井底泥中沉积大量矿物分子,具有清热解毒的功效,以井底泥为基料,同时复配其他具有活性成分的辅料,制备得到的泥炙使用效果优越。同时,海藻糖具有优异的保持细胞活力和生物大分子活性的特性,皮肤细胞,尤其是表皮细胞在高温、高寒、干燥、强紫外线辐射等环境下,极易失去水分发生角质化,甚至脱落使皮肤受损。海藻糖在这种情况下能够在细胞表层形成一层特殊的保护膜,从而保护皮肤不至受损。
优选的,所述明胶的分子量为20000~30000。
通过采用上述技术方案,在泥炙的制备过程中,明胶作为载体,使海藻糖搭建在多肽分子链中,通过调节明胶的分子量,海藻糖在明胶上的搭建能力最佳。
优选的,所述中药混合物为肉桂、苍耳子、附子、生姜、独活、细辛、鹿茸、藏红花、当归、川芎、泽兰叶、鸡血藤。
优选的,所述中药混合物中肉桂、苍耳子、附子、生姜、独活、细辛、鹿茸、藏红花、当归、川芎、泽兰叶、鸡血藤的质量比为2.7∶3.2∶2.5∶2.3∶0.8∶1.3∶1.6∶2.5∶0.3∶2.7∶2.4∶1.7。
通过采用上述技术方案,组成中药混合物的12种中药药材均为祛风散痛,温热补体的中药药材,通过12种中药药材的复配使用,使泥炙具有优越的使用效果。
肉桂:适宜平素畏寒怕冷,四肢手脚发凉、胃寒冷痛、食欲不振、呕吐清水、腹部隐痛喜暖、肠鸣泄泻者食用;
苍耳子:发散风寒,通鼻窍,祛风湿,止痛;
附子:回阳救逆,温补脾肾,散寒止痛,大辛大热,温阳逐寒;
生姜:为芳香性辛辣健胃药,有温暖、兴奋、发汗、止呕、解毒等作用;
独活:祛风胜湿,散寒止痛;
细辛:祛风散寒、止痛通窍、止咳平喘;
鹿茸:滋补强壮剂,对虚弱、神经衰弱等有疗效;
藏红花:活血痛红、散瘀止痛、安神养血、滋阴壮阳;
当归:具有补血和血,调经止痛,润燥滑肠;
川芎:胸胁疼痛;头痛眩晕,风寒湿痹;
泽兰叶:血虚有火,渐至不通;
鸡血藤:具有活血补血,调经止痛,舒筋活络之功效。
本发明的另一目的在于提供上述所述泥炙的制备方法。
本发明的上述目的是通过以下技术方案得以实现的,一种泥炙的制备方法,至少包含以下步骤:
打粉:分别取肉桂、苍耳子、附子、生姜、独活、细辛、鹿茸、藏红花、当归、川芎、泽兰叶、鸡血藤,利用球磨机将12种中药材研磨成细粉,相互混合均匀后为中药混合物;
第一步混合:取明胶、海藻糖、蒸馏水加入反应釜A中,升高反应釜A的温度,搅拌直至明胶完全溶解,成为胶液;
起泡:降低反应釜A的温度,反应釜A内胶液成为半凝胶态后,向反应釜A中通入氮气;
第二步混合:将蜂蜡加入反应釜B中,升高反应釜B的温度,待成为液体后,加入中药混合物,继续搅拌;
互混:向反应釜B内部的混合物加入反应釜A中,继续搅拌;
第三部混合:向反应釜A中加入井底泥,搅拌均匀后,制备得到泥炙。
通过采用上述技术方案,首先将海藻糖溶解在明胶胶体中,同时降低反应釜A的温度,当明胶胶体成为半凝胶状态后,向反应釜A通入氮气,使半凝胶状态的胶体出现若干气泡孔。之后在半凝胶状态的胶体中加入蜂蜡、研磨后的中药混合物以及井底泥,研磨后的中药混合物以及井底泥填充在半凝胶状态的胶体空隙中。
优选的,所述第一步混合过程中,反应釜A的温度为60~65℃,搅拌速度为30~35r/min,搅拌时间为15~19min。
优选的,所述起泡过程中,反应釜A的温度为40~45℃,氮气流量为30~34m2/h。
优选的,所述第二步混合过程中,反应釜B的温度为50~54℃,搅拌速度为20~24r/min,搅拌时间为25~27min。
优选的,所述互混过程中,反应釜A的温度为40~44℃,搅拌速度为30~35r/min,搅拌时间为20~30min。
优选的,所述第三步混合过程中,反应釜A的温度为30~34℃,搅拌速度为50~56r/min,搅拌时间为10~20min。
通过采用上述技术方案,在反应过程中,由于加入的海藻糖以及中药混合物中含有大量的活性成分,在制备泥炙的过程中,需要微调各个反应步骤的反应温度、反应时间以及搅拌速度,使海藻糖以及中药混合物在不丧失大量活性成分的同时,制备得到的泥炙使用性能更加优越。
综上所述,本发明具有以下有益效果:
1、泥炙在使用过程中,需要对泥炙进行加热,使泥炙内部的活性成分释放。泥炙附着在皮肤表层的区域会在高温,以及活性成分较高的情况下,皮肤表层失水过多,造成皮肤表层一定程度的损伤。泥炙中添加的海藻糖具有优异的保持细胞活力,以及生物大分子活性的特性。皮肤表皮的细胞在受到高温的作用下,海藻糖可以在细胞表层形成一层保护膜,在防止皮肤表层水分流失的同时,促进泥炙中活性成分的吸收。
2、海藻糖以及中药药材嫁接在明胶胶体中,在泥炙的使用过程中,胶体对活性成分有一定的包覆作用,在涂覆有泥炙的皮肤区域不覆盖保鲜膜的情况下,泥炙中的活性成分不与外界空气接触发生反应,泥炙的使用性能更加优越。
具体实施方式
本发明实施例中所涉及的所有物质均为市售。
各实施例中所用到原料的规格如表1所示。
表1以下各实施例中所用到样品的规格
组分 | 规格 | 厂家/产地 |
井底泥 | 云南 | |
蜂蜡 | 医药级 | 康伟业科技有限公司 |
明胶 | 医药级 | 领诺化工有限公司 |
海藻糖 | 医药级 | 中诺生物科技有限公司 |
肉桂 | 一等级 | 聚春堂中药材销售有限公司 |
苍耳子 | 一等级 | 聚春堂中药材销售有限公司 |
附子 | 一等级 | 聚春堂中药材销售有限公司 |
生姜 | 一等级 | 聚春堂中药材销售有限公司 |
独活 | 一等级 | 聚春堂中药材销售有限公司 |
细辛 | 一等级 | 聚春堂中药材销售有限公司 |
鹿茸 | 一等级 | 聚春堂中药材销售有限公司 |
藏红花 | 一等级 | 聚春堂中药材销售有限公司 |
当归 | 一等级 | 聚春堂中药材销售有限公司 |
川芎 | 一等级 | 聚春堂中药材销售有限公司 |
泽兰叶 | 一等级 | 聚春堂中药材销售有限公司 |
鸡血藤 | 一等级 | 聚春堂中药材销售有限公司 |
各实施例中原料的含量见表2。
表2泥炙中各原料的含量
其中实施例1至实施例6中,明胶的分子量为20000~30000。
各实施例中泥炙的制备方法如下:
打粉:分别取肉桂、苍耳子、附子、生姜、独活、细辛、鹿茸、藏红花、当归、川芎、泽兰叶、鸡血藤,利用球磨机将12种中药材研磨成细粉,相互混合均匀后为中药混合物;
第一步混合:取明胶、海藻糖、蒸馏水加入反应釜A中,升高反应釜A的温度至T1,搅拌速度为v1,搅拌时间t1,明胶完全溶解后成为胶液;
起泡:降低反应釜A的温度至T2,反应釜A内胶液成为半凝胶态后,向反应釜A中通入氮气,氮气流量为S;
第二步混合:将蜂蜡加入反应釜B中,升高反应釜B的温度至T3,待成为液体后,加入中药混合物,继续搅拌,搅拌速度为v2,搅拌时间t2;
互混:向反应釜B内部的混合物加入反应釜A中,反应釜A的温度为T4,搅拌速度为v3,搅拌时间t3;
第三部混合:向反应釜A中加入井底泥,反应釜A的温度为T5,搅拌速度为v4,搅拌时间t4,搅拌均匀后,制备得到泥炙。
各实施例中工艺参数如表3所示。
表3各实施例中的工艺参数
以上各实施例制备的泥炙所采用的评价指标及检测方法如下:
临床试验:本发明使用的中药药材均为祛风散痛,温热补体的中药药材,本发明制备得到的泥炙用于治疗处于亚健康状态,即长期劳累或压力过大而致身体虚弱,精力不足,体力不支的人群。其中治疗人群集中在21-41岁范围内,共对600例患者进行临床观察。其中,患者随机分成6组,分别使用实施例1至实施例6制备得到的泥炙进行治疗。使用方法为,将泥炙用微波炉加热至完全融化,后降温至40℃,主要涂覆在患者的背部,治疗30min后换掉,每天一次,四个月为一疗程。测试者根据使用效果进行评分,评分标准采用10分制,1分最差,10分最佳,最终结果取平均值。
保湿度测试:患者结束治疗后,清理掉背部的泥炙,用清水清洗干净后,立即使用干净的纸巾将皮肤表面的水珠拭干后,立即利用皮肤湿度测试仪对皮肤表层的的湿度进行测试。之后30min后对皮肤表层的水分进行测试。
以上各实施例的性能指标如表4所示。
表4各实施例制备的泥炙治疗效果的测试
性能测试 | 实施例1 | 实施例2 | 实施例3 | 实施例4 | 实施例5 | 实施例6 |
治疗效果测试 | 9.8 | 9.6 | 9.5 | 9.3 | 9.5 | 9.7 |
保湿度(%) | 65 | 61 | 63 | 60 | 59 | 64 |
30min保湿度 | 34 | 32 | 30 | 29 | 31 | 34 |
皮肤状态测试 | 良好 | 良好 | 良好 | 良好 | 良好 | 良好 |
从表4可以看出,经过每组100人的测试,本发明制备得到的泥炙能有效解决患者亚健康的问题,同时,在泥炙治疗过程中,海藻糖在皮肤表层形成一层保护膜,在保护皮肤得到同时,同时促进中药中的活性成分快速吸收,表明制备得到的泥炙具有良好的保湿性能,优越的治疗效果。
制作对比例。
对比例1:不加入海藻糖;
对比例2:不加入明胶;
对比例3:明胶的分子量为35000~45000;
对比例4:起泡过程中不通入氮气。
对比例1至对比例4中的制备过程、使用方法、检测方法与实施例1一致。对比例1至对比例4的性能指标如表5所示。
表5各对比例制备的泥炙的清洁度测试
性能测试 | 对比例1 | 对比例2 | 对比例3 | 对比例4 |
治疗效果测试 | 7.1 | 6.3 | 6.8 | 6.2 |
保湿度(%) | 32 | 20 | 25 | 19 |
30min保湿度 | 10 | 9 | 12 | 7 |
皮肤状态测试 | 干燥 | 干燥 | 干燥 | 干燥 |
从表5中可以看出,对比例中不加入海藻糖,泥炙在使用过程中不能在皮肤表层形成一层保护膜,由于在使用泥炙治疗过程中一直处于高温状态,皮肤内部的水分大量排出,导致治疗结束后,皮肤表层失水过多而干燥,同时,不添加海藻糖,皮肤对泥炙中活性成分的吸收能力下降,对应的,泥炙的治疗效果不佳。
对比例2中不加入明胶,在泥炙的制备过程中,原材料中的活性成分不能在明胶的多肽分子链上搭建,只均匀混合在泥炙的基料中,泥炙在使用过程中不在外部敷设保险膜的情况下,外部空气极易通过井底泥之间的空隙进入泥炙中,泥炙中的活性成分与空气接触发生反应,泥炙中活性成分的含量下降,相应的,被皮肤所吸收的含量下降,其治疗效果减弱。
对比例3中明胶的分子量较高,明胶中的多肽分子链相互聚集,海藻糖以及活性成分不容易搭接在明胶的分子链中,或者是搭接量较少,过量的活性成分还是分散在井底泥中,在治疗过程中,泥炙中的活性成分与空气接触发生氧化,导致泥炙的治疗效果减弱。
对比例4在起泡过程中不通入氮气,明胶胶体在成为半凝胶状态时,仅仅通过反应釜的搅拌引入气泡,由于引入的气泡含量较少,半凝胶状态下的明胶内部孔隙较少,引入中药药材的能力下降,其中药药材中的活性成分搭接在明胶分子链上的能力下降,从而导致泥炙的治疗效果减弱。
本具体实施例仅仅是对本发明的解释,其并不是对本发明的限制,本领域技术人员在阅读完本说明书后可以根据需要对本实施例做出没有创造性贡献的修改,但只要在本发明的权利要求范围内都受到专利法的保护。
Claims (10)
1.一种泥炙,其特征是,按重量份数计,其原料包括,井底泥23~29份,蜂蜡17~21份,明胶5~9份,海藻糖13~17份,中药混合物24~30份。
2.根据权利要求1所述的泥炙,其特征是,所述明胶的分子量为20000~30000。
3.根据权利要求1所述的泥炙,其特征是,所述中药混合物为肉桂、苍耳子、附子、生姜、独活、细辛、鹿茸、藏红花、当归、川芎、泽兰叶、鸡血藤。
4.根据权利要求3所述的泥炙,其特征是,按重量分数计,所述中药混合物中肉桂、苍耳子、附子、生姜、独活、细辛、鹿茸、藏红花、当归、川芎、泽兰叶、鸡血藤的质量比为2.7∶3.2∶2.5∶2.3∶0.8∶1.3∶1.6∶2.5∶0.3∶2.7∶2.4∶1.7。
5.一种泥炙的制备方法,其特征是,至少包含以下步骤:
打粉:分别取肉桂、苍耳子、附子、生姜、独活、细辛、鹿茸、藏红花、当归、川芎、泽兰叶、鸡血藤,利用球磨机将12种中药材研磨成细粉,相互混合均匀后为中药混合物;
第一步混合:取明胶、海藻糖、蒸馏水加入反应釜A中,升高反应釜A的温度,搅拌直至明胶完全溶解,成为胶液;
起泡:降低反应釜A的温度,反应釜A内胶液成为半凝胶态后,向反应釜A中通入氮气;
第二步混合:将蜂蜡加入反应釜B中,升高反应釜B的温度,待成为液体后,加入中药混合物,继续搅拌;
互混:向反应釜B内部的混合物加入反应釜A中,继续搅拌;
第三部混合:向反应釜A中加入井底泥,搅拌均匀后,制备得到泥炙。
6.根据权利要求5所述的泥炙的制备方法,其特征是,所述第一步混合过程中,反应釜A的温度为60~65℃,搅拌速度为30~35r/min,搅拌时间为15~19min。
7.根据权利要求5所述的泥炙的制备方法,其特征是,所述起泡过程中,反应釜A的温度为40~45℃,氮气流量为30~34m2/h。
8.根据权利要求5所述的泥炙的制备方法,其特征是,所述第二步混合过程中,反应釜B的温度为50~54℃,搅拌速度为20~24r/min,搅拌时间为25~27min。
9.根据权利要求5所述的泥炙的制备方法,其特征是,所述互混过程中,反应釜A的温度为40~44℃,搅拌速度为30~35r/min,搅拌时间为20~30min。
10.根据权利要求5所述的泥炙的制备方法,其特征是,所述第三步混合过程中,反应釜A的温度为30~34℃,搅拌速度为50~56r/min,搅拌时间为10~20min。
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