CN106943503A - 一种用于治疗三叉神经痛的中药组合物及制备方法 - Google Patents

一种用于治疗三叉神经痛的中药组合物及制备方法 Download PDF

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CN106943503A
CN106943503A CN201710186948.4A CN201710186948A CN106943503A CN 106943503 A CN106943503 A CN 106943503A CN 201710186948 A CN201710186948 A CN 201710186948A CN 106943503 A CN106943503 A CN 106943503A
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chinese medicine
trigeminal neuralgia
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罗倩茹
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Chengdu Hai Qing Biological Science And Technology Co Ltd
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Abstract

本发明属于中药制剂领域,目的是根据中医对三叉神经痛的认识机理而提供的一种用于治疗三叉神经痛的中药组合物,所述中药组合物的各个组分及其质量份比如下:白芷95g、苍术95g、金银花220g、白芍200g、远志120g、酸枣仁120g、白术120g、枸杞子150g、合欢皮120g、香附120g、川芎95g、蒲公英250g、白蒺藜95g、黄柏120g、没药150g、防风120g、乳香120g、肉桂40g、甘草110g;本发明提供的药物是一个标本兼治的中药组方。

Description

一种用于治疗三叉神经痛的中药组合物及制备方法
技术领域
[0001]本发明属于中药制剂领域,具体涉及一种用于治疗三叉神经痛的中药组合物,特 别是供三叉神经痛患者使用的中药组合物及制备方法的领域。
背景技术
[0002] 三叉神经痛是最常见的脑神经疾病,以一侧面部三叉神经分布区内反复发作的阵 发性剧烈痛为主要表现,国内统计的发病率52.2/10万,女略多于男,发病率可随年龄而增 长。三叉神经痛多发生于中老年人,右侧多于左侧。该病的特点是:在头面部三叉神经分布 区域内,发病骤发,骤停、闪电样、刀割样、烧灼样、顽固性、难以忍受的剧烈性疼痛。说话、洗 脸、刷牙或微风拂面,甚至走路时都会导致阵发性时的剧烈疼痛。疼痛历时数秒或数分钟, 疼痛呈周期性发作,发作间歇期同正常人一样。三叉神经痛的发作常无预兆,而疼痛发作一 般有规律。每次疼痛发作时间仅持续数秒到数分钟骤然停止。初期起病时发作次数较少,间 歇期亦长,数分钟、数小时不等,随病情发展,发作逐渐频繁,间歇期逐渐缩短,疼痛亦逐渐 加重而剧烈。夜晚疼痛发作减少。间歇期无任何不适;诱发因素:说话、吃饭、洗脸、剃须、刷 牙以及风吹等均可诱发疼痛发作,以致病人精神萎靡不振,行动谨小慎微,甚至不敢洗脸、 刷牙、进食,说话也小心,惟恐引起发作。那么,就如何找到一种可有效治疗三叉神经痛的中 药组合物,是本领域技术人员亟待要解决的问题。
发明内容
[0003]随着我国中医中药学的不断发展,在治疗三叉神经痛上,人们逐渐意识到了中医 治疗三叉神经痛的优点,且在治疗过程中疗效好、见效快、毒副作用小等优势,针对现有西 医治疗三叉神经痛的现状,本发明的目的是在于提供一种用于治疗三叉神经痛的中药组合 物,以解决三叉神经痛患者早日恢复健康的问题。该药物是以常见的中药为原料,通过选择 合理的药物及质量份比,可有效治疗上述三叉神经痛一证。
[0004]为达到上述发明的目的,本发明所采用的技术方案为:提供一种用于治疗三叉神 经痛的中药组合物及制备方法,其特征在于,所述中药组合物的各个组分及其质量份比如 下所示: 白芷30〜120g、苍术30〜120g、金银花150〜280g、白芍100〜250g、远志50〜160g、酸枣 仁60〜l6〇g、白术8〇〜l6〇g、枸杞子100〜2〇0g、合欢皮1〇〇〜16〇g、香附8〇〜16〇g、川号5〇〜 120g、蒲公英100〜350g、白漠藜60〜120g、黄柏80〜160g、没药50〜200g、防风80〜160g、乳 香5〇〜160g、肉桂20〜6〇g、甘草3〇〜i5〇g。
[0005] —种用于治疗三叉神经痛的中药组合物及制备方法,其特征在于,所述中药组合 物的各个组分及其质量份比如下所示: 白芷40〜10%、苍术40〜105g、金银花170〜25〇g、白芍115〜22〇g、远志60〜140g、酸枣 仁7〇〜140g、白术9〇〜140g、枸杞子US〜i7〇g、合欢皮香附9〇〜14〇g、川芎6〇〜 l〇5g、蒲公英115〜310g、白蒺藜70〜l〇5g、黄柏90〜140g、没药60〜170g、防风90〜140g、乳 香60〜140g、肉桂30〜50g、甘草40〜130g。
[0006] —种用于治疗三叉神经痛的中药组合物及制备方法,其特征在于,所述“最佳方 案”的中药组合物的各个组分及其质量份比如下所示: 白芷95g、苍术95g、金银花220g、白芍200g、远志120g、酸枣仁120g、白术120g、枸杞子 150g、合欢皮120g、香附120g、川考95g、蒲公英250g、白蒺藜95g、黄柏120g、没药150g、防风 120g、乳香 120g、肉桂 40g、甘草 110g。
[0007] —种用于治疗三叉神经痛的中药组合物及制备方法,其特征在于,所述方法包括 如下步骤制备而成: A、 将上述原料中药拣去杂质、粉尘及干燥后,按照质量份比共研为极细末待用; B、 按照传统制备中药胶囊剂的方法,将研磨好的极细末药物过筛后,放入药器中混合 均匀,然后制备成胶囊剂(其胶囊锁合后的总长度为23.3mm,药粉容量0.4〜0.5g/粒),分装 密封即可。
[°008] 一种用于治疗三叉神经痛的中药组合物及制备方法,其特征在于,所述服用方法 为:将制备好的胶囊剂药物以每日三次服用,早中晚各服一次,给药量2g/次,饭前服。15天 为一个疗程,服药2〜6个疗程后,症状逐渐缓解或明显好转或痊愈。
[0009] 本发明组方中的各原料中药在中国药典、中国辞典以及中华本草中均有详细的记 载。本发明选用其中最常见的中药为原料,充分发挥各组分的药理功效: 白芷,性味:味辛、性温,具有祛风除湿、通窃止痛、消肿排脓之功效,用于治疗感冒头 痛、眉棱骨痛、牙痛、鼻塞、鼻渊、湿胜久泻、妇女白带、痈疽疮疡、毒蛇咬伤; 苍术,性味:味辛、苦、性温,具有燥湿健脾、祛风湿、明目之功效,用于治疗湿困脾胃、倦 怠嗜卧、胞痞腹胀、食欲不振、哎吐泄泻、痰饮、湿肿、表证夹湿、头身重痛、痹证温性、肢节酸 痛重着、痿襞、夜盲; 金银花,性味:甘、寒具有清热解毒之功效,用于治疗温病发热、热毒血痢、痈肿疔疮、喉 痹及多种感染性疾病; 白芍,性味:苦、酸、微寒,具有养血和营、缓急止痛、敛阴平肝之功效,用于治疗月经不 调、经行腹痛、崩漏、自汗、盗汗、胁肋脘腹疼痛、四肢挛痛、头痛、眩晕等症; 远志,性味:辛、苦、性微温,具有宁心安神、祜痰开窍、解毒消肿之功效,用于治疗心神 不安、惊悸失眠、健忘、惊痫、咳嗽痰多、痈疽发背、乳房肿痛; 酸枣仁,性味:甘、平,具有宁心安神、养肝、敛汗之功效,用于治疗虚烦不眠、惊悸怔忡、 体虚自汗、盗汗等症; 白术,性味:味苦、甘、性温,具有健脾益气、燥湿利水、止汗、安胎之功效,用于治疗脾气 虚弱、神疲乏力、食少少腹胀、大便溏薄、水饮内停、小便不利、水肿、痰饮眩晕、温痹酸痛、气 虚自汗、胎动不安; > 枸杞子,性味:味甘、性平,具有养肝、滋肾、润肺之功效,用于治疗肝肾亏虚、头晕目眩、 目视一清、腰膝酸软、阳痿贵精、虚劳咳嗽、消渴引饮; 合欢皮,性味:甘、平,具有解郁、和血、宁心、消痈肿之功效,用于治疗心神不安、忧郁、 失眠、肺痈、痈肿、瘰疠、筋骨折伤等病症; 香附,性味:味辛、微寒,无毒,具有理气解郁、调经止痛、安胎之功效,用于治疗胁肋胀 痛、乳房胀育、疝气疼痛、月经不调、脘腹痞满疼痛、嗳气吞酸、呕恶、经行腹痛、崩漏带下、胎 动不安、肝郁气滞、消化不良,经闭痛经; 川芎,性味:辛、温,具有行气开郁、法风燥湿、活血止痛之功效,用于治疗风冷头痛旋 晕、胁痛腹疼、寒痹筋挛、经闭、难产、产后瘀阻块痛、痈疽疮疡、月经不调、瘕腹痛、胸胁刺 痛、跌扑肿痛、风湿痹痛; 蒲公英,性味:味苦、甘、性寒,具有清热解毒、消痈散结之功效,用于治疗乳痈、肺痈、肠 痈、痄腮、疔毒疮肿、目赤肿痛、感冒发热、咳嗽、咽喉肿痛、胃火、肠炎、痢疾、肝炎、胆吓炎、 尿路感染、蛇虫咬伤; 白蒺藜,性味:苦、辛、平,具有平肝解郁、祛风明目之功效,用于治疗肝阳眩晕头痛、肝 郁胁痛、风热头痛、目赤肿痛、皮肤瘙痒等症; 黄柏,性味:苦、寒,具有清热燥湿、泻火解毒、除骨蒸清虚热之功效,用于治疗湿热泻 痢、黄疸、带下、热淋、脚气、痿辟、骨蒸劳热、盗汗、遗精、疮疡肿毒、湿瘆瘙痒; 没药,性味:苦、平,具有散瘀止痛,外用消肿生肌之功效,用于治疗跌打淤血肿痛、痈疽 肿痛、胸腹诸痛,外用治疮口久不收敛等病症; 防风,性味:味辛、甘、性微温,具有祜风解表、胜湿止痛、解痉、止痒之功效,用于治疗外 感风寒、头痛身痛、风湿痹痛、骨节酸痛、腹痛泄泻、肠风下血、破伤风、风疹瘙痒、疮疡初起; 乳香,性味:辛苦、温,具有调气活血、定痛、追毒之功效,用于治疗气血凝滞、心腹疼痛、 痈疮肿毒、跌打损伤、痛经、产后瘀血刺痛等病症; 肉桂,性味:辛、甘、热,具有补火助阳、引火归源、散寒止痛、温经通脉之功效,用于治疗 肾阳不足、命门火畏寒肢冷、腰膝酸软、阳痿遗精、小便不利或频数、短气喘促、浮肿尿少诸 证、命门火衰、火不归源、戴阳、格阳、及上热下寒、面赤足冷、头晕耳鸣、口舌糜破、脾肾虚 寒、脘腹冷痛、食减便溏、肾虚腰痛、寒湿痹痛、寒疝疼痛、宫冷不孕、痛经经闭、产后瘀滞腹 痛、阴疽流注、或虚寒痈疡脓成不溃、或溃后不敛; 甘草,性味:甘、平,具有和中缓急、润肺、解毒、调和诸药之功效,用于治疗脾胃虚弱、 食少、腹痛便溏、劳倦发热、肺痿咳嗽、心悸、惊痫,生用、治咽喉肿痛、消化性溃疡、痈疽疮 疡、解药毒及食物中毒。
[0010] 本发明药物是基于中医治疗三叉神经痛的原则,从依据疼痛病理机制及药理作用 认为:就三叉神经痛,本发明所提供的药物中的各原料中药药效共奏,对上述疾病有很好的 治疗效果。
具体实施方式
[0011] 本发明就是针对上述三叉神经痛的治疗而提出的一种中药配方,采用该配方制备 的药物药效好,见效快,是一个标本兼治的中药组方,特别适合临床使用。下面结合本发明 的具体实施方式作进一步详细的描述: 实施例1: 一种用于治疗三叉神经痛的中药组合物,其特征在于,所述中药组合物的各个组分及 其质量份比如下所示: 白i£95g、苍术95g、金银花220g、白芍200g、远志120g、酸枣仁120g、白术120g、枸杞子 150g、合欢皮120g、香附120g、川芎95g、蒲公英250g、白蒺藜95g、黄柏120g、没药150g、防风 120g、乳香 120g、肉桂 4〇g、甘草 l10g。
[0012] 实施例2: 一种用于治疗三叉神经痛的中药组合物,其特征在于,所述中药组合物的各个组分及 其质量份比如下所示: 白芷105g、苍术l〇5g、金银花250g、白芍220g、远志140g、酸枣仁140g、白术140g、枸杞子 l7〇g、合欢皮140g、香附140g、川夸l〇5g、蒲公英310g、白蒺藜105g、黄柏140g、没药170g、防 风l4〇g、乳香l4〇g、肉桂50g、甘草130g。
[0013] 实施例3: 一种用于治疗三叉神经痛的中药组合物,其特征在于,所述中药组合物的各个组分及 其质量份比如下所示: 白i£l2〇g、莶术l2〇g、金银花28〇g、白芍25〇g、远志WOg、酸枣仁ie〇g、白术160g、枸杞子 200g、合欢皮i6〇g、香附16〇g、川芎12〇g、蒲公英35〇g、白蒺藜12〇g、黄柏16〇g、没药2〇〇g、防 风160g、乳香160g、肉桂6〇g、甘草]_5〇g。
[0014]典型病例 经临床诊断治疗三叉神经痛患者共89〇例,年龄为42岁以上的5妨例,只有344例为42岁 下。8%例患者中症状逐渐缓解或痊愈的69〇例,有效的2〇〇例,总有效率达丨〇〇%。

Claims (3)

1.一种用于治疗三叉神经痛的中药组合物,其特征在于,所述中药组合物的各个组分 及其质量份比如下所示: 白芷30〜120g、苍术30〜120g、金银花150〜280g、白芍100〜250g、远志50〜160g、酸枣 仁6〇〜l6〇g、白术8〇〜l6〇g、枸杞子100〜2〇〇g、合欢皮则〜丨6^、香附80〜160g、川夸5〇〜 l2〇g、蒲公英100〜35〇g、白蒺藜㈤〜i2〇g、黄桕80〜160g、没药50〜200g、防风80〜160g、乳 香5〇〜160g、肉桂20〜60g、甘草30〜150g。
2.根据权利要求1所述的用于治疗三叉神经痛的中药组合物,其特征在于,所述中药组 合物的各个组分及其质量份比如下所示: 一白止40〜105g、仓术40〜l〇5g、金银花1了〇〜25〇g、白芍lls〜22〇g、远志6〇〜14〇g、酸枣 仁70〜140:白术90〜140g、枸杞子115〜170g、合欢皮115〜140g、香附9〇〜14〇g、川与6卜 l〇5g、蒲公央II5〜310g、白疾藜7〇〜l〇5g、黄柏9〇〜14〇g、没药6〇〜1?〇g、防风9〇〜14收、乳 香60〜140g、肉桂30〜50g、甘草40〜130g。
3.棚权求1至2臓關于治疗三叉神经義巾舰合物斯 药组合物的各个组分及其质量份比如下所示: 1 白芷95g、苍术%g、金银花220g、白芍200g、远志12〇g、酸束仁12白术12
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60146820A (en) * 1983-12-30 1985-08-02 Eiju Kurihara Preparation of bath agent consisting essentially of beehive
CN103263531A (zh) * 2013-05-30 2013-08-28 崔新明 一种治疗三叉神经痛的中药组合物及其制备方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60146820A (en) * 1983-12-30 1985-08-02 Eiju Kurihara Preparation of bath agent consisting essentially of beehive
CN103263531A (zh) * 2013-05-30 2013-08-28 崔新明 一种治疗三叉神经痛的中药组合物及其制备方法

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