CN106942247A - Emamectin-benzoate effervescent tablet and preparation method thereof - Google Patents
Emamectin-benzoate effervescent tablet and preparation method thereof Download PDFInfo
- Publication number
- CN106942247A CN106942247A CN201710264981.4A CN201710264981A CN106942247A CN 106942247 A CN106942247 A CN 106942247A CN 201710264981 A CN201710264981 A CN 201710264981A CN 106942247 A CN106942247 A CN 106942247A
- Authority
- CN
- China
- Prior art keywords
- benzoate
- emamectin
- effervescent tablet
- acid
- tablet according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of preparation method of emamectin-benzoate effervescent tablet.Emamectin-benzoate effervescent tablet, the composition that it is formulated is as follows, by percentage to the quality：Methylaminoemamectin benzoate 1 5%, acid source 10 20%, alkali source 10 20%, dispersant 2 6%, wetting agent 2 4%, adhesive 2 6%, disintegrant 3 20%, filler 19 70%.Preparation method：（1）Well mixed be added in pulverizer of raw material is crushed, and obtains pulvis；（2）Pulvis is added to compressing tablet in tablet press machine.Emamectin-benzoate effervescent tablet produced by the present invention has processing simple, and metering is accurate, and performance is stable, storage, transport, it is easy to use, the features such as security is good, while the problem of solving emamectin-benzoate easy photodissociation, extends the storage period of preparation.
Description
Technical field
The present invention relates to the technology of preparing of emamectin-benzoate effervescent tablet.
Background technology
Emamectin-benzoate has stomach toxicity and action of contace poison, to the active high of lepidopteran insect larvae,
And also there is preferable prevention effect to root knot nematode.Emamectin-benzoate has as biological pesticide
The features such as ultra high efficiency, low toxicity, low-residual, be the important product of control of insect on the crops such as current vegetables, fruit tree, cotton and paddy rice
Kind.
Emamectin-benzoate insecticidal spectrum is wide, and bioactivity is high, and with low toxicity, environmental protection, difficulty develops immunity to drugs
The features such as.However, the existing processing formulation of emamectin-benzoate is mainly missible oil, microemulsion, aqueous emulsion and suspension
Agent, wherein, a large amount of organic solvents and emulsifying agent are used in missible oil and microemulsion process, production cost is high, and easily pollution
Environment；Active constituent content is low in aqueous emulsion and suspending agent, easily occurs layering, precipitation and breast analysis during storage and use
Deng physical stability problem, and liquid preparation production, storage and transport are inconvenient.Emamectin-benzoate can also
Water dispersible granules are processed into, but forming particle needs to add the adhesive of larger proportion, so as to cause granula disintegration slow.
Effervescent tablet is to meet water using acid source and alkali source to produce CO2, make the piece of tablet fater disintegration formation unit for uniform suspension
Shape formulation.Compared with liquid preparation, effervescent tablet has metering accurate, and processing is simple, and production cost is low, stores, transports and makes
Use the advantages of facilitating.Compared with other solid pharmaceutical preparations (such as water dispersible granules), effervescent tablet has disintegration, rate of dispersion fast,
Hardness is high, the features such as transporting and use more convenient.However, at present effervescent tablet mainly use wet granulation, its tedious process,
And part wet granulation wastes a large amount of organic solvents.For example, the Publication No. CN102823589A authorized,
Water is required in the effervescent tablet patent such as CN101874491A, CN101658165A, CN102177906A, its preparation process or organic
Solvent, preparation method contains drying course, and needs soda acid being divided into two parts preparation.
The content of the invention
It is an object of the invention to provide a kind of emamectin-benzoate effervescent tablet and preparation method thereof, this hair
The emamectin-benzoate effervescent tablet of bright use dry process has simple to operate, and metering is accurate, and disintegration is quick,
Safety and conveniently during production, transport, storage and use, can both be watered spraying and use, and also can directly be thrown into paddy field, and be a kind of
Safe and environment-friendly Labor-saving formulation.
The purpose of the present invention is achieved through the following technical solutions, a kind of emamectin-benzoate effervescent tablet
Agent, according to mass percent meter, is made up of following raw materials according：
Wherein acid source is that acid source is one kind in tartaric acid, citric acid, fumaric acid, hexanedioic acid and malic acid, and alkali source is carbon
One kind in sour sodium, sodium acid carbonate, potassium carbonate, saleratus and calcium carbonate, dispersant is lignin sulfonate, modification is wooden
A kind of to several in plain Sulfonates and naphthalenesulfonate formaldehyde condensation compound class, wetting agent is alkylnaphthalene sulfonate, alkylsurfuric acid
Salt, sulfonate, aliphatic acid or fatty acid ester sulfate, the one of phosphate are to several, and binding agent is polyvinylpyrrolidone, poly- second
One kind in enol, polyethylene glycol, hydroxymethyl cellulose, xanthans and Sodium Polyacrylate, disintegrant is soluble starch, hard charcoal
One kind in black, diatomite, urea, ammonium sulfate, filler is in kaolin, diatomite, precipitated calcium carbonate, attapulgite and clay
One kind.
A kind of emamectin-benzoate effervescent tablet preparation method, comprises the following steps：
(1) all components are mixed in proportion to be added in pulverizer and be crushed to more than 200 mesh, prepared uniform
Pulvis.
(2) pulvis obtained in the step of weighing required quality (1), is added to compressing tablet in tablet press machine, that is, obtains methylamino
Abamectin benzoate effervescent tablet.
It is preferred that, the tablet quality is in 2-10g.
Compared with prior art, the invention has the advantages that：
First, using direct powder compression effervescent tablet is made in emamectin-benzoate by the present invention, is kept away
Exempt from the drawbacks such as the production, storage, transport inconvenience of liquid preparation presence, while the problem of water dispersible granules disintegration is slow is solved,
And it is more simple and environmentally-friendly compared with wet granulation, also comply with the formulations of pesticide and process laborsaving, safe and environment-friendly developing direction.
Second, effervescent tablet produced by the present invention has performance stable, safety during production, transport, storage and use
And the advantages of facilitate.
3rd, emamectin-benzoate effervescent tablet produced by the present invention has processing simple, and metering is accurate,
Performance is stable, storage, transport, easy to use, the features such as security is good, while it is easy to solve emamectin-benzoate
The problem of photodissociation, extend the storage period of preparation.
Brief description of the drawings
Fig. 1 emamectin-benzoate effervescent tablet Making programme figures；
Fig. 2 emamectin-benzoate effervescent tablet outside drawings；
Figure is disintegrated in Fig. 3 emamectin-benzoate effervescent tablet water；
Fig. 4 emamectin-benzoate effervescent tablet suspension figures.
Embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, it is right below in conjunction with drawings and Examples
The present invention is further elaborated.It should be appreciated that specific embodiment described herein is only to explain the present invention,
It is not intended to limit the present invention.
Embodiment 1
1) 1g Methylaminoemamectin benzoates, 4g tartaric acid, 4g sodium acid carbonates, 0.8g alkylnaphthalenes base flow acid are taken
Sodium salt, 0.8g sodium lignin sulfonates, 1.2g polyvinylpyrrolidones, 2g diatomite, 6.2g kaolin is added in pulverizer and crushed
More than 200 mesh, prepare 20g pulvis.
2) take the pulvis in 8.5g steps (1) to be added to compressing tablet in tablet press machine, that is, 8.5g emamectin benzoate benzene is made
Formates effervescent tablet.Making programme is shown in Fig. 1, and product appearance is shown in Fig. 2.
Embodiment 2
1) 1g Methylaminoemamectin benzoates, 4g tartaric acid, 4g sodium acid carbonates, 0.8g alkylnaphthalenes base flow acid are taken
Sodium salt, 0.8g 2- naphthalene sulfonic acid formaldehyde polymer sodium salts, 1.2g polyvinylpyrrolidones, 2g diatomite, 6.2g kaolin adds powder
200 mesh are crushed in broken machine, 20g pulvis is prepared.
2) take the pulvis in 8.5g steps (1) to be added to compressing tablet in tablet press machine, that is, 8.5g emamectin benzoate benzene is made
Formates effervescent tablet.Making programme is shown in Fig. 1, and product appearance is shown in Fig. 2.
Embodiment 3
1) 1g Methylaminoemamectin benzoates, 4g tartaric acid, 4g sodium acid carbonates, 0.8g alkylnaphthalenes base flow acid are taken
Sodium salt, 0.8g modified lignin mahogany sulfonates, 1.2g polyvinylpyrrolidones, 2g diatomite, 6.2g kaolin is added in pulverizer
200 mesh are crushed to, 20g pulvis is prepared.
2) take the pulvis in 8.5g steps (1) to be added to compressing tablet in tablet press machine, that is, 8.5g emamectin benzoate benzene is made
Formates effervescent tablet.Making programme is shown in Fig. 1, and product appearance is shown in Fig. 2.
Embodiment 4
1) 1g Methylaminoemamectin benzoates, 4g tartaric acid, 4g sodium acid carbonates, 0.8g alkylnaphthalenes base flow acid are taken
Sodium salt, 0.8g sodium lignin sulfonates, 1.2g polyvinylpyrrolidones, 2g starch, 6.2g kaolin adds in pulverizer and crushes 200
Mesh, prepares 20g pulvis.
2) take the pulvis in 8.5g steps (1) to be added to compressing tablet in tablet press machine, that is, 8.5g emamectin benzoate benzene is made
Formates effervescent tablet.Making programme is shown in Fig. 1, and product appearance is shown in Fig. 2.
Embodiment 5
1) 1g Methylaminoemamectin benzoates, 4g tartaric acid, 4g sodium acid carbonates, 0.8g alkylnaphthalenes base flow acid are taken
Sodium salt, 0.8g2- naphthalene sulfonic acid formaldehyde polymer sodium salts, 1.2g polyvinylpyrrolidones, 2g starch, 6.2g kaolin, which is added, to be crushed
200 mesh are crushed in machine, 20g pulvis is prepared.
2) take the pulvis in 8.5g steps (1) to be added to compressing tablet in tablet press machine, that is, 8.5g emamectin benzoate benzene is made
Formates effervescent tablet.Making programme is shown in Fig. 1, and product appearance is shown in Fig. 2.
Embodiment 6
1) 1g Methylaminoemamectin benzoates, 4g tartaric acid, 4g sodium acid carbonates, 0.8g alkylnaphthalenes base flow acid are taken
Sodium salt, 0.8g modified lignin mahogany sulfonates, 1.2g polyvinylpyrrolidones, 2g starch, 6.2g kaolin adds powder in pulverizer
Broken 200 mesh, prepares 20g pulvis.
2) take the pulvis in 8.5g steps (1) to be added to compressing tablet in tablet press machine, that is, 8.5g emamectin benzoate benzene is made
Formates effervescent tablet.Making programme is shown in Fig. 1, and product appearance is shown in Fig. 2.
The product obtained to above-mentioned 6 embodiments carries out quality and stability test, the results are shown in Table 1：
The quality control index test result of the emamectin-benzoate effervescent tablet of table 1
Disintegration result is shown in Fig. 3.Suspensibility test result is shown in Fig. 4.
Note：Method of testing is specific as follows：
1. disintegration time
The Effervescent tablet disintegration time requirement of different quality is different, plunges the sample into the glass equipped with 400mL standard hard waters and burns
It is qualified less than 7min in cup (volume is 500mL).
2. suspensibility
It is qualified more than 60% into active ingredient after suspension 30min to take 1g sample preparations.
3. hardness
Tested using hardness tester, hardness reaches 5 and above to be qualified.
4. heat storage stability
Taken out after (54 ± 2) DEG C thermostatic drying chamber, storage 14d are placed in after sample is sealed, active ingredient is compared with heat storage
>=95% is qualified.
It follows that this effervescent tablet has the features such as being disintegrated quick, suspensibility height, hardness and qualified stability.
Presently preferred embodiments of the present invention is the foregoing is only, is not intended to limit the invention, all essences in the present invention
Any modification, equivalent and improvement made within refreshing and principle etc., should be included within the scope of the present invention.
Claims (9)
1. emamectin-benzoate effervescent tablet, it is characterized in that, the composition of the effervescent tablet formula is as follows, with matter
Measure percentages：Methylaminoemamectin benzoate 1-5%, acid source 10-20%, alkali source 10-20%, dispersant 2-6%, profit
Humectant 2-4%, adhesive 2-6%, disintegrant 3-20%, filler 19-70%.
2. emamectin-benzoate effervescent tablet according to claim 1, it is characterised in that the acid source is
Any one in tartaric acid, citric acid, fumaric acid, hexanedioic acid and malic acid or two or more any mixture.
3. emamectin-benzoate effervescent tablet according to claim 1, it is characterised in that the alkali source is
Any one in sodium carbonate, sodium acid carbonate and saleratus, potassium carbonate, calcium carbonate or two or more any mixed
Compound.
4. emamectin-benzoate effervescent tablet according to claim 1, it is characterised in that the dispersant
For any one in lignin sulfonate, modified lignin mahogany sulfonate class and naphthalenesulfonate formaldehyde condensation compound class or appoint
Two kinds of mixtures of meaning or any three kinds of mixtures.
5. emamectin-benzoate effervescent tablet according to claim 1, it is characterised in that the wetting agent
For alkylnaphthalene sulfonate, alkyl sulfate, sulfonate, aliphatic acid, fatty acid ester sulfate and phosphate any one or appoint
Anticipate two or more mixture.
6. emamectin-benzoate effervescent tablet according to claim 1, it is characterised in that described adhesive
To be any one in polyvinylpyrrolidone, polyvinyl alcohol, polyethylene glycol, hydroxymethyl cellulose, xanthans and Sodium Polyacrylate
Kind.
7. emamectin-benzoate effervescent tablet according to claim 1, it is characterised in that the disintegrant
For any one in soluble starch, white carbon, diatomite, urea, ammonium sulfate.
8. emamectin-benzoate effervescent tablet according to claim 1, it is characterised in that the filler is
Any one in kaolin, diatomite, precipitated calcium carbonate, attapulgite and clay.
9. the preparation method of the emamectin-benzoate effervescent tablet according to claim any one of 1-8, its
It is characterised by, comprises the following steps：
（1）It is added in pulverizer and is crushed after all components are mixed in proportion, prepares uniform pulvis；It is described to crush
Fineness is more than 200 mesh；
（2）Weigh step（1）In obtained pulvis, be added to compressing tablet in tablet press machine, that is, obtain emamectin benzoate benzoic acid
Salt effervescent tablet agent, tablet quality is in 2-10 g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710264981.4A CN106942247A (en) | 2017-04-21 | 2017-04-21 | Emamectin-benzoate effervescent tablet and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710264981.4A CN106942247A (en) | 2017-04-21 | 2017-04-21 | Emamectin-benzoate effervescent tablet and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106942247A true CN106942247A (en) | 2017-07-14 |
Family
ID=59476427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710264981.4A Pending CN106942247A (en) | 2017-04-21 | 2017-04-21 | Emamectin-benzoate effervescent tablet and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106942247A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107434753A (en) * | 2017-07-26 | 2017-12-05 | 南京大学 | Effervescent tablet of 5 amino-laevulic acids and its derivative and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1524421A (en) * | 2003-02-24 | 2004-09-01 | 李建中 | Pesticidal composition containing emamectin and organic phosphors compounds |
| CN1720798A (en) * | 2004-07-16 | 2006-01-18 | 沈阳化工研究院 | Water dispersible tablet of flumorph |
| CN1947504A (en) * | 2006-11-01 | 2007-04-18 | 张少武 | Water dispersible pesticide effervescence tablets compositions and method for preparing the same |
| CN101999381A (en) * | 2010-12-10 | 2011-04-06 | 江苏省农业科学院 | Emamectin benzoate thiodicarb insecticide |
| CN103651424A (en) * | 2012-09-18 | 2014-03-26 | 青岛星牌作物科学有限公司 | Effervescent granule containing chlorantraniliprole and emamectin benzoate and preparation method thereof |
-
2017
- 2017-04-21 CN CN201710264981.4A patent/CN106942247A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1524421A (en) * | 2003-02-24 | 2004-09-01 | 李建中 | Pesticidal composition containing emamectin and organic phosphors compounds |
| CN1720798A (en) * | 2004-07-16 | 2006-01-18 | 沈阳化工研究院 | Water dispersible tablet of flumorph |
| CN1947504A (en) * | 2006-11-01 | 2007-04-18 | 张少武 | Water dispersible pesticide effervescence tablets compositions and method for preparing the same |
| CN101999381A (en) * | 2010-12-10 | 2011-04-06 | 江苏省农业科学院 | Emamectin benzoate thiodicarb insecticide |
| CN103651424A (en) * | 2012-09-18 | 2014-03-26 | 青岛星牌作物科学有限公司 | Effervescent granule containing chlorantraniliprole and emamectin benzoate and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 李守君 等: "甲维盐泡腾片对大豆蚜虫防治效果研究", 《佳木斯大学学报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107434753A (en) * | 2017-07-26 | 2017-12-05 | 南京大学 | Effervescent tablet of 5 amino-laevulic acids and its derivative and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102165956B (en) | Pesticide composite containing bispyribac-sodium and penoxsulam and application thereof | |
| CN104886121B (en) | A kind of glyphosate dry suspending agent, its preparation method and its application | |
| CN103689007B (en) | A kind of Gentrin Knotweed P.E solid pharmaceutical preparation and preparation method thereof and application | |
| CN104054735B (en) | Containing the wheat field herbicide composition of flucarbazone | |
| CN103518764A (en) | Acaricidal composition and application thereof | |
| CN103299994B (en) | Solid microemulsion and preparation method thereof | |
| KR20150031438A (en) | Granular hydrating agent, and method for producing same | |
| CN102369922B (en) | Pyrazosulfuron water dispersible granule and preparation method thereof | |
| CN104872133A (en) | Paraquat-fluoroglycofen ethyl water-soluble granule and preparation method thereof | |
| CN103518729A (en) | Insecticidal acaricidal composition and application thereof | |
| CN106942247A (en) | Emamectin-benzoate effervescent tablet and preparation method thereof | |
| CN106359422B (en) | Emamectin-benzoate and lufenuron synergy dry suspending agent and preparation method thereof | |
| CN101554161A (en) | Dimethomorph-mancozeb water dispersible granule and preparation method thereof | |
| CN101642105B (en) | Uniconazole water dispersible granules and preparation method thereof | |
| CN101543220B (en) | Atrazine high-hard water resistance water dispersible granules and preparation method thereof | |
| CN102550569A (en) | Plant growth regulator mixing chlormequat chloride and uniconazole | |
| CN104886060A (en) | Paraquat - B fluoroglycofen effervescent granules and preparation method | |
| CN102450258A (en) | Naphthylacetic acid and naphthylacetic acid saline dispersible granules/or tablets and preparation method thereof | |
| CN106259322A (en) | A kind of pesticide multicomponent mixture compounds dry suspending agent and preparation method thereof | |
| CN103371158B (en) | A kind of Herbicidal combinations containing AC322140 | |
| CN104365593A (en) | S-abscisic acid (S-ABA) effervescent granule and preparation method thereof | |
| CN107593700A (en) | A kind of Tea Saponin effervescence granular and its application | |
| CN108294011B (en) | Soluble tablet containing chlorobromoisocyanuric acid and kasugamycin and preparation method thereof | |
| CN102132699B (en) | Paclobutrazol water dispersible granules/tablets and preparation method thereof | |
| CN106614646A (en) | Pesticide effervescing agent based on cycloxaprid and tea saponin and preparation method of pesticide effervescing agent |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170714 |
|
| RJ01 | Rejection of invention patent application after publication |