CN106937635B - A kind of bactericidal composition of fluorine-containing azoles bacterium acyl azanol and jinggangmeisu - Google Patents
A kind of bactericidal composition of fluorine-containing azoles bacterium acyl azanol and jinggangmeisu Download PDFInfo
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- CN106937635B CN106937635B CN201710214581.2A CN201710214581A CN106937635B CN 106937635 B CN106937635 B CN 106937635B CN 201710214581 A CN201710214581 A CN 201710214581A CN 106937635 B CN106937635 B CN 106937635B
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
- A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
Abstract
The invention discloses the bactericidal compositions and its application on prevention and treatment banded sclerotial blight, gibberella zeaze petch of wheat and barley of a kind of fluorine-containing azoles bacterium acyl azanol and jinggangmeisu, composition is by the first active constituent fluorine azoles bacterium acyl azanol, second active constituent jinggangmeisu and auxiliary agent composition, the weight ratio of first active constituent and the second active constituent is 80:1~1:80, and the sum of content is the 1%~90% of the composition total weight.This composition can be configured to the suspending agent agriculturally allowed, dispersible oil-suspending agent, wettable powder, water dispersible granules, soluble powder, suspension seed-coating agent, Waterless Seed Dressing agent dosage form.Instant component is reasonable, and bactericidal effect is good, and its activity and bactericidal effect are not the active simple superposition of each component, compared with existing single formulation, in addition to significant bactericidal effect, and have significant synergistic effect, good to crop safety.The present invention has significant control efficiency to banded sclerotial blight, gibberella zeaze petch of wheat and barley etc..
Description
Technical field
The present invention relates to the bactericidal compositions of a kind of fluorine-containing azoles bacterium acyl azanol and jinggangmeisu, by the first active constituent fluorine azoles
Bacterium acyl azanol, the second active constituent jinggangmeisu and auxiliary agent composition, belong to agriculture chemical compounding applied technical field.
Background technique
Fluorine azoles bacterium acyl azanol, English common name pydiflumetofen, chemical name: 3-(difluoromethyl)-N- methoxyl group-
1- methyl-N- [(RS) -1- methyl -2-(2,4,6- trichlorophenyls) ethyl] pyrazole-4-carboxamide.It is that Switzerland Syngenta crop protects
Protect a kind of succinate dehydrogenase inhibitors class fungicide of Co., Ltd's research and development.Fluorine azoles bacterium acyl azanol wide spectrum is efficiently suitable for more
Kind of crop, especially to leaf spot and powdery mildew activity highest, to the disease for being agriculturally difficult to prevent and treat such as botrytis (Botrytis
Spp.), sclerotinite (SclerotiniaSpp.) and stick spore bacterium (Corynespora) etc. spp. disease caused by pathogens is high
Effect, these diseases will cause the heavy losses of grape, peanut and potatoes and other crops yield, and peasant is selectable anti-
It is limited to control means.Fluorine azoles bacterium acyl azanol prevent and treat also breakthroughly on cereal by sickle-like bacteria (Fusarium) caused by disease, such as it is red
Mildew etc..
Jinggangmeisu, English common name validamycin are a kind of secondary metabolites that actinomyces generate, have relatively strong
Absorbability, easily by somatic cells absorb and conducted rapidly in it, interfere and inhibit somatic cells growth and development.It is main to use
In rice sheath blight disease, it can also be used to which the crop diseases such as rice green smut, corn northern and southern leaf blight and vegetables and cotton, beans are prevented
It controls.Also there is studies in China to show that jinggangmeisu, being capable of strong inhibition fusarium graminearum under certain treatment dosage at present
Biochemical reaction in DON toxin biosynthesis early stage approach.
Gibberella zeaze petch of wheat and barley generally occurs in the whole world, is distributed mainly on moist and half tide wet zone, and especially weather is wet more
The Temperate Region in China of rain is aggrieved serious.All can be aggrieved from seedling to heading, mainly cause withered seedling, brown foot rot, stalk rotten and fringe corruption, wherein
Causing harm, the most serious is fringe corruption.It is affected by environment bigger due to the resistance category horizontal resistance of gibberella zeaze petch of wheat and barley, it is difficult to resist disease
Bacterium infects harm, and therefore, prevention and treatment head blight most efficient method is chemical prevention.Wheat scab is the Major Diseases of wheat
One of.China prevents and treats the medicament of head blight based on thiophanate-methyl, carbendazim at present, but is used for a long time, and gibberellic hypha is to it
Resistance is produced.
Applicant has been surprisingly found that through test, by the mechanism of action different fluorine azoles bacterium acyl azanol and composite jinggangmycin, application
In banded sclerotial blight, Fusarium (Fusarium spp.) disease, especially prevention and treatment gibberella zeaze petch of wheat and barley, significant effect, synergistic effect are aobvious
It writes.
Summary of the invention
That the purpose of the present invention is to provide a kind of components is reasonable, synergistic effect is significant, bactericidal effect is good, drug cost is low,
To the bactericidal composition of fluorine-containing the azoles bacterium acyl azanol and jinggangmeisu of crop safety.
Another object of the present invention is to provide the bactericidal composition dosage forms of fluorine-containing azoles bacterium acyl azanol and jinggangmeisu.
A further object of the present invention is to provide above-mentioned compositions in prevention and treatment banded sclerotial blight, Fusarium (Fusarium
Spp. the application on) disease, especially gibberella zeaze petch of wheat and barley.
To achieve the above object, the technical scheme is that in this way solving:
A kind of bactericidal composition of fluorine-containing azoles bacterium acyl azanol and jinggangmeisu, which is characterized in that
(1) first active constituent: fluorine azoles bacterium acyl azanol；
(2) second active constituents: jinggangmeisu.
Jinggangmeisu contains six kinds of A, B, C, D, E, F similar aminoglucan glycoside derivatives, and component A is jinggangmeisu
Main active component, the present invention involved in jinggangmeisu be jinggangmycin A.
The weight ratio of first active constituent and the second active constituent is 80:1~1:80, and the sum of content is that the composition is total
The 1%~90% of weight.
Further, the weight ratio of the first active constituent and the second active constituent is 60:1~1:60, and the sum of content is described
The 2%~80% of composition total weight.
Further, the weight ratio of the first active constituent and the second active constituent is 40:1~1:40, and the sum of content is institute
State the 5%~70% of composition total weight.
The bactericidal composition of a kind of fluorine-containing azoles bacterium acyl azanol of the present invention and jinggangmeisu is according to those skilled in the art of the present technique
The preparation formulation that known method can be prepared be suspending agent, dispersible oil-suspending agent, wettable powder, water dispersible granules,
Soluble powder, suspension seed-coating agent, Waterless Seed Dressing agent.
To suspending agent, workable auxiliary agent has: emulsifier for example calcium dodecyl benzene sulfonate (agriculture breast 500#), Nongru-700 #,
Agriculture breast 2201, this disk -60#, emulsifier T-60(common name: anhydrous sorbitol single-hard ester acid ester polyoxyethylene ether), TX-10(it is logical
With name: octylphenol polyethylene ethylene oxide (10) ether), agriculture breast 1601#, agriculture breast 600#, agriculture breast 400#；Dispersing agent such as polycarboxylate, wooden
One of plain sulfonate, alkylnaphthalene sulfonate are a variety of；Wetting agent such as alkyl sulfate, alkylsulfonate, in naphthalene sulfonate
It is one or more；It is one or more in antifreezing agent such as ethylene glycol, propylene glycol, glycerol, urea, inorganic salts such as sodium chloride；Increase
Thick dose such as white carbon black, it is polyvinyl alcohol, bentonite, one or more in aluminium-magnesium silicate；Defoaming agent for example silicone oil, silicone compound,
One of C10-20 saturated fat acid compounds, C8-10 fatty alcohols, hexanol, butanol, octanol are a variety of；Disintegrating agent is such as
It is ammonium sulfate, urea, sucrose, one or more in glucose；Stabilizer such as triphenyl phosphite, epoxychloropropane, aceticanhydride；Water is
Deionized water.
To dispersible oil-suspending agent, workable auxiliary agent has: dispersing agent such as polycarboxylate, lignosulfonates, alkylnaphthalene
Sulfonate (dispersing agent NNO), the U.S. TERSPERSE 2020(Huntsman Corporation HUNTSMAN produce, alkyl naphthalene sulfonic acid salt) in
It is one or more；Emulsifier such as BY(castor oil polyoxyethylene ether) series emulsifier (BY-110, BY-125, BY-140), agriculture breast
700#(common name: alkyl phenol formaldehyde resin polyoxyethylene ether), agriculture breast 2201, this disk -60#(common name: sorbitol anhydride list is stearic
Acid esters), Tween-60 #(common name: sorbitan monostearate polyoxyethylene ether), agriculture breast 1601#(common name: phenethyl
Phenol polyoxyethylene poly-oxygen propylene aether), TERSPERSE 4894(Huntsman Corporation, the U.S. produce) one of or it is a variety of；Wetting
Agent such as alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, alkyl phenol polyoxyethylene ether phosphate, phenethyl phenol polyoxy second
Alkenyl ether phosphate, alkyl sulfate, alkylsulfonate, naphthalene sulfonate, Huntsman Corporation, the U.S. TERSPERSE 2500(go out
Product) in it is one or more；It is thickener such as white carbon black, polyvinyl alcohol, bentonite, one or more in aluminium-magnesium silicate；Antifreezing agent is such as
It is one or more in ethylene glycol, propylene glycol, glycerol, urea, inorganic salts such as sodium chloride；Decentralized medium for example soybean oil, rapeseed oil,
It is small wheat oil, methyl oleate, diesel oil, machine oil, one or more in mineral oil.
To wettable powder, workable auxiliary agent has: dispersing agent such as polycarboxylate, lignosulfonates, polyoxyethylene is poly-
Oxypropylene group ether block copolymers, alkyl naphthalene formaldehyde condensate sulfonate, alkylphenol-polyethenoxy base ether phosphate, poly alkyl alcohol
Ethylene oxide ether phosphate, it is one or more in alkylphenol polyoxyethylene ether sulfonate；Wetting agent such as alkyl sulfate, alkyl sulphur
One of hydrochlorate, alkylnaphthalene sulfonate are a variety of；Filler for example ammonium sulfate, urea, sucrose, glucose, diatomite, kaolin,
One of white carbon black, light calcium, talcum powder, attapulgite, clay are a variety of.
To water dispersible granules, workable auxiliary agent has: dispersing agent such as polycarboxylate (TERSPERSE 2700, T36, GY-
D06 etc.), lignosulfonates, one of alkylnaphthalene sulfonate or a variety of；Wetting agent for example alkyl sulfate, alkylsulfonate,
One of naphthalene sulfonate is a variety of；It is disintegrating agent such as ammonium sulfate, sodium sulphate, polyvinylpyrrolidone, starch and its derivative, swollen
Moisten one of soil or a variety of；Binder such as starch, glucose, polyvinyl alcohol, polyethylene glycol, sodium carboxymethylcellulose, sucrose
One of or it is a variety of；One of filler such as diatomite, kaolin, white carbon black, light calcium, talcum powder, attapulgite, clay or
It is a variety of.
To soluble powder, workable auxiliary agent has: dispersing agent such as polycarboxylate, lignosulfonates, polyoxyethylene is poly-
Oxypropylene group ether block copolymers, alkyl naphthalene formaldehyde condensate sulfonate, alkylphenol-polyethenoxy base ether phosphate, poly alkyl alcohol
It is one or more in ethylene oxide ether phosphate, alkylphenol polyoxyethylene ether sulfonate；Wetting agent such as alkyl sulfate, alkyl sulphur
One of hydrochlorate, alkylnaphthalene sulfonate etc. are a variety of；Filler such as ammonium sulfate, urea, sucrose, glucose, white carbon black, inorganic salts
One of class etc. is a variety of.
To suspension seed-coating agent, workable auxiliary agent has: (soluble starch gathers film forming agent such as polysaccharide high-molecular compound
Propylene graft copolymer, xanthan gum, microorganism mucilage), cellulose derivative (hydroxypropyl methyl cellulose, carboxymethyl cellulose
Plain sodium, ethyl cellulose), seaweeds such as sodium alginate, agar, rosin, paraffin, gelatin, pectin, polyvinyl alcohol, polyethylene glycol,
Polyvinyl acetate, polyacrylamide, polyvinylpyrrolidone and polyhydric alcohol polymer water solubility composite, inorganic binder
It is one of (aluminium-magnesium silicate, clay, waterglass, gypsum) etc. or a variety of；Dispersing agent such as polycarboxylate, lignosulfonates, alkane
Base naphthalene sulfonate, TERSPERSE 2020(Huntsman Corporation, the U.S. produce, alkyl naphthalene sulfonic acid salt) etc. one of or it is a variety of；
Emulsifier such as Nongru-700 #(common name: alkyl phenol formaldehyde resin polyoxyethylene ether), agriculture breast 2201, this disk -60#(common name: mountain
Pears alcohol acid anhydride monostearate), emulsifier T-60(common name: sorbitan monostearate polyoxyethylene ether), agriculture breast 1601#
(common name: phenethyl phenol polyoxyethylene poly-oxygen propylene aether), TERSPERSE 4894(Huntsman Corporation, the U.S. produce) etc. in
It is one or more；Wetting agent such as alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, alkylphenol-polyethenoxy base ether phosphorus
Acid esters, phenethyl phenol polyoxyethylene groups ether phosphate, alkyl sulfate, alkylsulfonate, naphthalene sulfonate, TERSPERSE 2500
It is one of (Huntsman Corporation, U.S. product) etc. or a variety of；One of thickener such as xanthan gum, polyvinyl alcohol, bentonite etc.
Or it is a variety of；One of preservative such as formaldehyde, benzoic acid, sodium benzoate etc. is a variety of；Defoaming agent such as silicone oil, silicone chemical combination
One of object, C10-20 saturated fat acid compounds, C8-10 fatty alcohols, hexanol, butanol, octanol etc. are a variety of；It is antifreeze
One of agent such as ethylene glycol, propylene glycol, glycerol, urea, inorganic salts such as sodium chloride etc. is a variety of；Water is deionized water.
To Waterless Seed Dressing agent, workable auxiliary agent has: wetting agent such as alkylphenol polyoxyethylene ether formaldehyde condensate sulfate,
Alkylphenol-polyethenoxy base ether phosphate, phenethyl phenol polyoxyethylene groups ether phosphate, alkyl sulfate, alkylsulfonate, naphthalene
Sulfonate, TERSPERSE 2500(Huntsman Corporation, the U.S. produce) etc. one of or it is a variety of；Dispersing agent such as polycarboxylate, wood
Mahogany sulfonate, alkylnaphthalene sulfonate, TERSPERSE 2020(Huntsman Corporation, the U.S. produce, alkyl naphthalene sulfonic acid salt) etc. in
It is one or more；Film forming agent such as polysaccharide high-molecular compound is (soluble starch, polypropylene graft copolymer, xanthan gum, micro-
Biological mucilage), cellulose derivative (hydroxypropyl methyl cellulose, sodium carboxymethylcellulose, ethyl cellulose), seaweeds such as
Sodium alginate, agar, rosin, paraffin, gelatin, pectin, polyvinyl alcohol, polyethylene glycol, polyvinyl acetate, polyacrylamide,
Polyvinylpyrrolidone and polyhydric alcohol polymer water solubility composite, inorganic binder (aluminium-magnesium silicate, clay, waterglass, stone
Cream) etc. one of or it is a variety of；Filler such as diatomite, kaolin, white carbon black, light calcium, talcum powder, attapulgite, in clay
It is one or more.
Instant component is reasonable, to Fusarium (Fusarium spp.) disease, especially gibberella zeaze petch of wheat and barley control efficiency
Good, drug cost is low, and its activity and bactericidal effect are not the active simple superposition of each component, compared with existing single formulation
Compared with, it has significant synergies, it is good to crop safety, meet the security requirement of pesticidal preparations.
Specific embodiment
Synergy measurement to wheat scab.
In order to prevent and treat the wheat scab in agricultural production, carried out with fluorine azoles bacterium acyl azanol bacterium and jinggangmeisu mutually multiple
The synergy research matched, the specific method is as follows.
Subjects be small bakanae disease (FusaHum graminearum).Fluorine azoles bacterium acyl azanol, jinggangmeisu is former
Medicine is configured to required medical fluid according to the matched proportion density of setting, spare.Test method refers to " NY/T 1156.2-2006 agriculture
Bioassay test criterion fungicide part 2 in coyote hole: inhibit disease fungus mycelia growth test Plating ".
Aseptically, the culture medium melted in advance is quantitatively adding in sterile conical flask, from low concentration to high concentration
Medical fluid is successively quantitatively drawn, above-mentioned conical flask is separately added into, sufficiently shakes up.Then equivalent pours into the training that 3 diameter above are 9cm
It supports in ware, the drug containing tablet of respective concentration is made.Processing without medicament is repeated 4 times as blank control.
By cultured pathogen, aseptically, with the punch of diameter 5mm, bacteria cake is cut from colony edge, used
Bacterium disease is inoculated in drug containing tablet center by inoculator, and mycelia is face-up, covers ware lid, sets the incubator culture of preference temperature.
Pathogen hypha growth condition is investigated according to the growing state of bacterium in blank control culture dish, uses vernier caliper measurement
Colony diameter, crossing method are vertically respectively surveyed once, are averaged.
Mycelial growth inhibition rate=(blank control colony diameter-chemicals treatment colony diameter)/blank control colony diameter ×
100
The bactericidal composition pair of fluorine-containing azoles bacterium acyl azanol and jinggangmeisu provided by the invention is evaluated using co-toxicity coefficient method
The synergistic effect of wheat scab seeks regression equation with the logarithm of drug concentration and preventive effect probability value, and medicament pair is calculated
EC50Value, then acquires co-toxicity coefficient.Synergy with co-toxicity coefficient evaluation compound drug to wheat scab, it is malicious altogether to be
Number>120 is expressed as synergistic effect, and co-toxicity coefficient is expressed as summation action between 80~120, and co-toxicity coefficient<80 are expressed as short of money
Anti- effect.
1 fluorine azoles bacterium acyl azanol of table is with jinggangmeisu mixture to the toxicity test result of wheat scab
Synergy measurement result shows: fluorine azoles bacterium acyl azanol and jinggangmeisu are mixed in ratio 100:1~1:100 of table 1
With showing different activity to fusarium graminearum: when ratio is 80:1~1:80, showing as synergistic effect；Especially when
When ratio is 40:1~1:40, synergistic effect is the most significant.
Synergy measurement to rice sheath blight disease.
In order to prevent and treat the rice sheath blight disease in agricultural production, carried out with fluorine azoles bacterium acyl azanol bacterium and jinggangmeisu mutually multiple
The synergy research matched, the specific method is as follows.
Subjects be rice sheath blight disease (Rhizoctonia solani).Raw medicine is configured to the test medicine needed,
Test method is with reference to " the 4th part of farm-chemical indoor determination test rule fungicide: inhibition disease fungus mycelia growth test
Plating " and " the 6th part of farm-chemical indoor determination test rule fungicide: mixed synergy measurement ".
5 various concentration gradients are arranged in single dose and each Mixed Pharmacy first, and (on the basis of preliminary experiment, bacteriostasis rate exists
It is set in the range of 5%~90% by geometric progression).Aseptically, the sterilizing culture that will be melted in advance according to test process
Base is quantitatively adding in sterile conical flask, is reached high concentration from low concentration and is successively quantitatively drawn medical fluid, and above-mentioned conical flask is separately added into
In, sufficiently shake up.Then equivalent is poured into the culture dish that 4 diameters are 9cm, and the drug containing tablet of respective concentration is made.If being free of
Blank control is done in the processing of medicament, and every processing is repeated 4 times.
Aseptically by cultured pathogen, the sterilization punchers for being 5mm with diameter cut bacterium from colony edge
Bacterium disease is inoculated in drug containing tablet center with inoculator by cake, and mycelia is face-up, covers ware lid, sets in the incubator of preference temperature
Culture.Pathogen hypha growth condition is investigated according to the growing state of bacterium in blank control culture dish.It is straight with calliper to measure bacterium colony
Diameter, unit be millimeter (mm), each bacterium colony diameter is measured perpendicularly using the crisscross method, take its average value.According to each medicine
Agent log concentration value and corresponding mycelial growth inhibition rate probability value make regression analysis, find out the EC of each medicament50Value.
The co-toxicity coefficient (CTC) of mixture is calculated with Sun Yunpei's Method, and reagent agent is evaluated to the activity of germ with this.Compounding
The co-toxicity coefficient (CTC) >=120 of preparation shows as synergistic effect；CTC≤80 show as antagonism；80 < CTC < 120 performance
For summation action.
2 fluorine azoles bacterium acyl azanol bacterium of table and jinggangmeisu measure the mixed synergy of rice sheath blight disease
Synergy measurement result shows: fluorine azoles bacterium acyl azanol and jinggangmeisu are mixed in ratio 100:1~1:100 of table 1
With showing different activity to rice sheath blight disease: when ratio is 90:1~1:90, showing as synergistic effect；Especially when than
When example is 40:1~1:40, synergistic effect is the most significant.
In order to better illustrate the present invention, the content of present invention is described further below with reference to embodiment.
Example of formulations 1
Weigh 160 grams of fluorine azoles bacterium acyl azanols, 40 grams of jinggangmeisus, 50 grams of alkylphenol-polyethenoxy base ether phosphates, 50 grams
Sodium lignin sulfonate, 30 grams of alkyl phenol formaldehyde resin polyoxyethylene ethers, 15 grams of bentonites, 10 grams of xanthan gum, 50 grams of urea, 1 gram
Benzoic acid, 8 are restrained oneself alcohol, and deionized water adds to 1000 gram weight parts.For above-mentioned raw materials through mixing, high speed shear disperses 30min, uses sand
Grinding machine is sanded to partial size D9020% fluorine azoles bacterium acyl azanol jinggangmeisu suspending agent is made after less than 10 μm.
Example of formulations 2
Weigh 40 grams of fluorine azoles bacterium acyl azanols, 200 grams of jinggangmeisus, 55 grams of alkyl polyoxyethylene ether sodium sulfonates, 15 grams of alkyl
Fluosite polyoxyethylene ether, 20 grams of aluminium-magnesium silicates, 40 grams of ethylene glycol, 3 grams of benzoic acid, 15 grams of butanol, deionized water add to
1000 gram weight parts.For above-mentioned raw materials through mixing, high speed shear disperses 30min, is sanded with sand mill to partial size D90After 10 μm
24% fluorine azoles bacterium acyl azanol jinggangmeisu ester suspending agent is made.
Example of formulations 3
Weigh 200 grams of fluorine azoles bacterium acyl azanols, 40 grams of jinggangmeisus, 40 grams of alkyl phenol polyoxyethylene ether phosphates, 50 grams it is poly-
Ethylene oxide polyoxypropylene block copolymers, 40 grams of Tween-60 #, 30 grams of Nongru-700 #, 30 grams of calcium dodecyl benzene sulfonates, 15 grams
Organobentonite, 12 grams of polyvinyl alcohol, 10 grams of BHT, cottonseed oil supply 1000 grams.Above-mentioned raw materials are sanded through mixing with sand mill
Obtaining 24% fluorine azoles bacterium acyl azanol jinggangmeisu less than 5 μm to partial size can be dispersed oil-suspending agent.
Example of formulations 4
Weigh 40 grams of fluorine azoles bacterium acyl azanols, 160 grams of jinggangmeisus, 60 grams of BY-110,30 grams of TERSPERSE 2020(alkyl
Naphthalenesulfonate), 50 grams of fatty alcohol polyoxyethylene ether, 35 grams of agriculture breast 1601#, 20 grams of gas-phase silicas, 25 grams of epoxychloropropane,
Palm oil supplies 1000 grams.Above-mentioned raw materials are sanded with sand mill through mixing and obtain 24% fluorine azoles bacterium acyl hydroxyl less than 5 μm to partial size
Oil-suspending agent can be dispersed in amine jinggangmeisu.
Example of formulations 5
Weigh 50 grams of fluorine azoles bacterium acyl azanols, 250 grams of jinggangmeisus, 50 grams of pull open powder BX(nekals), 20 grams
Alkylphenol-polyethenoxy base ether phosphate, 15 grams of lauryl sodium sulfate, talcum powder are filled up to 1000 grams.Above-mentioned raw materials are through mixed
Conjunction, ultra micro air-flow crushing, hybrid technique step are prepared into 30% fluorine azoles bacterium acyl azanol jinggangmeisu wettable powder.
Example of formulations 6
Weigh 150 grams of fluorine azoles bacterium acyl azanols, 300 grams of jinggangmeisus, 60 grams of T36(polycarboxylic acid salts), 30 grams of Ufoxane
3A(lignin sulfonate), 30 grams of lauryl sodium sulfate, kaolin fills up to 1000 grams.Above-mentioned raw materials are through mixing, ultra micro
Air-flow crushing, hybrid technique step are prepared into 45% fluorine azoles bacterium acyl azanol jinggangmeisu wettable powder.
Example of formulations 7
Weigh 100 grams of fluorine azoles bacterium acyl azanols, 300 grams of jinggangmeisus, 30 grams of GY-D06,40 grams of sodium lignin sulfonates, 20 grams
Nekal BX (nekal), 15 grams of K-12(lauryl sodium sulfate), light calcium adds to 1000 gram weight parts.Above-mentioned original
Expect that the method for frequent regulation water intaking dispersible granule mixes, ultra micro air-flow crushing, mixing, granulation step produce 40% fluorine azoles bacterium acyl
Azanol jinggangmeisu water dispersible granules.
Example of formulations 8
Weigh 60 grams of fluorine azoles bacterium acyl azanols, 300 grams of jinggangmeisus, 30 grams of GY-D06(polycarboxylates), 50 grams of sulfomethylated lignins
Sour sodium, 30 grams of lauryl sodium sulfate, 25 grams of sodium alkyl sulfonates, attapulgite add to 1000 gram weight parts.Above-mentioned raw materials are frequent
Method i.e. mixing, ultra micro air-flow crushing, mixing, the granulation step of regulation water intaking dispersible granule produces 36% fluorine azoles bacterium acyl azanol
Jinggangmeisu water dispersible granules.
Example of formulations 9
Weigh 40 grams of fluorine azoles bacterium acyl azanols, 200 grams of jinggangmeisus, 50 grams of alkyl sulfonic acid calcium, 40 grams of calcium lignosulfonates, 30
Gram nekal, 50 grams of sodium alkyl sulfonates, ammonium sulfate add to 100 gram weight parts.Above-mentioned raw materials are through mixing, air-flow crushing
24% fluorine azoles bacterium acyl azanol jinggangmeisu soluble powder is made afterwards.
Example of formulations 10
Weigh 120 grams of fluorine azoles bacterium acyl azanols, 240 grams of jinggangmeisus, 40 grams of polycarboxylic acids calcium, 30 grams of polycarboxylates
2700,20 grams of nekals of TERSPERSE, 20 grams of lauryl sodium sulfate, white carbon black add to 1000 gram weight parts.
36% fluorine azoles bacterium acyl azanol jinggangmeisu soluble powder is made through mixing in above-mentioned raw materials after air-flow crushing.
Example of formulations 11
Weigh 30 grams of fluorine azoles bacterium acyl azanols, 90 grams of jinggangmeisus, 30 grams of (Huntsman Corporations, the U.S. of TERSPERSE 4894
Produce), 10 grams of polycarboxylate TERSPERSE 2700 (Huntsman Corporation, the U.S. products), 10 grams of TERSPERSE 2500 it is (beautiful
Huntsman Corporation, state produce), 20 grams of polyvinylpyrrolidones, 2 grams of xanthan gum, 50 grams of ethylene glycol, 3 grams of benzoic acid, 5 grams of organosilicons
Defoaming agent (trade name: the Nanjing s-29 "four news" (new ideas applied chemistry product company produces), deionized water adds to 1000 gram weight parts.Above-mentioned original
Material is mixed, and high speed shear disperses 30min, and the suspension kind of 12% fluorine azoles bacterium acyl azanol jinggangmeisu is made after being sanded with sand mill
Clothing agent.
Example of formulations 12
50 grams of fluorine azoles bacterium acyl azanols, 50 grams of jinggangmeisus, 30 grams of Huntsman Corporations, the U.S. TERSPERSE 4894(are weighed to go out
Product), 10 grams of TERSPERSE 2020(Huntsman Corporations, the U.S. produce), 20 grams of phenethyl phenol polyoxyethylene groups ether phosphates, 30
Gram hydroxypropyl methyl cellulose, 5 grams of bentonites, 50 grams of propylene glycol, 4 grams of sodium benzoates, 5 grams of organic silicon defoamer (trade names: s-
29 Nanjing "four news" (new ideas applied chemistry product companies produce), deionized water adds to 1000 gram weight parts.Above-mentioned raw materials are cut at a high speed through mixing
Cutting dissipates 30min, and 10% fluorine azoles bacterium acyl azanol jinggangmeisu suspension seed-coating agent is made after being sanded with sand mill.
Example of formulations 13
Weigh 40 grams of fluorine azoles bacterium acyl azanols, 80 grams of jinggangmeisus, 30 grams of alkylphenol-polyethenoxy base ether phosphates, 20 grams of benzene
Ethyl phenol polyoxyethylene groups ether phosphate, 40 grams of polycarboxylic acids receive, 20 grams of hydroxypropyl methyl celluloses, and diatomite complements to 1000 grams
Parts by weight.Through air-flow crushing after above-mentioned raw materials mixing, 12% fluorine azoles bacterium acyl azanol jinggangmeisu Waterless Seed Dressing agent is made.
Example of formulations 14
Weigh 20 grams of fluorine azoles bacterium acyl azanols, 60 grams of jinggangmeisus, 50 grams of alkylphenol-polyethenoxy base ether formaldehyde condensation products sulphur
Hydrochlorate, 40 grams of alkylnaphthalene sulfonates, 20 grams of sodium carboxymethylcelluloses, white carbon black complement to 1000 gram weight parts.Above-mentioned raw materials are mixed
Through air-flow crushing after conjunction, 8% fluorine azoles bacterium acyl azanol jinggangmeisu Waterless Seed Dressing agent is made.
Biological Examples 1: prevention and treatment gibberella zeaze petch of wheat and barley field trial.
2016 Baoji, Shaanxi province city, the village Ying Touzhen Zhang Jia, Mei County carried out example of formulations 1~14 prevent and treat wheat it is red mould
The field control effectiveness test of disease.Pass through the effect with comparison medicament 200g/L fluorine azoles bacterium acyl azanol suspending agent, 5% jinggangmeisu aqua
It compares, demonstrates the control efficiency of the invention to gibberella zeaze petch of wheat and barley and the safety to wheat.
Trial crops are wheat, controlling object be wheat scab (Fusarium graminearum).Test is located at treasured
The Mei County Ji Shi Ying Touzhen, experimental plot topography is flat, and soil is medium loam, middle fertility, pH value 7.1, fertilizer and water management during test
It is medium.See Table 3 for details for test medicine and dosage.Separately set blank control, 4 repetitions of every processing, every 30 ㎡ of cell, totally 68 cells,
Random district's groups arrangement.Dilutable preparation 1-10 is administered for the first time at wheat flowering initial stage, is spaced 7 days using conventional spray-on process
It sprays second, mu is administered liquid 45kg, is uniformly sprayed at leave dual sides.Example of formulations 11-14 is using seed pelleting and mixes
The method application of kind.
Investigation and statistical method: state of an illness radix, wheat milk stage 10d or so investigation prevention effect to before harvesting are investigated before application
Fruit.5 points of every cell diagonal line samplings, every 100~200 fringes of investigation account for the percentage of entire fringe area with withered fringe area to divide
Grade records sick spike numbers at different levels and total spike number.Stage division:
0 grade: full fringe is disease-free；
1 grade: 1/4 or less withered fringe area Zhan Quansui area；
3 grades: the 1/4~1/2 of withered fringe area Zhan Quansui area；
5 grades: the 1/2~3/4 of withered fringe area Zhan Quansui area；
7 grades: 3/4 or more of withered fringe area Zhan Quansui area.
Disease index=[∑ (disease spike numbers at different levels × opposite value of series)/(investigating total spike number × 7)] × 100
Control efficiency (%)=(blank district disease index-chemicals treatment district disease index)/blank district state of an illness refers to
Number × 100
3 fluorine azoles bacterium acyl azanol of table and validamycin composition prevent and treat wheat scab field test results
Table of field test results are bright, and the above example of formulations has good control efficiency to wheat scab, red to wheat
8 days preventive effects reach 92% or more after the 2nd medicine of mildew, hence it is evident that better than the preventive effect of two single doses.By to 8 days difference after medicine
Significance analysis, preventive effect difference reach extremely significant level.
Security survey to wheat is observed after spray for several days after the 1st day and medicine, and each test process is to wheat without phytotoxicity
Phenomenon occurs.
Biological Examples 2: prevention and treatment rice sheath blight disease field trial.
Example of formulations 1~14 has been carried out in Junichiro Koizumi village, xiangtan, hunan province county within 2016 prevent and treat the examination of rice sheath blight disease field
It tests.By being compared with the effect of comparison medicament 200g/L fluorine azoles bacterium acyl azanol suspending agent, 5% jinggangmeisu aqua, demonstrate
Control efficiency of the present invention to rice sheath blight disease and the safety to rice.
Trial crops are rice, controlling object be rice sheath blight disease (Rhizoctonia solani).Test is located at Hunan
Xiangtan County Junichiro Koizumi village, province, experimental plot topography is flat, and soil is loam, and fertility is higher, pH value 7.2, during test in fertilizer and water management
Deng.See Table 4 for details for test medicine and dosage.Separately set blank control, 4 repetitions of every processing, every 30 ㎡ of cell, totally 68 cells, with
The arrangement of machine district's groups.Using conventional spray-on process, mu is administered liquid 45kg, is uniformly sprayed at leave dual sides.
Investigation and statistical method: investigating state of an illness radix before application, 10d is reinvestigated once after last time is administered, and investigates 2 altogether
It is secondary.According to rice leaf sheath and blade damage symptom grading, as unit of strain, 5 points of every cell diagonal line samplings, every tune
Connected 5 clumps are looked into, totally 25 clumps, record total strain number, diseased plant number and sick series.
0 grade: complete stool is disease-free；
1 grade: quaterfoil and its following leaf sheath, blade morbidity (with sword-like leave for first leaf)；
3 grades: third blade and its following leaf sheath, blade morbidity；
5 grades: second blades and its following leaf sheath, blade morbidity；
7 grades: sword-like leave blade and its following leaf sheath, blade morbidity；
9 grades: complete stool morbidity, it is withered ahead of time.
Disease index=[∑ (the disease numbers of sheets at different levels × opposite value of series)/(investigation total leaf number × 9)] × 100
Control efficiency (%)=[1- (the preceding disease index of control application × disease index after processing application)/it is (sick after control application
Disease index before feelings index × processing is administered] × 100
4 fluorine azoles bacterium acyl azanol of table and validamycin composition prevent and treat rice sheath blight disease field test results
Table of field test results are bright, and the above example of formulations has good control efficiency to rice sheath blight disease, to rice line
10 days preventive effects reach 94% or more after the 2nd medicine of blight, hence it is evident that better than the preventive effect of two single doses.By to 10 days differences after medicine
Different significance analysis, preventive effect difference reach extremely significant level.
Security survey to rice is observed after spray for several days after the 1st day and medicine, and each test process is to rice without phytotoxicity
Phenomenon occurs.
From above embodiments as it can be seen that fluorine azoles bacterium acyl azanol and jinggangmeisu are answered according to weight ratio for 90:1~1:90
Match, can be made into wettable powder, water dispersible granules, suspending agent, suspoemulsion, dispersible agent, dispersible oil-suspending agent, super-low capacity
Liquor is measured, has significant control efficiency to banded sclerotial blight, Fusarium disease fungus disease especially gibberella zeaze petch of wheat and barley, synergistic effect is bright
It is aobvious, dosage and drug cost are reduced, and to crop safety, therefore produce and have wide practical use.
In conclusion composition of the invention is to banded sclerotial blight, Fusarium disease fungus disease especially gibberella zeaze petch of wheat and barley
Control efficiency is significant, is using two kinds of active components compound scheme, activity and bactericidal effect are not that each component is active simple
Superposition, compared with existing single formulation, in addition to apparent bactericidal effect, also have significant synergies, prevention and treatment at
This reduction meets the security requirement of pesticidal preparations to crop safety.
Claims (4)
1. a kind of bactericidal composition of fluorine-containing azoles bacterium acyl azanol and jinggangmeisu, which is characterized in that by the first active constituent fluorine azoles
Bacterium acyl azanol, the second active constituent jinggangmeisu and auxiliary agent composition, the weight ratio of the first active constituent and the second active constituent are
60:1~1:60, the sum of content are the 2%~80% of the composition total weight.
2. the bactericidal composition of fluorine-containing azoles bacterium acyl azanol and jinggangmeisu according to claim 1, which is characterized in that first is living
Property ingredient and the weight ratio of the second active constituent be 40:1~1:40, the sum of content is the 5%~70% of the composition total weight.
3. the bactericidal composition of fluorine-containing azoles bacterium acyl azanol and jinggangmeisu according to claim 1, which is characterized in that described group
Conjunction agent type be suspending agent, dispersible oil-suspending agent, wettable powder, water dispersible granules, soluble powder, suspension seed-coating agent,
Waterless Seed Dressing agent.
4. the bactericidal composition of fluorine-containing azoles bacterium acyl azanol and jinggangmeisu is in prevention and treatment banded sclerotial blight, red mould according to claim 1
Application in disease.
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| CN107258795A (en) * | 2017-07-04 | 2017-10-20 | 江苏丘陵地区镇江农业科学研究所 | A kind of bactericidal composition for being used to prevent and treat wheat scab |
| CN108605960A (en) * | 2018-05-23 | 2018-10-02 | 深圳诺普信农化股份有限公司 | A kind of bactericidal composition containing fluorine azoles bacterium acyl azanol and its application |
| CN109169673A (en) * | 2018-08-17 | 2019-01-11 | 陕西上格之路生物科学有限公司 | A kind of bactericidal composition containing fluorine azoles bacterium acyl azanol and cyflufenamid |
| CN109169692A (en) * | 2018-08-17 | 2019-01-11 | 陕西上格之路生物科学有限公司 | A kind of bactericidal composition containing fluorine azoles bacterium acyl azanol and Mancozeb |
| CN109090160A (en) * | 2018-09-14 | 2018-12-28 | 安徽省益农化工有限公司 | A kind of bactericidal aqueous emulsion of the environment-friendly type containing a variety of Chinese medicine composition |
| CN113243370A (en) * | 2021-05-28 | 2021-08-13 | 浙江省桐庐汇丰生物科技有限公司 | Kasugamycin-containing bactericidal composition |
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