CN106929568A - 用于治疗、诊断和监控狼疮的方法 - Google Patents
用于治疗、诊断和监控狼疮的方法 Download PDFInfo
- Publication number
- CN106929568A CN106929568A CN201611005880.7A CN201611005880A CN106929568A CN 106929568 A CN106929568 A CN 106929568A CN 201611005880 A CN201611005880 A CN 201611005880A CN 106929568 A CN106929568 A CN 106929568A
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- Prior art keywords
- variation
- locus
- lupus
- subject
- snp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Transplantation (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27851009P | 2009-10-07 | 2009-10-07 | |
| US61/278,510 | 2009-10-07 | ||
| CN201080055282.5A CN102803509B (zh) | 2009-10-07 | 2010-10-06 | 用于治疗、诊断和监控狼疮的方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201080055282.5A Division CN102803509B (zh) | 2009-10-07 | 2010-10-06 | 用于治疗、诊断和监控狼疮的方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106929568A true CN106929568A (zh) | 2017-07-07 |
Family
ID=43857111
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110273784.5A Pending CN113025703A (zh) | 2009-10-07 | 2010-10-06 | 用于治疗、诊断和监控狼疮的方法 |
| CN201611005880.7A Pending CN106929568A (zh) | 2009-10-07 | 2010-10-06 | 用于治疗、诊断和监控狼疮的方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110273784.5A Pending CN113025703A (zh) | 2009-10-07 | 2010-10-06 | 用于治疗、诊断和监控狼疮的方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US20130034544A1 (enExample) |
| EP (3) | EP3219813B1 (enExample) |
| JP (2) | JP5937008B2 (enExample) |
| KR (2) | KR101953075B1 (enExample) |
| CN (2) | CN113025703A (enExample) |
| BR (1) | BR112012007778A2 (enExample) |
| CA (1) | CA2777055C (enExample) |
| RU (2) | RU2596391C2 (enExample) |
| WO (1) | WO2011044205A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113025703A (zh) | 2009-10-07 | 2021-06-25 | 弗·哈夫曼-拉罗切有限公司 | 用于治疗、诊断和监控狼疮的方法 |
| US20130310266A1 (en) * | 2010-09-03 | 2013-11-21 | Immport Therapeutics, Inc. | Methods and Compositions For The Diagnosis And Treatment Of Cancer and Autoimmune Disorders |
| KR20140034529A (ko) | 2012-09-12 | 2014-03-20 | 삼성전기주식회사 | 전기 동도금 장치 |
| KR101491214B1 (ko) * | 2012-10-10 | 2015-02-06 | 가톨릭대학교 산학협력단 | 1q25.1(RABGAP1L) 위치, 6p21.32 (C4) 위치 및 10q21.3위치의 DNA 복제 수 변이 검출용 프라이머를 포함하는 전신성 홍반성 루푸스 발병 위험도 예측용 조성물 |
| WO2014058254A1 (ko) * | 2012-10-10 | 2014-04-17 | 가톨릭대학교 산학협력단 | 1q25.1(RABGAP1L) 위치, 6P21.32 (C4) 위치 및 10q21.3위치의 DNA 복제 수 변이 검출용 프라이머를 포함하는 전신성 홍반성 루푸스 발병 위험도 예측용 조성물 |
| CN106460054A (zh) * | 2014-03-21 | 2017-02-22 | 新加坡科技研究局 | 癌症中的融合基因 |
| DE102017107661A1 (de) | 2017-04-10 | 2018-10-11 | Universität Rostock | SH2B-Adapterprotein-3 für die Vorhersage einer Knochenmarkantwort und Immunantwort |
| KR20190034511A (ko) | 2019-03-22 | 2019-04-02 | 아주대학교산학협력단 | Aimp1을 포함하는 전신 홍반성 루프스 진단용 바이오마커 조성물 및 이를 이용한 전신 홍반성 루프스 진단 방법 |
| WO2021127589A1 (en) * | 2019-12-18 | 2021-06-24 | The Children's Hospital Of Philadelphia | Novel druggable targets for the treatment of inflammatory diseases such as systemic lupus erythematosus (sle) and methods for diagnosis and treatment using the same |
| JP7162406B1 (ja) * | 2021-07-15 | 2022-10-28 | 富士フイルム株式会社 | 細胞の品質管理方法及び細胞を製造する方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008144761A2 (en) * | 2007-05-21 | 2008-11-27 | Genentech, Inc. | Methods and compositions for identifying and treating lupus |
| CN101378764A (zh) * | 2005-12-09 | 2009-03-04 | 贝勒研究院 | 通过血液白细胞微阵列分析对系统性红斑狼疮的诊断、预后和疾病发展的监测 |
| CN101443040A (zh) * | 2006-03-16 | 2009-05-27 | 基因技术股份有限公司 | 用cd4抗体治疗狼疮的方法 |
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| US4657760A (en) | 1979-03-20 | 1987-04-14 | Ortho Pharmaceutical Corporation | Methods and compositions using monoclonal antibody to human T cells |
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| US4683203A (en) | 1984-04-14 | 1987-07-28 | Redco N.V. | Immobilized enzymes, processes for preparing same, and use thereof |
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| ATE390933T1 (de) | 1995-04-27 | 2008-04-15 | Amgen Fremont Inc | Aus immunisierten xenomäusen stammende menschliche antikörper gegen il-8 |
| WO1996034096A1 (en) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
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| US20100099101A1 (en) * | 2008-09-26 | 2010-04-22 | Genentech, Inc. | Methods for treating, diagnosing, and monitoring lupus |
| CN113025703A (zh) | 2009-10-07 | 2021-06-25 | 弗·哈夫曼-拉罗切有限公司 | 用于治疗、诊断和监控狼疮的方法 |
-
2010
- 2010-10-06 CN CN202110273784.5A patent/CN113025703A/zh active Pending
- 2010-10-06 CA CA2777055A patent/CA2777055C/en active Active
- 2010-10-06 CN CN201611005880.7A patent/CN106929568A/zh active Pending
- 2010-10-06 EP EP17158497.2A patent/EP3219813B1/en active Active
- 2010-10-06 US US13/501,448 patent/US20130034544A1/en not_active Abandoned
- 2010-10-06 RU RU2012118596/10A patent/RU2596391C2/ru active
- 2010-10-06 KR KR1020187002464A patent/KR101953075B1/ko not_active Expired - Fee Related
- 2010-10-06 EP EP20198258.4A patent/EP3839068A3/en not_active Withdrawn
- 2010-10-06 JP JP2012533270A patent/JP5937008B2/ja not_active Expired - Fee Related
- 2010-10-06 WO PCT/US2010/051589 patent/WO2011044205A1/en not_active Ceased
- 2010-10-06 RU RU2016131167A patent/RU2016131167A/ru not_active Application Discontinuation
- 2010-10-06 BR BR112012007778-3A patent/BR112012007778A2/pt not_active Application Discontinuation
- 2010-10-06 EP EP10822583.0A patent/EP2486152B1/en active Active
- 2010-10-06 KR KR1020127011605A patent/KR101824744B1/ko not_active Expired - Fee Related
-
2016
- 2016-02-10 US US15/040,949 patent/US10053734B2/en active Active
- 2016-05-11 JP JP2016095330A patent/JP6321717B2/ja not_active Expired - Fee Related
-
2018
- 2018-08-20 US US16/105,426 patent/US20190211398A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101378764A (zh) * | 2005-12-09 | 2009-03-04 | 贝勒研究院 | 通过血液白细胞微阵列分析对系统性红斑狼疮的诊断、预后和疾病发展的监测 |
| CN101443040A (zh) * | 2006-03-16 | 2009-05-27 | 基因技术股份有限公司 | 用cd4抗体治疗狼疮的方法 |
| WO2008144761A2 (en) * | 2007-05-21 | 2008-11-27 | Genentech, Inc. | Methods and compositions for identifying and treating lupus |
Non-Patent Citations (2)
| Title |
|---|
| GIBSON AW ET AL.: "Novel Single Nucleotide Polymorphisms in the Distal IL-10 Promoter Affect IL-10 Production and Enhance the Risk of Systemic Lupus Erythematosus", 《JOURNAL OF IMMUNOLOGY》 * |
| SUAREZ-GESTAL M ET AL.: "Replication of recently identified systemic lupus erythematosus genetic associations: a case-control study", 《ARTHRITIS RESEARCH & THERAPY》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2011044205A1 (en) | 2011-04-14 |
| EP3219813A2 (en) | 2017-09-20 |
| CN102803509A (zh) | 2012-11-28 |
| EP3839068A3 (en) | 2021-10-20 |
| BR112012007778A2 (pt) | 2020-08-11 |
| EP3219813B1 (en) | 2020-11-18 |
| JP5937008B2 (ja) | 2016-06-22 |
| EP2486152A4 (en) | 2013-05-22 |
| CA2777055C (en) | 2021-04-06 |
| KR20180012344A (ko) | 2018-02-05 |
| EP3219813A3 (en) | 2018-01-10 |
| HK1176384A1 (zh) | 2013-07-26 |
| US20130034544A1 (en) | 2013-02-07 |
| JP6321717B2 (ja) | 2018-05-09 |
| JP2013507127A (ja) | 2013-03-04 |
| US20190211398A1 (en) | 2019-07-11 |
| RU2012118596A (ru) | 2013-11-20 |
| KR101953075B1 (ko) | 2019-02-27 |
| CA2777055A1 (en) | 2011-04-14 |
| KR20120100969A (ko) | 2012-09-12 |
| RU2016131167A (ru) | 2018-12-07 |
| EP2486152A1 (en) | 2012-08-15 |
| US20160273044A1 (en) | 2016-09-22 |
| JP2017012158A (ja) | 2017-01-19 |
| KR101824744B1 (ko) | 2018-03-15 |
| EP2486152B1 (en) | 2017-12-06 |
| EP3839068A2 (en) | 2021-06-23 |
| CN113025703A (zh) | 2021-06-25 |
| US10053734B2 (en) | 2018-08-21 |
| RU2596391C2 (ru) | 2016-09-10 |
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| EP2612924B1 (en) | Methods and compositions for identifying and treating lupus | |
| CN102803509B (zh) | 用于治疗、诊断和监控狼疮的方法 | |
| HK1237003A1 (en) | Methods for treating, diagnosing, and monitoring lupus | |
| HK1176384B (en) | Methods for treating, diagnosing, and monitoring lupus |
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