CN106924701A - It is a kind of to treat medicine of vasculitis and preparation method thereof - Google Patents
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/268—Asarum (wild ginger)
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- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
Medicine of vasculitis and preparation method thereof is treated the invention discloses a kind of, it is prepared from according to a certain weight ratio by scorpio, radix aconiti sinensis, RADIX ACONITI KUSNEZIFFII, Radix Angelicae Sinensis, the Radix Astragali, ganoderma lucidum, monkshood, rhizoma zingiberis, asarum, evodia rutaecarpa, toad skin, centipede, medicine of the present invention has expelling wind and relieving convulsion, Tongluo Jiedu, antalgic, inducing diuresis for removing edema, promoting pus discharge and tissue regeneration, clearing heat and detoxicating function, for treating vasculitis instant effect, good effect, does not recur.
Description
Technical field
Medicine of vasculitis and preparation method thereof is treated the present invention relates to a kind of, belongs to the field of Chinese medicines.
Background technology
During vasculitis is a kind of rare chronic recurrent, the segmental diseases associated with inflammation of parteriole and vein, lower limb are more
See.Show as suffering limb ischemic, pain, Charcot's syndrome, pulsation of foot dorsal artery decrease or disappear and migrans Superficial phlebitis, sternly
Severe one has acra ulcer and necrosis.Because western medicine side effect is big, therefore people are to the Chinese medicine of effectively treatment vasculitis
In the presence of great demand, up to now, it has not been found that on relevant report of the invention.
The content of the invention
The present inventor have found effectively treatment vascular finally according to the checking repeatedly of research and the clinical test of theory of traditional Chinese medical science
Scorching medicine, so as to complete the present invention.
It is an object of the invention to provide a kind of Chinese medicine composition of effective treatment vasculitis.
Another object of the present invention just there is provided the preparation method of the Chinese medicine composition.
Medicine of the present invention is selection scorpio, radix aconiti sinensis, RADIX ACONITI KUSNEZIFFII, Radix Angelicae Sinensis, the Radix Astragali, ganoderma lucidum, monkshood, rhizoma zingiberis, asarum, Wu Zhu
Cornel, toad skin, centipede are combined preparation, and these drug regimens are caused into each efficacy of drugs produces synergy such that it is able to
Effectively treat vasculitis.Wherein from scorpio because its nature and flavor is salty pungent, put down, it is poisonous, there is wind-dispelling, only convulsion, dredging collateral, the work(of removing toxic substances
Can, convulsion , Dian Epilepsy is controlled, apoplexy, hemiplegia, Kou Yan wai are oblique, antimigraine, arthralgia pain due to rheumatism, lockjaw, scrofula,
Rubella sore swells.From radix aconiti sinensis, different name monkshood, its nature and flavor is pungent, heat, poisonous, enters spleen, the warp of the gate of vitality two, there is dispellieg cold and dampness, dissipates ailment said due to cold or exposure,
Wen Jing, the function of analgesic controls wind-cold-dampness arthralgia, severe and wadering arthralgia bitterly, spasm of limbs, hemiplegia, head wind headache, trusted subordinate's crymodynia, cloudy subcutaneous ulcer
Pyogenic infections.From RADIX ACONITI KUSNEZIFFII, different name radix aconiti agrestis, its nature and flavor is pungent, and heat, poisonous, enter liver, spleen, lung channel search wind prevailing over dampness, and eliminating cold to stop pain is opened
Phlegm, the function of detumescence controls wind-cold-dampness arthralgia, paralysis due to windstroke, lockjaw, head wind, coldness and pain in the epigastrium, phlegm addiction, air parcel, cold dysentery, larynx numbness, carbuncle
Subcutaneous ulcer, furunculosis, scrofula.From Radix Angelicae Sinensis because its nature and flavor sweet, acrid, warm, enters the heart, liver, the spleen channel, there are benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, profit
The function of dry laxation, controls irregular menstruation, and Amenorrhea stomachache , Disorder lumps in the abdomen knot gathers, and uterine bleeding, headache due to deficiency of blood, dizziness, Impotence numbness, intestinal dryness is difficult just, red
Weight, ulcer sores, metal-inflicted wound, injury from falling down after dysentery.From the Radix Astragali because its nature and flavor is sweet, tepor enters lung, the spleen channel, raw with beneficial
Solid table is defended, inducing diuresis for removing edema, eliminating toxic, the function of myogenic controls spontaneous perspiration, and night sweat, blood-arthralgia, edema, ulcer is not burst or burst and holds back long；Process with having
The function of bowl spares benefit, controls internal injury overstrain, and splenasthenic diarrhea, prolapse of the anus, deficiency of vital energy blood takes off, and collapses band and the disease of all laboured breathing deficiency of blood.From spirit
Sesame is put down because its nature and flavor is sweet, and the thoughts of returning home, lung, liver and kidney channel have invigorating qi for tranquilization, and relieving cough and asthma function controls dizziness egersis, palpitaition
Shortness of breath, consumptive disease cough and asthma.It is poisonous from monkshood because its property acrid-sweet flavor, warm, enter the heart, spleen, kidney channel, there is back sun to mend fire, cold dispelling is removed
Wet function, controls yin excess network sun, and loss of YANG due to profuse perspiration is told profit and fainted inverse, trusted subordinate's crymodynia, and Spleen diarrhea cold dysentery, tinea pedis oedema, children shy slowly, wind
The disease of cold-dampness Bi , Wei lame contractions, cloudy subcutaneous ulcer sore leakage and all chronic diseaseses.From rhizoma zingiberis because its nature and flavor is pungent, heat, enter spleen, stomach,
Lung channel, has middle benefit gas by trembling with fear, and the function of Back to Yang Tongmai controls trusted subordinate's crymodynia, vomits and diarrhoea, and cold weak pulse of limb, cold drink is breathed with cough, wind-cold-dampness arthralgia, sun
Void is told, is defeated in battle, lower blood.From asarum because its nature and flavor is pungent, temperature enters lung, kidney channel, there is wind-dispelling, and function surreptitiously is opened in cold dispelling, water-filling,
Air-cooled headache is controlled, nasosinusitis, analgesic, phlegm and retained fluid coughs inverse, arthralgia pain due to rheumatism.From evodia rutaecarpa because its nature and flavor is arduous, temperature is poisonous, enters
Liver, stomach, there is middle benefit gas, analgesic, qi-regulating, the function of eliminating dampness, control inverse acid regurgitation of vomitting, and jueyin headache, the cold syndrome in infant is vomited and diarrhoea, abdominal distention, pin
Gas, hernia, aphthous ulcer, dentalgia, eczema, impetigo.Cool from toad skin because its nature and flavor is pungent, micro- poison has clearing heat and detoxicating,
The function of sharp water dissipate-swelling, controls ulcer, pyogenic infections, scrofula, tumour, infantile malnutrition due to digestive disturbances or intestinalparasites abdominal distension, chronic bronchitis.From centipede because its nature and flavor
Pungent, temperature is poisonous, enters Liver Channel, there is wind-dispelling, calms the frightened, and attacks poison, and the function of dissipating bind controls apoplexy, frightened Epilepsy, lockjaw, pertussis, Ji scrofula,
Tuberculosis , Disorder buildup blocks, sore swollen toxin, wind tinea, white bald, anal fistula is scalded.
Specific embodiment
The drug dose of instant component is also that inventor summarizes what is drawn by largely groping, and the consumption of each component is following heavy
All there is preferable curative effect in the range of amount：
4-8 grams of scorpio, 4-8 grams of radix aconiti sinensis, 4-8 grams of RADIX ACONITI KUSNEZIFFII, 5-15 grams of Radix Angelicae Sinensis, 10-20 grams of the Radix Astragali, 10-20 grams of ganoderma lucidum, monkshood
10-20 grams, 5-15 grams of rhizoma zingiberis, 4-8 grams of asarum, 5-15 grams of evodia rutaecarpa, 5-15 grams of toad skin, 10-14 grams of centipede.
Preferably：
6 grams of scorpio, 6 grams of radix aconiti sinensis, 6 grams of RADIX ACONITI KUSNEZIFFII, 10 grams of Radix Angelicae Sinensis, 15 grams of the Radix Astragali, 15 grams of ganoderma lucidum, 15 grams of monkshood, 10 grams of rhizoma zingiberis,
6 grams of asarum, 10 grams of evodia rutaecarpa, 10 grams of toad skin, 12 grams of centipede.
The preparation method of medicine of the present invention is as follows
First, get the raw materials ready
1st, scorpio：Clear water floats the matter that desalts, and dries, or low baking temperature roasting is used；
2nd, radix aconiti sinensis：Impurity is picked, ash bits are cleaned, dried；
3rd, RADIX ACONITI KUSNEZIFFII：Crude drug is taken, impurity is removed, cleaning, drying, the used time smashs to pieces；
4th, Radix Angelicae Sinensis：Impurity is picked, is cleaned, vexed profit is slightly dried in the air, and section is dried；
5th, the Radix Astragali：Net impurity is picked, the root head and hollow larger root of residual is removed, is soaked in water, pulled out, cut in time after running through
Piece, dries；
6th, ganoderma lucidum：Impurity is removed, is cleaned, softened, cut sheet, dried, weed out chip；
7th, monkshood：It is soaked in water, pulls out, cut into slices, dries；
8th, rhizoma zingiberis：Net impurity is picked, is soaked in water 3-6 hours, pulled out, cut into slices or dice after vexed profit, dried；
9th, asarum：Cleared impurity, is sprayed with water and moistened, and timely segment is dried；
10th, evodia rutaecarpa：Crude drug is taken, carpopodium, branch and impurity is removed, chip is weeded out；
11st, toad skin：Impurity, chip are removed, a pawl is cut off, diced；
12nd, centipede：Wipe net, remove cephalopodium, cut and use.
2nd, prepare
1st, by the scorpio of the weight, radix aconiti sinensis, RADIX ACONITI KUSNEZIFFII, Radix Angelicae Sinensis, the Radix Astragali, ganoderma lucidum, monkshood, rhizoma zingiberis, asarum, evodia rutaecarpa, toad
Skin, centipede are put into container, grind into powder；
2nd, the powder that will be ground to form adds vaseline to be adjusted to ointment and obtains final product.
Scorpio has wind-dispelling in prescription, only convulsion, dredging collateral, and the function of removing toxic substances is monarch drug in a prescription；Radix aconiti sinensis has dispellieg cold and dampness, dissipates ailment said due to cold or exposure, temperature
Through the function of analgesic；The Radix Astragali is beneficial to defend solid table, inducing diuresis for removing edema, eliminating toxic, the function of myogenic, and the two is ministerial drug, and three taste medicines are sent out jointly
Expelling wind and relieving convulsion is waved, Tongluo Jiedu, antalgic, inducing diuresis for removing edema, the effect of promoting pus discharge and tissue regeneration, treatment vasculitis effect is comprehensive, and with
Expelling wind and relieving convulsion, Tongluo Jiedu can effect a permanent cure based on promoting pus discharge and tissue regeneration, and toad skin has clearing heat and detoxicating, and the function of sharp water dissipate-swelling is adjutant, centipede
There is wind-dispelling, calm the frightened, attack poison, to make medicine, all medicines are to take stopgap measures to the function of dissipating bind with being left.
Medicine of the present invention has expelling wind and relieving convulsion, and Tongluo Jiedu, antalgic, inducing diuresis for removing edema, promoting pus discharge and tissue regeneration is clearing heat and detoxicating
Function, for treating vasculitis, short treating period, instant effect, non-relapse after healing.
The beneficial effect of medicine of the present invention is expanded on further below by way of test example, these test examples include this hair
The animal toxicity test report of bright medicine and clinical observation on the therapeutic effect data.
The animal toxicity test report of [test example 1] medicine of the present invention：
Rabbit 30 is taken, male and female dual-purpose, 2.0-2.5kg of body weight is divided to two groups, and every group 15, one of which is tested for overdose
Group, another group is normal amount test group.The part rabbit hair is pulled out, medicine end is spread on into rabbit surface, the daily dressing of super quantity group three times,
The daily dressing of normal amount is twice, continuous to use 7 days, the reaction of observation administration daily, is as a result showing two groups of rabbit activities, diet just
Often, medicine is without bad toxic and side effect.
The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention
1st, physical data
Accept vasculitis out-patient totally 27 for medical treatment.
2nd, diagnostic criteria
Classical symptom shows as suffering limb ischemic, pain, Charcot's syndrome, pulsation of foot dorsal artery decrease or disappearance and migrans table is shallow
Phlebitis, severe patient has acra ulcer and necrosis.
3rd, treatment method
From above-mentioned ointment application suffering limb sole center, early, middle and late each 1 time daily, 10 days is a course for the treatment of, continuously takes 4 treatments
Journey.
4th, efficacy assessment standard
It is effective：Vasculitis syndromes disappear, and constitution recovers normal, recovery from illness；
Take a turn for the better：Vasculitis syndromes are clearly better, limping, pain relief, progressively recover normal；
It is invalid：Improvement standard person is not reached.
5th, treatment results（See the table below）
In above-mentioned treatment, with drug therapy vasculitis patient 27 of the present invention, as a result effective 22, obvious effective rate is 81.5%, good
Turn 3, improvement rate is 11.1%, and invalid 2, total effective rate is 92.6%.
Claims (3)
1. a kind of medicine for treating vasculitis, it is characterised in that：It is made up of the bulk drug in following weight range：
4-8 grams of scorpio, 4-8 grams of radix aconiti sinensis, 4-8 grams of RADIX ACONITI KUSNEZIFFII, 5-15 grams of Radix Angelicae Sinensis, 10-20 grams of the Radix Astragali, 10-20 grams of ganoderma lucidum, monkshood
10-20 grams, 5-15 grams of rhizoma zingiberis, 4-8 grams of asarum, 5-15 grams of evodia rutaecarpa, 5-15 grams of toad skin, 10-14 grams of centipede.
2. medicine according to claim 1, wherein the consumption of each bulk drug is：
6 grams of scorpio, 6 grams of radix aconiti sinensis, 6 grams of RADIX ACONITI KUSNEZIFFII, 10 grams of Radix Angelicae Sinensis, 15 grams of the Radix Astragali, 15 grams of ganoderma lucidum, 15 grams of monkshood, 10 grams of rhizoma zingiberis,
6 grams of asarum, 10 grams of evodia rutaecarpa, 10 grams of toad skin, 12 grams of centipede.
3. the preparation method of medicine according to claim 1 or claim 2, it comprises the following steps：
（One）Get the raw materials ready
（1）Scorpio：Clear water floats the matter that desalts, and dries, or low baking temperature roasting is used；
（2）Radix aconiti sinensis：Impurity is picked, ash bits are cleaned, dried；
（3）RADIX ACONITI KUSNEZIFFII：Crude drug is taken, impurity is removed, cleaning, drying, the used time smashs to pieces；
（4）Radix Angelicae Sinensis：Impurity is picked, is cleaned, vexed profit is slightly dried in the air, and section is dried；
（5）The Radix Astragali：Net impurity is picked, the root head and hollow larger root of residual is removed, is soaked in water, pulled out, cut in time after running through
Piece, dries；
（6）Ganoderma lucidum：Impurity is removed, is cleaned, softened, cut sheet, dried, weed out chip；
（7）Monkshood：It is soaked in water, pulls out, cut into slices, dries；
（8）Rhizoma zingiberis：Net impurity is picked, is soaked in water 3-6 hours, pulled out, cut into slices or dice after vexed profit, dried；
（9）Asarum：Cleared impurity, is sprayed with water and moistened, and timely segment is dried；
（10）Evodia rutaecarpa：Crude drug is taken, carpopodium, branch and impurity is removed, chip is weeded out；
（11）Toad skin：Impurity, chip are removed, a pawl is cut off, diced；
（12）Centipede：Wipe net, remove cephalopodium, cut and use；
（Two）Prepare
（1）By the scorpio of the weight, radix aconiti sinensis, RADIX ACONITI KUSNEZIFFII, Radix Angelicae Sinensis, the Radix Astragali, ganoderma lucidum, monkshood, rhizoma zingiberis, asarum, evodia rutaecarpa, toad
Skin, centipede are put into container, grind into powder；
（2）The powder that will be ground to form adds vaseline to be adjusted to ointment and obtains final product.
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| Application Number | Priority Date | Filing Date | Title |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104027775A (en) * | 2014-01-15 | 2014-09-10 | 解程 | Traditional Chinese medicine for treating thromboangiitis obliterans |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104027775A (en) * | 2014-01-15 | 2014-09-10 | 解程 | Traditional Chinese medicine for treating thromboangiitis obliterans |
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Application publication date: 20170707 |