CN106924589A - 一种治疗痤疮粉刺的内服药物及其制备方法 - Google Patents

一种治疗痤疮粉刺的内服药物及其制备方法 Download PDF

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CN106924589A
CN106924589A CN201710087837.8A CN201710087837A CN106924589A CN 106924589 A CN106924589 A CN 106924589A CN 201710087837 A CN201710087837 A CN 201710087837A CN 106924589 A CN106924589 A CN 106924589A
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罗兴兰
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Sichuan Shuangxin Biological Technology Co Ltd
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Abstract

本发明属于中药制剂领域，目的是根据中医治疗痤疮粉刺的认识机理而提供的一种治疗痤疮粉刺的内服药物，所述药物的各个组分及其质量份比如下：茯苓10～16g、桑白皮6～15g、地骨皮15～35g、桔梗3～10g、牡丹皮8～16g、生地黄10～25g、连翘6～16g、薏苡仁10～35g、女贞子6～16g、陈皮3～10g、白花蛇舌草50～80g、白术10～16g、蒲公英10～35g、皂刺3～10g、丹参5～16g、川芎5～12g；本发明提供的药物是一个很好的中药组方。

Description

一种治疗痤疮粉刺的内服药物及其制备方法
技术领域
本发明属于中药制剂领域，具体涉及一种治疗痤疮粉刺的内服药物，特别是供痤疮粉刺患者使用的内服药物及其制备方法的领域。
背景技术
据有关资料显示：痤疮是毛囊皮脂腺单位的一种慢性炎症性皮肤病，主要好发于青少年，对青少年的心理和社交影响很大，但青春期后往往能自然减轻或痊愈。临床表现以好发于面部的粉刺、丘疹、脓疱、结节等多形性皮损为特点。
临床表现：皮损好发于面部及上胸背部。痤疮的非炎症性皮损表现为开放性和闭合性粉刺。闭合性粉刺（又称白头）的典型皮损是约1毫米大小的肤色丘疹，无明显毛囊开口。开放性粉刺（又称黑头）表现为圆顶状丘疹伴显著扩张的毛囊开口。粉刺进一步发展会演变成各种炎症性皮损，表现为炎性丘疹、脓疱、结节和囊肿。炎性丘疹呈红色，直径1～5毫米不等；脓疱大小一致，其中充满了白色脓液；结节直径大于5毫米，触之有硬结和疼痛感；囊肿的位置更深，充满了脓液和血液的混合物。这些皮损还可融合形成大的炎性斑块和窦道等。炎症性皮损消退后常常遗留色素沉着、持久性红斑、凹陷性或肥厚性瘢痕。临床上根据痤疮皮损性质和严重程度将痤疮分为3度、4级：1级（轻度）：仅有粉刺；2级（中度）：除粉刺外，还有一些炎性丘疹；3级（中度）：除粉刺外，还有较多的炎性丘疹或脓疱；4级（重度）：除有粉刺、炎性丘疹及脓疱外，还有结节、囊肿或瘢痕。
那么，就如何找到一种可有效治疗痤疮粉刺的中药组合物，是本领域技术人员亟待要解决的问题。
发明内容
随着我国中医中药学的不断发展，在治疗痤疮粉刺上，人们逐渐意识到了中医治疗痤疮粉刺的优点，且在治疗过程中疗效好、见效快、毒副作用小等优势，针对现有西医治疗痤疮粉刺的现状，本发明的目的是在于提供一种治疗痤疮粉刺的内服药物，以解决痤疮粉刺患者早日恢复健康的问题。该药物是以常见的中药为原料，通过选择合理的药物及质量份比，可有效治疗上述痤疮粉刺。
为达到上述发明的目的，本发明所采用的技术方案为：提供一种治疗痤疮粉刺的内服药物及其制备方法，其特征在于，所述药物的各个组分及其质量份比如下所示：
茯苓10～16g、桑白皮6～15g、地骨皮15～35g、桔梗3～10g、牡丹皮8～16g、生地黄10～25g、连翘6～16g、薏苡仁10～35g、女贞子6～16g、陈皮3～10g、白花蛇舌草50～80g、白术10～16g、蒲公英10～35g、皂刺3～10g、丹参5～16g、川芎5～12g。
一种治疗痤疮粉刺的内服药物及其制备方法，其特征在于，所述药物的各个组分及其质量份比如下所示：
茯苓11～14g、桑白皮7～13g、地骨皮18～31g、桔梗5～9g、牡丹皮9～14g、生地黄11～22g、连翘7～14g、薏苡仁11～31g、女贞子7～14g、陈皮5～9g、白花蛇舌草58～70g、白术11～14g、蒲公英11～31g、皂刺5～9g、丹参6～14g、川芎6～11g。
一种治疗痤疮粉刺的内服药物及其制备方法，其特征在于，所述“最佳方案”的药物的各个组分及其质量份比如下所示：
茯苓12g、桑白皮12g、地骨皮28g、桔梗8g、牡丹皮12g、生地黄120g、连翘12g、薏苡仁28g、女贞子12g、陈皮8g、白花蛇舌草60g、白术12g、蒲公英28g、皂刺8g、丹参12g、川芎10g。
一种治疗痤疮粉刺的内服药物及其制备方法，其特征在于，所述方法包括如下步骤制备而成：
A、将上述原料中药拣去杂质和粉尘后，按照质量份比分别粉碎成粗粒状包煎；
B、①将包好的原料中药放入冷开水中浸泡50min，然后再将浸泡好的药物和浸泡药物的澄清液一并放入砂锅内，注入过药65mm的冷开水进行第一次武火煎煮，待煎煮到12min时，转文火熬制35 min，滤取药液；②药渣中再次注入过药60mm的微温开水进行第二次武火煎煮，待煎煮到10min时，转文火熬制30 min，滤取药液；③将两次药液混合浓缩成50%的中药液320ml（毫升）即可。
一种治疗痤疮粉刺的内服药物及其制备方法，其特征在于，所述服用方法为：将制备好的中药液以一天服用，每日一剂，早晚分服，给药量160ml（毫升）/次，趁温服。15天为一个疗程，服药2～4个疗程后，症状消失，病获痊愈。
本发明组方中的各原料中药在中国药典、中国辞典以及中华本草中均有详细的记载。本发明选用其中最常见的中药为原料，充分发挥各组分的药理功效：
茯苓，性味：甘、淡、平，具有利水药、渗湿利尿药之功效，用于治疗小便不利、水肿胀满、痰饮咳逆、呕吐、脾虚食少、泄泻、心悸不安、失眠健忘、遗精白浊；
桑白皮，性味：甘、寒，具有泻肺平喘、利水消肿之功效，用于治疗肺热喘咳、水肿胀满尿少、面目肌肤浮肿；
地骨皮，性味：甘、寒，具有清热、凉血之功效，用于治疗虚劳潮热盗汗、肺热咳喘、吐血、衄血、血淋、消渴、高血压、痈肿、恶疮等症；
桔梗，性味：性平、味苦、辛，有小毒，具有祛痰、利咽、宣肺、排脓、利五脏、补气血、补五劳、养气之功效，用于治疗咽喉肿痛、肺痈吐脓、咳嗽痰多、痢疾腹痛、胞满胁痛、口舌生疮、赤目肿痛、小便癃闭等病症；
牡丹皮，性味：辛苦、凉、微寒，具有清热、活血散瘀之功效，用于治疗温热病热入血分、发斑、吐衄、热泪盈眶病菌后期热伏阴分发热、阴虚骨蒸潮热、血滞经闭、痛经、痈肿疮毒、跌扑伤痛、风湿热痹等症；
生地黄，性味：甘、寒，具有清热凉血、养阴、生津之功效，用于治疗热病舌绛烦渴、阴虚内热、骨蒸劳热、内热消渴、吐血、衄血、发斑发疹等症；
连翘，性味：苦、性微寒，具有清热解毒、消肿散结之功效，用于治疗风热感冒、温病、热淋尿闭、痈疽、肿毒、瘰疬、瘿瘤、喉痹等症；
薏苡仁，性味：甘、淡、微寒，具有利湿健脾、舒筋除痹、清热排脓之功效，用于治疗水肿、脚气、小便淋沥、湿温病、泄泻带下、风湿痹痛、筋脉拘挛、肺痈、肠痈、扁平疣等症；
女贞子，性味：甘、苦、性凉，具有补益肝肾、清虚热、明目之功效，用于治疗头昏目眩、腰膝酸软、遗精、耳鸣、须发早白、骨蒸潮热、目暗不明；
陈皮，性味：苦、辛、温，具有理气健脾、燥湿化痰之功效，用于治疗胸脘胀满、食少吐泻、咳嗽痰多；
白花蛇舌草，性味：苦甘、寒，无毒，具有清热解毒、利湿之功效，用于治疗肺热喘咳、咽喉肿痛、肠痈、疖肿疮疡、毒蛇咬伤、热淋涩痛、水肿、痢疾、肠炎、湿热黄疸、癌肿等症；
白术，性味：甘、温，具有健脾益气、燥湿利水、止汗、安胎之功效，用于治疗脾虚食少、腹胀泄泻、痰饮眩悸、水肿、自汗、胎动不安等疾病；
蒲公英，性味：味苦；甘、性寒，具有清热解毒、消痈散结之功效，用于治疗乳痈、肺痈、肠痈、痄腮、疔毒疮肿、目赤肿痛、感冒发热、咳嗽、咽喉肿痛、胃火、肠炎、痢疾、肝炎、胆吓炎、尿路感染、蛇虫咬伤；
皂刺，性味：辛、温，具有消肿托毒、排脓、杀虫之功效，用于治疗痈疽初起或脓成不溃、外治疥癣麻风；
丹参，性味：味苦、性微寒，具有活血祛瘀、调经止痛、养血安神、凉血消痈之功效，用于治疗妇女月经不调、痛经、经闭、产后瘀滞腹痛、心腹疼痛、癥瘕积聚、热痹肿痛、跌打损伤、热入营血、烦躁不安、心烦失眠、痈疮肿毒；
川芎，性味：辛、温，具有行气开郁、法风燥湿、活血止痛之功效，用于治疗风冷头痛旋晕、胁痛腹疼、寒痹筋挛、经闭、难产、产后瘀阻块痛、痈疽疮疡、月经不调、瘕腹痛、胸胁刺痛、跌扑肿痛、风湿痹痛。
本发明药物是基于中医治疗痤疮粉刺的原则，从依据痤疮粉刺的病理机制及药理作用认为：就痤疮粉刺，本发明所提供的药物中的各原料中药药效共奏，对上述疾病有很好的治疗效果。
具体实施方式
本发明就是针对上述痤疮粉刺的治疗而提出的一种中药配方，采用该配方制备的药物药效好，见效快，是一个标本兼治的中药组方，特别适合临床使用。下面结合本发明的具体实施方式作进一步详细的描述：
实施例1：
一种治疗痤疮粉刺的内服药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
茯苓12g、桑白皮12g、地骨皮28g、桔梗8g、牡丹皮12g、生地黄120g、连翘12g、薏苡仁28g、女贞子12g、陈皮8g、白花蛇舌草60g、白术12g、蒲公英28g、皂刺8g、丹参12g、川芎10g。
实施例2：
一种治疗痤疮粉刺的内服药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
茯苓14g、桑白皮13g、地骨皮31g、桔梗9g、牡丹皮14g、生地黄22g、连翘14g、薏苡仁31g、女贞子14g、陈皮9g、白花蛇舌草70g、白术14g、蒲公英31g、皂刺9g、丹参14g、川芎11g。
实施例3：
一种治疗痤疮粉刺的内服药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
茯苓16g、桑白皮15g、地骨皮35g、桔梗10g、牡丹皮16g、生地黄25g、连翘16g、薏苡仁35g、女贞子16g、陈皮10g、白花蛇舌草80g、白术16g、蒲公英35g、皂刺10g、丹参16g、川芎12g。
典型病例
经临床诊断治疗痤疮粉刺患者共986例，年龄为21岁以上的533例，只有453例为21岁以下。986例患者中痊愈的885例，有效的80例，无效21例。总有效率达97%。

Claims (3)

1.一种治疗痤疮粉刺的内服药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
茯苓10～16g、桑白皮6～15g、地骨皮15～35g、桔梗3～10g、牡丹皮8～16g、生地黄10～25g、连翘6～16g、薏苡仁10～35g、女贞子6～16g、陈皮3～10g、白花蛇舌草50～80g、白术10～16g、蒲公英10～35g、皂刺3～10g、丹参5～16g、川芎5～12g。
2.根据权利要求1所述的治疗痤疮粉刺的内服药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
茯苓11～14g、桑白皮7～13g、地骨皮18～31g、桔梗5～9g、牡丹皮9～14g、生地黄11～22g、连翘7～14g、薏苡仁11～31g、女贞子7～14g、陈皮5～9g、白花蛇舌草58～70g、白术11～14g、蒲公英11～31g、皂刺5～9g、丹参6～14g、川芎6～11g。
3.根据权利要求1至2所述的治疗痤疮粉刺的内服药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
茯苓12g、桑白皮12g、地骨皮28g、桔梗8g、牡丹皮12g、生地黄120g、连翘12g、薏苡仁28g、女贞子12g、陈皮8g、白花蛇舌草60g、白术12g、蒲公英28g、皂刺8g、丹参12g、川芎10g。
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101862411A (zh) * 2010-07-13 2010-10-20 张贺亭 用于治疗痤疮粉刺的中药组合物
CN103830614A (zh) * 2012-11-26 2014-06-04 雷建 一种治疗痤疮粉刺的中药组合物
CN104547732A (zh) * 2014-11-27 2015-04-29 林康艺 一种治疗痤疮粉刺的中药组合物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101862411A (zh) * 2010-07-13 2010-10-20 张贺亭 用于治疗痤疮粉刺的中药组合物
CN103830614A (zh) * 2012-11-26 2014-06-04 雷建 一种治疗痤疮粉刺的中药组合物
CN104547732A (zh) * 2014-11-27 2015-04-29 林康艺 一种治疗痤疮粉刺的中药组合物

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