CN106924378A - A kind of lipstick made from Chinese medicine prevented and treated and/or treat chronic cheilitis - Google Patents
A kind of lipstick made from Chinese medicine prevented and treated and/or treat chronic cheilitis Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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Abstract
The present invention relates to a kind of lipstick made from Chinese medicine prevented and treated and/or treat chronic cheilitis, the lipstick made from Chinese medicine is prepared by methods described below：(1) 1.5 parts of beeswax, 2.0 parts of vaseline are taken, heating water bath fusing obtains mixed liquor 1；(2) 1.0 parts of lanolin, 5.0 parts of Chinese medical extract are taken, heating water bath fusing obtains mixed liquor 2；(3) mixed liquor 1 is mixed with mixed liquor 2, adds 0.5 part of azone to be well mixed, be placed in 50 60 DEG C of addition Peppermint essential oils, it is canned after mixing.With everyday skincare be combined traditional Chinese medicine by the present invention; theory joint is actual; it is derivative to release the new lipstick made from Chinese medicine with therapeutic effect; its preparation process is simple, raw material are easy to get, low cost; for chronic cheilitis effect is significant; difficulty in relapse after healing is controlled, with marketing application value higher.
Description
Technical field
It is a kind of Chinese herbal medicine lip prevented and treated and/or treat chronic cheilitis specifically the present invention relates to technical field of traditional Chinese medicines
Cream.
Background technology
Chronic cheilitis is a kind of with the red and swollen, rotten to the corn of lip, incrustation, chap, a canescence scales of skin that peel off as main clinical manifestation
Chronic disease.Clinical illness rate in recent years just in the trend of cumulative year after year, there are about 0.21% in 2010 in the U.S. according to statistics
Suffer from this disease, chronic cheilitis in 2013 has 48,000,000 or so trouble in French illness rate up to 0.35%, cut-off to China in 2014
Person suffers from chronic cheilitis.It can be seen that, this disease causes strong influence to human health, how to find effective for this disease
Remedy measures, with great clinical research meaning and market value.Because the etiology and pathogenesis of chronic cheilitis are still not clear, at present
Definite effective immunotherapy targeted autoantibody medicine is there is no, doctor trained in Western medicine is mainly treated with antibiotic, hormone medicine, is aided with vitamin etc. daily
Nurse, though these methods can obtain certain effect, can not all effect a radical cure, really release patient suffering.The chronic cheilitis course of disease is touching,
The easy recurrent exerbation of disease feelings, suffers from patient's abnormal pain bitter.Therefore, patient is for developing effective pure natural shielding demand pole
It is high.
《The Yellow Emperor's Canon of Internal Medicine》In have cloud：" The mouth is the body opening or window of the spleen, and its China is in lip ", " lip person, the official of spleen ".China is early in the Ming Dynasty
《The surgery orthodox school exfoliative inflammation of lips》In i.e. recognize：" it is suffered from lower lip and itches and swells, and ruptures flowing water, does not ache for the exfoliative inflammation of lips, positive bright rising up of the stomach-fire
It is refractory." it is thus regarded that this sick cause of disease is retention of heat in the spleen and stomach, exopathogen is felt again, wind-heat is mutually fought, on smoke in lip, then lip redness is itched pain.
And wind victory is then taken off, heat victory is then done, therefore sees that lip ftractures, dry, pain.It can be seen that, the morbidity close association of taste and the exfoliative inflammation of lips.Therefore control
It is inside and outside to control together when and with Gu protects taste during treatment while exopathogen is dispersed.External therapy, is a big feature therapies of TCM surgery.
Compared to the interior cure by nursing one's health the vital organs of the human body, external therapy directly acts on affected part skin damaged because of it, with strong points, and curative effect is more
For obvious., in the different phase of disease, from different therapeutic dosage forms, and diagnosis and treatment should from different drug matching for it
With.It flexibly dynamically selects medicine with the change of the state of an illness, has stronger specific aim for the treatment of disease.
Lip gloss, now has become one of indispensable skin care item in modern's daily life, at home and abroad, each department, each
There is great market scale on age bracket, each professional work post, the general marketplace of each arrangement of consumption level.As masses are for profit
The demand of lipstick is gradually steadily improved, and has been made increasingly in major brand marketers product composition also in lip gloss, characteristic, effect
Many research, hopes and meets popular different demands, makes a bigger marketplace platform.Current in the market both domestic and external is visible
Lipstick, only with the basic effect such as moist, moisturizing, sun-proof, it is adaptable to the general population that lip is easily dried, chapped.And for that
A bit for a long time by the crowds of exfoliative inflammation of lips puzzlement, these common lip gloss do not have protection effect, therefore need badly a kind of new convenient easy
Take and the lipstick with therapeutic effect alleviates the lip skin damaged of exfoliative inflammation of lips patient.Traditional Chinese medicine is to be subject to both at home and abroad at present increasingly
A kind of supplement and alternative medicine of many concerns, and satisfaction of producing effects.The present invention adds Chinese herbal medicine element in traditional lip gloss, for
The state of an illness feature of chronic cheilitis, immunotherapy targeted autoantibody is carried out from correspondence Chinese medicine and preparation.The diagnosis and treatment characteristic of the traditional Chinese medical science is embodied,
Chronic cheilitis patient can be effectively treated, the recurrence of cheilitis can be prevented again so that the touching refractory course of disease is controlled, real solution
Certainly clinical thorny problem.With everyday skincare be combined Chinese herbal medicine by the present invention, and theory joint is actual, derivative to release new having concurrently
Prevention and the lip gloss of therapeutic effect, with application value higher.
The content of the invention
First purpose of the invention is directed to deficiency of the prior art, there is provided chronic lip is prevented and/or treated to one kind
Scorching Chinese medical extract.
Second object of the present invention is directed to deficiency of the prior art, there is provided the use of Chinese medical extract as described above
On the way.
Third object of the present invention is directed to deficiency of the prior art, there is provided chronic lip is prevented and treated and/or treated to one kind
Scorching lipstick made from Chinese medicine.
To realize above-mentioned first purpose, the present invention is adopted the technical scheme that：
It is a kind of prevent and/or treatment chronic cheilitis Chinese medical extract, the active constituents of medicine of the Chinese medical extract is
Extracted by the bulk drug of following weight portion：Asian puccoon 35-45 parts, madder 15-25 parts, licorice 15-25 parts.
Further, the active component of the Chinese medical extract is extracted by the bulk drug of following weight portion：Asian puccoon 38-42
Part, madder 18-22 parts, licorice 18-22 parts.
Further, the active component of the Chinese medical extract is extracted by the bulk drug of following weight portion：40 parts of Asian puccoon,
20 parts of madder, 20 parts of licorice.
Further, the preparation method of the Chinese medical extract is as follows：Raw material is weighed according to the weight portion described in claim 1
Medicine, adds 30 times of boiling water water extraction 2h, second plus 20 times of boiling water water extraction 2h for the first time, filters, merging filtrate, and filtrate is at 60 DEG C
In the environment of be condensed into density for 1.05-1.10g/cm3Chinese medical extract.
To realize above-mentioned second purpose, the present invention is adopted the technical scheme that：
As above application of any Chinese medical extract in the medicine for preparing prevention and/or treatment chronic cheilitis.
Further, the medicine also includes the auxiliary material for pharmaceutically allowing, and the auxiliary material for pharmaceutically allowing includes but do not limit
In：Mannitol, sorbierite, sodium pyrosulfite, sodium hydrogensulfite, sodium thiosulfate, cysteine hydrochloride, TGA, egg ammonia
Acid, injection Vitamin B_6 DTA disodiums, Ethylenediaminetetraacetic Acid Calcium Salt, the carbonate of monovalence alkali metal, acetate, phosphate or its aqueous solution, hydrochloric acid,
Acetic acid, sulfuric acid, phosphoric acid, amino acid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextrose
Glycosides, glycine, starch, sucrose, lactose, mannitol, silicon derivative, cellulose and its derivates, alginates, gelatin, poly- second
Alkene pyrrolidone, glycerine, POLYSORBATE 80, agar, calcium carbonate, calcium bicarbonate, surfactant, polyethylene glycol, cyclodextrin, β-ring paste
Essence, phospholipid material, kaolin, talcum powder, calcium stearate, magnesium stearate, paraffin, vaseline.
Further, the chronic cheilitis is chronic dry and cracked property cheilitis.
To realize above-mentioned 3rd purpose, the present invention is adopted the technical scheme that：
A kind of lipstick made from Chinese medicine prevented and treated and/or treat chronic cheilitis, the lipstick made from Chinese medicine is by methods described below
Prepare：
(1) 1.5 parts of beeswax, 2.0 parts of vaseline are weighed, heating water bath fusing obtains mixed liquor 1；
(2) 1.0 parts of lanolin, as above any 5.0 parts described of Chinese medical extract are weighed, heating water bath fusing must mix
Liquid 2；
(3) mixed liquor 1 is mixed with mixed liquor 2, adds 0.5 part of azone to be well mixed, be placed in 50-60 DEG C of addition peppermint essence
Oil, it is canned after mixing.
Further, the addition of the Peppermint essential oil is 0.1-50 parts.
Further, the chronic cheilitis is chronic dry and cracked property cheilitis.
The invention has the advantages that：
1st, lipstick made from Chinese medicine flavour of a drug number of the invention is few, raw material are easy to get, preparation process is simple, low cost, for chronic
Cheilitis effect is significant, controls difficulty in relapse after healing.
2nd, in lipstick made from Chinese medicine of the invention, the madder has significant synergy with Asian puccoon, greatly improves
Therapeutic action of the Chinese herbal medicine to inflammation, curative effect is more significantly.
3rd, in lipstick made from Chinese medicine of the invention, the proportioning of the Chinese medicine material is to screen to obtain by many experiments, tool
The advantage of effective in cure good, effect is significant.
Specific embodiment
The invention will be further elucidated with reference to specific embodiments.It should be understood that these embodiments are merely to illustrate this hair
Bright rather than limitation the scope of the present invention.In addition, it is to be understood that after the content for having read record of the present invention, art technology
Personnel can make various changes or modifications to the present invention, and these equivalent form of values equally fall within the application appended claims and limited
Fixed scope.
The Chinese medicine composition (one) of chronic cheilitis is prevented or treated to embodiment 1
Raw material is weighed according to weight portion：40 parts of Asian puccoon, 20 parts of madder, 20 parts of licorice.
The Chinese medicine composition (two) of chronic cheilitis is prevented or treated to embodiment 2
Raw material is weighed according to weight portion：35 parts of Asian puccoon, 15 parts of madder, 15 parts of licorice.
The Chinese medicine composition (three) of chronic cheilitis is prevented or treated to embodiment 3
Raw material is weighed according to weight portion：45 parts of Asian puccoon, 25 parts of madder, 25 parts of licorice.
The Chinese medicine composition (four) of chronic cheilitis is prevented or treated to embodiment 4
Raw material is weighed according to weight portion：45 parts of Asian puccoon, 25 parts of madder, 15 parts of licorice.
The Chinese medicine composition (five) of chronic cheilitis is prevented or treated to embodiment 5
Raw material is weighed according to weight portion：45 parts of Asian puccoon, 15 parts of madder, 15 parts of licorice.
The Chinese medicine composition (six) of chronic cheilitis is prevented or treated to embodiment 6
Raw material is weighed according to weight portion：38 parts of Asian puccoon, 18 parts of madder, 18 parts of licorice.
The Chinese medicine composition (seven) of chronic cheilitis is prevented or treated to embodiment 7
Raw material is weighed according to weight portion：42 parts of Asian puccoon, 18 parts of madder, 18 parts of licorice.
The Chinese medicine composition (eight) of chronic cheilitis is prevented or treated to embodiment 8
Raw material is weighed according to weight portion：42 parts of Asian puccoon, 22 parts of madder, 18 parts of licorice.
The Chinese medicine composition (nine) of chronic cheilitis is prevented or treated to embodiment 9
Raw material is weighed according to weight portion：42 parts of Asian puccoon, 22 parts of madder, 22 parts of licorice.
The preparation (one) of chronic cheilitis Chinese medical extract is prevented or treated to embodiment 10
Weight portion as described in embodiment 1 weighs Chinese medicine material, and 30 times of boiling water water extraction 2h is added for the first time, Jia 20 for the second time
Boiling water water extraction 2h again, filtering, merging filtrate, filtrate is condensed into density for 1.05-1.10g/cm in the environment of 60 DEG C3In
Medicament extract.
The preparation (two) of chronic cheilitis Chinese medical extract is prevented or treated to embodiment 11
Weight portion as described in embodiment 2 weighs Chinese medicine material, and 30 times of boiling water water extraction 2h is added for the first time, Jia 20 for the second time
Boiling water water extraction 2h again, filtering, merging filtrate, filtrate is condensed into density for 1.05-1.10g/cm in the environment of 60 DEG C3In
Medicament extract.
The preparation (three) of chronic cheilitis Chinese medical extract is prevented or treated to embodiment 12
Weight portion as described in embodiment 3 weighs Chinese medicine material, and 30 times of boiling water water extraction 2h is added for the first time, Jia 20 for the second time
Boiling water water extraction 2h again, filtering, merging filtrate, filtrate is condensed into density for 1.05-1.10g/cm in the environment of 60 DEG C3In
Medicament extract.
The preparation (one) of chronic cheilitis lipstick made from Chinese medicine is prevented or treated to embodiment 13
(1) 1.5 parts of beeswax, 2.0 parts of vaseline are weighed, heating water bath fusing obtains mixed liquor 1；
(2) 5.0 parts of Chinese medical extract prepared by 1.0 parts of lanolin, embodiment 10 is weighed, heating water bath fusing obtains mixed
Close liquid 2；
(3) mixed liquor 1 is mixed with mixed liquor 2, adds 0.5 part of azone to be well mixed, be placed in 50-60 DEG C of addition peppermint essence
10 parts of oil, it is canned after mixing.
The preparation (two) of chronic cheilitis lipstick made from Chinese medicine is prevented or treated to embodiment 14
(1) 1.5 parts of beeswax, 2.0 parts of vaseline are weighed, heating water bath fusing obtains mixed liquor 1；
(2) 5.0 parts of Chinese medical extract prepared by 1.0 parts of lanolin, embodiment 11 is weighed, heating water bath fusing obtains mixed
Close liquid 2；
(3) mixed liquor 1 is mixed with mixed liquor 2, adds 0.5 part of azone to be well mixed, be placed in 50-60 DEG C of addition peppermint essence
10 parts of oil, it is canned after mixing.
The preparation (three) of chronic cheilitis lipstick made from Chinese medicine is prevented or treated to embodiment 15
(1) 1.5 parts of beeswax, 2.0 parts of vaseline are weighed, heating water bath fusing obtains mixed liquor 1；
(2) 5.0 parts of Chinese medical extract prepared by 1.0 parts of lanolin, embodiment 12 is weighed, heating water bath fusing obtains mixed
Close liquid 2；
(3) mixed liquor 1 is mixed with mixed liquor 2, adds 0.5 part of azone to be well mixed, be placed in 50-60 DEG C of addition peppermint essence
10 parts of oil, it is canned after mixing.
Embodiment 16
(1) raw material is weighed according to weight portion：30 parts of Asian puccoon, 30 parts of madder, 30 parts of licorice；Add 30 times of boiling water for the first time
Water extraction 2h, second plus 20 times of boiling water water extraction 2h, filtering, merging filtrate, filtrate is condensed into density and is in the environment of 60 DEG C
1.05-1.10g/cm3Chinese medical extract；
(2) 1.5 parts of beeswax, 2.0 parts of vaseline are weighed, heating water bath fusing obtains mixed liquor 1；
(3) 1.0 parts of lanolin, 5.0 parts of Chinese medical extract are weighed, heating water bath fusing obtains mixed liquor 2；
(4) mixed liquor 1 is mixed with mixed liquor 2, adds 0.5 part of azone to be well mixed, be placed in 50-60 DEG C of addition peppermint essence
10 parts of oil, it is canned after mixing.
Embodiment 17
(1) raw material is weighed according to weight portion：50 parts of Asian puccoon, 10 parts of madder, 10 parts of licorice；Add 30 times of boiling water for the first time
Water extraction 2h, second plus 20 times of boiling water water extraction 2h, filtering, merging filtrate, filtrate is condensed into density and is in the environment of 60 DEG C
1.05-1.10g/cm3Chinese medical extract；
(2) 1.5 parts of beeswax, 2.0 parts of vaseline are weighed, heating water bath fusing obtains mixed liquor 1；
(3) 1.0 parts of lanolin, 5.0 parts of Chinese medical extract are weighed, heating water bath fusing obtains mixed liquor 2；
(4) mixed liquor 1 is mixed with mixed liquor 2, adds 0.5 part of azone to be well mixed, be placed in 50-60 DEG C of addition peppermint essence
10 parts of oil, it is canned after mixing.
Embodiment 18 treats the animal experiment of chronic cheilitis
Using Kunming mouse, totally 50, female half and half is randomly divided into 5 groups, every group 10.Two are smeared in mouse right ear
Toluene 0.03mL/ is only.After causing inflammation 0.5h, respectively in mouse right ear inflammation part uniform application equivalent Chinese herbal medicine lip of the invention
Cream.Cervical dislocation puts to death mouse after 4h, cuts left and right auricle and removes the medicine of the wide residual of auris dextra, and card punch lays mouse respectively
Left and right ear.Weighed with assay balance, calculate ear swelling rate.Ear swelling rate=(auris dextra sheet weight-left auricle weight)/left auricle
Weight × 100%.Statistics is as shown in the table.
| Test group | N (only) | Ear swelling rate |
| Embodiment 13 | 10 | 44.85±21.60 |
| Embodiment 14 | 10 | 65.40±35.55 |
| Embodiment 15 | 10 | 62.60±32.25 |
| Embodiment 16 | 10 | 93.95±39.65 |
| Embodiment 17 | 10 | 96.45±38.80 |
The above results show, with the mouse group that the lipstick made from Chinese medicine of Isodose is coated, embodiment 13, embodiment 14,
The ear swelling rate of embodiment 15 is less than embodiment 16 and the test group of embodiment 17, illustrates lipstick made from Chinese medicine paraxylene of the invention
Caused inflammation has obvious mitigation and regressive effect.Compare in group, the medicine group ear swelling rate of wherein embodiment 13 is substantially less than
Embodiment 14 and the (P of embodiment 15<0.05), the group of this explanation embodiment 13 (i.e. 40 parts of Asian puccoon, 20 parts of madder, 20 parts of licorice)
Compound is best of breed.
Embodiment 19 treats the clinical trial of chronic cheilitis
1 case
Selection in July, -2016 in October, 2014 is in the chronic non-specific of the attached Yueyang hospital admission of Shanghai Univ. of Traditional Chinese Medicine
Property cheilitis patient 180, wherein man 83, female 97, age 12-55 Sui, average age 23.55 years old.
1.1 diagnostic criteria
Chronic dry and cracked property cheilitis：Lip mucous membrane mild swelling, dry, shrinkage has a little white thin scab, and mucous membrane lacks bullet
Property, scab can be formed as deep as bleeding is caused under mucous membrane by 2-3 bar chap lines.
1.2 inclusive criterias
Meet diagnostic criteria, and do not enter related treatment in medical first 1 month.Patient knows the inside story and voluntarily adds clinic to grind
Study carefully.
1.3 exclusion standards
(1) gestation, preparation pregnancy or women breast-feeding their children；
(2) serious cardiovascular and cerebrovascular, liver, kidney and haematopoietic disorder, moderate above diabetes, osteoporosis are merged；
(3) patient with mental illness；
(4) compliance is poor, subject refuses and researcher thinks that the patient of clinical test should not be participated in.
1.4 reject standard
(1) mismatch, be late for medication or the patient voluntarily treated using other method during studying；
(2) there is serious adverse reaction, it is impossible to continual cure person；
(3) need to take other drugs during treating, it is possible to interfere with result of study person.
2 treatment methods
2.1 oral cavity propaganda and education：Ring licks lip, stings the bad habits such as lip；Drink more water, absorb water fruits and vegetables more, diet is excessively boiling hot, pungent
Irritable food, wine for giving off smoking；Do not abuse cosmetics；To be worn masks when in the big environment of very cold, drying, wind；Avoid day
Light is exposed to the sun.
2.2 drug therapies
Patient is equally divided into 6 groups, respectively control group, treatment group one, treatment group two, treatment group three, treatment group four, control
Treatment group five, compares two-by-two between 6 groups, in the not statistically significant (P of the aspect comparing difference such as sex, age, the course of disease and clinical manifestation
>0.05), with comparativity.
Control group：Oral 21 Jin Weita multivitamin and minerals tablets, 1 tablet once, and 2 times a day, is within 1 week 1 course for the treatment of, treats four treatments
Curative effect is judged after journey.
Treatment group one：The lipstick made from Chinese medicine of embodiment 13 is given, 2-4g uniform application lips affected part, morning and evening each one are taken daily
Secondary, treatment judges curative effect after 2 months.
Treatment group two：The lipstick made from Chinese medicine of embodiment 14 is given, 2-4g uniform application lips affected part, morning and evening each one are taken daily
Secondary, treatment judges curative effect after 2 months.
Treatment group three：The lipstick made from Chinese medicine of embodiment 15 is given, 2-4g uniform application lips affected part, morning and evening each one are taken daily
Secondary, treatment judges curative effect after 2 months.
Treatment group four：The lipstick made from Chinese medicine of embodiment 16 is given, 2-4g uniform application lips affected part, morning and evening each one are taken daily
Secondary, treatment judges curative effect after 2 months.
Treatment group five：The lipstick made from Chinese medicine of embodiment 17 is given, 2-4g uniform application lips affected part, morning and evening each one are taken daily
Secondary, treatment judges curative effect after 2 months.
3 curative effect determinate standards
3.1 observation index and scoring
Will before treatment, treatment end when, 3rd month after treatment, 6 months, 9 months, the subjective symptom of 12 months patients and
Sign carries out objective record, according to it is light, in, severe be respectively divided into 0,1,2,3 grades.
(1) independently feel to be divided into by patient：0 be without pain and the dry sensation of itching, 1 for slightly dry it is even have that pain of itching is uncomfortable, 2 is battle array
Hair property itch or pain, dries obvious, and 3 is serious to dry, and is that continuation pain of itching causes trismus.
(2) hyperemia/swelling：0 is nothing, and 1 to involve 1/3 vermilion border, and 2 to involve 2/3 vermilion border, and 3 is to involve full vermilion border.
(3) furfur/incrustation：0 is nothing, and 1 is a small amount of furfur or a small amount of crust, 2 is obvious furfur, forms a scab and involves whole lip
Red portion, 3 be serious furfur, tie scab and involve mouth week skin.
(4) chap：0 is nothing, and 1, to dry a little, sees unobvious crackle, and 2 is substantially to dry and occur when movable longitudinal splitting
Line, 3 is have obvious crackle with a little oozing of blood.
(5) it is rotten to the corn：0 is nothing, and rotten to the corn face is 1 less than 2mm, and rotten to the corn face is 2 less than half lip more than 2mm, and upper lip or lower lip are big
It is 3 that area is rotten to the corn, and it is 4 that lips large area is rotten to the corn.
(6) lip week skin：0 is nothing, and 1 slightly to dry, furfur, 2 is large area furfur, sees fine cracks, flush,
3 have obvious crackle, flush, incrustation, pigmentation for skin.
Improvement standard is cured in 3.2 clinical diagnosises：
Reference《Clinical disease diagnosis are according to healing improvement standard》Efficacy assessment standard：
Score * 100% before therapeutic index=(being scored after score-treatment before treatment)/treatment.
Recovery from illness：Vermilion border mucous membrane recovers normal, and therapeutic index is 95%~100%；
It is effective：Vermilion border sings and symptoms substantially mitigates, and therapeutic index is 61%~95%；
Take a turn for the better：Vermilion border sings and symptoms slightly has and goes down, and therapeutic index is 20%~60%；
It is invalid：Vermilion border sings and symptoms does not mitigate or aggravates, and therapeutic index is less than 20%；
Will recovery from illness, effective total, calculating effective percentage=(recovery from illness number+effective number)/sum.
4 results
During treatment end and terminate after Follow-up results, it is as shown in the table.
| Group | It is efficient after treatment | 3rd month effective percentage | 6th month effective percentage | 9th month effective percentage | 12nd month effective percentage |
| Control group | 73.3% (22/30) | 70.00% (21/30) | 53.3% (16/30) | 53.3% (16/30) | 53.3% (16/30) |
| Treatment group one | 96.7% (29/30) | 96.7% (29/30) | 96.7% (29/30) | 96.7% (29/30) | 96.7% (29/30) |
| Treatment group two | 83.3% (25/30) | 80.0% (24/30) | 80.0% (24/30) | 80.0% (24/30) | 80.0% (24/30) |
| Treatment group three | 86.6% (26/30) | 83.3% (25/30) | 83.3% (25/30) | 83.3% (25/30) | 83.3% (25/30) |
| Treatment group four | 66.7% (20/30) | 66.7% (20/30) | 50.0% (15/30) | 50.0% (15/30) | 50.0% (15/30) |
| Treatment group five | 63.3% (19/30) | 63.3% (19/30) | 53.3% (16/30) | 53.3% (16/30) | 53.3% (16/30) |
By the above results as can be seen that lipstick made from Chinese medicine chronic cheilitis of the invention with preferable curative effect, the present invention
Lipstick made from Chinese medicine compare with control group, treatment group one, treatment group two, the raising evident in efficacy for the treatment of group three；In of the invention
Herbal medicine lipstick compares with treatment group four, treatment group five, treatment group one, treatment group two, the raising evident in efficacy for the treatment of group three；In group
Compare, treatment group one it is evident in efficacy higher than treatment group two and treatment group three, and treatment group one long-term efficacy (3-12
Month) other treatment group is also significantly better than, illustrate the composition of embodiment 13 (i.e. 40 parts of Asian puccoon, 20 parts of madder, 20 parts of licorice)
It is best of breed.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
Member, on the premise of the inventive method is not departed from, can also make some improvement and supplement, and these are improved and supplement also should be regarded as
Protection scope of the present invention.
Claims (10)
1. it is a kind of prevent and/or treatment chronic cheilitis Chinese medical extract, it is characterised in that the medicine of the Chinese medical extract is lived
Property composition be by following weight portion bulk drug extract：Asian puccoon 35-45 parts, madder 15-25 parts, licorice 15-25 parts.
2. Chinese medical extract according to claim 1, it is characterised in that the active component of the Chinese medical extract is under
What the bulk drug of row weight portion was extracted：Asian puccoon 38-42 parts, madder 18-22 parts, licorice 18-22 parts.
3. Chinese medical extract according to claim 1, it is characterised in that the active component of the Chinese medical extract is under
What the bulk drug of row weight portion was extracted：40 parts of Asian puccoon, 20 parts of madder, 20 parts of licorice.
4. Chinese medical extract according to claim 1, it is characterised in that the preparation method of the Chinese medical extract is as follows：Press
Bulk drug is weighed according to the weight portion described in claim 1,30 times of boiling water water extraction 2h, second plus 20 times of boiling water are added for the first time
Water extraction 2h, filtering, merging filtrate, filtrate is condensed into density for 1.05-1.10g/cm in the environment of 60 DEG C3Traditional Chinese medicine extraction
Thing.
5. any Chinese medical extracts of claim 1-4 prepare prevention and/or treatment chronic cheilitis medicine in should
With.
6. application according to claim 5, it is characterised in that the medicine also includes the auxiliary material for pharmaceutically allowing.
7. application according to claim 5, it is characterised in that the chronic cheilitis is chronic dry and cracked property cheilitis.
8. it is a kind of prevent and treat and/or treatment chronic cheilitis lipstick made from Chinese medicine, it is characterised in that the lipstick made from Chinese medicine is by as follows
Prepared by methods described：
(1) 1.5 parts of beeswax, 2.0 parts of vaseline are weighed, heating water bath fusing obtains mixed liquor 1；
(2) any 5.0 parts described of the Chinese medical extract of 1.0 parts of lanolin, claim 1-4 is weighed, heating water bath fusing obtains mixed
Close liquid 2；
(3) mixed liquor 1 is mixed with mixed liquor 2, adds 0.5 part of azone to be well mixed, be placed in 50-60 DEG C of addition Peppermint essential oil,
It is canned after mixing.
9. lipstick made from Chinese medicine according to claim 8, it is characterised in that the addition of the Peppermint essential oil is 0.1-50 parts.
10. lipstick made from Chinese medicine according to claim 8, it is characterised in that the chronic cheilitis is chronic dry and cracked property cheilitis.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108434261A (en) * | 2018-05-29 | 2018-08-24 | 上海市第七人民医院 | A kind of Chinese medicine composition and application thereof prevented and/or treat chronic cheilitis |
| CN108653423A (en) * | 2018-07-05 | 2018-10-16 | 乙丙丁健康产业（深圳）有限公司 | A kind of Chinese medicine composition and its preparation prevented or treat chronic cheilitis |
| CN108853346A (en) * | 2018-09-25 | 2018-11-23 | 河南中医药大学 | A kind of external-applied ointment for treating cheilitis |
| CN110038083A (en) * | 2018-01-16 | 2019-07-23 | 成都中医药大学 | A kind of demulcen cream and its preparation method and application |
| CN111358719A (en) * | 2020-03-18 | 2020-07-03 | 西北师范大学白银师科创新研究院 | Chinese herbal medicine lipstick with cheilitis preventing function and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103655814A (en) * | 2013-11-26 | 2014-03-26 | 上海中医药大学附属岳阳中西医结合医院 | Chinese medicine composition for treating psoriasis and application of medicament |
-
2017
- 2017-03-27 CN CN201710187284.3A patent/CN106924378B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103655814A (en) * | 2013-11-26 | 2014-03-26 | 上海中医药大学附属岳阳中西医结合医院 | Chinese medicine composition for treating psoriasis and application of medicament |
Non-Patent Citations (2)
| Title |
|---|
| 林俊华: "《临床中医美容学》", 31 July 2004, 中国医药科技出版社 * |
| 陈贵廷等: "《实用中西医结合诊断治疗学》", 31 July 1991, 中国医药科技出版社 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110038083A (en) * | 2018-01-16 | 2019-07-23 | 成都中医药大学 | A kind of demulcen cream and its preparation method and application |
| CN108434261A (en) * | 2018-05-29 | 2018-08-24 | 上海市第七人民医院 | A kind of Chinese medicine composition and application thereof prevented and/or treat chronic cheilitis |
| CN108434261B (en) * | 2018-05-29 | 2021-01-01 | 上海市第七人民医院 | Traditional Chinese medicine composition for preventing and/or treating chronic cheilitis and application thereof |
| CN108653423A (en) * | 2018-07-05 | 2018-10-16 | 乙丙丁健康产业（深圳）有限公司 | A kind of Chinese medicine composition and its preparation prevented or treat chronic cheilitis |
| CN108853346A (en) * | 2018-09-25 | 2018-11-23 | 河南中医药大学 | A kind of external-applied ointment for treating cheilitis |
| CN111358719A (en) * | 2020-03-18 | 2020-07-03 | 西北师范大学白银师科创新研究院 | Chinese herbal medicine lipstick with cheilitis preventing function and preparation method thereof |
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