CN106893666A - A kind of multi-functional biomedical instrument - Google Patents
A kind of multi-functional biomedical instrument Download PDFInfo
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- CN106893666A CN106893666A CN201710271938.0A CN201710271938A CN106893666A CN 106893666 A CN106893666 A CN 106893666A CN 201710271938 A CN201710271938 A CN 201710271938A CN 106893666 A CN106893666 A CN 106893666A
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M45/00—Means for pre-treatment of biological substances
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Abstract
This application discloses a kind of multi-functional biomedical instrument, including working host, ozone generator, cover body and base plate, working host includes pedestal and is arranged at the function cabin of pedestal；Ozone generator is located in pedestal；Working host is positioned on base plate；Cover body is covered on base plate and forms confined space, and pedestal, function cabin and ozone generator are respectively positioned in confined space.Thus, confined space is formed by cover body and base plate, working host is placed in confined space, then carried out disinfection by ozone generator, can make working host before every task starts or after the completion of can carry out ozonization, it is ensured that operation sample and working environment it is not contaminated.Working host is capable of achieving various functions such as the recovery of freeze-stored cell dry type, incubated microorganism, microwell plate constant temperature oscillation, seesaw shaking table, metal bath, incubated, the cell heat shock culture of biological indicator by coordinating different functional units.
Description
Technical field
The present invention relates to Biomedical Instruments, more particularly to a kind of multi-functional biomedical instrument for being capable of ozonization.
Background technology
It is liquid nitrogen frozen to the important way that cell biological resource is preserved in cell biology, will cell
Freeze in liquid nitrogen container, when experiment needs, further take out freeze-stored cell and recovered.In cell recovery, optimum operation be by
The cell cryopreservation tube that liquid nitrogen container has just taken out is rapidly heated to 37 DEG C, is allowed to run through most easily damaged -5~0 DEG C of cell, with
Avoid ice crystal from recrystallizing to cell damage, cause the death of cell.
In current practical operation, experimenter grips 2~4 cell cryopreservation tubes by tweezers, in common water-bath
Make cell quick-thawing by acutely rocking, but this ordinary operation mode is difficult to complete the resuscitative efforts of high-volume cell；
There is company by adding single pallet in water-bath, realize while the way of many solencytes that thaw；But because cell freezes
Deposit self-temperature when pipe takes out from liquid nitrogen just to be spent more than subzero 100, while when many solencytes are put into water-bath, necessarily making
Water temperature into the region does not reach 37 DEG C in a long time, compared with conventional method defrosting single tube cell, extends cell recovery
Time, violate the principle of cell " freezing slowly instant ", increase the risk for repeating crystallization, reduce cytoactive.Water-bath is recovered
Cell also increases the possibility of cell contamination, it is impossible to meet cell produce, freeze, recovery whole process asepticization operation require.
Additionally, traditional cell recovery still needs artificial operation resuscitation process, it is impossible to ensure the correct time of recovery；And
Can not real-time monitoring resuscitator temperature change, it is impossible to ensure the accurate temperature of recovery, and traditional cell recovery instrument
Unitary function, it is impossible to enough ozonizations, sample is easily contaminated, and service efficiency is low.
The content of the invention
It is to provide a kind of multi-functional biomedical instrument that the purpose of the present invention is, in the above-mentioned prior art problem of solution
One or more.
According to an aspect of the present invention, there is provided a kind of multi-functional biomedical instrument, including working host, ozone occur
Device, cover body and base plate, working host include pedestal and are arranged at the function cabin of pedestal；Ozone generator is located in pedestal；Work
Main frame is positioned on base plate；Cover body is covered on base plate and forms confined space, and pedestal, function cabin and ozone generator are respectively positioned on closed
In space.
The present invention forms confined space by cover body and base plate, and working host is placed in confined space, then by ozone
Generator carries out disinfection, can make working host before every task starts or after the completion of can carry out ozonization, it is ensured that behaviour
Make sample and working environment is not contaminated.
In some embodiments：Function cabin includes nacelle and can be covered on the hatchcover of nacelle；Nacelle is provided with heat conduction support
Disk and the first heating element heater that heat conduction pallet can be heated；Hatchcover is provided with heat conducting cover plate and heat conducting cover plate can be carried out
Second heating element heater of heating, heat conducting cover plate is detachably arranged at hatchcover, headspace is provided between heat conducting cover plate and hatchcover；When
When hatchcover is covered on nacelle, working chamber is collectively forming between hatchcover and heat conduction pallet；Formed between heat conduction pallet and nacelle bottom
Convection space, nacelle bottom is provided with the first passage communicated with convection space；Hatchcover is provided with second communicated with headspace
Passage.Thus, dry type heating is carried out by heating element heater, the pallet and cover plate that recycling heat-conducting medium material is made are led
Heat, cell work chamber is collectively forming between heat conducting cover plate and heat conduction pallet carries out cell recovery, to replace traditional water bath device,
Using dry type cell recovery, it is to avoid the pollution risk that water-bath cell recovery brings；After heat conducting cover plate is dismantled so that work
Chamber becomes big, working chamber is turned into sealing state, can realize that microorganism is incubated, biological indicator is incubated, microwell plate
The function such as constant temperature oscillation and metal bath；When working chamber needs to start to lower the temperature or cool down, convection space, the first passage and second
Passage can carry out quick heat radiating cooling.
In some embodiments：First heating element heater and the second heating element heater are Peltier, Graphene Electric radiant Heating Film or pottery
Porcelain heating board.Thereby, it is possible to provide dry type heating, pollution risk will not be brought to cell recovery.
In some embodiments：The one side that heat conduction pallet is located at working chamber is plane, and heat conducting cover plate is located at working chamber
One side be plane.Thus, it is possible to carry out cell recovery to cell cryopreservation bag.
In some embodiments：The one side that heat conduction pallet is located at working chamber is provided with multiple the first half arc flutings, heat conduction
The one side that cover plate is located at working chamber is provided with multiple the second half arc flutings that tube chamber is cooperatively formed with the first half arc flutings.Thus, it is possible to
It is enough that cell recovery is carried out to cell cryopreservation tube.
In some embodiments：Working chamber includes freezing bag working chamber and cryopreservation tube working chamber；Heat conduction pallet is located at and freezes
The one side of bag working chamber is deposited for plane, heat conducting cover plate is plane positioned at the one side for freezing bag working chamber；Heat conduction pallet is located at
The one side of cryopreservation tube working chamber is provided with multiple the first half arc flutings, and the one side that heat conducting cover plate is located at cryopreservation tube working chamber is provided with
Multiple the second half arc flutings that tube chamber is cooperatively formed with the first half arc flutings.Thus, cell can be carried out to cell cryopreservation bag to answer
Soviet Union, can carry out cell recovery to cell cryopreservation tube again.
In some embodiments：The one side that heat conducting cover plate is located at working chamber is provided with heat conductive silica gel.Thus, heat conductive silica gel
The 3D shape of cell cryopreservation bag upper surface will be voluntarily adapted to, make it between heat conducting cover plate completely without air gap, can
Carry out uniform quick heating.
In some embodiments：The one side that heat conducting cover plate is located at working chamber is provided with heat conductive silica gel；The of heat conduction pallet
Half arc fluting surface is provided with heat conductive silica gel.Thus, heat conductive silica gel will voluntarily adapt to cell cryopreservation bag or cell cryopreservation pipe surface
3D shape, make its respectively between heat conducting cover plate and heat conduction pallet completely without air gap, can carry out uniform fast
Speed heating.
In some embodiments：Also include drive device and transmission device, function cabin is hinged and is arranged at pedestal, drive dress
Install and be placed in pedestal, drive device is done by actuator drives function cabin by fulcrum of the junction between function cabin and pedestal
Seesaw is moved；Drive device is motor, and transmission device includes first connecting rod and second connecting rod；First connecting rod one end is articulated with driving
Device output end, the first connecting rod other end is articulated with second connecting rod one end, and the second connecting rod other end is articulated with function cabin.Thus,
Seesaw motor function can be realized, drive device is done seesaw and moved by actuator drives function cabin, then drives working chamber
Interior cell cryopreservation bag or cell cryopreservation tube concussion, make the liquid of thawing mix in time, are heated evenly.
In some embodiments：Also include controller, touch screen, siren, indicator lamp, data-interface and at least one
Temperature sensor, heat conduction pallet and heat conducting cover plate are equipped with temperature sensor, and temperature sensor is positioned over working chamber for measurement
The temperature of interior article, temperature sensor is electrically connected with the controller, and controller can control the first heating element heater, the second heating unit
The open and close of part, drive device and ozone generator；Indicator lamp and siren are electrically connected with the controller, and controller can
Control indicator lamp and siren；Touch screen is electrically connected with the controller, and can select mode of operation and working procedure, defeated by touch screen
Enter control information, output data etc.；Data-interface can be installed on pedestal, and data line interface can network and downloading data.Thus,
Cell cryopreservation bag or the temperature of cell cryopreservation tube that temperature sensor is used in monitoring chamber, and the temperature signal is sent to
Controller, controller controlled according to the temperature signal unlatching of the first heating element heater, the second heating element heater and drive device with
Close；When the work of function cabin is completed, can be reminded by indicator lamp and siren.
In some embodiments：Also include shaking table pallet, shaking table pallet includes disk body and is arranged at disk body opposite sides
Card division, shaking table pallet can be positioned over function cabin top, the lower part of card division is stuck in function cabin side, the upper part energy of card division
Enough prevent the article on disk body from departing from.Thus, it is possible to realize seesaw shaking table function, when seesaw shaking table function is needed to use, will shake
Bed bracket disk is positioned in function cabin, then be will be equipped with glassware of liquid etc. and be positioned on shaking table pallet, and card division is formed with disk body
I-shape construction, card division is stuck in function cabin side, and shaking table pallet can be made to be fixed in function cabin, and card division is prevented from disk body
Article depart from, be then turned on drive device, swing up and down the two ends of shaking table pallet, realize seesaw shaking table function.Shaking table pallet
Disk body can also the second passage for covering of enclosure, working chamber is turned into sealing state.
In some embodiments：Also include board slot frame, board slot frame can be positioned over heat conduction pallet, and board slot frame is evenly equipped with many
Individual board slot, can agree with standard-sized microwell plate.Thereby, it is possible to realize microwell plate constant temperature oscillator function, when needs make
During with microwell plate constant temperature oscillator function, dismountable heat conducting cover plate on hatchcover is first removed, increase work cavity space, then by board slot
Frame is positioned on heat conduction pallet, then the samples such as ELISA Plate or Tissue Culture Plate are positioned in board slot, and constant temperature and seesaw are moved
Two kinds of functions are combined together, controller control the first heating element heater and the second heating element heater so that constant temperature is kept in working chamber,
The culture incubation and moving seesaw-type vibration of cell are carried out at a constant temperature.
In some embodiments：Also include biological indicator bracket, biological indicator bracket can be positioned over heat conduction support
On disk, and in working chamber.Thus, can be used in the homoisothermal cultivation process of all kinds of sterilizing effect monitoring biological indicators,
It is particularly suitable for the incubated monitoring of the periodicity of pressuresteam sterilization biological indicator and ethylene oxide sterilizing biological indicator.
During function incubated using biological indicator, dismountable heat conducting cover plate on hatchcover is first removed, increase work cavity space, by life
Thing indicator is positioned on biological indicator bracket, then biological indicator bracket is positioned on heat conduction pallet, covers hatchcover, will
Nacelle will be held in horizontal level, and controller controls the first heating element heater so that constant temperature is kept in working chamber, biology can be realized
The incubated function of indicator.
In some embodiments：Also include metal bath component, metal bath component can be positioned on heat conduction pallet.By
This, can realize metal bath function, and metal bath component is positioned on heat conduction pallet, and nacelle is held in horizontal level, at hatchcover
In open mode, temperature needed for being adjusted by controller.Can be applied to the preservation and reaction of sample, DNA cloning and electrophoresis it is pre-
Denaturation, serum solidification etc..
In some embodiments：Pedestal is provided with mounting groove, and ozone generator is arranged in mounting groove, installs at channel opening
It is ozone outlet, blower fan is provided between ozone generator and ozone outlet, blower fan can discharges ozone from ozone outlet.By
This, in the confined space that the ozone discharge that can be produced ozone generator is collectively forming full of cover body and base plate, improves ozone
The efficiency of sterilization.
In some embodiments：Heat conducting cover plate on hatchcover is dismountable, can increase the volume of working chamber, can be real
The incubated function of existing microorganism.When the incubated function of microorganism is needed to use, dismountable heat conduction on hatchcover is first removed
Cover plate, increases work cavity space, nacelle is held in into horizontal level and is fixed, and controller controls the first heating element heater so that work
Cavity temperature keeps constant temperature, and microbial culture dish is positioned in working chamber, only starts temperature incubation function, can carry out the perseverance of microorganism
Temperature culture.
Brief description of the drawings
Fig. 1 is a kind of structural representation of multi-functional biomedical instrument of the invention；
Fig. 2 is the knot of the first embodiment of the heat conduction pallet and heat conducting cover plate of a kind of multi-functional biomedical instrument of the invention
Structure schematic diagram；
Fig. 3 is the knot of the second embodiment of the heat conduction pallet and heat conducting cover plate of a kind of multi-functional biomedical instrument of the invention
Structure schematic diagram；
Fig. 4 is the knot of the 3rd embodiment of the heat conduction pallet and heat conducting cover plate of a kind of multi-functional biomedical instrument of the invention
Structure schematic diagram；
Fig. 5 is a kind of structural representation of the shaking table pallet of multi-functional biomedical instrument of the invention；
Fig. 6 is a kind of structural representation of the board slot frame of multi-functional biomedical instrument of the invention；
Specific embodiment
Illustrate below in conjunction with the accompanying drawings, the present invention is described in further detail.
As shown in figure 1, a kind of multi-functional biomedical instrument, including working host, ozone generator 14, cover body 7 and bottom
Plate 8, working host includes pedestal 1 and is arranged at the function cabin 2 of pedestal 1；Ozone generator 14 is located in pedestal 1；Working host
It is positioned on base plate 8；Cover body 7 is covered on base plate 8 and forms confined space, and pedestal 1, function cabin 2 and ozone generator 14 are respectively positioned on
In confined space；The side wall of cover body 7 is equipped with silica gel through hole 71, and silica gel through hole 71 can be used for wearing circuit；Cover body 7 and base plate 8
Between pad be provided with sealing gasket 72, it is possible to increase the sealing of cover body 7 and the junction of base plate 8.Thus, formed by cover body and base plate
Confined space, working host is placed in confined space, then is carried out disinfection by ozone generator, can make working host every
Before task starts or after the completion of can carry out ozonization, it is ensured that operation sample and working environment it is not contaminated.
Wherein, pedestal 1 has dug mounting groove, and ozone generator 14 is fixedly installed in mounting groove, is at installation channel opening
Ozone outlet 16, ozone outlet 16 can install screen pack, prevent debris from entering, between ozone generator 14 and ozone outlet 16
Blower fan 15 is provided with, blower fan 15 is fixedly installed in mounting groove, blower fan 15 can discharge ozone from ozone outlet 16.Thus, energy
Enough ozone discharges for producing ozone generator improve the efficiency of ozonization full of in confined space.
Wherein, function cabin 2 includes nacelle 3 and can be covered on the hatchcover 4 of nacelle 3, and specifically, the side of hatchcover 4 is cut with scissors
It is connected to the side of nacelle 3.Nacelle 3 is provided with heat conduction pallet 31 and the first heating element heater that can be heated to heat conduction pallet 31
32, specifically, heat conduction pallet 31 is arranged at the inside of nacelle 3, and the edge of heat conduction pallet 31 is fixedly connected in nacelle 3
Wall, the first heating unit 32 is attached at the back side of heat conduction pallet 31, and the back side of heat conduction pallet 31 is the side towards nacelle 3,
Heat conduction pallet 31 is metal tray in the present embodiment, it is preferred that by metallic aluminium is made, can carry out efficient heat transfer.Hatchcover 4 is provided with
Heat conducting cover plate 41 and the second heating element heater 42 that can be heated to heat conducting cover plate 41, heat conducting cover plate 41 are detachably arranged at cabin
Lid 4, is provided with headspace 43 between heat conducting cover plate 41 and hatchcover 4, specifically, heat conducting cover plate 41 is arranged at the inside of hatchcover 4,
The inwall ring of hatchcover 4 is evenly equipped with multiple slots, the edge of heat conducting cover plate 41 be evenly equipped with it is multiple corresponded with slot and
The inserted block that slot is fixed can be inserted, the second heating unit 42 is attached at the back side of heat conducting cover plate 41, the second heating unit 42
Connection be attached using being detachably connected head, the back side of heat conducting cover plate 41 is the side towards hatchcover 4, in this implementation
In example, heat conducting cover plate 41 is metal cover board, it is preferred that by metallic aluminium is made, being capable of efficient heat transfer.When hatchcover 4 is covered on nacelle 3
When, working chamber 23 is collectively forming between heat conducting cover plate 41 and heat conduction pallet 31, working chamber 23 can be used for placing cell cryopreservation bag
Or cell cryopreservation tube carries out cell recovery.Thus, dry type heating is carried out by heating element heater, recycles heat-conducting medium material to be made
Pallet and cover plate carry out heat conduction, cell recovery working chamber is collectively forming between heat conducting cover plate and heat conduction pallet, with replace tradition
Water bath device, using dry type cell recovery, it is to avoid the pollution risk that water-bath cell recovery brings；Additionally, working as conductive cover
After plate dismounting so that working chamber becomes big, can realize that microorganism is incubated, biological indicator is incubated, microwell plate constant temperature
The function such as vibration and metal bath.
Convection space 33 is formed between heat conduction pallet 31 and the bottom of nacelle 3, the bottom of nacelle 3 offers and the phase of convection space 33
The first logical passage 22；Hatchcover 4 is provided with the second passage 45 communicated with headspace 43.When working chamber needs to start cooling
Or during cooling, convection space, the first passage 22 and the second passage can carry out quick heat radiating cooling；When other functions of execution
When needing larger working chamber volume, after can the heat conducting cover plate 41 of hatchcover 4 be dismantled so that working chamber 23 becomes big, now, by shaking table
Pallet 9 is placed in the top of functional warehouse 2, can close the second passage 45, seals working chamber 23, and heat will not be made to leak.
Wherein, the first heating element heater 32 and the second heating element heater 42 are Peltier, Graphene Electric radiant Heating Film or ceramic heating plate.
Thereby, it is possible to provide dry type heating, pollution risk will not be brought to cell recovery.In the present embodiment, the first heating element heater 32
Peltier is with the second heating element heater 42, wherein, Peltier is semiconductor chilling plate, is also thermoelectric module, is a kind of heat
Pump, it is not necessary to any refrigerant, can continuously work, and not shaken and noise during work, long lifespan.Semiconductor chilling plate has two
Function is planted, can be freezed, and can heated, therefore can just replace discrete heating system and refrigeration system using an element.
Semiconductor chilling plate is electric current transducing type element, by the control of input current, is capable of achieving high-precision temperature control, is added
Temperature detection and microprocessor control device, it is easy to constitute automatic control system.Semiconductor chilling plate thermal inertia is very small, system
It is cold to heat the time quickly, in the case of the good cold end zero load of hot-side heat dissipation, it is powered less than one minute, cooling piece can just reach most
The big temperature difference.
Embodiment 1, as shown in Fig. 2 the one side that heat conduction pallet 31 is located at working chamber 23 is plane, heat conducting cover plate 41 is located at
The one side of working chamber 23 is plane.Thus, it is possible to carry out cell recovery to cell cryopreservation bag.
Embodiment 2, as shown in figure 3, the one side that heat conduction pallet 31 is located at working chamber 23 is provided with multiple the first half arc flutings,
Heat conducting cover plate 41 is located at the one side of working chamber 23, and to be provided with multiple the second half arcs that tube chamber is cooperatively formed with the first half arc flutings recessed
Groove.Thus, it is possible to carry out cell recovery to cell cryopreservation tube.
Embodiment 3, as shown in figure 4, working chamber 23 includes freezing bag working chamber and cryopreservation tube working chamber；31, heat conduction pallet
It is plane in the one side for freezing bag working chamber, heat conducting cover plate 41 is plane positioned at the one side for freezing bag working chamber；Heat conduction support
The one side that disk 31 is located at cryopreservation tube working chamber is provided with multiple the first half arc flutings, and heat conducting cover plate 41 is located at cryopreservation tube working chamber
One side is provided with multiple the second half arc flutings that tube chamber is cooperatively formed with the first half arc flutings.Thus, can be to cell cryopreservation bag
Cell recovery is carried out, cell recovery can be carried out to cell cryopreservation tube again.
Wherein, in above-described embodiment 1, heat conducting cover plate 41 can be sticked positioned at the one side of working chamber 23 thermal conductive silicon
Glue 44.Thus, heat conductive silica gel will voluntarily adapt to the 3D shape of cell cryopreservation bag upper surface, make it complete between heat conducting cover plate
There is no air gap, can uniformly be heated.In above-described embodiment 2 and 3, heat conducting cover plate 41 is located at the side of working chamber 23
Face is sticked heat conductive silica gel 44；The first half arc fluting surfaces of heat conduction pallet 31 are sticked and have heat conductive silica gel 44.Thus, heat conductive silica gel
The 3D shape of cell cryopreservation bag or cell cryopreservation pipe surface will voluntarily be adapted to, make its respectively with heat conducting cover plate and heat conduction pallet it
Between completely without air gap, uniform quick heating can be carried out.
In addition, it can include drive device 13 and transmission device 6, function cabin 2 is hinged and is arranged at pedestal 1, in this implementation
In example, function cabin 2 can be arranged at pedestal 1 by pillar 5, and the one end of pillar 5 is fixedly connected on pedestal 1, the other end hinge of pillar 5
The bottom of function cabin 2 is connected in succession.Drive device 13 is arranged at pedestal 1, in the present embodiment, can be dug in the upper side of pedestal 1
There is the groove for placing drive device 13.Drive device 13 is by the driving function cabin 2 of transmission device 6 around function cabin 2 and pedestal 1
Between junction do seesaw motion.Wherein, seesaw motion to do at the two ends of function cabin 2 rise and fall up and down motion.
Wherein, drive device 13 is motor, and specifically, drive device 13 is stepper motor, and transmission device 6 includes first
Connecting rod 61 and second connecting rod 62；The one end of first connecting rod 61 is articulated with the output end of drive device 13, and the other end of first connecting rod 61 is hinged
In the one end of second connecting rod 62, the other end of second connecting rod 62 is articulated with function cabin 2.Thus, it is possible to realize drive device by transmission
Do seesaw motion in device driving function cabin.
In order to realize Based Intelligent Control, the temperature sensor 21 of controller 11 and at least one, heat conduction pallet 31 can also be included
Temperature sensor 21 is equipped with heat conducting cover plate 51, temperature sensor 21 is used to measure the temperature for being positioned over article in working chamber 23
Degree, specifically, the probe of temperature sensor 21 may be located in working chamber 23, and controller 11 can be installed on pedestal 1, temperature
Sensor 21 is electrically connected with controller 11, and controller 11 can control the first heating element heater 32, the second heating element heater 42 and drive
The open and close of dynamic device 13.Thus, cell cryopreservation bag or cell cryopreservation tube that temperature sensor is used in monitoring chamber
Temperature, and the temperature signal is sent to controller, controller controls the first heating element heater, second according to the temperature signal
The open and close of heating element heater and drive device.
In addition, it can include siren, siren is electrically connected to controller 11, and siren is installed on pedestal 1.Thus,
When cell recovery is completed, warning reminding can be carried out by siren.Indicator lamp 14 can also be included, indicator lamp 14 is electrically connected to
Controller 11, indicator lamp 14 can be installed on pedestal 1.Thus, when cell recovery is completed, can be reminded by indicator lamp.
Touch screen 12 can also be included, touch screen 12 can be installed on pedestal 1, and be electrically connected to controller 11, touch screen 12 is used to set
Determine the running parameters such as heating-up temperature, motor speed.
When in use, this multi-functional biomedical instrument is positioned over smooth operating desk surface first, is then turn on electricity
Source, operates on the touch screen 12 of pedestal 1, the running parameter such as setting heating-up temperature, motor speed, preheats heat conduction pallet 31 and leads
Be placed in cell cryopreservation bag on the heat conduction pallet 31 of function cabin 2 to design temperature by hot cover plate 41, hatchcover 4 is closed, on hatchcover 4
Heat conductive silica gel 44 will voluntarily adapt to the 3D shape of cell cryopreservation bag upper surface, it is not completely between heat conducting cover plate 41 free
Air cleft gap.Then cell recovery is carried out, controller 11 sends control signal, the first heating element heater 32 and cabin in control nacelle 2
The second heating element heater 42 quick heat production simultaneously on lid 2, by heat conduction pallet 31, heat conducting cover plate 41 and heat conductive silica gel 44 by heat
Pass to cell cryopreservation bag.Controller 11 is simultaneously emitted by control signal to stepper motor 13, and stepper motor 13 starts running, passes through
Kinetic energy is passed to function cabin 2 by transmission device 6, drives function cabin 2 to do seesaw motion, then drives the cell in working chamber 23 to freeze
Bag concussion is deposited, the liquid of thawing is mixed in time, be heated evenly.When the liquid in cell cryopreservation bag melts, temperature increases to over 0
At~4 DEG C, temperature sensor 21 detects the temperature change of cell cryopreservation bag, by signal transmission to controller 11, sends negative anti-
Feedback signal, makes the second heating element heater 42 on the first heating element heater 32 and the hatchcover 2 in nacelle 2 terminate heating, stepper motor 13
Shut down, being simultaneously emitted by control information makes indicator lamp 14 light, and terminates siren sounding, teaching process person's cell recovery,
Cell cryopreservation bag is now taken out in time, you can carry out next step operation.Or when temperature sensor 21 detects cell cryopreservation bag
Temperature when meeting or exceeding 0~4 DEG C, signal is fed back into controller 11 immediately, send negative-feedback signal, make stepper motor 13
Shut down, the second heating element heater 42 on the first heating element heater 32 and hatchcover 2 in nacelle 2 terminates heating, switch to the mould that freezes
Formula, cools the temperature to and maintains 4 DEG C.Being simultaneously emitted by control information makes indicator lamp 14 light, and makes siren sounding, teaching process
Person's cell recovery terminates, and cell cryopreservation bag is now taken out in time, you can carry out next step operation.
Additionally, as shown in figure 5, also including shaking table pallet 9, shaking table pallet 9 includes disk body 91 and be integrally formed to be arranged at disk
The card division 92 of the opposite sides of body 91, shaking table pallet 9 can be positioned over the top of function cabin 2, and the lower part of card division 92 is stuck in function cabin 2
Side, the article that the upper part of card division 92 is prevented from disk body 91 departs from.Thus, it is possible to realize seesaw shaking table function, work as needs
During using seesaw shaking table function, shaking table pallet is positioned in function cabin, then will be equipped with glassware of liquid etc. and be positioned over to shake
On bed bracket disk, card division 92 forms I-shape construction with disk body 91, and the lower part of card division 92 is stuck in the side of function cabin 2, can make to shake
Bed bracket disk 9 is fixed in function cabin 2, and the article that the upper part of card division 92 is prevented from disk body departs from, and is then turned on drive device,
The two ends of shaking table pallet 9 are swung up and down, seesaw shaking table function is realized.When the function of needing larger working chamber volume is performed,
After can the heat conducting cover plate 41 of hatchcover 4 be dismantled so that working chamber 23 becomes big, now, shaking table pallet 9 is placed in the top of functional warehouse 2,
The second passage 45 can be closed, working chamber 23 is sealed, heat will not be made to leak.
Additionally, as shown in fig. 6, also including board slot frame 35, board slot frame 35 can be positioned over heat conduction pallet 31, and board slot frame 35 is equal
Multiple board slots 351 are furnished with, board slot 351 is dug in board slot frame 35, and board slot frame 35 plays a part of fixed microwell plate.Thereby, it is possible to
Microwell plate constant temperature oscillator function is realized, when microwell plate constant temperature oscillator function is needed to use, first board slot frame is positioned over and is led
On hot pallet, heat conducting cover plate 41 is removed, increase the space of working chamber 23, then the samples such as ELISA Plate or Tissue Culture Plate are positioned over
In board slot, hatchcover is covered, shaking table pallet 9 is placed in the top of functional warehouse 2, the second passage 45 can be closed, seal working chamber 23,
Controller controls the first heating element heater so that constant temperature is kept in working chamber, culture incubation and the seesaw of cell are carried out at a constant temperature
Formula vibrates.
Biological indicator bracket can also be included, biological indicator bracket can be positioned on heat conduction pallet 31, and is located at
In working chamber 23, biological indicator bracket is annular support body, and multiple test tube jacks are evenly equipped with annular support body.Thus, may be used
In for the homoisothermal cultivation process of all kinds of sterilizing effect monitoring biological indicators, it is particularly suitable for pressuresteam sterilization biology and refers to
Show the incubated monitoring of the periodicity of agent and ethylene oxide sterilizing biological indicator.Use the incubated function of biological indicator
When, biological indicator is positioned on biological indicator bracket, heat conducting cover plate 41 is removed, increase the space of working chamber 23, then will
Biological indicator bracket is positioned on heat conduction pallet, covers hatchcover, and shaking table pallet 9 is placed in into the top of functional warehouse 2, can close second
Passage 45, seals working chamber 23, and nacelle will be held in into horizontal level, and temperature control is constant, can realize that biology refers to
Show the incubated function of agent.
Metal bath component can also be included, metal bath component can be positioned on heat conduction pallet 31, and metal bath component includes
Metal heat carrier, heat carrier is provided with multiple test tube jacks.Thereby, it is possible to realize metal bath function, by metal bath components
It is positioned on heat conduction pallet, nacelle is held in horizontal level, hatchcover is in open mode, temperature needed for being adjusted by controller.
Can be applied to preservation and reaction, the predegeneration of DNA cloning and electrophoresis, serum solidification of sample etc..
Further, it is also possible to realize incubated (such as Micro-Organism Culture Dish) function of microorganism.When needing to use microorganism constant temperature
During culture function, heat conducting cover plate 41 is removed, increases the space of working chamber 23, then Micro-Organism Culture Dish is placed on heat conduction pallet 31,
Hatchcover 4 is covered, shaking table pallet 9 is placed in the top of functional warehouse 2, the second passage 45 can be closed, seal working chamber 23, nacelle 3
Horizontal level is kept, temperature is constantly maintained at design temperature (such as 35 DEG C or 37 DEG C).To avoid sample contamination and environmental protection, can
Function cabin 2 and pedestal 1 are arranged in the confined space that cover body 7 and base plate 8 are collectively forming jointly, it is ensured that security.Can also be
Under this functional mode, temperature is adjusted to 42 DEG C or other required temperature, for the treatment of cell heat shock.
The above is only one embodiment of the present invention, it is noted that to those skilled in the art,
Without departing from the concept of the premise of the invention, some similar deformations and improvement can also be made, these also should be regarded as this
Within the protection domain of invention.
Claims (15)
1. a kind of multi-functional biomedical instrument, it is characterised in that：Including working host, ozone generator (14), cover body (7) and
Base plate (8), the working host includes pedestal (1) and is arranged at the function cabin (2) of the pedestal (1)；The ozone generator
(14) in pedestal (1)；The working host is positioned on the base plate (8)；The cover body (7) is covered on the base plate
(8) confined space is formed, the pedestal (1), function cabin (2) and the ozone generator (14) are respectively positioned on the confined space
It is interior.
2. a kind of multi-functional biomedical instrument according to claim 1, it is characterised in that：The function cabin (2) includes
Nacelle (3) and the hatchcover (4) of the nacelle (3) can be covered on；The nacelle (3) is provided with heat conduction pallet (31) and can be to institute
State the first heating element heater (32) that heat conduction pallet (31) is heated；The hatchcover (4) is provided with heat conducting cover plate (41) and can be right
The second heating element heater (42) that the heat conducting cover plate (41) is heated, the heat conducting cover plate (41) is detachably arranged at the cabin
Lid (4), headspace (43) is provided between the heat conducting cover plate (41) and the hatchcover (4)；When the hatchcover (4) is covered on institute
When stating nacelle (3), working chamber (23) is collectively forming between the hatchcover (4) and the heat conduction pallet (31)；The heat conduction pallet
(31) convection space (33) is formed between the nacelle (3) bottom, nacelle (3) bottom is provided with and the convection space
(33) the first passage (22) for communicating；The hatchcover (4) is provided with the second passage communicated with the headspace (43)
(45)。
3. a kind of multi-functional biomedical instrument according to claim 2, it is characterised in that：First heating element heater
(32) and the second heating element heater (42) be Peltier, Graphene Electric radiant Heating Film or ceramic heating plate.
4. a kind of multi-functional biomedical instrument according to claim 2, it is characterised in that：Heat conduction pallet (31) position
Multiple the first half arc flutings are provided with the one side of the working chamber (23), the heat conducting cover plate (41) is positioned at the working chamber
(23) one side is provided with multiple the second half arc flutings that tube chamber is cooperatively formed with the first half arc fluting.
5. a kind of multi-functional biomedical instrument according to claim 2, it is characterised in that：Heat conduction pallet (31) position
It is plane in the one side of the working chamber (23), the heat conducting cover plate (41) is flat positioned at the one side of the working chamber (23)
Face.
6. a kind of multi-functional biomedical instrument according to claim 2, it is characterised in that：The working chamber (23) includes
Freeze bag working chamber and cryopreservation tube working chamber；The heat conduction pallet (31) is flat positioned at the one side for freezing bag working chamber
Face, the heat conducting cover plate (41) is plane positioned at the one side for freezing bag working chamber；The heat conduction pallet (31) is positioned at institute
The one side for stating cryopreservation tube working chamber is provided with multiple the first half arc flutings, and the heat conducting cover plate (41) works positioned at the cryopreservation tube
The one side in chamber is provided with multiple the second half arc flutings that tube chamber is cooperatively formed with the first half arc fluting.
7. a kind of multi-functional biomedical instrument according to any one of claim 5, it is characterised in that：The heat conducting cover plate
(41) one side positioned at the working chamber (23) is provided with heat conductive silica gel (44).
8. a kind of multi-functional biomedical instrument according to any one of claim 4 or 6, it is characterised in that：The heat conduction
Cover plate (41) is provided with heat conductive silica gel (44) positioned at the one side of the working chamber (23)；The first half arcs of the heat conduction pallet (31)
Groove surfaces are provided with heat conductive silica gel (44).
9. a kind of multi-functional biomedical instrument according to claim 2, it is characterised in that：Also include drive device (13)
With transmission device (6), the function cabin (2) is hinged and is arranged at the pedestal (1), and the drive device (13) is arranged at the base
Seat (1), the drive device (13) by transmission device (6) drive the function cabin (2) around function cabin (2) and pedestal (1) it
Between junction do seesaw motion；The drive device (13) is motor, the transmission device (6) including first connecting rod (61) and
Second connecting rod (62)；Described first connecting rod (61) one end is articulated with the drive device (13) output end, and first connecting rod (61) is another
One end is articulated with the second connecting rod (62) one end, and second connecting rod (62) other end is articulated with the function cabin (2).
10. a kind of multi-functional biomedical instrument according to claim 9, it is characterised in that：Also include controller (11),
Touch screen (12), siren, indicator lamp, data-interface and at least one temperature sensor (21), the heat conduction pallet (31) and
The heat conducting cover plate (51) is equipped with the temperature sensor (21), and the temperature sensor (21) is positioned over described for measurement
The temperature of working chamber (23) interior article, the temperature sensor (21) electrically connects with the controller (11), the controller
(11) first heating element heater (32), second heating element heater (42), the drive device (13) and described can be controlled
The open and close of ozone generator (14)；The indicator lamp and siren are electrically connected with the controller (11), the control
Device (11) processed can control the indicator lamp and siren；The touch screen (12) electrically connects with the controller (11), described
Touch screen (12) can be input into and output information.
A kind of 11. multi-functional biomedical instruments according to claim 9, it is characterised in that：Also include shaking table pallet
(9), the shaking table pallet (9) is including disk body (91) and is arranged at the card division (92) of the disk body (91) opposite sides, described to shake
Bed bracket disk (9) can be positioned over the function cabin (2) top, and the disk body (91) of the shaking table pallet (9) can close hatchcover (4)
On the second passage (45)；Card division (92) bottom is stuck in the function cabin (2) side, and card division (92) top can
Prevent the article on the disk body (91) from departing from.
A kind of 12. multi-functional biomedical instruments according to claim 10, it is characterised in that：Also include board slot frame
(35), the board slot frame (35) can be positioned over the heat conduction pallet (31), and the board slot frame (35) is evenly equipped with multiple board slots
(351)。
A kind of 13. multi-functional biomedical instruments according to claim 10, it is characterised in that：Also include biological indicator
Bracket, the biological indicator bracket can be positioned on the heat conduction pallet (31), and in the working chamber (23).
A kind of 14. multi-functional biomedical instruments according to claim 10, it is characterised in that：Also include metal bath group
Part, the metal bath component can be positioned on the heat conduction pallet (31).
A kind of 15. multi-functional biomedical instruments according to claim 1, it is characterised in that：The pedestal (1) is provided with peace
Tankage, the ozone generator (14) is arranged in the mounting groove, is ozone outlet (16) at the installation channel opening, described
It is provided with blower fan (15) between ozone generator (14) and the ozone outlet (16), the blower fan (15) can be by ozone from described
Ozone outlet (16) is discharged.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710271938.0A CN106893666A (en) | 2017-04-24 | 2017-04-24 | A kind of multi-functional biomedical instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710271938.0A CN106893666A (en) | 2017-04-24 | 2017-04-24 | A kind of multi-functional biomedical instrument |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106893666A true CN106893666A (en) | 2017-06-27 |
Family
ID=59197450
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710271938.0A Pending CN106893666A (en) | 2017-04-24 | 2017-04-24 | A kind of multi-functional biomedical instrument |
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| CN107746799A (en) * | 2017-11-21 | 2018-03-02 | 赛慕特生物工程（上海）有限公司 | A kind of hand-held dry type cell recovery instrument |
| CN107881101A (en) * | 2017-11-21 | 2018-04-06 | 赛慕特生物工程（上海）有限公司 | One kind rubs formula cell cryopreservation bag dry type recovery instrument |
| CN107907677A (en) * | 2017-11-15 | 2018-04-13 | 嘉兴科瑞迪医疗器械有限公司 | Incubating device above and below a kind of microplate of chemical illumination immunity analysis instrument |
| CN109609347A (en) * | 2019-02-15 | 2019-04-12 | 赛慕特生物工程（上海）有限公司 | A kind of cell cryopreservation bag dry type recovery device and working method |
| CN110257248A (en) * | 2019-07-12 | 2019-09-20 | 潍坊医学院 | Constant-temperature metal bath is used in the culture of large capacity stem cell |
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| CN109609347A (en) * | 2019-02-15 | 2019-04-12 | 赛慕特生物工程（上海）有限公司 | A kind of cell cryopreservation bag dry type recovery device and working method |
| CN109609347B (en) * | 2019-02-15 | 2024-04-16 | 江苏赛拉纳生物医药有限公司 | Dry-type resuscitator for cell cryopreservation bag and working method |
| CN110257248A (en) * | 2019-07-12 | 2019-09-20 | 潍坊医学院 | Constant-temperature metal bath is used in the culture of large capacity stem cell |
| CN110257248B (en) * | 2019-07-12 | 2024-04-26 | 潍坊医学院 | Constant temperature metal bath for large-capacity stem cell culture |
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Effective date of registration: 20171011 Address after: 200000 Shanghai city China (Shanghai) Free Trade Zone Branch Road No. 58 Building 2 Xiang B zone 2 room 209 Applicant after: Saimute Biological Engineering (Shanghai) Co., Ltd. Address before: 226000 3 West Port, nine port, Gangzha District, Jiangsu, Nantong Applicant before: He Xiangfeng Applicant before: Wang Xiaojun |