CN106885762A - Closed loop liquid drop microfluidic system based on capacitance detecting - Google Patents
Closed loop liquid drop microfluidic system based on capacitance detecting Download PDFInfo
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- CN106885762A CN106885762A CN201611247006.4A CN201611247006A CN106885762A CN 106885762 A CN106885762 A CN 106885762A CN 201611247006 A CN201611247006 A CN 201611247006A CN 106885762 A CN106885762 A CN 106885762A
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- 239000007788 liquid Substances 0.000 title claims abstract description 101
- 239000012530 fluid Substances 0.000 claims abstract description 25
- 238000005259 measurement Methods 0.000 claims abstract description 15
- 238000001514 detection method Methods 0.000 claims abstract description 4
- 229920002545 silicone oil Polymers 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 12
- 238000003672 processing method Methods 0.000 abstract description 6
- 238000012360 testing method Methods 0.000 abstract description 5
- 230000008569 process Effects 0.000 abstract description 4
- 230000004044 response Effects 0.000 abstract description 2
- 238000010586 diagram Methods 0.000 description 3
- 230000009471 action Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/02—Investigating particle size or size distribution
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
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Abstract
The invention discloses a kind of closed loop liquid drop microfluidic system based on capacitance detecting, the system includes supply source of the gas, pressure-reducing valve, pressure gauge, the first pneumatic proportional valve, the second pneumatic proportional valve, first pressure sensor, second pressure sensor, first liquid container, second liquid container, liquid fluid channel, detecting electrode and microprocessor.The present invention is solved in liquid drop microfluidic system, drop size is measured using image processing method, its measurement process is complicated, speed is slow and the problems such as expensive testing equipment, capacitance determining method is become one with closed loop liquid drop microfluidic system, drop size detection speed and closed-loop system dynamic responding speed can be improved, the drop size in liquid fluid channel can in real time be measured, realize the quick regulation and precise control of drop size, drop size dynamic response time is less than 0.5 s, degree of regulation is higher than 0.5%, liquid drop microfluidic system is met in biology, medical science, the multi-disciplinary application requirement such as chemistry.
Description
Technical field
The invention belongs to microfluidic art, it is related to a kind of drop microfluidic system.
Background technology
Liquid drop microfluidic system is a kind of important microfluidic system, and the system is related to hydrodynamics, biology, medical science, change
Multiple subjects such as and system control, wherein, discrete fine droplet and precise control drop chi how are formed in fluid channel
It is very little, it is the emphasis and difficult point of current liquid drop microfluidic system research, for liquid drop microfluidic system answering in interdisciplinary field
With very crucial.In order to realize the real-time regulation and precise control of liquid drop microfluidic system drop size, drop is met micro-fluidic
System the subjects such as biology, medical science, chemistry application requirement, it is necessary to improve the measuring speed and precision of drop size.At present, scheme
As processing method is the most frequently used drop size measurement method, image processing method needs the costliness such as microscope, high speed camera
Testing equipment, the quality requirement to shooting image is higher.Meanwhile, image processing process is complicated, and process time is more long, to a certain degree
On can influence the rapidity and real-time of drop size measurement.Capacitance determining method is applied to liquid drop microfluidic system, can be with
Drop size measurement speed is improved, the quick measurement of drop size is realized.Compared with image processing method, capacitance determining method is not
The measuring apparatus for needing microscope, high speed camera etc. expensive, testing cost is relatively low.Meanwhile, capacitance determining method time of measuring is short,
Speed is fast, can improve the dynamic characteristic of closed loop liquid drop microfluidic system, realizes the quick regulation and precise control of drop size.
The content of the invention
In order in solving liquid drop microfluidic system, drop size is measured using image processing method, its measurement process is complicated,
Speed is slow and the problems such as expensive testing equipment, micro-fluidic the invention provides a kind of closed loop drop based on capacitance detecting
System.The present invention becomes one capacitance determining method with closed loop liquid drop microfluidic system, can improve drop size detection speed
Degree and closed-loop system dynamic responding speed.
The purpose of the present invention is achieved through the following technical solutions：
A kind of closed loop liquid drop microfluidic system based on capacitance detecting, including it is supply source of the gas, pressure-reducing valve, pressure gauge, first pneumatic
Proportioning valve, the second pneumatic proportional valve, first pressure sensor, second pressure sensor, first liquid container, second liquid hold
Device, liquid fluid channel, detecting electrode and microprocessor, wherein：
The outlet of the gas access of the pressure-reducing valve and supply source of the gas, the gas vent of pressure-reducing valve ratio pneumatic with first respectively
The gas access connection of example valve and the second pneumatic proportional valve；
The gas vent of first pneumatic proportional valve is connected with the gas access of first liquid container, the second pneumatic proportional valve
Gas vent is connected with the gas access of second liquid container；
The liquid outlet of the first liquid container and second liquid container respectively with the first entrance of liquid fluid channel and second
Entrance is connected；
The detecting electrode is used to measure the drop size in liquid fluid channel, and detecting electrode is arranged in liquid fluid channel in pairs
Upper and lower both sides, the capacitance signal output end of detecting electrode is connected with the capacitance signal input of microprocessor；
The Stress control command signal output end of the microprocessor respectively with the first pneumatic proportional valve and the second pneumatic proportional valve
Stress control command signal input be connected；
The first pressure sensor is used to detect the gas driving pressure of first liquid container, and second pressure sensor is used to examine
Survey the gas pressure signal output of the gas driving pressure of second liquid container, first pressure sensor and second pressure sensor
End is connected with the pressure signal input end of microprocessor respectively.
The invention has the advantages that：
1）Drop size measurement speed is fast.When the drop in liquid fluid channel is by detecting electrode, by measuring detecting electrode
Two ends electric capacity changes with time, after microprocessor analysis are calculated, can be with quick obtaining drop size.
2）Drop size measurement high precision.Because detecting electrode has capacitance measurement precision higher and sensitivity, work as liquid
When drop in body fluid channel is by detecting electrode, detecting electrode two ends capacitance variations amplitude is larger, is detected by Rational choice
The capacitive measurement scales of electrode, can improve the certainty of measurement of drop size.
3）Drop size measurement low cost.Because capacitance determining method does not need the expensive survey such as microscope, high speed camera
Amount equipment, compares with image processing method, and its testing cost is relatively low.
4）Control accuracy is high, dynamic characteristic is good.Capacitance determining method is become one with closed loop liquid drop microfluidic system,
By improving the measuring speed and precision of drop size, the dynamic characteristic of closed loop liquid drop microfluidic system can be improved, realize drop
The quick regulation and precise control of size.
Brief description of the drawings
Fig. 1 is the fundamental diagram of the closed loop liquid drop microfluidic system based on capacitance detecting；
Fig. 2 is the fundamental diagram that detecting electrode measures drop size；
Fig. 3 is the control block diagram of capacitance detecting closed loop liquid drop microfluidic system；
In figure：1- supply source of the gas, 2- pressure-reducing valves, 3- pressure gauges, the pneumatic proportional valves of 4- first, the pneumatic proportional valves of 5- second, 6- the
One pressure sensor, 7- second pressures sensor, 8- first liquids container, 9- second liquids container, 10- liquid fluid channel, 11-
Drop, 12- detecting electrodes, microprocessor.
Specific embodiment
Technical scheme is further described below in conjunction with the accompanying drawings, but is not limited thereto, it is every to this
Inventive technique scheme is modified or equivalent, without deviating from the spirit and scope of technical solution of the present invention, all should be covered
In protection scope of the present invention.
As shown in figure 1, the present invention provide the closed loop liquid drop microfluidic system based on capacitance detecting by supply source of the gas 1, subtract
Pressure valve 2, the first pneumatic proportional valve 4, the second pneumatic proportional valve 5, first pressure sensor 6, second pressure sensor 7, the first liquid
Body container 8, second liquid container 9, liquid fluid channel 10, detecting electrode 12 and microprocessor 13 are constituted, wherein：
The outlet of the gas access of the pressure-reducing valve 2 and supply source of the gas 1, the gas vent of pressure-reducing valve 2 respectively with the first gas
Dynamic proportioning valve 4 is connected with the gas access of the second pneumatic proportional valve 5；
The gas vent of first pneumatic proportional valve 4 is connected with the gas access of first liquid container 8, the second pneumatic proportional valve
5 gas vent is connected with the gas access of second liquid container 9；
The liquid outlet of the first liquid container 8 and second liquid container 9 respectively with the first entrance of liquid fluid channel 10 and
Second entrance is connected；
The detecting electrode 12 is used to measure the size of drop 11 in liquid fluid channel 10, and detecting electrode 12 is arranged in liquid in pairs
The upper and lower both sides of fluid channel 10, the capacitance signal output end of detecting electrode 12 and the capacitance signal input phase of microprocessor 13
Even；
The Stress control command signal output end of the microprocessor 13 respectively with the first pneumatic proportional valve 4 and the second pneumatic proportional
The Stress control command signal input of valve 5 is connected；
The first pressure sensor 6 is used to detect the gas driving pressure of first liquid container 8, and second pressure sensor 7 is used
In the gas driving pressure of detection second liquid container 9, the gas pressure of first pressure sensor 6 and second pressure sensor 7
Signal output part is connected with the pressure signal input end of microprocessor 13.
Operation principle：As Figure 2-3, the first liquid is set up by the first pneumatic proportional valve 4 and the second pneumatic proportional valve 5 respectively
The gas driving pressure of body container 8 and second liquid container 9, by changing gas driving pressure, adjusts influent fluid channel
10 fluid flow.External air source successively fills two kinds the first of incompatible liquid by pressure-reducing valve 2 and pneumatic proportional valve entrance
In liquid container 8 and second liquid container 9, first liquid is measured by first pressure sensor 6 and second pressure sensor 7 respectively
The gas driving pressure of container 8 and second liquid container 9.As gas driving pressure increases, two kinds of incompatible liquid are in air pressure
Under driving, influent fluid channel 10.Two kinds of incompatible liquid meet in the intersection of liquid fluid channel 10, by two-phase liquid
Mutual extruding and shear action, discrete drop 11 is formed in liquid fluid channel 10, when liquid is by detecting electrode 12,
Detecting electrode 12 measures the size of drop 11 and feeds back to microprocessor 13, by the relatively actual size of drop 11 and setting drop 11
The difference of size, pressure controling signal is sent to the first pneumatic proportional valve 4 and the second pneumatic proportional valve 5 by microprocessor 13, is adjusted
The gas driving pressure of section first liquid container 8 and second liquid container 9 so that the size of actual drop 11 and the setting chi of drop 11
It is very little to be consistent.
In the present invention, the supply gas pressure size of the supply source of the gas is 1~2 bar, blob length chi in liquid fluid channel
Very little adjustable range is 50~500 μm.
In the present invention, the capacitance measurement minimum resolution of the detecting electrode is 0.01 pF, and measurement range is 0.1~4.0
pF。
In the present invention, silicone oil is filled in first liquid container, water is filled in second liquid container.
The present invention can in real time measure the drop size in liquid fluid channel, realize the quick regulation of drop size and accurate
Control, drop size dynamic response time is less than 0.5 s, and degree of regulation is higher than 0.5%, meet liquid drop microfluidic system it is biological,
The multi-disciplinary application requirement such as medical science, chemistry.
Claims (6)
1. a kind of closed loop liquid drop microfluidic system based on capacitance detecting, it is characterised in that the closed loop liquid based on capacitance detecting
Drop microfluidic system is passed by supply source of the gas, pressure-reducing valve, pressure gauge, the first pneumatic proportional valve, the second pneumatic proportional valve, first pressure
Sensor, second pressure sensor, first liquid container, second liquid container, liquid fluid channel, detecting electrode and microprocessor structure
Into, wherein：
The outlet of the gas access of the pressure-reducing valve and supply source of the gas, the gas vent of pressure-reducing valve ratio pneumatic with first respectively
The gas access connection of example valve and the second pneumatic proportional valve；
The gas vent of first pneumatic proportional valve is connected with the gas access of first liquid container, the second pneumatic proportional valve
Gas vent is connected with the gas access of second liquid container；
The liquid outlet of the first liquid container and second liquid container respectively with the first entrance of liquid fluid channel and second
Entrance is connected；
The detecting electrode is used to measure the drop size in liquid fluid channel, and detecting electrode is arranged in liquid fluid channel in pairs
Upper and lower both sides, the capacitance signal output end of detecting electrode is connected with the capacitance signal input of microprocessor；
The Stress control command signal output end of the microprocessor respectively with the first pneumatic proportional valve and the second pneumatic proportional valve
Stress control command signal input be connected；
The first pressure sensor is used to detect the gas driving pressure of first liquid container, and second pressure sensor is used to examine
Survey the gas pressure signal output of the gas driving pressure of second liquid container, first pressure sensor and second pressure sensor
End is connected with the pressure signal input end of microprocessor respectively.
2. the closed loop liquid drop microfluidic system based on capacitance detecting according to claim 1, it is characterised in that the supply
The supply gas pressure size of source of the gas is 1~2 bar.
3. the closed loop liquid drop microfluidic system based on capacitance detecting according to claim 1, it is characterised in that described first
Two kinds of incompatible liquid are filled in liquid container and second liquid container.
4. the closed loop liquid drop microfluidic system based on capacitance detecting according to claim 1, it is characterised in that the detection
The capacitance measurement minimum resolution of electrode is 0.01 pF, and measurement range is 0.1~4.0 pF.
5. the closed loop liquid drop microfluidic system based on capacitance detecting according to claim 3, it is characterised in that described first
Silicone oil is filled in liquid container, water is filled in second liquid container.
6. the closed loop liquid drop microfluidic system based on capacitance detecting according to claim 1, it is characterised in that the liquid
The adjustable range of blob length size is 50~500 μm in fluid channel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201611247006.4A CN106885762A (en) | 2016-12-29 | 2016-12-29 | Closed loop liquid drop microfluidic system based on capacitance detecting |
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| CN201611247006.4A CN106885762A (en) | 2016-12-29 | 2016-12-29 | Closed loop liquid drop microfluidic system based on capacitance detecting |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107497504A (en) * | 2017-07-24 | 2017-12-22 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | Drop formation control device |
| CN108333115A (en) * | 2018-03-01 | 2018-07-27 | 北京天健惠康生物科技有限公司 | A kind of microlayer model detection device |
| CN108514895A (en) * | 2018-03-01 | 2018-09-11 | 北京天健惠康生物科技有限公司 | A kind of microlayer model generates and monitoring device |
| CN111307693A (en) * | 2020-02-24 | 2020-06-19 | 东南大学 | Passive wireless multi-stage droplet micro-fluidic detection device |
| CN113670983A (en) * | 2020-05-14 | 2021-11-19 | 格芯(美国)集成电路科技有限公司 | System and method for measuring electrical properties of materials |
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Application publication date: 20170623 |