CN106860851A - It is a kind of to prevent and treat rape pollen active peptide of prostatic disorders and preparation method thereof - Google Patents
It is a kind of to prevent and treat rape pollen active peptide of prostatic disorders and preparation method thereof Download PDFInfo
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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Abstract
It is especially a kind of with rape pollen active peptide for preventing and treating prostatic disorders and preparation method thereof the present invention relates to traditional Chinese medicine and technical field of biology.It is with rape pollen as major ingredient, through ultramicro grinding, homogenate, enzymolysis, centrifugation rape pollen active peptide liquid；Chinese herbal medicine is through broken, boiling, enzymolysis, the Chinese herbal medicine active peptide liquid of centrifugation；Addition oligoisomaltose, grape seed extract are after compounding sterilizing by the filling freeze-drying of lyophilized technique specification into bottled freeze-dried powder product；It is filling into oral liquid product by oral liquid process specification；The spray drying of hybrid peptide liquid or freeze-drying are prepared into powdery granule, it is filling into capsule product by capsule manufacturing techniques specification.Its component is respectively：Rape pollen active peptide 40% 60%；Active Chinese drug component peptide 5% 20%；Oligoisomaltose 5% 15%；Weight percentages of components sum described in grape seed extract 1% 5% is 100%.Preparation technology of the present invention is rigorous rationally, and strong operability is adapted to large-scale production.
Description
Technical field
The present invention relates to traditional Chinese medicine and technical field of biology.It is especially a kind of with the rape pollen for preventing and treating prostatic disorders
Active peptide and preparation method thereof.
Background technology
Hyperplasia of prostate and prostatitis are the common diseases of male prostate.Hyperplasia of prostate, is male elderly patients
One of common disease.With the increase at age, menfolk more or less has the phenomenon of hyperplasia of prostate.There is research table
After bright hyperplasia of prostate is started from 40 years old, but the elderly of more than 60 years old is more common.Prostatitis inflammation disease is sometimes with premature ejaculation simultaneously
Occur, the cardinal symptom of hyperplasia of prostate has a dysuria, the lighter's total urination time of getting up at night increases, after having urine retention or having urinated
The phenomenon of also a small amount of discharge;There is uroflow and attenuates in severe patient, even the phenomenon that can not arranged;It is often accompanied by soreness of waist pain in the back, four simultaneously
The symptoms such as myasthenia of limbs, seminal emission.Prostate is an organ of male reproductive system.Prostate morbidity can not only cause it is local not
Accommodate symptom, it is often more important that, can also cause constitutional symptom and discomfort, or even cause the malignant diseases such as uremia, tumour.Prostatitis
Harm of the gland disease to human body is many, in addition to the symptoms such as underbelly pain, dysuria, and can also result in body its
The change of his function, and it is different with course of disease length and severe extent.As people's rhythm of life is accelerated, work dinner party pressure
Increase, prostatic disorders are also increasingly to the development that becomes younger after 30 years old.
Modern medical therapy prostatic disorders can only be single the bacteroidal acute prostatitis disease for the treatment of, for vast
Chronic prostatitis or hyperplasia patient also only have a kind of rape pollen preparation " Qian Lie Kang " medicine.The development of prostate and physiology shape
The maintenance of state is depended on enough male sex hormones in vivo, especially the balance of male sex hormone and female hormone, and prostate is fertile
Big pathogenesis is adjusted with internal system and control imbalance is relevant, contained glutamic acid, proline etc. more than 20 in rape pollen
Amino acid is planted, the blood circulation of prostata tissue can be improved, mitigate oedema, alleviate the urethremphraxis that hypertrophy of the prostate causes.
Flavonoid substances therein have very strong anti-oxidation function, are also the jinx of hyperplasia of prostate.
Rape pollen is the pollen of the most rich product of China, higher containing flavonols, solid with anti arteriosclerosis, reducing blood lipid and courage
The effects such as alcohol, analgesia, radioresistance, treatment constipation, it is effective to prostatitic treatment, and hypertrophy of the prostate, prostate can be prevented
Dysfunction, can also treat varicose ulcer.Rape pollen can strengthen capillary intensity, reduction blood fat, to treatment sugar
Urine disease, anaemia, constipation, cancer-resisting etc. are all effective in cure.
Rape pollen kidney-nourishing, consolidate, strong waist, it is and higher containing flavonols, it is bent with antiatherosclerosis, treatment vein
Extensional ulcer, reduction cholesterol and radiation-resistant effect.As the pollen of plant essence, before more than 2000 years, just by me
Ancestors understanding and utilize.Pollen is the sperm of plant, and it breeds life, and nutrition is most abundant, is best east in plant
West.But pollen is molecular by spore, and with one layer of acidproof, alkaline-resisting, corrosion resistant hard chitin outer wall, this just have impact on
Imitate composition fully absorbs utilization, at present in the world also without the breaking trachytectum technology in complete meaning, because chitinase is also
There is no industrialized production.Simply mechanical breaking-wall method or the wind-tunnel broken wall having, smash hard spore coat, and this also simply promotes to absorb
, can not fundamentally give full play to the effect that rape pollen prevents and treats prostatic disorders.And during single formula is not so good as
Medicine compound clinical prevention effect is good.
Active peptide is more than the 1000 kinds of general name of peptide（Such as Soybean Peptide, sea cucumber peptide etc. is the one kind in active peptide）.It is people's
Grow, metabolism, disease and aging play key effect in dead process.Active peptide is most important in human body
Active material.Exactly because it in vivo secretory volume increase or reduce, the mankind is had childhood, childhood, adult is old
Until the dead cycle.And this cycle that active peptide has just broken life is taken, so as to reach extending life, effectively slow down and decline
Old miraculous effects.Peptide is in vivo as carrier and means of transport, and the nutrient delivery that people are eaten usually is each to human body
Individual position, gives full play to its function；Peptide is in vivo as neurotransmitter, transmission information；Peptide has extremely strong activity and many
Sample, fully adjustable human body physiological function, enhancing Human Physiology activity；Peptide can not only provide growth in humans's development required battalion
Material is supported, and with special biological function, thrombus, high fat of blood, hypertension can be prevented and treated, anti-aging is antifatigue, improved
Immunity of organisms, promotes human body various to protein, vitamin, amino acid, calcium, iron, zinc, selenium, magnesium, copper etc. beneficial to human body micro-
The absorption of secondary element；Some small peptides have former food protein or other composition unexistent important physiological functions of amino acid.
The less small peptide of some molecular weight in biologically active peptide, with amino acid transport function phase ratio, the small peptide in biologically active peptide has
Absorb quick, low consumption and undersaturated feature.Therefore how will have prevent and treat prostatic disorders function rape pollen and in
Herbal medicine makes function and absorbs more preferable active peptide, preferably reaches the purpose that traditional Chinese medicine preventives treatment of disease, and really realizes that Chinese medicine is modern
Change, it has also become traditional Chinese medicine and technical field of biology problem urgently to be resolved hurrily.
The content of the invention
It is the invention provides a kind of nutritious, good absorbing and tired with significantly resisting to overcome the deficiencies in the prior art
Labor, strengthen immunity, active peptide of preventing and treating prostate series of disease and preparation method thereof.One kind of the present invention prevents and treats prostatic disorders
Rape pollen active peptide and preparation method thereof be, with rape pollen and animals and plants Chinese herbal medicine primary raw material, to take Traditional Chinese Medicine to match somebody with somebody
Square and rigorous Chinese medicine preparation specification, is prepared from the advanced processing technology of modern biotechnology, its operation scientific and precise, behaviour
The property made is strong.
The purpose of the present invention is achieved through the following technical solutions：A kind of rape pollen activity for preventing and treating prostatic disorders
Peptide and preparation method thereof, it is characterized in that including rape pollen active peptide, active Chinese drug component peptide, oligoisomaltose composition.
Its component is respectively：Rape pollen active peptide 40%-60%;Active Chinese drug component peptide 5%-20%；Oligoisomaltose 5%-15%；Grape pip
Weight percentages of components sum described in extract 1%-5% is 100%.
Rape pollen active peptide of the present invention and preparation method thereof be with rape pollen as raw material, through broken, homogenate,
Enzymolysis, the rape pollen active peptide liquid of centrifugation.
Active Chinese drug component peptide of the present invention is with pumpkin seeds, the membrane of a chicken's gizzard, the root of kudzu vine, hedgehog skin, rhodiola root, aspongopus, mountain
One or more combination raw materials in medicine, the Radix Astragali, after being processed using traditional Chinese medicine concocted specification, through broken, homogenate, are steamed
The Chinese herbal medicine active peptide liquid boil, digest, being centrifuged.
Oligoisomaltose of the present invention is excipient or sweetener, is also feature prebiotics.
Grape seed extract of the present invention is OPC, is a kind of safe plant powerful antioxidant, can be reduced
Hydrochloric acid in gastric juice is to the destruction of peptide matters heightening the effect of a treatment.
The present invention is a kind of to prevent and treat rape pollen active peptide of prostatic disorders and preparation method thereof, it is characterised in that through following
Step is implemented：
1st, the preparation of rape pollen active peptide：Choosing the absolute oil cauliflower powder that dries fresh then carries out break process；Addition is broken
The water of 10-15 times of rape pollen weight is diluted immersion 30 minutes, crushes the rape pollen after homogenate and adjusts pH value 5-7, adds
Cellulase, pectase, neutral proteinase, papain（1:1:1:2）Multienzyme is digested, and enzyme dosage is every gram of rape flower
Powder adds 5000-10000 enzyme-activity unit（u）, between 50-60 degrees Celsius of temperature control, digest 3-6 hours；Enzymolysis finishes boiling
Hydro-thermal bath cools down centrifugation, centrifuge speed 4000-10000rpm or so after going out enzyme 10-20 minutes, obtains final product rape pollen active peptide
Liquid, places refrigeration standby.
2nd, the preparation of animality active Chinese drug component peptide：Animality Chinese medicine is weighed, break process after being processed by Chinese medicine preparation specification；
The pure water of broken 5-20 times of the animality Chinese medicine of addition is homogenized with historrhexis's machine, animality Chinese medicine homogenate digester
Cooled after boiling 40-90 minutes, collect upper strata grease and abandon.PH value 6-7 is adjusted into the homogenate of degreasing animality Chinese medicine, animality is added
The 1-5% proteolytic enzymes of Chinese medicine weight are digested, and between 50-60 degrees Celsius of temperature control, enzymolysis is added dynamic after 4-8 hours
The dusty yeast of physical property Chinese medicine weight 0.5-1% carries out deodorant, and temperature control stirs between 30-40 degrees Celsius, 1-2 hours
Centrifugation, centrifuge speed 8000-12000rpm or so are cooled down after boiling water heating bath is gone out enzyme 10-20 minutes afterwards, animality Chinese medicine is obtained final product
Active peptide liquid, places refrigeration standby.
3rd, the preparation of vegetalitas active Chinese drug component peptide：Vegetalitas Chinese medicine is weighed, break process after being processed by Chinese medicine preparation specification；
The water of addition broken 10-20 times of vegetalitas Chinese medicine cooled down after heating is boiled 60-90 minutes, is crossed 80 mesh sieves and is filtered off the dregs of a decoction, plus
Cellulase, pectase, papain（1:1:1）Multienzyme enzymolysis is carried out, enzyme dosage is every gram of vegetalitas Chinese medicine addition 3000-
8000 enzyme-activity units（u）, temperature control between 45-60 degrees Celsius, digest 2-4 hours；Enzymolysis finishes boiling water heating bath and goes out enzyme
Centrifugation, centrifuge speed 6000-10000rpm or so are cooled down after 10-20 minutes, vegetalitas active Chinese drug component peptide liquid is obtained final product, placed cold
Hide standby.
4th, allocate：Take animality active Chinese drug component peptide liquid, step that the rape pollen active peptide liquid, step 2 that step 1 obtains are obtained
The rapid 3 vegetalitas active Chinese drug component peptide liquid for obtaining, weighing oligoisomaltose powder and grape seed extract carries out compound allotment.
5th, deployed hybrid peptide liquid puts stainless steel cask and enters steam sterilization cabinet and carries out sterilization, and steam sterilization cabinet is warming up to 105-
120 degrees Celsius of sterilizations 15-40 minutes, can be filling into oral liquid product according to oral liquid process specification after cooling；Can be by
Hybrid peptide liquid is according to freeze dryer freeze-drying on the filling lyophilized bottle of lyophilized technique specification into bottled freeze-dried powder product；Can be by hybrid peptide
Liquid is spray-dried or freeze-drying is prepared into powdery granule, filling into capsule product by capsule manufacturing techniques specification.
Step 2 of the present invention, described proteolytic enzyme are trypsase, flavor protease, compound protease, Papain
One or more combination in enzyme, neutral proteinase.
The present invention is raw material from rape pollen, animals and plants Chinese herbal medicine, and a large amount of activity peptide components are generated by controlled enzymatic hydrolysis,
Its nutritive value and absorption rate and edible safety are greatly improved, anti-oxidant, anti-fatigue active enhancing, prevent and treat prostate
Effect of series of disease also accordingly strengthens, and alleviates the raw meat bitter taste of Chinese medicine, is aided with the oligomeric different malt with prebiotics title
Sugar, not only improves mouthfeel, also breeds gut flora, improves gastrointestinal function, promotes absorption.The vegetalitas of addition resists by force
Oxidant grape seed extract is effectively protected destruction of the peptide matters from hydrochloric acid in gastric juice, active ingredient is preferably absorbed profit
With.A kind of rape pollen active peptide for preventing and treating prostatic disorders of the present invention is filling lyophilized according to lyophilized technique specification by hybrid peptide liquid
Freeze dryer freeze-drying is into bottled freeze-dried powder product, the additive-free preservative of vacuum freeze drying, safe, shelf-life on bottle
It is long；Filling into oral liquid product according to oral liquid process specification, color is natural, distinctive natural flavour mountaineous good mouthfeel；Will
Hybrid peptide liquid is spray-dried or freeze-drying is prepared into powdery granule, filling into capsule product by capsule manufacturing techniques specification,
Take easy to carry.Preparation technology of the present invention is rigorous rationally, and strong operability is especially suitable for large-scale production.
Specific embodiment
With reference to embodiment, the present invention will be further described
Embodiment one, 1, the preparation of rape pollen active peptide liquid：The absolute oil cauliflower powder 20kg that dries fresh then is chosen to be broken
Broken treatment；The water of broken 10 times of the rape pollen weight of addition is diluted immersion 30 minutes, crushes the rape pollen after homogenate and adjusts
PH value 6, adds cellulase, pectase, neutral proteinase, papain（1:1:1:2）Multienzyme is digested, and enzyme dosage is
Every gram of rape pollen adds 9500 enzyme-activity units（u）, 50 degrees Celsius of temperature control, enzymolysis 4.5 hours；Enzymolysis finishes boiling water heat
Bathe the enzyme that goes out and centrifugation is cooled down after 10 minutes, centrifuge speed 9000rpm or so obtains final product rape pollen active peptide liquid, places refrigeration standby
With.
2nd, the preparation of animality active Chinese drug component peptide：Animality Chinese medicine hedgehog skin 5kg the membrane of a chicken's gizzard 5kg aspongopus 3kg are weighed, is pressed
Break process after the processing of Chinese medicine preparation specification；The pure water of broken 15 times of the animality Chinese medicine of addition is carried out even with historrhexis's machine
Slurry, cools after animality Chinese medicine homogenate digester is boiled 60 minutes, collects upper strata grease and abandons.By degreasing animality Chinese medicine
PH value 7 is adjusted in homogenate, adds trypsase, papain, flavor protease multienzyme（1:1:1）Multienzyme is digested, enzyme dosage
It is that every gram of animality Chinese medicine adds 8000 enzyme-activity units（u）, 55 degrees Celsius of temperature control, after digesting 6 hours, addition animality
The dusty yeast of Chinese medicine weight 1% carries out deodorant, and temperature control stirs between 40 degrees Celsius, and boiling water heating bath is gone out after 1.5 hours
Enzyme cools down centrifugation after 10 minutes, centrifuge speed 12000rpm or so obtains final product animality active Chinese drug component peptide liquid, places refrigeration standby
With.
3rd, the preparation of vegetalitas active Chinese drug component peptide：Vegetalitas root of kudzu vine 1.5kg rhodiola root 1.5kg pumpkin seeds 2kg Chinese medicines are weighed,
Break process after being processed by Chinese medicine preparation specification；The water of broken 20 times of the vegetalitas Chinese medicine of addition carries out cold after heating is boiled 90 minutes
But, the dregs of a decoction, plus cellulase, pectase, papain are filtered off with 80 mesh sieves（1:1:1）Multienzyme enzymolysis is carried out, enzyme dosage is
Every gram of vegetalitas Chinese medicine adds 5000 enzyme-activity units（u）, temperature control at 50 degrees Celsius, digest 3 hours；Enzymolysis finishes boiling water
The heating bath enzyme that goes out cools down centrifugation after 10 minutes, centrifuge speed 10000rpm or so obtains final product vegetalitas active Chinese drug component peptide liquid, places cold
Hide standby.
4th, allocate：Take animality active Chinese drug component peptide liquid, step that the rape pollen active peptide liquid, step 2 that step 1 obtains are obtained
The rapid 3 vegetalitas active Chinese drug component peptide liquid for obtaining, weighing oligoisomaltose powder 13kg grape seed extracts 2kg carries out compound tune
Match somebody with somebody.
5th, deployed hybrid peptide liquid puts stainless steel cask and enters steam sterilization cabinet and carries out sterilization, and steam sterilization cabinet is warming up to 120
Degree Celsius sterilization 20 minutes, after cooling can addition pure water it is filling into oral liquid product according to oral liquid process specification；
Can be by hybrid peptide liquid according to freeze dryer freeze-drying on the filling lyophilized bottle of lyophilized technique specification into bottled freeze-dried powder product；Can mix
Close the spray drying of peptide liquid or freeze-drying is prepared into powdery granule, it is filling into capsule product by capsule manufacturing techniques specification.
Embodiment two, 1, the preparation of rape pollen active peptide liquid：The absolute oil cauliflower powder 25kg that dries fresh then is chosen to enter
Row break process；The water of broken 8 times of the rape pollen weight of addition is diluted immersion 30 minutes, crushes the rape pollen after homogenate
PH value 6.5 is adjusted, cellulase, pectase, neutral proteinase, papain is added（1:1:1:2）Multienzyme is digested, and enzyme is used
Amount is that every gram of rape pollen adds 10000 enzyme-activity units（u）, 55 degrees Celsius of temperature control, enzymolysis 6 hours；Enzymolysis finishes boiling
Hydro-thermal is bathed the enzyme that goes out and centrifugation is cooled down after 15 minutes, and centrifuge speed 8000rpm or so obtains final product rape pollen active peptide liquid, places cold
Hide standby.
2nd, the preparation of animality active Chinese drug component peptide：Animality Chinese medicine hedgehog skin 6kg the membrane of a chicken's gizzard 6kg aspongopus 4kg are weighed, is pressed
Break process after the processing of Chinese medicine preparation specification；The pure water of broken 13 times of the animality Chinese medicine of addition is carried out even with historrhexis's machine
Slurry, cools after animality Chinese medicine homogenate digester is boiled 90 minutes, collects upper strata grease and abandons.By degreasing animality Chinese medicine
PH value 6.5 is adjusted in homogenate, adds compound protease, papain, flavor protease（1:1:1）Multienzyme is digested, enzyme dosage
It is that every gram of animality Chinese medicine adds 10000 enzyme-activity units（u）, 55 degrees Celsius of temperature control, enzymolysis is after 5.5 hours, and addition is dynamic
The dusty yeast of physical property Chinese medicine weight 1% carries out deodorant, and temperature control stirs at 40 degrees Celsius, and boiling water heating bath is gone out enzyme after 1 hour
Centrifugation, centrifuge speed 12000rpm or so are cooled down after 15 minutes, animality active Chinese drug component peptide liquid is obtained final product, refrigeration is placed standby.
3rd, the preparation of vegetalitas active Chinese drug component peptide：Weigh vegetalitas root of kudzu vine 2kg rhodiola root 2kg pumpkin seeds 2.5kg Chinese yams 2kg
Chinese medicine, break process after being processed by Chinese medicine preparation specification；The water of broken 15 times of the vegetalitas Chinese medicine of addition carries out heating and boils 60 points
Cooled down after clock, the dregs of a decoction, plus cellulase, pectase, papain are filtered off with 80 mesh sieves（1:1:1）Carry out multienzyme enzymolysis, enzyme
Consumption is that every gram of vegetalitas Chinese medicine adds 4000 enzyme-activity units（u）, temperature control at 45 degrees Celsius, digest 4 hours；Digest
Finish the boiling water heating bath enzyme that goes out and centrifugation cooled down after 10 minutes, centrifuge speed 7000rpm or so obtains final product vegetalitas active Chinese drug component peptide liquid,
Place refrigeration standby.
4th, allocate：Take animality active Chinese drug component peptide liquid, step that the rape pollen active peptide liquid, step 2 that step 1 obtains are obtained
The rapid 3 vegetalitas active Chinese drug component peptide liquid for obtaining, weigh oligoisomaltose powder 16kg, grape seed extract 2.5kg and are combined
Allotment.
5th, deployed hybrid peptide liquid puts stainless steel cask and enters steam sterilization cabinet and carries out sterilization, and steam sterilization cabinet is warming up to 115
Degree Celsius sterilization 40 minutes, after cooling can addition pure water it is filling into oral liquid product according to oral liquid process specification；
Can be by hybrid peptide liquid according to freeze dryer freeze-drying on the filling lyophilized bottle of lyophilized technique specification into bottled freeze-dried powder product；Can mix
Close the spray drying of peptide liquid or freeze-drying is prepared into powdery granule, it is filling into capsule product by capsule manufacturing techniques specification.
Embodiment three, 1, the preparation of rape pollen active peptide liquid：The absolute oil cauliflower powder 15kg that dries fresh then is chosen to enter
Row break process；The water of broken 15 times of the rape pollen weight of addition is diluted immersion 30 minutes, crushes the rape flower after homogenate
Powder adjusts pH value 6, adds cellulase, pectase, neutral proteinase, papain（1:1:1:2）Multienzyme is digested, and enzyme is used
Amount is that every gram of rape pollen adds 8000 enzyme-activity units（u）, 58 degrees Celsius of temperature control, enzymolysis 4.5 hours；Enzymolysis finishes boiling
Hydro-thermal is bathed the enzyme that goes out and centrifugation is cooled down after 12 minutes, and centrifuge speed 6000rpm or so obtains final product rape pollen active peptide liquid, places cold
Hide standby.
2nd, the preparation of animality active Chinese drug component peptide：Animality Chinese medicine hedgehog skin 4kg aspongopus 2.5kg are weighed, by Chinese medicine big gun
Break process after specification processing processed；The pure water of broken 12 times of the animality Chinese medicine of addition is homogenized with historrhexis's machine, dynamic
Physical property Chinese medicine homogenate digester is cooled after boiling 70 minutes, is collected upper strata grease and is abandoned.Degreasing animality Chinese medicine is homogenized and is adjusted
PH value 6, adds trypsase, papain, compound protease（1:1:1）Multienzyme is digested, and enzyme dosage is every gram of animal
Property Chinese medicine add 9000 enzyme-activity units（u）, 58 degrees Celsius of temperature control, after digesting 7 hours, addition animality Chinese medicine weight 1%
Dusty yeast carry out deodorant, temperature control stirs at 40 degrees Celsius, after 1 hour boiling water heating bath go out enzyme cooled down after 12 minutes from
The heart, centrifuge speed 11000rpm or so, obtain final product animality active Chinese drug component peptide liquid, place refrigeration standby.
3rd, the preparation of vegetalitas active Chinese drug component peptide：Vegetalitas root of kudzu vine 2kg pumpkin seeds 2.5kg Chinese medicines are weighed, by Chinese medicine preparation
Break process after specification processing；The water of addition broken 12 times of vegetalitas Chinese medicine cooled down after heating is boiled 55 minutes, uses 80 mesh
The dregs of a decoction, plus cellulase, pectase, papain are removed in sieving（1:1:2）Multienzyme enzymolysis is carried out, enzyme dosage is every gram of vegetalitas
Chinese medicine adds 3000 enzyme-activity units（u）, temperature control at 55 degrees Celsius, digest 2.5 hours；Enzymolysis finishes boiling water heating bath and goes out enzyme
Centrifugation, centrifuge speed 5000rpm or so are cooled down after 12 minutes, vegetalitas active Chinese drug component peptide liquid is obtained final product, refrigeration is placed standby.
4th, allocate：Take animality active Chinese drug component peptide liquid, step that the rape pollen active peptide liquid, step 2 that step 1 obtains are obtained
The rapid 3 vegetalitas active Chinese drug component peptide liquid for obtaining, weighing oligoisomaltose powder 9kg, grape seed extract 1.5kg carries out compound tune
Match somebody with somebody.
5th, deployed hybrid peptide liquid puts stainless steel cask and enters steam sterilization cabinet and carries out sterilization, and steam sterilization cabinet is warming up to 112
Degree Celsius sterilization 40 minutes, after cooling can addition pure water it is filling into oral liquid product according to oral liquid process specification；
Can be by hybrid peptide liquid according to freeze dryer freeze-drying on the filling lyophilized bottle of lyophilized technique specification into bottled freeze-dried powder product；Can mix
Close the spray drying of peptide liquid or freeze-drying is prepared into powdery granule, it is filling into capsule product by capsule manufacturing techniques specification.
Example IV, 1, the preparation of rape pollen active peptide liquid：The absolute oil cauliflower powder 18kg that dries fresh then is chosen to enter
Row break process；The water of broken 14 times of the rape pollen weight of addition is diluted immersion 30 minutes, crushes the rape flower after homogenate
Powder adjusts pH value 6, adds cellulase, pectase, neutral proteinase, papain（1:1:1:2）Multienzyme is digested, and enzyme is used
Amount is that every gram of rape pollen adds 8500 enzyme-activity units（u）, 56 degrees Celsius of temperature control, enzymolysis 3 hours；Enzymolysis finishes boiling water
The heating bath enzyme that goes out cools down centrifugation after 13 minutes, centrifuge speed 5000rpm or so obtains final product rape pollen active peptide liquid, places refrigeration
It is standby.
2nd, the preparation of animality active Chinese drug component peptide：Animality Chinese medicine hedgehog skin 4kg the membrane of a chicken's gizzard 3.5kg are weighed, by Chinese medicine big gun
Break process after specification processing processed；The pure water of broken 14 times of the animality Chinese medicine of addition is homogenized with historrhexis's machine, dynamic
Physical property Chinese medicine homogenate digester is cooled after boiling 50 minutes, is collected upper strata grease and is abandoned.Degreasing animality Chinese medicine is adjusted into pH value
6.5, add trypsase, neutral proteinase, flavor protease（1:1:1）Multienzyme is digested, and enzyme dosage is every gram of animality
Chinese medicine adds 9500 enzyme-activity units（u）, 55 degrees Celsius of temperature control, after digesting 7.5 hours, addition animality Chinese medicine weight 1%
Dusty yeast carry out deodorant, temperature control stirs at 40 degrees Celsius, after 1 hour boiling water heating bath go out enzyme cooled down after 15 minutes from
The heart, centrifuge speed 12000rpm or so, obtain final product animality active Chinese drug component peptide liquid, place refrigeration standby.
3rd, the preparation of vegetalitas active Chinese drug component peptide：Vegetalitas root of kudzu vine 2kg pumpkin seeds 2.5kg Radix Astragali 3kg Chinese medicines are weighed, in pressing
Break process after the processing of medicine concocted specification；The water of addition broken 16 times of vegetalitas Chinese medicine cooled down after heating is boiled 75 minutes,
The dregs of a decoction, plus cellulase, pectase are filtered off with 80 mesh sieves（1:1）Double enzyme enzymolysis are carried out, enzyme dosage is that every gram of vegetalitas Chinese medicine adds
Plus 3500 enzyme-activity units（u）, temperature control at 58 degrees Celsius, digest 2.5 hours；Enzymolysis finishes boiling water heating bath and goes out enzyme 10 minutes
Cooling centrifugation afterwards, centrifuge speed 4000rpm or so, obtain final product vegetalitas active Chinese drug component peptide liquid, place refrigeration standby.
4th, allocate：Take animality active Chinese drug component peptide liquid, step that the rape pollen active peptide liquid, step 2 that step 1 obtains are obtained
The rapid 3 vegetalitas active Chinese drug component peptide liquid for obtaining, weigh oligoisomaltose powder 12kg, grape seed extract 1.8kg and are combined
Allotment.
5th, deployed hybrid peptide liquid puts stainless steel cask and enters steam sterilization cabinet and carries out sterilization, and steam sterilization cabinet is warming up to 113
Degree Celsius sterilization 40 minutes, after cooling can addition pure water it is filling into oral liquid product according to oral liquid process specification；
Can be by hybrid peptide liquid according to freeze dryer freeze-drying on the filling lyophilized bottle of lyophilized technique specification into bottled freeze-dried powder product；Can mix
Close the spray drying of peptide liquid or freeze-drying is prepared into powdery granule, it is filling into capsule product by capsule manufacturing techniques specification.
Embodiment five, 1, the preparation of rape pollen active peptide liquid：The absolute oil cauliflower powder 16kg that dries fresh then is chosen to enter
Row break process；The water of broken 13 times of the rape pollen weight of addition is diluted immersion 30 minutes, crushes the rape flower after homogenate
Powder adjusts pH value 6, adds cellulase, pectase, neutral proteinase, papain（1:1:1:2）Multienzyme is digested, and enzyme is used
Amount is that every gram of rape pollen adds 8000 enzyme-activity units（u）, 52 degrees Celsius of temperature control, enzymolysis 4.5 hours；Enzymolysis finishes boiling
Hydro-thermal is bathed the enzyme that goes out and centrifugation is cooled down after 13 minutes, and centrifuge speed 5000rpm or so obtains final product rape pollen active peptide liquid, places cold
Hide standby.
2nd, the preparation of animality active Chinese drug component peptide：Animality Chinese medicine the membrane of a chicken's gizzard 3kg, aspongopus 3kg are weighed, by Chinese medicine preparation
Break process after specification processing；The pure water of broken 15 times of the animality Chinese medicine of addition is homogenized with historrhexis's machine, animal
Property Chinese medicine homogenate digester is cooled after boiling 55 minutes, is collected upper strata grease and is abandoned.Degreasing animality Chinese medicine is adjusted into pH value
6.5, add neutral proteinase, papain, flavor protease multienzyme（1:1:1）Multienzyme is digested, and enzyme dosage is every gram
Animality Chinese medicine adds 8000 enzyme-activity units（u）, 57 degrees Celsius of temperature control, after digesting 6.5 hours, addition animality Chinese medicine
The dusty yeast of weight 1% carries out deodorant, and temperature control stirs in 36 degrees Celsius, and boiling water heating bath went out enzyme after 15 minutes after 1 hour
Cooling centrifugation, centrifuge speed 10000rpm or so, obtain final product animality active Chinese drug component peptide liquid, place refrigeration standby.
3rd, the preparation of vegetalitas active Chinese drug component peptide：Vegetalitas pumpkin seeds 5kg root of kudzu vine 3.5kg Chinese medicines are weighed, by Chinese medicine preparation
Break process after specification processing；The water of addition broken 15 times of vegetalitas Chinese medicine cooled down after heating is boiled 80 minutes, uses 80 mesh
The dregs of a decoction, plus cellulase, pectase, papain are removed in sieving（1:1:1）Multienzyme enzymolysis is carried out, enzyme dosage is every gram of vegetalitas
Chinese medicine adds 3000 enzyme-activity units（u）, temperature control at 50 degrees Celsius, digest 2 hours；Enzymolysis finishes boiling water heating bath and goes out enzyme 10
Centrifugation, centrifuge speed 5000rpm or so are cooled down after minute, vegetalitas active Chinese drug component peptide liquid is obtained final product, refrigeration is placed standby.
4th, allocate：Take animality active Chinese drug component peptide liquid, step that the rape pollen active peptide liquid, step 2 that step 1 obtains are obtained
The rapid 3 vegetalitas active Chinese drug component peptide liquid for obtaining, weigh oligoisomaltose powder 10kg, grape seed extract 1.2kg and are combined
Allotment.
5th, deployed hybrid peptide liquid puts stainless steel cask and enters steam sterilization cabinet and carries out sterilization, and steam sterilization cabinet is warming up to 112
Degree Celsius sterilization 40 minutes, after cooling can addition pure water it is filling into oral liquid product according to oral liquid process specification；
Can be by hybrid peptide liquid according to freeze dryer freeze-drying on the filling lyophilized bottle of lyophilized technique specification into bottled freeze-dried powder product；Can mix
Close the spray drying of peptide liquid or freeze-drying is prepared into powdery granule, it is filling into capsule product by capsule manufacturing techniques specification.
Embodiment six, 1, the preparation of rape pollen active peptide liquid：The absolute oil cauliflower powder 12kg that dries fresh then is chosen to enter
Row break process；The water of broken 12 times of the rape pollen weight of addition is diluted immersion 30 minutes, crushes the rape flower after homogenate
Powder adjusts pH value 6, adds cellulase, pectase, neutral proteinase, papain（1:1:1:2）Multienzyme is digested, and enzyme is used
Amount is that every gram of rape pollen adds 7500 enzyme-activity units（u）, 50 degrees Celsius of temperature control, enzymolysis 5 hours；Enzymolysis finishes boiling water
The heating bath enzyme that goes out cools down centrifugation after 13 minutes, centrifuge speed 6000rpm or so obtains final product rape pollen active peptide liquid, places refrigeration
It is standby.
2nd, the preparation of animality active Chinese drug component peptide：Weigh animality Chinese medicine hedgehog skin 3kg, aspongopus 2kg and press Chinese medicine preparation
Break process after specification processing；The pure water of broken 12 times of the animality Chinese medicine of addition is homogenized with historrhexis's machine, animal
Property Chinese medicine homogenate digester is cooled after boiling 60 minutes, is collected upper strata grease and is abandoned.Degreasing animality Chinese medicine is adjusted into pH value
6.5, add compound protease, trypsase, flavor protease（1:1:1）Multienzyme is digested, and enzyme dosage is every gram of animality
Chinese medicine adds 8000 enzyme-activity units（u）, 57 degrees Celsius of temperature control, after digesting 6. hours, addition animality Chinese medicine weight 1%
Dusty yeast carry out deodorant, temperature control stirs at 40 degrees Celsius, after 1 hour boiling water heating bath go out enzyme cooled down after 15 minutes from
The heart, centrifuge speed 9000rpm or so, obtain final product animality active Chinese drug component peptide liquid, place refrigeration standby.
3rd, the preparation of vegetalitas active Chinese drug component peptide：Vegetalitas pumpkin seeds 3.5kg rhodiola root 2.5kg Chinese medicines are weighed, by Chinese medicine
Break process after concocted specification processing；The water of addition broken 15 times of vegetalitas Chinese medicine cooled down after heating is boiled 80 minutes, is used
80 mesh sieves filter off the dregs of a decoction, plus cellulase, pectase, papain（1:1:1）Multienzyme enzymolysis is carried out, enzyme dosage is every gram of plant
Physical property Chinese medicine adds 3500 enzyme-activity units（u）, temperature control at 50 degrees Celsius, digest 2.5 hours；Enzymolysis finishes boiling water heating bath
The enzyme that goes out cools down centrifugation after 10 minutes, centrifuge speed 5000rpm or so obtains final product vegetalitas active Chinese drug component peptide liquid, places refrigeration standby
With.
4th, allocate：Take animality active Chinese drug component peptide liquid, step that the rape pollen active peptide liquid, step 2 that step 1 obtains are obtained
The rapid 3 vegetalitas active Chinese drug component peptide liquid for obtaining, weighing oligoisomaltose powder 8.5kg, grape seed extract 1kg carries out compound tune
Match somebody with somebody.
5th, deployed hybrid peptide liquid puts stainless steel cask and enters steam sterilization cabinet and carries out sterilization, and steam sterilization cabinet is warming up to 110
Degree Celsius sterilization 40 minutes, after cooling can addition pure water it is filling into oral liquid product according to oral liquid process specification；
Can be by hybrid peptide liquid according to freeze dryer freeze-drying on the filling lyophilized bottle of lyophilized technique specification into bottled freeze-dried powder product；Can mix
Close the spray drying of peptide liquid or freeze-drying is prepared into powdery granule, it is filling into capsule product by capsule manufacturing techniques specification.
A kind of rape pollen active peptide for preventing and treating prostatic disorders prepared by the present invention is by hybrid peptide liquid according to lyophilized technique
Into bottled freeze-dried powder product, the additive-free preservative of vacuum freeze drying is pacified for freeze dryer freeze-drying on the filling lyophilized bottle of specification
Quan Xinggao, long shelf-life；Addition pure water is filling into oral liquid product according to oral liquid process specification, and color is natural, special
The natural flavour mountaineous good mouthfeel having；The spray drying of hybrid peptide liquid or freeze-drying are prepared into powdery granule, by capsule manufacture
Technological specification is filling into capsule product, takes easy to carry.Present invention composition takes Traditional Chinese Medicine formula and rigorous Chinese medicine preparation
Specification, is prepared from the advanced processing technology of modern biotechnology, and its operation scientific and precise is reasonable, strong operability, very
It is adapted to large-scale production.
Claims (9)
1. a kind of to prevent and treat rape pollen active peptide of prostatic disorders and preparation method thereof, it is characterized in that including rape flower
Powder active peptide, active Chinese drug component peptide, oligoisomaltose composition, the percentage by weight of its component are respectively：Rape pollen active peptide
40%-60%;Active Chinese drug component peptide 5%-20%；Oligoisomaltose 5%-15%；Composition weight percentage described in grape seed extract 1%-5%
It is 100% than sum.
2. according to claim 1 it is of the invention it is a kind of prevent and treat rape pollen active peptide of prostatic disorders and preparation method thereof,
It is characterized in that：Described rape pollen active peptide is with rape pollen as raw material, through what is crushed, be homogenized, digest, be centrifuged
Rape pollen active peptide liquid.
3. according to claim 1 it is of the invention it is a kind of prevent and treat rape pollen active peptide of prostatic disorders and preparation method thereof,
It is characterized in that：Described active Chinese drug component peptide be with pumpkin seeds, the membrane of a chicken's gizzard, the root of kudzu vine, hedgehog skin, rhodiola root, aspongopus, Chinese yam,
One or more combination raw materials in the Radix Astragali, after being processed using traditional Chinese medicine concocted specification, through broken, homogenate, boiling,
Enzymolysis, the Chinese herbal medicine active peptide liquid of centrifugation.
4. according to claim 1 it is of the invention it is a kind of prevent and treat rape pollen active peptide of prostatic disorders and preparation method thereof,
It is characterized in that：Described oligoisomaltose is excipient or sweetener, is also feature prebiotics.
5. according to claim 1 it is of the invention it is a kind of prevent and treat rape pollen active peptide of prostatic disorders and preparation method thereof,
It is characterized in that：Described grape seed extract is OPC, is a kind of safe plant powerful antioxidant, can reduce hydrochloric acid in gastric juice
To the destruction of peptide matters heightening the effect of a treatment.
6. a kind of rape pollen active peptide for preventing and treating prostatic disorders of the present invention and its preparation side according to claim 1-5
Method, it is characterised in that by the following steps：
（1）, rape pollen active peptide preparation：Choosing the absolute oil cauliflower powder that dries fresh then carries out break process；Addition is broken
The water of broken 10-15 times of rape pollen weight is diluted immersion 30 minutes, crushes the rape pollen after homogenate and adjusts pH value 5-7, plus
Enter cellulase, pectase, neutral proteinase, papain（1:1:1:2）Multienzyme is digested, and enzyme dosage is every gram of rape
Pollen adds 5000-10000 enzyme-activity unit（u）, between 50-60 degrees Celsius of temperature control, digest 3-6 hours；Enzymolysis is finished
Boiling water heating bath cools down centrifugation, centrifuge speed 4000-10000rpm or so after going out enzyme 10-20 minutes, obtains final product rape pollen activity
Peptide liquid, places refrigeration standby；
（2）, animality active Chinese drug component peptide preparation：Animality Chinese medicine is weighed, break process after being processed by Chinese medicine preparation specification；Add
Plus the pure water of broken 10-15 times of animality Chinese medicine is homogenized with historrhexis's machine, animality Chinese medicine homogenate digester
Cooled after boiling 40-90 minutes, collect upper strata grease and abandon；
PH value 6-8 is adjusted into the homogenate of degreasing animality Chinese medicine, adds proteolytic enzyme to be digested, during enzyme dosage is every gram of animality
Medicine adds 5000-10000 enzyme-activity unit（u）, between 50-60 degrees Celsius of temperature control, enzymolysis adds animal after 4-8 hours
The dusty yeast of property Chinese medicine weight 0.5-1% carries out deodorant, and temperature control stirs between 30-40 degrees Celsius, after 1-2 hours
Boiling water heating bath cools down centrifugation, centrifuge speed 8000-12000rpm or so after going out enzyme 10-20 minutes, obtains final product the work of animality Chinese medicine
Property peptide liquid, place refrigeration it is standby；
（3）, vegetalitas active Chinese drug component peptide preparation：Vegetalitas Chinese medicine is weighed, break process after being processed by Chinese medicine preparation specification；Add
Plus the water of broken 10-20 times of vegetalitas Chinese medicine cooled down after heating is boiled 60-90 minutes, cross 80 mesh sieves and filter off the dregs of a decoction, plus it is fine
The plain enzyme of dimension, pectase, papain（1:1:1）Multienzyme enzymolysis is carried out, enzyme dosage is every gram of vegetalitas Chinese medicine addition 3000-
8000 enzyme-activity units（u）, temperature control between 45-60 degrees Celsius, digest 2-4 hours；Enzymolysis finishes boiling water heating bath and goes out enzyme
Centrifugation, centrifuge speed 6000-10000rpm or so are cooled down after 10-20 minutes, vegetalitas active Chinese drug component peptide liquid is obtained final product, placed cold
Hide standby；
（4）, allotment：Take step（1）Rape pollen active peptide liquid, the step for obtaining（2）The animality active Chinese drug component peptide liquid that obtains,
Step（3）The vegetalitas active Chinese drug component peptide liquid for obtaining, weighing oligoisomaltose powder and grape seed extract carries out compound allotment；
（5）, deployed mixed active peptide liquid put stainless steel cask and enter steam sterilization cabinet and carry out sterilization, steam sterilization cabinet is warming up to
105-120 degrees Celsius of sterilization 15-40 minutes, after cooling can addition pure water it is filling into mouth according to oral liquid process specification
Take liquid product；Hybrid peptide liquid can be produced according to freeze dryer freeze-drying on the filling lyophilized bottle of lyophilized technique specification into bottled freeze-dried powder
Product；The spray drying of hybrid peptide liquid or freeze-drying can be prepared into powdery granule, by the filling plastic of capsule manufacturing techniques specification
Capsule product.
7. it is according to claim 6 it is a kind of prevent and treat rape pollen active peptide of prostatic disorders and preparation method thereof, it is special
Levy and be：Cellulase, pectase, neutral proteinase, four kinds of enzymes of papain of described enzymolysis rape pollen, its composition
Weight ratio is 1：1：1：2.
8. it is according to claim 6 it is a kind of prevent and treat rape pollen active peptide of prostatic disorders and preparation method thereof, it is special
Levy and be：The proteolytic enzyme of described enzymolysis animality Chinese medicine is trypsase, flavor protease, compound protease, pawpaw
One or more combination in protease, neutral proteinase.
9. it is according to claim 6 it is a kind of prevent and treat rape pollen active peptide of prostatic disorders and preparation method thereof, it is special
Levy and be：The cellulase of described enzymolysis of plants Chinese medicine, pectase, three kinds of enzymes of papain, its composition weight ratio be
1：1：1.
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Application publication date: 20170620 |