CN106860505A - A kind of medicine for preventing and treating porcine contagious pleuropneumonia - Google Patents
A kind of medicine for preventing and treating porcine contagious pleuropneumonia Download PDFInfo
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Abstract
The invention mainly relates to cultural technique field, a kind of medicine for preventing and treating porcine contagious pleuropneumonia is disclosed, be made up of following raw material：Egg shell, tip or stalactite, marmor serpentinatum, Tilmicosin pre-mixing agent, florfenicol powder, Carbaspirin calcium powder, asafoetide extract, peanut coat extract, lentinan, beta glucan, elemene, glycine betaine, brewer's yeast；There is preferable prevention effect to porcine contagious pleuropneumonia, the incidence of porcine contagious pleuropneumonia is down to 0%, cure rate reaches 98%, reduces the use of antibiotic, saves aquaculture cost, the income of cultivation peasant household is improved 11.4%；Medicine adds egg shell, is extracted together with tip or stalactite and marmor serpentinatum, increases multiple nutritional components, promote absorption of the pig to nutrient, improve the resistance against diseases of pig, reduce the generation of various diseases, the quality and mouthfeel of pork are improved, increases the income of raiser.
Description
Technical field
The invention mainly relates to cultural technique field, more particularly to a kind of medicine for preventing and treating porcine contagious pleuropneumonia.
Background technology
Porcine contagious pleuropneumonia is a kind of highly infectious breathing problem for causing pig by Actinobacillus pleuropneumoniae,
It is characterized with acute hemorrhagic cellulosic pleuropneumonia and chronic fibro disposition necrotizing pleuropneumonia, is a kind of worldwide disease
Disease, acute to break out swinery, morbidity and mortality are generally 50% or so, and the death rate of most acute is given up to 80~100%
Cultivation peasant household causes very big economic loss.
Current porcine contagious pleuropneumonia is treated using antibiotic mostly, it is impossible to play prevention effect, substantial amounts of anti-
Raw element easily makes germ develop immunity to drugs, and therapeutic effect is gradually deteriorated, and residual can be also caused in pig body, influences pork quality,
Harm can also be produced to human body.
The content of the invention
In order to make up the defect of prior art, it is an object of the invention to provide a kind of medicine for preventing and treating porcine contagious pleuropneumonia
Thing.
A kind of medicine for preventing and treating porcine contagious pleuropneumonia, is made up of the raw material of following weight portion：Egg shell 72 ~ 74, goose
Pipe stone 56 ~ 58, marmor serpentinatum 51 ~ 53, Tilmicosin pre-mixing agent 2.4 ~ 2.6, florfenicol powder 2.1 ~ 2.3, Carbaspirin calcium powder 2.1
~ 2.3, asafoetide extract 1.6 ~ 1.8, peanut coat extract 1.6 ~ 1.8, lentinan 0.23 ~ 0.25, beta glucan 0.23 ~
0.25th, elemene 0.07 ~ 0.09, glycine betaine 0.06 ~ 0.08, brewer's yeast 3 ~ 5.
Described egg shell, is the egg shell of generation after green shell hatching of breeding eggs.
Described asafoetide extract, asafoetide is crushed to, and is placed in temperature for 40 ~ 45 DEG C, mass concentration are 1.3 ~ 1.5%
Soaked 30 ~ 40 minutes in edible alkali solution, remove stink, cleaned with clear water, add 70 ~ 80 times of water of amount of asafoetide weight, heating
It is original 1/20 to be concentrated into volume, crosses and filters precipitation, and it is 4 ~ 6% that filtrate is dried to water content, obtains asafoetide extract.
Described peanut coat extract, peanut coat is fried to burnt odor, adds 60 ~ 70 times of volume fractions of amount of peanut coat weight
It is 3 ~ 4% acetum, in 32 ~ 34kHz ultrasounds 40 ~ 50 minutes, heating was boiled, and it is original 1/15 to be concentrated into volume, filtering
It is 7 ~ 9% by freeze-drying to water content except precipitation, obtains peanut coat extract.
Described lentinan, purity is 96 ~ 100%.
Described brewer's yeast, activated, viable count is 109~1010CFU/ml。
A kind of preparation method of the medicine for preventing and treating porcine contagious pleuropneumonia, specifically includes following steps：
（1）Egg shell is crushed, 80 ~ 90 DEG C is placed in and is stir-fried 10 ~ 15 minutes, obtain stir-fry egg-shell meal；
（2）Tip or stalactite and marmor serpentinatum are crushed to 80 ~ 100 mesh, in after 160 ~ 170 DEG C of calcinations 12 ~ 14 minutes, goose pipe are added immediately
3 ~ 4 times of temperature of amount of stone weight are 1 ~ 10 DEG C of water, are stirred, and naturally cool to room temperature, obtain stone flour slurry；
（3）Egg-shell meal will be fried and add stone flour slurry, be slowly added to the vinegar that 100 ~ 120 times of volume fractions of amount of egg shell weight are for 7 ~ 9%
Acid solution, in 40 ~ 45 DEG C, 36 ~ 38kHz ultrasounds 20 ~ 25 minutes, heating boils that to be concentrated into volume be original 1/15, increases various
Nutritional ingredient, promotes absorption of the pig to nutrient, improves the resistance against diseases of pig, reduces the generation of various diseases, and filtering must be carried
Take liquid；
（4）Asafoetide extract and peanut coat extract are added into extract solution, is well mixed, add brewer's yeast, it is quiet in 20 ~ 22 DEG C
Put fermentation 3 ~ 4 days, promote each composition fusion, improve the performance of drug effect, be heated to 60 ~ 70 DEG C, be incubated 25 ~ 30 minutes, must ferment
Liquid；
（5）Lentinan, beta glucan, elemene and glycine betaine are added into zymotic fluid, is stirred to being completely dissolved, freeze-drying is extremely
Water content is 8 ~ 10%, obtains mixed powder；
（6）Tilmicosin pre-mixing agent, florfenicol powder and Carbaspirin calcium powder are added into mixed powder, effect complements each other, promoted
The performance of each composition drug effect, can provide nutrition, also can antibacterial sterilization, kill pathogenic microorganism, strengthen pig resistance against diseases, keep away
Exempt to develop immunity to drugs antibiotic and antibiotic residue, improve the quality and mouthfeel of pork, be well mixed, obtain preventing and treating pig transmissible
The medicine of pleuropneumonia；
（7）Vacuum packaging, inspection, obtains finished product.
The application method of the medicine of the preventing and treating porcine contagious pleuropneumonia, will prevent and treat the medicine of porcine contagious pleuropneumonia
Pig feed is added, is well mixed, addition is the piglet at 0.3 ~ 0.4%, 2 weeks ~ 7 monthly ages of pig feed weight, every 2 ~ 3 days
Addition once, August and the pig after August age, addition in every 4 ~ 5 days is once.
It is an advantage of the invention that：The medicine of a kind of preventing and treating porcine contagious pleuropneumonia that the present invention is provided, to pig transmissible
Pleuropneumonia has preferable prevention effect, the incidence of porcine contagious pleuropneumonia is down to 0%, and cure rate reaches 98%, subtracts
The use of few antibiotic, saves aquaculture cost, the income of cultivation peasant household is improved 11.4%；Medicine adds egg shell, with goose
Guan Shi and marmor serpentinatum are extracted repeatedly together, and recovery rate improves 27.3%, increase multiple nutritional components, promote pig to nutrition unit
The absorption of element, improves the resistance against diseases of pig, reduces the generation of various diseases；Various plants extract is added, with a small amount of antibiotic
Compatibility, effect complements each other, and promotes the performance of each composition drug effect, can provide nutrition, also can antibacterial sterilization, the killing micro- life of cause of disease
Thing, strengthens the resistance against diseases of pig, reduces the generation of porcine contagious pleuropneumonia, it is to avoid antibiotic is developed immunity to drugs and antibiotic
Residual, improves the quality and mouthfeel of pork, increases the income of raiser.
Specific embodiment
Below the present invention is illustrated with specific embodiment.
Embodiment 1
A kind of medicine for preventing and treating porcine contagious pleuropneumonia, is made up of the raw material of following weight portion：Egg shell 72, tip or stalactite 56,
Marmor serpentinatum 51, Tilmicosin pre-mixing agent 2.4, florfenicol powder 2.1, Carbaspirin calcium powder 2.1, asafoetide extract 1.6, peanut coat
Extract 1.6, lentinan 0.23, beta glucan 0.23, elemene 0.07, glycine betaine 0.06, brewer's yeast 3.
Described egg shell, is the egg shell of generation after green shell hatching of breeding eggs.
Described asafoetide extract, asafoetide is crushed to, be placed in temperature for 40 ~ 45 DEG C, mass concentration be 1.3% it is edible
Soaked 30 minutes in aqueous slkali, remove stink, cleaned with clear water, add 70 times of water of amount of asafoetide weight, heating is concentrated into volume
It is original 1/20, crosses and filter precipitation, it is 4 ~ 6% that filtrate is dried to water content, obtains asafoetide extract.
Described peanut coat extract, peanut coat is fried to burnt odor, and the volume fraction for adding 60 times of amounts of peanut coat weight is
3% acetum, ultrasonic 40 minutes in 32kHz, heating is boiled, and it is original 1/15 to be concentrated into volume, is crossed and is filtered precipitation, will
Freeze-drying to water content is 7 ~ 9%, obtains peanut coat extract.
Described lentinan, purity is 96 ~ 100%.
Described brewer's yeast, activated, viable count is 109~1010CFU/ml。
A kind of preparation method of the medicine for preventing and treating porcine contagious pleuropneumonia, specifically includes following steps：
（1）Egg shell is crushed, 80 ~ 90 DEG C is placed in and is stir-fried 15 minutes, obtain stir-fry egg-shell meal；
（2）Tip or stalactite and marmor serpentinatum are crushed to 80 mesh, in after 170 DEG C of calcinations 14 minutes, adding 4 times of amounts of tip or stalactite weight immediately
Temperature be 5 DEG C of water, stir, naturally cool to room temperature, obtain stone flour slurry；
（3）Egg-shell meal will be fried and add stone flour slurry, be slowly added to the acetic acid that 120 times of volume fractions measured of egg shell weight are 9% molten
Liquid, in 45 DEG C, 36kHz ultrasounds 25 minutes, heating is boiled and is concentrated into volume for original 1/15, increases multiple nutritional components, is promoted
Absorption of the pig to nutrient, improves the resistance against diseases of pig, reduces the generation of various diseases, and filtering obtains extract solution；
（4）Asafoetide extract and peanut coat extract are added into extract solution, is well mixed, add brewer's yeast, in 22 DEG C of standings
Fermentation 4 days, promotes each composition fusion, improves the performance of drug effect, is heated to 70 DEG C, is incubated 25 minutes, obtains zymotic fluid；
（5）Lentinan, beta glucan, elemene and glycine betaine are added into zymotic fluid, is stirred to being completely dissolved, freeze-drying is extremely
Water content is 8 ~ 10%, obtains mixed powder；
（6）Tilmicosin pre-mixing agent, florfenicol powder and Carbaspirin calcium powder are added into mixed powder, effect complements each other, promoted
The performance of each composition drug effect, can provide nutrition, also can antibacterial sterilization, kill pathogenic microorganism, strengthen pig resistance against diseases, keep away
Exempt to develop immunity to drugs antibiotic and antibiotic residue, improve the quality and mouthfeel of pork, be well mixed, obtain preventing and treating pig transmissible
The medicine of pleuropneumonia；
（7）Vacuum packaging, inspection, obtains finished product.
The application method of the medicine of the preventing and treating porcine contagious pleuropneumonia, will prevent and treat the medicine of porcine contagious pleuropneumonia
Pig feed is added, is well mixed, addition is the 0.3% of pig feed weight, the piglet at 2 weeks ~ 7 monthly ages, added within every 2 ~ 3 days
Once, August and the pig after August age, addition in every 4 ~ 5 days is once.
Embodiment 2
A kind of medicine for preventing and treating porcine contagious pleuropneumonia, is made up of the raw material of following weight portion：Egg shell 73, tip or stalactite 57,
Marmor serpentinatum 52, Tilmicosin pre-mixing agent 2.5, florfenicol powder 2.2, Carbaspirin calcium powder 2.2, asafoetide extract 1.7, peanut coat
Extract 1.7, lentinan 0.25, beta glucan 0.24, elemene 0.08, glycine betaine 0.07, brewer's yeast 4.
Described egg shell, is the egg shell of generation after green shell hatching of breeding eggs.
Described asafoetide extract, asafoetide is crushed to, be placed in temperature for 40 ~ 45 DEG C, mass concentration be 1.4% it is edible
Soaked 35 minutes in aqueous slkali, remove stink, cleaned with clear water, add 75 times of water of amount of asafoetide weight, heating is concentrated into volume
It is original 1/20, crosses and filter precipitation, it is 4 ~ 6% that filtrate is dried to water content, obtains asafoetide extract.
Described peanut coat extract, peanut coat is fried to burnt odor, and the volume fraction for adding 65 times of amounts of peanut coat weight is
3.5% acetum, ultrasonic 45 minutes in 33kHz, heating is boiled, and it is original 1/15 to be concentrated into volume, is crossed and is filtered precipitation,
It is 7 ~ 9% by freeze-drying to water content, obtains peanut coat extract.
Described lentinan, purity is 96 ~ 100%.
Described brewer's yeast, activated, viable count is 109~1010CFU/ml。
Preparation and application, with embodiment 1.
Embodiment 3
A kind of medicine for preventing and treating porcine contagious pleuropneumonia, is made up of the raw material of following weight portion：Egg shell 74, tip or stalactite 58,
Marmor serpentinatum 53, Tilmicosin pre-mixing agent 2.6, florfenicol powder 2.3, Carbaspirin calcium powder 2.3, asafoetide extract 1.8, peanut coat
Extract 1.8, lentinan 0.25, beta glucan 0.25, elemene 0.09, glycine betaine 0.08, brewer's yeast 5.
Described egg shell, is the egg shell of generation after green shell hatching of breeding eggs.
Described asafoetide extract, asafoetide is crushed to, be placed in temperature for 40 ~ 45 DEG C, mass concentration be 1.5% it is edible
Soaked 40 minutes in aqueous slkali, remove stink, cleaned with clear water, add 80 times of water of amount of asafoetide weight, heating is concentrated into volume
It is original 1/20, crosses and filter precipitation, it is 4 ~ 6% that filtrate is dried to water content, obtains asafoetide extract.
Described peanut coat extract, peanut coat is fried to burnt odor, and the volume fraction for adding 70 times of amounts of peanut coat weight is
4% acetum, ultrasonic 50 minutes in 34kHz, heating is boiled, and it is original 1/15 to be concentrated into volume, is crossed and is filtered precipitation, will
Freeze-drying to water content is 7 ~ 9%, obtains peanut coat extract.
Described lentinan, purity is 96 ~ 100%.
Described brewer's yeast, activated, viable count is 109~1010CFU/ml。
Preparation and application, with embodiment 1.
Comparative example 1
Removal egg shell, tip or stalactite and marmor serpentinatum, remaining preparation and application, with embodiment 1.
Comparative example 2
Removal Tilmicosin pre-mixing agent, florfenicol powder and Carbaspirin calcium powder, remaining preparation and application, with embodiment 1.
Comparative example 2
Removal asafoetide extract and peanut coat extract, remaining preparation and application, with embodiment 1.
Comparative example 3
Removal lentinan, beta glucan, elemene and glycine betaine, remaining preparation and application, with embodiment 1.
Comparative example 4
Removal brewer's yeast and step（4）Fermentation, remaining preparation and application, with embodiment 1.
Comparative example 5
Removal step（1）Stir-fry, remaining preparation and application, with embodiment 1.
Comparative example 6
Removal step（2）Calcination, remaining preparation and application, with embodiment 1.
Comparative example 7
Removal step（4）Heating and insulation, remaining preparation and application, with embodiment 1.
Comparative example 8
The medicaments Ospen of existing conventional control porcine contagious pleuropneumonia.
The prevention effect of the medicine of embodiment and comparative example preventing and treating porcine contagious pleuropneumonia：
Healthy, the sizable 3 monthly age piglet 1100 of random selection, is randomly divided into 11 groups, every group 100, respectively to each group
The piglet feeding group medicine, carry out feeding according to the application method of each medicine, free water, other management methods are identical,
The tested time is 120 days, records the sick situation of piglet, and random selection is suitable with porcine contagious pleuropneumonia 2 days, symptom
10 monthly age pigs 1100, are randomly divided into 11 groups, every group 100, are treated with the medicine of embodiment and comparative example respectively, record
The prevention effect of the medicine of the cure rate of porcine contagious pleuropneumonia, embodiment and comparative example preventing and treating porcine contagious pleuropneumonia is shown in
Table 1.
Table 1：The prevention effect of the medicine of embodiment and comparative example preventing and treating porcine contagious pleuropneumonia
| Project | Pleuropneumonia rate/(%) | Cure rate/(%) | Brickpox rate/(%) | Antibiotic |
| Embodiment 1 | 0 | 97 | 3 | Do not detect |
| Embodiment 2 | 0 | 98 | 3 | Do not detect |
| Embodiment 3 | 1 | 97 | 5 | Do not detect |
| Comparative example 1 | 9 | 86 | 11 | Do not detect |
| Comparative example 2 | 7 | 89 | 8 | Do not detect |
| Comparative example 3 | 9 | 87 | 10 | Do not detect |
| Comparative example 4 | 6 | 91 | 9 | Do not detect |
| Comparative example 5 | 6 | 89 | 7 | Do not detect |
| Comparative example 6 | 5 | 87 | 8 | Do not detect |
| Comparative example 7 | 5 | 92 | 7 | Do not detect |
| Comparative example 8 | 2 | 93 | 4 | Detection |
From the results shown in Table 1, the medicine of the preventing and treating porcine contagious pleuropneumonia of embodiment, porcine contagious pleuropneumonia rate
Substantially low compared with comparative example with brickpox rate, porcine contagious pleuropneumonia cure rate is substantially high compared with comparative example, is not detected in pork residual
The antibiotic for staying, illustrating the medicine of the preventing and treating porcine contagious pleuropneumonia of present invention offer has preferable prevention effect.
Claims (8)
1. it is a kind of prevent and treat porcine contagious pleuropneumonia medicine, it is characterised in that be made up of the raw material of following weight portion：Egg shell
72 ~ 74, tip or stalactite 56 ~ 58, marmor serpentinatum 51 ~ 53, Tilmicosin pre-mixing agent 2.4 ~ 2.6, florfenicol powder 2.1 ~ 2.3, kappa
Woods calcium powder 2.1 ~ 2.3, asafoetide extract 1.6 ~ 1.8, peanut coat extract 1.6 ~ 1.8, lentinan 0.23 ~ 0.25, β-Portugal gather
Sugar 0.23 ~ 0.25, elemene 0.07 ~ 0.09, glycine betaine 0.06 ~ 0.08, brewer's yeast 3 ~ 5.
2. it is according to claim 1 preventing and treating porcine contagious pleuropneumonia medicine, it is characterised in that described egg shell,
It is the egg shell produced after green shell hatching of breeding eggs.
3. the medicine of preventing and treating porcine contagious pleuropneumonia according to claim 1, it is characterised in that described asafoetide is extracted
Thing, asafoetide is crushed to, and is placed in temperature for 40 ~ 45 DEG C, mass concentration to soak 30 ~ 40 points in 1.3 ~ 1.5% edible alkali solution
Clock, is cleaned with clear water, adds 70 ~ 80 times of water of amount of asafoetide weight, and it is original 1/20 that heating is concentrated into volume, cross filter it is heavy
Form sediment, it is 4 ~ 6% that filtrate is dried to water content, obtains asafoetide extract.
4. it is according to claim 1 preventing and treating porcine contagious pleuropneumonia medicine, it is characterised in that described peanut coat is carried
Take thing, peanut coat fried to burnt odor, add 60 ~ 70 times of volume fractions of amount of peanut coat weight for 3 ~ 4% acetum, in 32 ~
34kHz ultrasounds 40 ~ 50 minutes, heating is boiled, and it is original 1/15 to be concentrated into volume, is crossed and is filtered precipitation, by freeze-drying to containing
Water is 7 ~ 9%, obtains peanut coat extract.
5. it is according to claim 1 preventing and treating porcine contagious pleuropneumonia medicine, it is characterised in that described mushroom is more
Sugar, purity is 96 ~ 100%.
6. it is according to claim 1 preventing and treating porcine contagious pleuropneumonia medicine, it is characterised in that described beer ferment
Mother, activated, viable count is 109~1010CFU/ml。
7. described in a kind of claim 1 prevent and treat porcine contagious pleuropneumonia medicine preparation method, it is characterised in that including with
Lower step：
（1）Egg shell is crushed, 80 ~ 90 DEG C is placed in and is stir-fried 10 ~ 15 minutes, obtain stir-fry egg-shell meal；
（2）Tip or stalactite and marmor serpentinatum are crushed to 80 ~ 100 mesh, in after 160 ~ 170 DEG C of calcinations 12 ~ 14 minutes, goose pipe are added immediately
3 ~ 4 times of temperature of amount of stone weight are 1 ~ 10 DEG C of water, are stirred, and naturally cool to room temperature, obtain stone flour slurry；
（3）Egg-shell meal will be fried and add stone flour slurry, be slowly added to the vinegar that 100 ~ 120 times of volume fractions of amount of egg shell weight are for 7 ~ 9%
Acid solution, in 40 ~ 45 DEG C, 36 ~ 38kHz ultrasounds 20 ~ 25 minutes, heating boils that to be concentrated into volume be original 1/15, and filtering must be carried
Take liquid；
（4）Asafoetide extract and peanut coat extract are added into extract solution, is well mixed, add brewer's yeast, it is quiet in 20 ~ 22 DEG C
Put fermentation 3 ~ 4 days, be heated to 60 ~ 70 DEG C, be incubated 25 ~ 30 minutes, obtain zymotic fluid；
（5）Lentinan, beta glucan, elemene and glycine betaine are added into zymotic fluid, is stirred to being completely dissolved, freeze-drying is extremely
Water content is 8 ~ 10%, obtains mixed powder；
（6）Tilmicosin pre-mixing agent, florfenicol powder and Carbaspirin calcium powder are added into mixed powder, is well mixed, pig must be prevented and treated
The medicine of contagious pleuropneumonia；
（7）Vacuum packaging, inspection, obtains finished product.
8. the application method of the medicine of porcine contagious pleuropneumonia is prevented and treated described in a kind of any one of claim 1 ~ 7, and its feature exists
In the medicine that will prevent and treat porcine contagious pleuropneumonia adds pig feed, is well mixed, and addition is pig feed weight
The piglet at 0.3 ~ 0.4%, 2 weeks ~ 7 monthly ages, addition in every 2 ~ 3 days once, August and the pig after August age, addition in every 4 ~ 5 days is once.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114522144A (en) * | 2022-01-13 | 2022-05-24 | 河南百草元兽药有限公司 | Tilmicosin premix particles and preparation method thereof |
| CN114712313A (en) * | 2021-11-26 | 2022-07-08 | 湖南佳锐思生物科技有限公司 | Method for preparing efficient tilmicosin premix through adsorption crystallization and application of efficient tilmicosin premix |
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| CN103143019A (en) * | 2013-03-15 | 2013-06-12 | 湖南泰谷生物科技股份有限公司 | Compound preparation for treating porcine contagious pleuropneumonia and respiratory tract mixed infection and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114712313A (en) * | 2021-11-26 | 2022-07-08 | 湖南佳锐思生物科技有限公司 | Method for preparing efficient tilmicosin premix through adsorption crystallization and application of efficient tilmicosin premix |
| CN114712313B (en) * | 2021-11-26 | 2023-09-22 | 湖南湘农动物药业有限公司 | Method for preparing efficient tilmicosin premix by adsorption crystallization and application thereof |
| CN114522144A (en) * | 2022-01-13 | 2022-05-24 | 河南百草元兽药有限公司 | Tilmicosin premix particles and preparation method thereof |
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