CN106860063A - A kind of cosmetics - Google Patents
A kind of cosmetics Download PDFInfo
- Publication number
- CN106860063A CN106860063A CN201710215761.2A CN201710215761A CN106860063A CN 106860063 A CN106860063 A CN 106860063A CN 201710215761 A CN201710215761 A CN 201710215761A CN 106860063 A CN106860063 A CN 106860063A
- Authority
- CN
- China
- Prior art keywords
- cosmetics
- rgt
- skin
- polypeptide
- sunburn
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000002537 cosmetic Substances 0.000 title claims abstract description 40
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 51
- 229920001184 polypeptide Polymers 0.000 claims abstract description 49
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 49
- 206010042496 Sunburn Diseases 0.000 claims abstract description 22
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 12
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 230000002087 whitening effect Effects 0.000 claims abstract description 7
- 235000011187 glycerol Nutrition 0.000 claims abstract description 6
- 229930014669 anthocyanidin Natural products 0.000 claims abstract description 5
- 150000001452 anthocyanidin derivatives Chemical class 0.000 claims abstract description 5
- 235000008758 anthocyanidins Nutrition 0.000 claims abstract description 5
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 5
- 239000004166 Lanolin Substances 0.000 claims abstract description 4
- 239000004359 castor oil Substances 0.000 claims abstract description 4
- 235000019438 castor oil Nutrition 0.000 claims abstract description 4
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims abstract description 4
- 229940039717 lanolin Drugs 0.000 claims abstract description 4
- 235000019388 lanolin Nutrition 0.000 claims abstract description 4
- 229940075507 glyceryl monostearate Drugs 0.000 claims abstract description 3
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims abstract description 3
- 230000001815 facial effect Effects 0.000 claims description 5
- 239000006071 cream Substances 0.000 claims description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims 2
- 210000000845 cartilage Anatomy 0.000 claims 1
- 229910052938 sodium sulfate Inorganic materials 0.000 claims 1
- 235000011152 sodium sulphate Nutrition 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 17
- KXKPYJOVDUMHGS-OSRGNVMNSA-N chondroitin sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](OS(O)(=O)=O)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O1 KXKPYJOVDUMHGS-OSRGNVMNSA-N 0.000 abstract description 3
- 229940099259 vaseline Drugs 0.000 abstract description 3
- 230000036558 skin tension Effects 0.000 abstract description 2
- 235000008935 nutritious Nutrition 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 31
- 210000003491 skin Anatomy 0.000 description 31
- 210000002752 melanocyte Anatomy 0.000 description 17
- 239000000243 solution Substances 0.000 description 14
- 238000000034 method Methods 0.000 description 12
- 210000001519 tissue Anatomy 0.000 description 12
- 238000012360 testing method Methods 0.000 description 10
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 8
- 101100099277 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) rgt-1 gene Proteins 0.000 description 8
- 239000000463 material Substances 0.000 description 7
- 235000015097 nutrients Nutrition 0.000 description 7
- 238000002360 preparation method Methods 0.000 description 7
- 230000003020 moisturizing effect Effects 0.000 description 6
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 201000001441 melanoma Diseases 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 230000036541 health Effects 0.000 description 4
- 239000002953 phosphate buffered saline Substances 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 239000006285 cell suspension Substances 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 210000003764 chromatophore Anatomy 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 244000025254 Cannabis sativa Species 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 244000194101 Ginkgo biloba Species 0.000 description 2
- 235000008100 Ginkgo biloba Nutrition 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 241000382353 Pupa Species 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- 102000004142 Trypsin Human genes 0.000 description 2
- 108090000631 Trypsin Proteins 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 230000001464 adherent effect Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 239000003792 electrolyte Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 206010020718 hyperplasia Diseases 0.000 description 2
- 230000002147 killing effect Effects 0.000 description 2
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 2
- 229910052753 mercury Inorganic materials 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 239000012588 trypsin Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 1
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 description 1
- 241001116389 Aloe Species 0.000 description 1
- 241000205585 Aquilegia canadensis Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 208000031868 Calculus ureteric Diseases 0.000 description 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 1
- 241000756943 Codonopsis Species 0.000 description 1
- 244000077995 Coix lacryma jobi Species 0.000 description 1
- 235000007466 Corylus avellana Nutrition 0.000 description 1
- 240000003211 Corylus maxima Species 0.000 description 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000735527 Eupatorium Species 0.000 description 1
- 241000576429 Forsythia suspensa Species 0.000 description 1
- 240000008669 Hedera helix Species 0.000 description 1
- 206010020649 Hyperkeratosis Diseases 0.000 description 1
- 208000001126 Keratosis Diseases 0.000 description 1
- 240000007890 Leonurus cardiaca Species 0.000 description 1
- 235000000802 Leonurus cardiaca ssp. villosus Nutrition 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- 244000246386 Mentha pulegium Species 0.000 description 1
- 235000016257 Mentha pulegium Nutrition 0.000 description 1
- 235000004357 Mentha x piperita Nutrition 0.000 description 1
- 235000014676 Phragmites communis Nutrition 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 239000012980 RPMI-1640 medium Substances 0.000 description 1
- 244000088415 Raphanus sativus Species 0.000 description 1
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 description 1
- 241000238370 Sepia Species 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical class [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 206010041303 Solar dermatitis Diseases 0.000 description 1
- 244000185386 Thladiantha grosvenorii Species 0.000 description 1
- 235000011171 Thladiantha grosvenorii Nutrition 0.000 description 1
- 241000218989 Trichosanthes Species 0.000 description 1
- 208000000014 Ureteral Calculi Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 238000012550 audit Methods 0.000 description 1
- 229940116229 borneol Drugs 0.000 description 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 238000000205 computational method Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 229960001484 edetic acid Drugs 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000013100 final test Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 230000003861 general physiology Effects 0.000 description 1
- YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 description 1
- SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 1
- -1 glycerol monostearate Ester Chemical class 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 230000002390 hyperplastic effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- XRRQZKOZJFDXON-UHFFFAOYSA-N nitric acid;silver Chemical compound [Ag].O[N+]([O-])=O XRRQZKOZJFDXON-UHFFFAOYSA-N 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000009465 prokaryotic expression Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 235000020095 red wine Nutrition 0.000 description 1
- 229940119485 safflower extract Drugs 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 235000015099 wheat brans Nutrition 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Cosmetics (AREA)
- Peptides Or Proteins (AREA)
Abstract
The invention discloses a kind of cosmetics, the cosmetics are made up of following components in percent by weight：Polypeptide 0.01%, lanolin 7 10%, vaseline 5 9%, saualane 4 8%, the % of glyceryl monostearate 6, castor oil 1%, whitening agent 0.1 0.25%, glycerine 15 20%, sodium chondroitin sulfate 0.1 0.5%, anthocyanidin 1%, water surplus.Cosmetics of the invention can thoroughly dispel sunburn, nutritious, smooth and glossy, to improving skin tension and crease-resistant having remarkable result, the also effect with skin whitening.
Description
Technical field
The present invention relates to a kind of cosmetics, and in particular to a kind of cosmetics for dispelling sunburn.
Background technology
Sunburn, mainly the factor such as is stimulated to cause with ultraviolet, toxin buildup, cell.The shape of sunburn is presented
Oval projections are smooth, the dark-brown of color one or it is filbert based on.There is preceding stern outside, the back of the hand, small the position for easily occurring
, there is sunburn initial stage meeting feels pain, itch, peel, eventually forming color spot in leg front side and face.Distinguish face sunburn master
See whether appear in the bridge of the nose and cheek outside, the spot based on particle point-like sepia.
The cosmetics for the maintenance of sunburn have many kinds in the prior art, such as, CN103655387A discloses one
Preventing and treating solar dermatitis plant essence facial mask is planted, with following formula (component and its percentage by weight %):Radix Angelicae Sinensis tail 6.0-12.0；
Lunar caustic grass 4.0-10.0；Talcum powder 10.0-15.0；Aloe 6.0-15.0；Root of Chinese trichosanthes
3.0-6.0；Coix seed 9.0-30.0；Borneol 3.0-10.0；Eupatorium 6.0-12.0；Honey 3.0-10.0.The cosmetic
The medium-height grass explosive component of the selected reasonable compatibility of product, forms through special process configuration.But substantial amounts of Chinese herbal medicine is with the addition of in the facial mask
Composition, as a result complicated, preparation is not easy, and cost is also more high, and further raising is awaited in economy.
A kind of medicine of sunburn, including honeysuckle 4-10 parts, capsule of weeping forsythia 2-5 parts, Momordica grosvenori are disclosed in CN 104306861A
10-25 parts, vitamin B6 3-8 parts, Radix Codonopsis 5-11 parts, motherwort 6-11 parts, 5-10 parts of radish skin, EXOCARPIUM CITRULLI 5-10 parts, celestial being
6-8 parts of the palm, peppermint 5-6 parts, fructus amomi 5-12 parts, wheat bran 8-12 parts, calcium tablet 2-5 parts, red wine 12-15 and Semen Lablab Album 5-12 parts of preparation
.The medicine is rich in a large amount of vitamins, and the composition for repairing skin collagen containing mass efficient, is conducive to disappearing
Except sunburn and reparation skin.Sunburn can be effectively eliminated and the collagen layer of skin is repaired.And it is strong in compatibility
Kang Heli, meets the health demand of skin and body.But, the same medicine is also the use of substantial amounts of Chinese herbal medicine, composition
It is especially complex, also await discussion for the homogeneity and stability of drug effect, and also preparation technology is complicated, and cost is equally higher
It is high.
Disclose one kind in CN106265414A to dispel sunburn facial mask, its active ingredient includes following raw material：Reed
5-8 parts of luxuriant growth extract, ginkgo biloba p.e 0.5-0.8 parts, 1-2 parts of bee pupa extract, safflower extract 0.2-0.4 parts, every
Mask carriers are loaded with the active ingredient 15-25ml.The facial mask of the invention has remarkable effect for sunburn.Make in the invention
Ginkgo biloba p.e and bee pupa extract are all the higher materials of cost, and the technique extracted is also complex,
Quality Control is not particularly easy to realize, and does not have especially significant effect in terms of effect, therefore, there is huge improvement empty
Between.
Defect based on prior art, has huge demand in the prior art for the cosmetics for the treatment of sunburn, because
This, based on drawbacks described above, the present invention proposes following technical scheme.
The content of the invention
The present invention provides a kind of cosmetics, can effectively dispel sunburn.
One aspect of the present invention, there is provided a kind of cosmetics that can kill human melanoma cell, including using SEQ
ID No:Any described polypeptides of 1-11, described polypeptide corresponds to be named as shown in RGT-1~11 respectively.The polypeptide is applicant
Obtained by library screening by early stage.
The present invention additionally provides a kind of cosmetics, the cosmetics are except containing SEQ ID No:Any described polypeptides of 1-11
Outside, also there is anthocyanidin.
It is face cream the present invention additionally provides a kind of cosmetics, including following components in percent by weight：SEQ ID
No:1-11 any described polypeptide 0.01%, lanolin 7-10%, vaseline 5-9%, saualane 4-8%, glycerol monostearate
Ester 6%, castor oil 1%, whitening agent 0.1-0.25%, glycerine 15-20%, sodium chondroitin sulfate 0.1-0.5%, anthocyanidin 1%,
Water surplus.
The present invention additionally provides a kind of method for being prepared into human melanoma cell suspension, first, using bubble absorption method
Obtain the epidermal tissue of adult.In this step, with alcohol by skin degerming after, syringe is positioned on skin, with 200-300
The suction adsorption skin of millimetres of mercury is up to 60-120 minute, skin is formed bubble, then epidermal tissue is cut, typically and
Speech, the melanocyte of the horn cell containing about 86-90% and 5-7% in epidermal tissue.Then, the epidermal tissue that will be cut
After chopping, first soaked with tryptose solution, then move into tryptose-ethylenediamine tetra-acetic acid (trypsin-EDTA) solution, made black
Chromatophore is separated from epidermal tissue, epidermal cell is finally collected in eccentric fashion, and cultivated in Tissue Culture Dish.Wherein
Horn cell is reduced rapidly because that cannot grow, melanocyte then persistent hyperplastic, and is obtained close to the thin of black chromatophore
Blood race group.Because melanocyte belongs to adherent-type cells (adherent cell), therefore trypsase need to be utilized
(Trypsin) attachment protein between cell and culture dish is decomposed, allows melanocyte to split away off, this is to collect adherent-type cells
Conventional method.Then, the melanocyte that washing is obtained.Afterwards, with about 1.2-1.5X106The density of/ml, melanin is thin
Born of the same parents are resuspended in Han Shi nutrient solutions (Ham's F12).Han Shi nutrient solutions (Ham's F12) are common commercially available nutrient solution,
The growth of the elementary cells such as embedded amine groups acid, carbohydrate, aliphatic acid, salt must material.Except Han Shi nutrient solutions (Ham's F12)
Outward, also can be using DMEM, minimum basic culture solution (MEM), phosphate buffered saline (PBS), RPMI-1640, general physiology food
Salt solution (normal saline) or other physiology compatibility solution are prepared.Finally, by melanin cell suspension cell count,
Equivalent is distributed into test tube, to carry out follow-up experiment.
Experimental technique is killed the present invention additionally provides a kind of human melanoma cell, by SEQ ID NO of the present invention：1~11
Polypeptide described in one, addition enters containing in melanocyte nutrient solution, and addition is 0.01% (m/v)；Cell is in 37 DEG C
Culture 5h, 10h, 12h, detect the quantity of wherein living cells respectively, analyze cell kill rate.
Technique effect
The present invention kills polypeptide by providing specific melanocyte, and the local melanin of specific kill is thin
Born of the same parents, so as to provide last guarantee thoroughly to remove sunburn.In addition, by adding anthocyanidin in cosmetics, so as to have
The sunburn for having been formed of the elimination skin surface of effect, the two combination, then by adding whitening agent and other materials
Combination, effected a permanent cure so as to take stopgap measures, so that thoroughly dispelling sunburn reaches the effect not recurred.And cosmetics of the invention, battalion
Support abundant, it is smooth and glossy, to improve skin tension and it is crease-resistant have remarkable result, the special also effect with skin whitening.Most
For importantly, the present invention is with low cost, materials are easy, particularly suitable large area is promoted the use of.
Brief description of the drawings
Fig. 1 is culture human melanoma cell flow chart；
Fig. 2 treats the compares figure of front face skin；
Fig. 3 treats the compares figure of rear face skin.
Specific embodiment
Following example illustrate each aspect of the present invention content.They are only used to illustrate, do not limit model of the invention
Enclose, the conventional change or addition that those skilled in the art are carried out on this basis also belongs to the scope of protection of the invention,
Should be any limitation as.
The batch of the human melanoma cell of embodiment 1 is obtained
First, the epidermal tissue of adult is obtained using bubble absorption method.In this step, with alcohol by skin degerming after,
Syringe is positioned on skin, is up to 100 minutes with the suction adsorption skin of 200-300 millimetress of mercury, skin is formed bubble,
Epidermal tissue is cut again, it is however generally that, the melanin of the horn cell containing about 86-90% and 5-7% is thin in epidermal tissue
Born of the same parents.Then, after the epidermal tissue's chopping that will be cut, first soaked with 5% tryptose solution, then move into tryptose-ethylenediamine tetrem
In sour (trypsin-EDTA) solution, melanocyte is separated from epidermal tissue, finally collect table in the way of 5000g is centrifuged
Chrotoplast, and cultivated in Tissue Culture Dish.Wherein horn cell is reduced rapidly because that cannot grow, and melanocyte then continues
Hyperplasia, and obtain the cell populations close to black chromatophore.Because melanocyte belongs to adherent-type cells (adherent
Cell), therefore 3% trypsase (Trypsin) need to be utilized to decompose the attachment protein between cell and culture dish, allows melanocyte
Split away off.Then, the melanocyte that PBS washings are obtained.Afterwards, with about 1.5X106The density of/ml, by melanocyte
It is resuspended in Han Shi nutrient solutions (Ham's F12).Finally, by melanin cell suspension cell count, equivalent is distributed into
In test tube, the density of cell is 100g/mL or so in each test tube, to carry out follow-up experiment.
The preparation of the polypeptide of embodiment 2
In the way of Peptide systhesis, or express and purify in the way of the prokaryotic expression that those skilled in the art commonly use
Obtain SEQ ID NO：Polypeptide shown in 1~11, is respectively designated as shown in RGT-1~11.
The melanocyte of embodiment 3 kills experiment
By SEQ ID NO of the present invention：1~11 any described polypeptide, addition enters and contains the examination of melanocyte nutrient solution
Guan Zhong, initial cell concentration is 200/mL, and the addition of polypeptide is 0.01% (m/v)；Cell cultivates 5h, 10h in 37 DEG C,
12h, detects the quantity of wherein living cells, analysis cell kill rate respectively (each does 3 repetitions).Result is as shown in table 1 below,
Each result P values are respectively less than 0.05.
| Product category | 5h living cells surpluses | 10h living cells surpluses | 12h living cells surpluses |
| PBS control | 195 | 183 | 170 |
| RGT-1 polypeptides | 22 | 18 | 1 |
| RGT-2 polypeptides | 40 | 23 | 2 |
| RGT-3 polypeptides | 43 | 20 | 1 |
| RGT-4 polypeptides | 50 | 19 | 1 |
| RGT-5 polypeptides | 39 | 30 | 4 |
| RGT-6 polypeptides | 40 | 31 | 2 |
| RGT-7 polypeptides | 32 | 29 | 5 |
| RGT-8 polypeptides | 29 | 30 | 4 |
| RGT-9 polypeptides | 55 | 38 | 8 |
| RGT-10 polypeptides | 60 | 43 | 8 |
| RGT-11 polypeptides | 46 | 32 | 5 |
Table 1
From the results shown in Table 1, polypeptide of the invention has the effect for preferably killing melanocyte, and kills
The dead time is shorter, with the characteristic for killing effect is significant.And, detected by Electronic Speculum and found, the nucleus of melanocyte
Cell death caused by first dissolving.
The preparation of the cosmetics of embodiment 4
SEQ ID No are taken respectively:RGT-1 polypeptides 0.01%, lanolin 10% described in 1, vaseline 5%, saualane
4%th, glyceryl monostearate 6%, castor oil 1%, whitening agent 0.25%, glycerine 20%, sodium chondroitin sulfate 0.5%, cyanine
Element 1%, is sufficiently stirred for making to be completely dissolved, and mixes, and adjusts the pH to 6.5 of solution, finally supplies formula total amount with purified water, degerming
Filtering, as packing, finished product cosmetics.
The preparation of cosmetics RGT-2~11 of embodiment 5
According to the method for embodiment 4, by SEQ ID NO：2~11 polypeptides replace RGT-1 polypeptides respectively, remaining component and system
Preparation Method and embodiment 4 are identical, prepare the cosmetics.
The security verification of embodiment 6
Test material and method
Animal：Regular grade experimental animal White Rabbit.Body looks into animal no abnormality seen.
Environmental condition：Room temperature：25 DEG C, relative humidity：68%；
Test method：
Foundation《Cosmetics health specification》(version in 2007) acute skin irritation is tested, and tests first 24 hours, will be tested
Back part of animal backbone diamond wool is cut, 3 centimetres of unhairing scope, 3 centimetres of X.Take and tested be directly applied to right side skin without 0.5 gram of originality
On skin, covered with clean gauze, with nonirritant immobilization with adhesive tape 2 hours.Other side is negative control.After removing tested material
Observe animal subject contact site dermoreaction and keep a record within 1 hour, 24 hours, 72 hours 48 hours.
Conclusion：
Under this experimental condition, tested material contain the cosmetics of polypeptide of the present invention to White Rabbit acute skin irritation test by
Skin irritatin strength grading is nonirritant.Control cosmetics are also nonirritant.
The freckle effect of embodiment 7 is verified
1st, patient's selection:Selection sunburn patient (signature Informed Consent Form simultaneously audits approval through Ethics Committee), is
Women, is randomly divided into two groups.Treatment group:220, each polypeptide correspondence 20, average age 25 years old, the course of disease 1 month, using reality
The polypeptide cosmetic for applying example 4 and 5 is treated；Control group:20, average age 25 years old, the course of disease 3 months is more using not containing
The cosmetics of the embodiment 4 of peptide are treated.Two groups are compared at aspects such as age, sex, the weight of the state of an illness, the courses of disease, with can
Than property (P>0.05).
2nd, treatment method：Treatment group is to be based respectively on the cosmetics that embodiment 4 and 5 is prepared, and is respectively applied to day sooner or later
Sunburn site of disease 1 time, the course for the treatment of 1 month；Control group:Give and do not contain the cosmetics of polypeptide as control in embodiment 4, also smear
In sunburn site of disease 1 time, the course for the treatment of 1 month.Treatment phase asks that all patients disable other all effect type cosmetics, goes out
Note sun-proof.Control group patient needs periodic monitoring liver function and blood fat, without exception to continue to take.30d is 1 course for the treatment of.
3rd, efficacy determination
Methods of marking:1. scored according to skin damaged area:It is 0 point, skin damaged area without skin damaged<3cm2It is 1 point, skin damaged area 3-
5cm2It is 2 points, skin damaged area>5cm2It is 3 points；2. scored according to skin damaged shade:Normal skin tone is 0 point；If being in light brown
1 point, dark brown is 2 points, and dark brown is 3 points；3. total mark is the summation of area integral and color integration.The computational methods of index
For:Total mark before (total mark after total mark one is treated before treatment)/treatment.
Curative effect determinate standard:It is basic to cure:Visually the area of visible color spot disappears more than 90%, and color spot color disappears substantially
Lose, calculated according to point system, decline index >=0.8 after treatment；It is effective；Visually visible color spot area disappears more than 60%, color
The color of spot is substantially thin out compared with pre-treatment, is calculated according to point system, decline index >=0.5 after treatment；Effectively:Naked eyes can
See that color spot area disappears more than 30%, color spot color is thin out, calculated according to point system, decline index >=0.3 after treatment；Nothing
Effect:Visually the area regression of visible color spot is less than 30%, and color spot color has no significant change, is calculated according to point system, treatment
Decline index afterwards and be less than or equal to 0.Total effective rate=(basic healing ten effective ten is effective) number of cases/total number of cases × 100%.
Statistical method:Analysis is carried out using statistics software SPSS15.0, enumeration data is distinguished with measurement data
Using χ2The method that inspection is checked with t, P<0.05 has statistical significance.
Comparitive study:Two groups of patients complete Ureteral Calculus, and treatment group's total effective rate is more than 95%, and control group is 0%, treats
Effect compares significant difference (χ2<2.21,P<0.05) 2, are shown in Table.
Table 2
From table 2 it can be seen that therapeutic effect of the invention is preferably, with preferable application prospect.Using RGT-1 polypeptides
One patient of cosmetic treatment by taking pictures, from the result of Fig. 2 and Fig. 3 can be seen that treatment rear face spot obtains it is preferable
Treatment be almost recovered.Remaining polypeptide effect is similar to, herein not textures one by one.
The cosmetics moisturizing degree of embodiment 8 and moisture preserving time are detected
MMV (moisturemeasurementvalue) method detection MMV values reflect the ability of keratoderma combination water.Adopt
The aquation of skin is tested with CM825 type skin oil-water soda acids tester.Its measuring principle is because cuticula contains greatly
The electrolyte of amount, the electrolyte existed in water is conductive, and this phenomenon is also produced in skin surface, by test probe with
After skin contact, the change of electrical conductivity reflects the hydration status of skin.
Subject is health without dermopathic volunteer.Experimental condition is that the temperature and humidity of environment during testing is constant,
Temperature is 25 DEG C ± 2 DEG C, and relative humidity is 40%~60%.
Health is chosen without dermopathic volunteer 12, is tested.Method of testing is：1. the 4 pieces of surveys of left and right forearm are determined
Examination region, region area is 4cmX4cm, and the blank value in the region is tested respectively.2. sample is coated on test zone, consumption is
2mg/cm2.3. final test is carried out using rear 120min, 5 points of every piece of domain test are averaged.Moistening effect is evaluated
Judgement schematics：With respect in moisturizing rate/%=(P sample t=x-P blank)/(P mark t=x-P blank) X100% formulas：P samples t=x-
Use the electrical conductivity of product after certain hour；The electrical conductivity of P blank-be not coated with sample；P mark t=x- use reference after certain hour
The electrical conductivity of thing, moisturizing rate situation (%) result that cosmetics of the invention and glycerine compare is as shown in the table：
| Product category | Moisturizing rate |
| Control | 0.48 |
| RGT-1 polypeptides | 0.78 |
| RGT-2 polypeptides | 0.75 |
| RGT-3 polypeptides | 0.74 |
| RGT-4 polypeptides | 0.76 |
| RGT-5 polypeptides | 0.74 |
| RGT-6 polypeptides | 0.70 |
| RGT-7 polypeptides | 0.80 |
| RGT-8 polypeptides | 0.76 |
| RGT-9 polypeptides | 0.77 |
| RGT-10 polypeptides | 0.75 |
| RGT-11 polypeptides | 0.76 |
Table 3
From in terms of above table, the moisturizing rate of cosmetics of the invention apparently higher than glycerine moisturizing situation, while also illustrating
Polypeptide of the invention has significant facilitation for improving the moistening effect of cosmetics.
Above content is to combine specific preferred embodiment Jin ー steps made for the present invention to describe in detail, it is impossible to assert
Specific implementation of the invention is confined to these explanations.For general technical staff of the technical field of the invention,
On the premise of not departing from present inventive concept, some simple deduction or replace can also be made, should be all considered as belonging to of the invention
Protection domain.
Sequence table
The ＞ gold of ＜ 110 is prosperous
A kind of cosmetics of the ＞ of ＜ 120
〈160〉11
〈210〉1
〈211〉27
〈212〉PRT
The ＞ artificial sequences of ＜ 213
〈400〉RGT-1
RIWPVMDQRDRQQHHPWYQRAPCRNQG
〈210〉2
〈211〉25
〈212〉PRT
The ＞ artificial sequences of ＜ 213
〈400〉RGT-2
VCCCRSTHKPQFCLQLMINFKQFAP
〈210〉3
〈211〉24
〈212〉PRT
The ＞ artificial sequences of ＜ 213
〈400〉RGT-3
IMGHREQFPRIPRNRPKWHAHWWW
〈210〉4
〈211〉26
〈212〉PRT
The ＞ artificial sequences of ＜ 213
〈400〉RGT-4
STRRWPKPSTPQSYLEVEQEEMYQPR
〈210〉5
〈211〉21
〈212〉PRT
The ＞ artificial sequences of ＜ 213
〈400〉RGT-5
IQIPTKSSSRTFLSKIPLDMP
〈210〉6
〈211〉20
〈212〉PRT
The ＞ artificial sequences of ＜ 213
〈400〉RGT-6
NAEQLYDHNIQWLYAMYWVE
〈210〉7
〈211〉23
〈212〉PRT
The ＞ artificial sequences of ＜ 213
〈400〉RGT-7
QHPQRLKRSRPETHSMMQPKVWY
〈210〉8
〈211〉25
〈212〉PRT
The ＞ artificial sequences of ＜ 213
〈400〉RGT-8
DYGPRVVFQQWMKSNRWNWHMNDVV
〈210〉9
〈211〉27
〈212〉PRT
The ＞ artificial sequences of ＜ 213
〈400〉RGT-9
GHQWYSQTRFEYDDLKIWGKCTFHELS
〈210〉10
〈211〉26
〈212〉PRT
The ＞ artificial sequences of ＜ 213
〈400〉RGT-10
WHGTTMWHVQFRSSFWAAWWMTPRLC
〈210〉11
〈211〉17
〈212〉PRT
The ＞ artificial sequences of ＜ 213
〈400〉RGT-11
WHTSHRFKRHPEWHLLI
Claims (6)
1. a kind of cosmetics, are made up of following components in percent by weight：Polypeptide 0.01%, lanolin 7-10%, all scholars
Woods 5-9%, saualane 4-8%, the % of glyceryl monostearate 6, castor oil 1%, whitening agent 0.1-0.25%, glycerine 15-20%, cartilage
Plain sodium sulphate 0.1-0.5%, anthocyanidin 1%, balance of water.
2. cosmetics as claimed in claim 1, it is characterised in that：The polypeptide sequence such as SEQ ID NO：Any one of 1-11 institute
Show.
3. a kind of polypeptide, it is characterised in that：Sequence such as SEQ ID No:Shown in 1-11 is any.
4. the polypeptide described in claim 3 is being prepared with the purposes in the cosmetics for dispelling sunburn function.
5. purposes as claimed in claim 4, it is characterised in that：The cosmetics are facial mask or face cream.
6. cosmetics as described in claim any one of 1-2, it is characterised in that：It has the function of dispelling sunburn.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710215761.2A CN106860063B (en) | 2017-04-04 | 2017-04-04 | A cosmetic |
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|---|---|---|---|---|
| US20020035243A1 (en) * | 1998-11-26 | 2002-03-21 | Dominik Imfeld | Transport system conjugates |
| CN101601635A (en) * | 2008-06-13 | 2009-12-16 | 殷勤伟 | The prescription of little RNA/DNA whitening product and manufacture method |
| CN103565674A (en) * | 2013-11-03 | 2014-02-12 | 上海方木精细化工有限公司 | Jojoba oil vanishing cream |
| CN105662925A (en) * | 2016-02-23 | 2016-06-15 | 孟繁好 | Cosmetic with freckle removing function |
| CN105935343A (en) * | 2016-05-30 | 2016-09-14 | 哈尔滨源茂达生物技术有限公司 | Whitening and spot removing polypeptide essence and preparation method thereof |
| CN106074285A (en) * | 2016-07-17 | 2016-11-09 | 孟繁好 | A kind of cosmetics with moisturizing whitening acne-removal function |
-
2017
- 2017-04-04 CN CN201710215761.2A patent/CN106860063B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020035243A1 (en) * | 1998-11-26 | 2002-03-21 | Dominik Imfeld | Transport system conjugates |
| CN101601635A (en) * | 2008-06-13 | 2009-12-16 | 殷勤伟 | The prescription of little RNA/DNA whitening product and manufacture method |
| CN103565674A (en) * | 2013-11-03 | 2014-02-12 | 上海方木精细化工有限公司 | Jojoba oil vanishing cream |
| CN105662925A (en) * | 2016-02-23 | 2016-06-15 | 孟繁好 | Cosmetic with freckle removing function |
| CN105935343A (en) * | 2016-05-30 | 2016-09-14 | 哈尔滨源茂达生物技术有限公司 | Whitening and spot removing polypeptide essence and preparation method thereof |
| CN106074285A (en) * | 2016-07-17 | 2016-11-09 | 孟繁好 | A kind of cosmetics with moisturizing whitening acne-removal function |
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