CN106857855A - A kind of infant formula rich in milk fat ball film and structured lipid OPO and preparation method thereof - Google Patents
A kind of infant formula rich in milk fat ball film and structured lipid OPO and preparation method thereof Download PDFInfo
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- CN106857855A CN106857855A CN201611180120.XA CN201611180120A CN106857855A CN 106857855 A CN106857855 A CN 106857855A CN 201611180120 A CN201611180120 A CN 201611180120A CN 106857855 A CN106857855 A CN 106857855A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
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- A23C9/16—Agglomerating or granulating milk powder; Making instant milk powder; Products obtained thereby
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- A—HUMAN NECESSITIES
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- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1526—Amino acids; Peptides; Protein hydrolysates; Nucleic acids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
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Abstract
The present invention relates to a kind of infant formula rich in milk fat ball film and structured lipid OPO and preparation method thereof.Total MFGM protein contents 0.146 0.438%, structured lipid OPO contents 2.07 5.17% in the infant formula；The present invention is with raw milk as primary raw material; after PURE WHEY of the addition rich in MFGM, mixed vegetable oil (being rich in structured lipid OPO), common PURE WHEY, lactose, oligosaccharides, mineral matter, vitamin and some optional nutritional ingredients (choline, inositol, taurine, carnitine etc.) carry out dispensing standardization, the infant formula for modulating has the effect for promoting infants growth and development.Promotion physical growth of infants, skeleton development, lifting Infants'feeding comfort level are reached, and reduces the purpose of intestines problem incidence, the formula is applied to the exploitation of baby and larger infant formula.
Description
Technical field
The invention belongs to formula milk technical field, and in particular to a kind of baby rich in milk fat ball film and structured lipid OPO
Youngster's prescription emulsifiable powder and preparation method thereof.
Background technology
The breastfeeding rate particularly Pure breast feeding rate of current China 0-6 month babies is still relatively low, prescription emulsifiable powder into
For Infants ' Parents are had to the selection made.It is main and the Milk Powder Formula For Infants of China are produced as most countries in the world
To refer to WHO correlation breast milk compositions and American-European countries's milk power for infant and young children into being grouped into design construction formula, and formulate state
Family's standard.But the nutrient health if appropriate for Chinese Infant and Children needs still to lack the research of correlation.Recently as to breast milk into
The further investigation for dividing finds that the content of many function ingredients and effect beneficial to infants growth and development are that cow's milk can not in breast milk
Analogy.Pointedly being developed for this contributes to the prescription emulsifiable powder of infant growth to be necessary.
The content of the invention
Milk fat ball film (MFGM) and the structured lipid OPO (i.e. oleic acid -2- of 1,3- bis- are rich in it is an object of the invention to provide one kind
The ester of palmitic acid three) infant formula and preparation method thereof, be especially added with rich in breast by infant formula
The PURE WHEY of fat globule membrane and the mixed vegetable oil rich in structured lipid OPO, to improve MFGM- eggs in babies ' formula milk powder
In vain, the oleic acid -2- palmitic acids of 1,3- bis- are sweet in lactoferrin, phosphatide, gangliosides, sphingomyelin, sialic acid etc. and fat
The content of oily three esters, reaches promotion physical growth of infants, and skeleton development lifts Infants'feeding comfort level, and reduce intestines problem
The purpose of incidence, the prescription emulsifiable powder is suitable for baby's (0-6 monthly ages) and larger baby (6-12 monthly ages).
The present invention is adopted the following technical scheme that：
A kind of prescription emulsifiable powder composition for contributing to infants growth and development, its active ingredient is included rich in milk fat ball film
PURE WHEY 20-80 weight portions, the mixed vegetable oil 80-300 weight portions rich in structured lipid OPO.
Preferably, the prescription emulsifiable powder composition for contributing to infants growth and development, its active ingredient includes being rich in butterfat
The PURE WHEY 25-75 weight portions of fat ball film, the mixed vegetable oil 100-250 weight portions rich in structured lipid OPO.
It is further preferred that the prescription emulsifiable powder composition for contributing to infants growth and development, its active ingredient includes richness
The weight portion of PURE WHEY 43 of creaminess fat ball film, the weight portion of mixed vegetable oil 203 rich in structured lipid OPO.
Further, functional active components mass fraction is as follows in the PURE WHEY rich in MFGM：
Total MFGM- albumen 3-7%,
Phosphatidase 5-9%,
Sphingomyelin 0.5-3%,
Sialic acid 1-3%,
Total lactoferrin 0.5-2%,
Immunoglobulin IgG 2-6%,
Lactadherin 0.5-2%,
Gangliosides 0.1-0.5%,
MUC1/Mucin1 1-3%.
The MUC1/Mucin1 is mucin -1 (MUC1/Mucin1).
Further, functional active components mass fraction is as follows in the PURE WHEY rich in MFGM：
Total MFGM- albumen 5.84%,
Phosphatide 7%,
Sphingomyelin 1.6%,
Sialic acid 2%,
Total lactoferrin 0.8%,
Immunoglobulin IgG 4%,
Lactadherin 1%,
Gangliosides 0.2%,
MUC1/Mucin1 1.4%.
The PURE WHEY rich in MFGM can be prepared by prior art conventional method.
The present invention also provides the preparation method of the above-mentioned PURE WHEY rich in MFGM, including：By raw milk pasteurize
(preferably 72 DEG C -85 DEG C, 5-15s) obtain whey liquid after removing cheese or casein afterwards；Remove the casein in the whey liquid
Particulate, fat and residue；Again through obtaining breast after the dilute cream in Overheating Treatment (preferably 60 DEG C -75 DEG C, 3-5min) removal whey
Take back material completely；Gained whey rewinding is heated to 50 DEG C -55 DEG C, with ceramic membrane filter, by gained filtrate through heat again after heavy filtration
Treatment (preferably 60 DEG C -75 DEG C, 3-5min) is spray-dried afterwards, obtains final product.
The rewinding of gained whey before filtration can be standby in 4 DEG C of -6 DEG C of refrigerations.
The preparation method process chart of the above-mentioned PURE WHEY rich in MFGM is shown in Fig. 1.
The PURE WHEY of the present invention PURE WHEY that especially prepared by the above method is main with general proteins powder
Difference is wherein functional active components (MFGM albumen, phosphatide, sphingomyelin, sialic acid, lactoferrin, immunoglobulin
IgG, lactadherin, gangliosides and MUC1 albumen) content it is relative improve, and in common PURE WHEY this 9 kinds of work(
Active trace or minor levels can be in, concrete function active component content excursion is as shown in table 1.
Functional active components relative amount in PURE WHEY of the table 1 rich in MFGM
Further, in the mixed vegetable oil rich in structured lipid OPO of the present invention：The mass fraction of structured lipid OPO >=
17%, and Sn-2 palmitic acids/total palmitic acid >=40% (mass fraction).
Further, OPO mass fraction is in structured lipid OPO of the present invention
20-30%, and Sn-2 palmitic acids/total palmitic acid is 40-50%.
It is preferred that OPO mass fraction is in structured lipid OPO of the present invention
28.1%, and Sn-2 palmitic acids/total palmitic acid is 46.95%.
The structured lipid OPO can be prepared by prior art conventional method.
The present invention also provides the preparation method of the above-mentioned mixed vegetable oil rich in structured lipid OPO, including：By palm oil in height
Lower point of fusing point carries component 80%PPP and 20%POP, then by 80%PPP and oleic acid with 3:1 mass ratio mix, be dissolved into just oneself
In alkane, (40 DEG C) carry out grease rearrangement reaction under fatty enzyme effect；Reaction terminate after filtering go to dezymotize, redistillation remove just oneself
Alkane, then vacuum removal free fatty, obtains semi-refined product；By the product and mixed vegetable oil (including palm-kernel oil, certain herbaceous plants with big flowers
One or more in flower seed oil, soybean oil, coconut oil etc.) mixing preparation, obtain final product.
Can be detected by gas chromatography during mixing preparation, if to meet the requirements refine obtaining finished product,
If the undesirable needs of Product checking are allocated, detected, analyzed again, finished product is finally given.
The preparation method process chart of the above-mentioned mixed vegetable oil rich in structured lipid OPO is shown in Fig. 2.
Mixed vegetable oil rich in structured lipid OPO of the present invention especially the above method prepare rich in structured lipid OPO
Mixed vegetable oil and common plant grease differ primarily in that wherein the ester content of bis- oleic acid -2- palmitic acids of 1,3- three should
More than 17g/100g, and Sn-2 palmitic acids/total palmitic acid ＞ 40%.
The present invention also provides a kind of infant formula rich in MFGM and structured lipid OPO, and it contains above-mentioned contributes to baby
The prescription emulsifiable powder composition that youngster grows, the matter of the PURE WHEY rich in milk fat ball film described in the infant formula
Amount fraction is 2.0-8.0%, and the mass fraction of the mixed vegetable oil rich in structured lipid OPO is 8.0-30.0%.
Preferably, the above-mentioned infant formula containing the above-mentioned prescription emulsifiable powder composition for contributing to infants growth and development,
The mass fraction of the PURE WHEY rich in MFGM is 2.5-7.5%, the mixed vegetable oil rich in structured lipid OPO
Mass fraction is 10-25%.
It is preferred that the above-mentioned infant formula containing the above-mentioned prescription emulsifiable powder composition for contributing to infants growth and development,
The mass fraction of the wherein described PURE WHEY rich in MFGM is 4.3%, the quality of the mixed vegetable oil rich in structured lipid OPO
Fraction is 20.3%.
Infant formula of the present invention also containing appropriate common PURE WHEY, lactose, oligosaccharides, mineral matter,
Vitamin and some optional nutritional ingredients (choline, inositol, taurine, carnitine etc.), the addition of these raw materials can be by GB
GB10765-2010 or GB GB10767-2010 standards are calculated.
Preferably, total MFGM- albumen quality fraction 0.146-0.438%, structured lipid OPO matter in the infant formula
Amount fraction 2.07-5.17%.
Specifically, infant formula of the present invention contains the component of following mass fraction：
Total MFGM- albumen 0.146-0.438%,
Phosphatidase 0 .175-0.525%,
Sphingomyelin 0.04-0.12%,
Sialic acid 0.05-0.18%,
Total lactoferrin 0.02-0.06%,
Immunoglobulin IgG 0.1-0.3%,
Lactadherin 0.025-0.075%,
Gangliosides 0.005-0.015%,
MUC1/Mucin 0.035-0.105%,
The ester 2.07-5.17% of -2 palmitic acid of bis- oleic acid of 1,3- three；
The mass fraction that wherein 2 palmitic acids account for total palmitic acid is 19.7-49.24%.(in specifically referring to every 100g milk powder
Content.)
It is preferred that infant formula of the present invention contains the component of following mass fraction：
Total MFGM- albumen 0.251%,
Phosphatidase 0 .301%,
Sphingomyelin 0.0688%,
Sialic acid 0.171%,
Total lactoferrin 0.0344%,
Immunoglobulin IgG 0.172%,
Lactadherin 0.043%,
Gangliosides 0.0086%,
MUC1/Mucin 0.0602%,
The ester 4.2% of -2 palmitic acid of bis- oleic acid of 1,3- three；
Wherein 2 palmitic acids account for the mass fraction of total palmitic acid for 40% (specifically refers to the content in every 100g milk powder.)
Infant formula of the present invention is rich in the lactalbumin of MFGM by addition with raw milk as primary raw material
Powder, mixed vegetable oil (be rich in structured lipid OPO), common PURE WHEY, lactose, oligosaccharides, mineral matter, vitamin and some
After optional nutritional ingredient (choline, inositol, taurine, carnitine etc.) carries out dispensing standardization, the infant formula tool for modulating
Play the role of to promote infants growth and development.The wherein addition of the PURE WHEY rich in MFGM for 25-75 kilograms in powder per ton,
The addition of the mixed vegetable oil rich in structured lipid OPO is 100-250 kilograms, function in thus obtained formula powder in powder per ton
The content of active component is as shown in table 2.
Table 2 has the content of function ingredients in the babies ' formula milk powder for promoting intestinal health
Infant milk powder of the present invention can be prepared by prior art conventional method；It is preferred that being prepared using wet method processing technology.
Specifically, it is of the present invention formula infant milk powder use wet method processing technology, technological process as shown in figure 3,
Including：By the net breast of raw milk (raw milk), pre-sterilizing, dispensing and standardization, homogeneous is sterilized, concentration, spray drying
Etc. step.
It is preferred that main technologic parameters are：Pre-sterilizing (85 DEG C -88 DEG C, 30s)；Homogeneous 15mPa；Sterilized (93 DEG C -95 DEG C,
15s)；Spray drying (150 DEG C -160 DEG C of EAT, 85 DEG C -90 DEG C of leaving air temp).
The present invention uses the new PURE WHEY rich in milk fat ball film (MFGM) and the mixing rich in structured lipid OPO
Vegetable oil is raw material, by being formulated adjustment bioactivator (MFGM- albumen, newborn iron egg of the lifting with specific function composition
In vain, phosphatide, gangliosides, sphingomyelin, sialic acid etc.) and fat in bis- oleic acid -2- palmitic acids of 1,3- three esters
Content, reaches promotion physical growth of infants, and skeleton development lifts Infants'feeding comfort level, and reduce intestines problem incidence
Purpose, the formula is applied to the exploitation of baby and larger infant formula.
Key point of the present invention
(1) selection of the raw material PURE WHEY rich in MFGM, it is desirable to which it must is fulfilled for listed several functional activities in table 1
The relative amount of component；The selection of raw material mix fat OPO must is fulfilled for content required in 5.1.
(2) for the addition of the PURE WHEY rich in MFGM in different phase or the formula powder of different constitution baby exploitations
Amount need to change according to actual conditions in the range of 25-75Kg/ tons of powder, and the addition of structured lipid OPO need to exist according to actual conditions
Change in the range of 100-250 kgs/tonne of powder.
(3) in order to investigate the common influences to baby intestinal development condition of MFGM and structured lipid OPO, using in baby intestinal
The colonisation of probiotics, baby's defecation situation and intestines problem incidence carry out overall merit.
(4) using the method for clinical test, growth hair of the formula milk rich in MFGM and structured lipid OPO to baby is evaluated
The influence (anthropometic, skeleton development) educated, for the clinical efficacy of new formula milk provides data supporting.
Beneficial effect of the present invention
The prescription emulsifiable powder for contributing to infants growth and development of present invention exploitation, by PURE WHEY of the addition rich in MFGM
With structured lipid OPO, improve formula in have specific function effect total MFGM- albumen, lactoferrin, IgG, lactadherin,
In MUC1/Mucin1, phosphatide, gangliosides, the content of 9 kinds of functional active components of sphingomyelin and sialic acid and fat
The content of OPO, matches the function ingredients of prescription emulsifiable powder and is closer to breast milk, so that
So that eating the intestinal growth level and growth level of the baby of the prescription emulsifiable powder close to breast feeding babies.Suitable for baby
Youngster and larger infant formula.
Brief description of the drawings
Fig. 1 is the preparation method flow chart of the whey powder rich in MFGM；
Fig. 2 is the preparation method flow chart of the mixed vegetable oil rich in structured lipid OPO；
Fig. 3 is with the infant formula processing process figure for promoting intestinal health；
Fig. 4 is demographics figure of three groups of baby Bone mineral density Z values more than 1 in experimental example 3；
Fig. 5 is three groups of infant faeces COMPARISON OF CHARACTERS figures in experimental example 3；
Fig. 6 compares figure for the disease condition between three groups of baby's 0-6 monthly ages in experimental example 3.
Specific embodiment
Following examples are used to illustrate the present invention, but are not limited to the scope of the present invention.It is unreceipted specific in embodiment
Technology or condition person, according to technology or condition described by document in the art, or are carried out according to product description.It is used
Reagent or the unreceipted production firm person of instrument, are the conventional products that can be commercially available by regular distributor.
Functional active components mass fraction is as follows in PURE WHEY rich in MFGM used below：
Total MFGM- albumen 5.84%,
Phosphatide 7%,
Sphingomyelin 1.6%,
Sialic acid 2%,
Total lactoferrin 0.8%,
Immunoglobulin IgG 4%,
Lactadherin 1%,
Gangliosides 0.2%,
MUC1/Mucin1 1.4%.
The preparation method of the above-mentioned PURE WHEY rich in MFGM, including：By raw milk pasteurize (72 DEG C -85 DEG C, 5-
15s) obtain whey liquid after removal cheese or casein afterwards；Remove casein micelle, the fatty and residue in the whey liquid；Again
Through obtaining whey rewinding after the dilute cream in Overheating Treatment (60 DEG C -75 DEG C, 3-5min) removal whey；Gained whey rewinding is added
Heat to 50 DEG C -55 DEG C, with ceramic membrane filter, after heavy filtration by gained filtrate through being heat-treated (60 DEG C -75 DEG C, 3-5min) again after
Spray drying, obtains final product.The rewinding of gained whey before filtration can be standby in 4 DEG C of -6 DEG C of refrigerations.Preparation method process chart is shown in figure
1。
In mixed vegetable oil rich in structured lipid OPO used below：Mass fraction >=17% of structured lipid OPO, and Sn-2
Palmitic acid/total palmitic acid >=40% (mass fraction).
The preparation method of the above-mentioned mixed vegetable oil rich in structured lipid OPO, including：Palm oil is divided under high-melting-point and puies forward group
Divide 80%PPP and 20%POP, then by 80%PPP and oleic acid with 3:1 mass ratio mixes, and is dissolved into n-hexane, in lipase
(40 DEG C) carry out grease rearrangement reaction under effect；Filtering goes to dezymotize after reaction terminates, and n-hexane is removed in redistillation, and then vacuum takes off
Except free fatty, semi-refined product is obtained；By the product and mixed vegetable oil (palm-kernel oil, sunflower oil, soybean oil, coconut palm
One or more in seed oil etc.) mixing preparation, obtain final product.
Can be detected by gas chromatography during mixing preparation, if to meet the requirements refine obtaining finished product,
If the undesirable needs of Product checking are allocated, detected, analyzed again, finished product is finally given.Preparation method technique stream
Journey figure is shown in Fig. 2.
Embodiment 1
A kind of prescription emulsifiable powder composition for contributing to infants growth and development, its active ingredient is included rich in milk fat ball film
The weight portion of PURE WHEY 43, the weight portion of mixed vegetable oil 203 rich in structured lipid OPO.
Embodiment 2
A kind of prescription emulsifiable powder composition for contributing to infants growth and development, its active ingredient includes being rich in milk fat ball film
The weight portion of PURE WHEY 25, the weight portion of mixed vegetable oil 100 rich in structured lipid OPO.
Embodiment 3
A kind of prescription emulsifiable powder composition for contributing to infants growth and development, its active ingredient includes being rich in milk fat ball film
The weight portion of PURE WHEY 25, the weight portion of mixed vegetable oil 250 rich in structured lipid OPO.
Embodiment 4
A kind of prescription emulsifiable powder composition for contributing to infants growth and development, its active ingredient includes being rich in milk fat ball film
The weight portion of PURE WHEY 75, the weight portion of mixed vegetable oil 100 rich in structured lipid OPO.
Embodiment 5
A kind of prescription emulsifiable powder composition for contributing to infants growth and development, its active ingredient includes being rich in milk fat ball film
The weight portion of PURE WHEY 75, the weight portion of mixed vegetable oil 250 rich in structured lipid OPO.
Embodiment 6
A kind of infant formula rich in MFGM and structured lipid OPO, it to contain and contribute to infant physical growth described in embodiment 1
The prescription emulsifiable powder composition of development, the mass fraction of the PURE WHEY rich in MFGM is described in the infant formula
4.3%, the mass fraction of the mixed vegetable oil rich in structured lipid OPO is 20.3%.The infant formula also contains
Appropriate common PURE WHEY, lactose, oligosaccharides, mineral matter, vitamin and some optional nutritional ingredient (choline, inositol, oxen
Sulfonic acid, carnitine etc.), based on the addition of these raw materials is carried out by GB GB10765-2010 or GB GB10767-2010 standards
Calculate.
The infant formula contains the component of following mass fraction：
Total MFGM- albumen 0.251%,
Phosphatidase 0 .301%,
Sphingomyelin 0.0688%,
Sialic acid 0.171%,
Total lactoferrin 0.0344%,
Immunoglobulin IgG 0.172%,
Lactadherin 0.043%,
Gangliosides 0.0086%,
MUC1/Mucin 0.0602%,
The ester 4.2% of -2 palmitic acid of bis- oleic acid of 1,3- three；
The mass fraction that wherein 2 palmitic acids account for total palmitic acid is 40% (referring to the content in every 100g milk powder).
Embodiment 7
A kind of infant formula rich in MFGM and structured lipid OPO, it to contain and contribute to infant physical growth described in embodiment 2
The prescription emulsifiable powder composition of development, the mass fraction of the PURE WHEY rich in MFGM is described in the infant formula
2.5%, the mass fraction of the mixed vegetable oil rich in structured lipid OPO is 10%.The infant formula is also containing suitable
Measure common PURE WHEY, lactose, oligosaccharides, mineral matter, vitamin and some optional nutritional ingredient (choline, inositol, ox sulphurs
Acid, carnitine etc.), the addition of these raw materials is calculated by GB GB10765-2010 or GB GB10767-2010 standards.
Embodiment 8
A kind of infant formula rich in MFGM and structured lipid OPO, it to contain and contribute to infant physical growth described in embodiment 5
The prescription emulsifiable powder composition of development, the mass fraction of the PURE WHEY rich in MFGM is described in the infant formula
7.5%, the mass fraction of the mixed vegetable oil rich in structured lipid OPO is 25%.The infant formula is also containing suitable
Measure common PURE WHEY, lactose, oligosaccharides, mineral matter, vitamin and some optional nutritional ingredient (choline, inositol, ox sulphurs
Acid, carnitine etc.), the addition of these raw materials is calculated by GB GB10765-2010 or GB GB10767-2010 standards.
Institute of the invention is experimentally as follows：
1 product nutritional quality and safety detection
The detection of product nutritive index, physical and chemical index, microbiological indicator and organoleptic indicator is in strict accordance with food security country
The detection project and the method for inspection that standard infant formulation (GB-10765-2010) is specified are carried out.
2 infant formulas rich in MFGM and OPO feed evaluation method to the clinical of infants growth and development
Recruit Pure breast feeding and pure prescription emulsifiable powder feeding infant, the situation of growing at its 0-6 monthly age of follow-up investigation.
It is into group, wherein being by Growth and development index of Pure breast feeding group (BF) baby after the informed consent of acquisition parent/guardian
Normative reference, prescription emulsifiable powder feeding infant is divided to two groups, is given respectively into the common baby milk breast of group baby in random, double blinding method
Powder (FF1) and the infant formula (prepared by FF2, experimental example 1) rich in MFGM and OPO.
The inspection of 2.1 physical growth of infants
Body weight and height detection are monthly carried out to 6 monthly ages from birth to baby, the project is completed by health care professional.Adopt
Measured with " multi-functional mother and baby claims ", the instrument maximum range：100kg, minimum range：0.7kg, precision 0.1kg.Height is surveyed
Amount scope：41cm-85cm, certainty of measurement 0.1cm.
Obtain after the height and weight data at baby's each monthly age using Z values method to the growth level and nutrition shape of baby
Condition is estimated.Z-score method is a kind of method the most frequently used when carrying out at present.Using the Anthro of WHO in this research
Assessment of nutritional status of the Z values that (version3.2.2, April2011) software is calculated to infant colony.
The evaluation of 2.2 baby feel comfortable degree
Filled in the follow-up investigation token every first quarter moon of record baby by parent and delactation, milk of choking, vomiting phenomenon occur after each feeding
The situation of generation and there is unknown cause at no distant date and cry and scream the situation of number of times.Monthly questionnaire is withdrawn carries out computer data inputting, with
Track carries out statistical analysis after finishing.
2.3 bone density inspections
Operated using ultrasonic bone density instrument (Sunlight Miniomni) by health care professional when 6 monthly age of baby
Into.Baby's bone developmental state is estimated by Z values measured by instrument：Wherein -1<Z values<0：Normal range (NR), less than average
Level；0<Z values<1：Normal range (NR), higher than average level；-2<Z values<-1：Bone density is relatively low, it is proposed that diet and replenishers are adjusted
It is whole；-3<Z values<-2：Bone density is very low, it is proposed that hospital checks, symptomatic treatment；1<Z values：Bone density very well, continues to keep.
2.4 baby intestinal development conditions are assessed
2.4.1 in enteron aisle Bifidobacterium and lactobacillus field planting
Using high flux gene sequencing platform, by detecting 16S rDNA V3+V4 areas, three groups of baby intestinal floras are investigated
Middle Bifidobacterium and the relative abundance of lactobacillus.Infant faeces DNA is extracted using excrement genome extracts kit (DP328)
(Tiangeng biochemical technology Co., Ltd, China), operates according to specification and completes；It is sequenced using Miseq after library construction, is surveyed
Sequence strategy is PE250；The lower machine data obtained after sequencing are complete by processes such as removal low quality base, Ns, joint polluted sequences
Into data filtering, believable target sequence (Clean Reads) is obtained, for subsequent analysis.Then by the corresponding of both-end sequencing
Read1 and Read2 spliced using sequence assembly method PEAR.Spliced sequence utilizes software QIME 1.8.0 versions
It is analyzed.
2.4.2 baby's defecation situation is investigated
Follow-up investigation token record baby's stool interval and fecal character are filled in by parent, wherein fecal character mainly includes：
Water sample, loose stools, half form, shaping and stiff five kinds.Monthly questionnaire is withdrawn carries out computer data inputting, and tracking is counted after finishing
Analysis.
2.5 two weeks morbidity rates
Mark to record interior baby every two weeks by follow-up investigation by parent and suffer from breathing problem, enteron aisle class disease and skin disease
The number of times of disease, computing formula is as follows, and new prescription emulsifiable powder is investigated to the pathogenetic suppression of baby intestinal disease by two weeks morbidity rate
Make and use.Compare between group and be compared using Cruskal-wallis rank test methods.
Experimental example 1 is applied to the design with 1 section of prescription emulsifiable powder for promoting infants growth and development of 0-6 month infants
Especially from the PURE WHEY and the structured lipid OPO of special allotment in the cow's milk rich in MFGM, its
9 kinds of function ingredients contents are as shown in table 3 in middle whey powder；The ester of bis- oleic acid -2- palmitic acids of 1,3- three contains in structured lipid OPO
It is 28.1g/100g to measure, and the ratio that Sn-2 palmitic acids account for palmitic acid is 46.95%.
Be suitable for the 0-6 monthly ages rich in MFGM and structured lipid OPO, and the prescription emulsifiable powder of infants growth and development can be promoted to set
Meter is especially added with PURE WHEY (addition be powder per ton in 43Kg) rich in MFGM and special with raw milk as primary raw material
Adjustable structure fat OPO (addition is 203Kg in powder per ton), other principal ingredients include that lactose, PURE WHEY (contain alpha-whey
Albumen), galactooligosaccharide (GOS), FOS (FOS), polyfructosan (Polyfructose), DHA
(DHA, source split kettle algae), arachidonic acid (ARA), taurine, mineral matter, vitamin, nucleotides, VBT tartrate,
CPP (CPP), lutein, wherein main Macronutrient content is as shown in table 4.Table 5 shows and is drawn by whey powder
Comparision contents of the 9 kinds of functional active components for entering in breast milk, in inventive formulation and in normal control group, lead to as shown in Table 5
9 kinds of functional active components contents are higher than control formula milk group in the formula crossed after lactalbumin of the addition rich in MFGM, and
Its content for being relatively close to these functional active components in breast milk group.
Table 3 is from cow's milk rich in functional active components relative amount in MFGM PURE WHEYs
Table 4 has main magnanimity nutrient composition content table in the infant formula for promoting intestinal health
Table 5 has functional active components content in the infant formula for promoting intestinal health
The product nutritional quality of experimental example 2 and safety detection
Being sent out with promotion infant physical growth after whey powdered egg and structured lipid OPO of the addition prepared by experimental example 1 rich in MFGM
The prescription emulsifiable powder educated according to formula by the product obtained after pilot scale entrust Beijing Haidian Quality Supervision and Examination Institute according to
According to national food safety standard infant formula (GB-10765-2010) requirement checked item by item after, product items refer to
Mark is up to state standards, and product is qualified.
Infant formula of the experimental example 3 rich in MFGM and OPO is evaluated clinical nursing of infants growth and development
Influence of the infant formula rich in MFGM and OPO prepared by 1 experimental example 1 to physical growth of infants
Body weight and height data are compared with WHO recommendations under baby's each monthly age to being collected into, find no matter boy baby
Or girl baby, its body weight and height exceed or meet WHO proposed standards value with monthly age variation tendency (data are not given).Specifically
Result is analyzed to the Z values of infants growth and development as follows：
WAZ can be used as the Monitoring Indexes of children growth.WAZ is commonly used in the world as the malnutritive illness rate of judgement
Foundation, WAZ ＜ -2 are under-weight.As can be seen from Table 6 under each monthly age, three groups of baby's WAZ values are all higher than -2, and this explanation exists
Without the infant of low-birth weight in this research.But WAZ values are negative when two groups of milk powder feeding infants are born, and milk is found after Analysis of variance
Overall nutrition condition is substantially less than breast-feeding group (P during powder nursing group baby due<, and this significant difference lasts till 0.05)
During 2 monthly age of baby.And comparing the discovery of two group of formula milk powder group baby WAZ values, the average WAZ values of FF2 groups baby are less than FF1 during birth
Group baby, but by FF2 groups baby WAZ values after the nursing of 2 months be 2 times of FF1 group babies, and slightly below breast-feeding
Group.Disappeared since difference between each group 3 monthly ages, three groups of nutrition conditions of baby are without significant difference (P ＞ 0.05).This shows two
Planting formula milk contributes to the lifting of infant nutrition level, and the medium baby on the lower side of developmental level helps so that during for birth
Overall nutrition condition returns to breast feeding babies level.
Table 7 compares the speed of growth of three groups of babies within 6 monthly ages simultaneously, when WT0 and WT6 represent birth respectively in table and
Body weight during 6 monthly age, WAZ0 and WAZ6 represent the Z values of W/A respectively；△ WAZ represent the difference of WAZ6 and WAZ0.Analysis of variance table
There were significant differences for body weight WTO and Weight-for-Age WAZ0 during bright three groups of baby dues, but by △ between after the nursing of 6 months three groups
Without significant difference (p ＞ 0.05), this shows two kinds of speeds of growth of formula fed infant with breast-feeding group without notable to WAZ
Difference.
Further by BAZ value overall merits baby entirety nutrition and health status, as a result as shown in table 8.Can from table
In addition to finding out that FF2 group baby's BAZ values are significantly higher than BF groups and FF1 group babies when 3 monthly age, other monthly ages lower three groups of babies'
BAZ is without significant difference.
In summary analysis understands that the prescription emulsifiable powder rich in MFGM and OPO prepared by experimental example 1 has to physical growth of infants
Effect is obviously promoted, can keep baby's entirety nutrition and health status with breast feeding babies without significant difference.
WAZ values compare in the baby's 0-6 monthly ages of table 6
The body weight level of growth and the speed of growth at the baby's 0-6 monthly ages of table 7
BAZ values compare in the different feeding mode baby's 0-6 monthly ages of table 8
Evaluation of 2 babies to prescription emulsifiable powder comfort level
2.1 choke milk
The ratio of milk phenomenon generation of being choked after baby feeds daily is counted, three group difference analyses are carried out by Chi-square Test.
As can be seen from Table 9 during feeding without choke milk phenomenon generation baby's ratio in three groups with the growth at monthly age
Raise, this constantly exercise and grasps the method for sucking nipple or nipple showing baby when birth i.e., from 1 monthly age when about
More than the 50% baby milk phenomenon that will not choke will not choke milk phenomenon to more than 95% baby during 6 monthly age.And lateral comparison
The milk situation of choking of three groups of babies under each monthly age, the baby that as a result finding FF1 groups baby has 90% at 3 monthly age will not occur
Choke milk phenomenon, and the baby that BF groups and FF2 groups baby have 90% at 5 monthly age will not choke milk phenomenon.This result table
Bright two kinds of prescription emulsifiable powders will not cause due to milk powder design or raw material from etc. aspect problem and the baby that causes seriously choke milk
Phenomenon, prescription emulsifiable powder feeding infant milk phenomenon occurrence frequency of choking is consistent with breast feeding babies, in tolerance interval.
Without the statistical analysis of milk phenomenon generation of choking after the infant feeding breast milk of table 9 or milk powder
2.2 delactations
Delactation's phenomenon is, because baby's intestines and stomach are in the puberty, breast milk or prescription emulsifiable powder can not to be disappeared completely
The phenomenon changed and produce, is on the other hand also the important indicator for evaluating prescription emulsifiable powder security and scientific formulation.Can from table 10
There is serious delactation's phenomenon with two group of formula milk powder feeding infants in finding out this research (average delactation's number of times daily is more than 2 times)
With breast milk group without significant difference, this shows two kinds of prescription emulsifiable powder formula design sciences to ratio, rationally, for being in the puberty
The fragile enteron aisle comfort level of baby it is satisfactory.
The statistical analysis that delactation's phenomenon occurs after the infant feeding breast milk of table 10 or milk powder
2.3 vomitings
Proportion without vomiting phenomenon during three groups of babies are from birth to 1 monthly age as shown in Table 11 reaches 60%, with
The monthly age three groups of growth without vomiting phenomenon proportion gradually rise.Particularly point out FF2 groups baby satisfaction at 4 monthly age
More than 90% is reached, it is suitable with BF group ratios, and FF1 group babies are significantly higher than, and this significant difference lasted till for 6 monthly ages,
Final BF groups baby and FF2 group infant vomiting satisfactions at 6 monthly age reach more than 95%, and FF1 groups baby expiring now
Meaning degree is lower slightly (80%).
The statistical analysis occurred without vomiting phenomenon after the infant feeding breast milk of table 11 or milk powder
2.4 cry and scream
In this research baby " the crying and screaming of unknown cause (stops crying after excluding feeding, diaper-exchanging and reduction/increase clothes
It is noisy) " proportion produces significant difference (as shown in table 12) in three groups between the 0-2 monthly ages, the generation between three groups since 3 monthly ages
Ratio without significant difference, wherein monthly age of statistical result showed 1 and FF2 groups and this unhealthy emotion of BF group babies occur during 2 monthly age
Ratio quite, but is substantially less than FF1 group babies.
There is unknown cause and cry and scream the statistical analysis of phenomenon in the baby of table 12
Note：Stop crying and screaming after excluding feeding, diaper-exchanging and reduction/increase clothes
In summary analysis can be seen that two kinds of prescription emulsifiable powder formulas designs rationally, science, the interim intestines of infant development
Road has good adaptability to two kinds of prescription emulsifiable powders, but FF2 groups eat the comfortable of the prescription emulsifiable powder baby rich in MFGM and OPO
Spend evaluation result closer to breast feeding babies (BF).
Influence of 3.3 infant formulas rich in MFGM and OPO to baby's skeleton development
Bone mineral density Z values are the direct evaluation indexes to baby's skeleton development.Fig. 4 shows three groups of babies at 6 monthly ages
When Bone mineral density result, as can be seen from the figure in three groups of babies prescription emulsifiable powder feeding infant Z values (skeleton development is very more than 1
Number ratio well) is higher than breast-feeding group, and number ratio of the FF2 group baby Z values more than 1 is higher than between FF1 groups, but three groups
Carry out after Chi-square Test without significant difference (P ＞ 0.05).Analysis reason be probably due in prescription emulsifiable powder especially reinforcing calcium and
Vitamin D is obviously promoted effect for baby's skeleton development, and the prescription emulsifiable powder for being rich in structured lipid OPO can further promote
Absorption of baby's body to calcium, and then so that the good person of skeleton development accounts for the ratio highest of total number of persons in FF2 group babies.
The influence that 3.4 infant formulas rich in MFGM and OPO are developed to baby intestinal
3.4.1 in baby intestinal Bifidobacterium and lactobacillus field planting
Using non-parametric test method (Cruskal-wallis rank tests) to two kinds of lactic acid bacterias in three groups of baby intestinals
Differences of the Lactobacillaceae and Bifidobacteriaceae under each monthly age is compared analysis, as a result such as the institute of table 13
Show.As seen from table, relative abundances of the Bifidobacteriaceae in three groups of baby intestinals changes without significant difference with the monthly age；
Lactobacillaceae produces significant difference (p ＜ 0.05) in baby 3,4 and 5 monthly age between group:Phase in FF1 group baby intestinals
BF groups are substantially less than to abundance, and the Cordycepps relative abundance is suitable with BF groups at 3 and 4 monthly age in FF2 group feeding infants enteron aisle,
BF groups are substantially less than during 5 monthly age.This shows the relative abundance of overall lactic acid bacteria in FF2 group baby intestinal floras closer to BF
Group.
Relative abundance Cruskal-wallis rank test p values in two kinds of lactic acid Cordycepps levels in 13 3 groups of baby intestinals of table
3.4.2 infant faeces proterties
The structured lipid OPO being especially added with this research has promotion calcium uptake, softens the effect of infant faeces.This research is examined
Three groups of babies are examined from 1 monthly age to the situation of change of 6 monthly age fecal characters, as a result as shown in Figure 5.It can be seen that from
It is half form that 1-6 monthly age breast feeding babies fecal characters are gradated by loose stools, and prescription emulsifiable powder feeding infant fecal character
It is gradually converted into based on shaping based on half form.But compare two group of formula milk powder nursing groups and find FF2 group baby's 1-3 monthly ages
When loose stools and half form relative scale be higher than FF1 groups, be to shape excrement to two group of formula fed infants during 6 monthly age
It is main.This result shows that the infant faeces proterties of FF2 groups is gradually converted into shaping compared with FF1 groups baby by loose stools and half form
Process is more releived, and shows that edible prescription emulsifiable powder of the addition rich in structured lipid OPO is matched somebody with somebody to baby intestinal comfort level higher than food sanitation standard
The baby of square milk powder.
Regulation of 3.5 infant formulas rich in MFGM and OPO to infant immunization function
Developing immune system is the important indicator that infantile health is grown up, and two kinds are compared by two weeks morbidity rate in this research
Feeding patterns, the disease condition of three groups of babies within the 0-6 monthly ages, compares three groups of immunocompetence developmental states of baby indirectly.Fig. 6
Represent that the disease condition between baby's 0-6 monthly ages totally compares, as can be seen from the figure formula fed infant suffers from respiratory tract disease
The ratio of disease is higher than breast-feeding group, and the ratio for suffering from disease of digestive tract is close with breast milk group, for this system of skin disease
Meter display FF1 groups baby is less than BF groups and FF2 group babies, but nothing between three kinds of incidence groups of disease in 6 months before statistical analysis
Significant difference (p ＞ 0.05).
Although above the present invention is described in detail with a general description of the specific embodiments,
On the basis of the present invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Cause
This, these modifications or improvements, belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (10)
1. a kind of prescription emulsifiable powder composition for contributing to infants growth and development, it is characterised in that its active ingredient is included rich in breast
The PURE WHEY 20-80 weight portions of fat globule membrane, the mixed vegetable oil 80-300 weight portions rich in structured lipid OPO.
2. prescription emulsifiable powder composition according to claim 1, it is characterised in that its active ingredient includes being rich in butter oil ball
The PURE WHEY 25-75 weight portions of film, the mixed vegetable oil 100-250 weight portions rich in structured lipid OPO；
Preferably, its active ingredient of the composition includes the weight portion of PURE WHEY 43 rich in milk fat ball film, rich in knot
The weight portion of mixed vegetable oil 203 of structure fat OPO.
3. prescription emulsifiable powder composition according to claim 1 and 2, it is characterised in that the lactalbumin rich in MFGM
Functional active components mass fraction is as follows in powder：
Total MFGM- albumen 3-7%,
Phosphatidase 5-9%,
Sphingomyelin 0.5-3%,
Sialic acid 1-3%,
Total lactoferrin 0.5-2%,
Immunoglobulin IgG 2-6%,
Lactadherin 0.5-2%,
Gangliosides 0.1-0.5%,
MUC1/Mucin1 1-3%；And/or,
In the mixed vegetable oil rich in structured lipid OPO：Mass fraction >=17% of structured lipid OPO, and Sn-2 palmitic acids/total
Palmitic acid >=40%.
4. prescription emulsifiable powder composition according to claim 1 and 2, it is characterised in that the lactalbumin rich in MFGM
Functional active components mass fraction is as follows in powder：
Total MFGM- albumen 5.84%,
Phosphatide 7%,
Sphingomyelin 1.6%,
Sialic acid 2%,
Total lactoferrin 0.8%,
Immunoglobulin IgG 4%,
Lactadherin 1%,
Gangliosides 0.2%,
MUC1/Mucin1 1.4%；And/or,
OPO mass fraction is 20-30% in the structured lipid OPO, and Sn-2 palmitic acids/
Total palmitic acid is 40-50%；
It is preferred that OPO mass fraction is 28.1% in the structured lipid OPO, and Sn-2
Palmitic acid/total palmitic acid is 46.95%.
5. the infant formula of prescription emulsifiable powder composition described in claim any one of 1-4 is contained, it is characterised in that the baby
The mass fraction of the PURE WHEY rich in milk fat ball film described in youngster's prescription emulsifiable powder is 2.0-8.0%, described rich in structure
The mass fraction of the mixed vegetable oil of fat OPO is 8.0-30.0%.
6. infant formula according to claim 5, it is characterised in that be rich in described in the infant formula
The mass fraction of the PURE WHEY of MFGM is 2.5-7.5%, the mass fraction of the mixed vegetable oil rich in structured lipid OPO
It is 10-25%；
It is preferred that the mass fraction of the PURE WHEY rich in MFGM described in the infant formula is 4.3%, rich in knot
The mass fraction of the mixed vegetable oil of structure fat OPO is 20.3%.
7. the infant formula according to claim 5 or 6, it is characterised in that the infant formula is also containing suitable
Measure common PURE WHEY, lactose, oligosaccharides, mineral matter, vitamin, and/or optional nutritional ingredient, the optional nutrition into
Point include one or more in choline, inositol, taurine, carnitine.
8. the infant formula according to claim any one of 5-7, it is characterised in that the infant formula contains
The component of following mass fraction：
Total MFGM- albumen 0.146-0.438%,
Phosphatidase 0 .175-0.525%,
Sphingomyelin 0.04-0.12%,
Sialic acid 0.05-0.18%,
Total lactoferrin 0.02-0.06%,
Immunoglobulin IgG 0.1-0.3%,
Lactadherin 0.025-0.075%,
Gangliosides 0.005-0.015%,
MUC1/Mucin 0.035-0.105%,
The ester 2.07-5.17% of -2 palmitic acid of 1,3- bis- oleic acid three, wherein the mass fraction that 2 palmitic acids account for total palmitic acid is
19.7-49.24%.
9. infant formula according to claim 8, it is characterised in that the infant formula contains following quality
The component of fraction：
Total MFGM- albumen 0.251%,
Phosphatidase 0 .301%,
Sphingomyelin 0.0688%,
Sialic acid 0.171%,
Total lactoferrin 0.0344%,
Immunoglobulin IgG 0.172%,
Lactadherin 0.043%,
Gangliosides 0.0086%,
MUC1/Mucin 0.0602%,
The ester 4.2% of -2 palmitic acid of bis- oleic acid of 1,3- three；The mass fraction that wherein 2 palmitic acids account for total palmitic acid is 40%.
10. the preparation method of infant formula described in any one of claim 5-9, it is characterised in that including：Raw milk is net
Breast, pre-sterilizing, dispensing and standardization, homogeneous are sterilized, concentration, spray drying；
Preferably, main technologic parameters are：85 DEG C -88 DEG C of pre-sterilizing, 30s；Homogeneous 15mPa；It is sterilized 93 DEG C -95 DEG C, 15s；Spray
Mist dries 150 DEG C -160 DEG C of EAT, 85 DEG C -90 DEG C of leaving air temp.
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