CN106359604B - A kind of infant formula and preparation method thereof promoting intestinal health - Google Patents
A kind of infant formula and preparation method thereof promoting intestinal health Download PDFInfo
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- CN106359604B CN106359604B CN201610721097.4A CN201610721097A CN106359604B CN 106359604 B CN106359604 B CN 106359604B CN 201610721097 A CN201610721097 A CN 201610721097A CN 106359604 B CN106359604 B CN 106359604B
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1526—Amino acids; Peptides; Protein hydrolysates; Nucleic acids; Derivatives thereof
Abstract
The present invention provides a kind of infant formula for promoting intestinal health, and the infant formula is to be modulated using raw milk as primary raw material by adding the PURE WHEY for being rich in MFGM and other ingredients.The present invention is raw material by selecting the novel PURE WHEY rich in MFGM, the bioactive substance with specific function ingredient is promoted by formula adjustment, such as MFGM albumen, the content of lactoferrin, phosphatide, gangliosides, sphingomyelin, sialic acid etc., reach the field planting for promoting probiotics in baby intestinal flora, the purpose of the content of immune factor and reduction intestines problem incidence in enteron aisle is improved, which is suitable for the exploitation of baby and larger infant formula.
Description
Technical field
The present invention relates to food engineering fields, specifically, be related to it is a kind of promote intestinal health infant formula and
Preparation method.
Background technique
Breast milk is the optimal natural food of baby, and nutriment abundant provides in breast milk for the growth and development of infant
Energy and nutritional need.But for some since itself or external factor cause breast milk insufficient or can not implement breast-feeding
Person, baby formula milk powder become its infant physical growth initial stage main breast milk replenishers or breast milk substitute.Therefore, infant matches
Using breast milk as standard, the Nomenclature Composition and Structure of Complexes on the basis of cow's milk by adjusting each nutrient is seeking it for the exploitation of square milk powder
It supports and functionally all close to breast milk.Recently as the further investigation discovery to breast milk composition, trace active ingredient butter oil
Content of the ball film (MFGM) in breast milk is much higher than in milk, and distinctive bioactive lipid and unique film egg in its component
It is white to facilitate the multiple functions such as the raising of infant's cognitive ability, intestinal growth, immune system maturation, become baby formula
The emphasis of milk powder research and development.
Currently, the research and application about MFGM focus mostly on greatly, component is separated, is identified and by zoopery to its function
In terms of energy Property Verification, and its application study in clinic is less.For its nutritive value, there are still a variety of hypothesis, lack true
Real reliable data supporting.My raw-food material Co., Ltd, Denmark dominates the clinical test follow-up investigation implemented 499
The healthy babies at name 6-11 monthly age, after supplement is rich in the albumen powder of MFGM in its congee powder, the growth and development of the 6 monthly ages above baby
Index and control group are without significant difference, but infantile diarrhea illness rate significantly reduces；Billeaud et al. assumes examination using non-pessimum
It tests method to evaluate the safety of the babies ' formula milk powder rich in MFGM and tolerance, the results showed that edible two kinds are rich in MFGM
The weight gain of formula milk baby is poor unlike control group, and baby all has good tolerance to both formula milks.
In the existing application for the PURE WHEY rich in MFGM in clinic, the congee in the diatery supplement of baby after 6 monthly ages
Middle addition is affected rich in the evaluation of its clinical efficacy of the albumen powder of MFGM by many factors such as other foods.And match in baby
The safety and tolerance of product have only been investigated in clinical research used in square milk powder, for wherein critical function component in baby
The specific effect played in vivo there is no further research.
The present invention is raw material by selecting the novel PURE WHEY rich in MFGM, and being promoted by formula adjustment has spy
The bioactive substance (MFGM albumen, lactoferrin, phosphatide, gangliosides, sphingomyelin, sialic acid) of different functional component
Content, reach promote baby intestinal flora in probiotics field planting, improve enteron aisle in immune factor content and reduce enteron aisle
The purpose of disease incident, the formula are suitable for the exploitation of baby and larger infant formula.
Summary of the invention
The purpose of the present invention is being rich in the PURE WHEY of milk fat ball film (MFGM) by selecting, formulated infant milk is improved
The content of total MFGM albumen, lactoferrin, phosphatide, gangliosides, sphingomyelin, sialic acid etc. in powder reaches and promotes baby
The normal field planting of youngster's intestinal flora improves the content of immune factor and the purpose for preventing intestines problem from occurring, the formula in enteron aisle
Exploitation suitable for baby and larger infant formula.
In order to achieve the object of the present invention, the milk power for infant and young children that the present invention designs passes through using raw milk as primary raw material
Addition rich in the PURE WHEY of MFGM, common PURE WHEY, fats, lactose, oligosaccharides, minerals, vitamin and
After some optional nutritional ingredients (choline, inositol, taurine, carnitine etc.) carry out ingredient standardization, the infant formula milk that modulates
Powder has the function of promoting baby intestinal health.
The present invention provides a kind of infant formula for promoting intestinal health, and the infant formula is to be with raw milk
Primary raw material is modulated by adding the PURE WHEY for being rich in MFGM and other ingredients；Wherein every 100 grams of babies match
The content of functional active components is as follows in square milk powder: total MFGM albumen 0.146-0.438g, phosphatidase 0 .175-0.525g, neurolemma
Phosphatidase 0 .04-0.12g, sialic acid 0.05-0.18g, lactoferrin 0.02-0.06g, Immunoglobulin IgG 0.1-0.3g, curdling
Collect element 0.025-0.075g, gangliosides 0.005-0.015g, MUC1 albumen 0.035-0.105g.(table 1)
Table 1 has the content of functional active components in the babies ' formula milk powder for promoting intestinal health
Preferably, the content of functional active components is as follows in every 100 grams of infant formulas: total MFGM albumen
0.251g, phosphatidase 0 .301g, sphingomyelin 0.0688g, sialic acid 0.171g, lactoferrin 0.0344g, immunoglobulin
IgG 0.172g, lactadherin 0.043g, gangliosides 0.0086g, MUC1 albumen 0.0602g.
Wet method processing technology can be used and prepare the infant formula: being rich in by being added in pre-sterilized raw milk
The PURE WHEY of MFGM and other ingredients are sterilized after homogeneous, and the infant formula is made in then concentrated, spray drying
Milk powder.
For the additive amount of the PURE WHEY rich in MFGM in different phase or the formula powder of different constitution baby exploitations
It need to be adjusted according to the actual situation, add the cream for being rich in MFGM into raw milk by the range of solid-liquid ratio 1-3:80Kg/L
Albumin powder.
Be rich in the PURE WHEY of MFGM used in the present invention, can be prepared according to following technique: raw milk passes through
Pasteurize (72 DEG C -85 DEG C, 5-15s) removes cheese or casein afterwards, obtains whey liquid；The casein removed in whey liquid is micro-
Residue in grain and fat and whey, the dilute cream removed in whey using (60 DEG C -75 DEG C, 3-5min) of heat treatment, institute
Whey rewinding is obtained to refrigerate at 4 DEG C -6 DEG C.So that whey rewinding temperature is risen to 50 DEG C -55 DEG C before filtering, (is cut using special filter membrane
Stay molecular weight 1kDa-100kDa) be filtered, the filtrate obtained after heavy filtration be heat-treated again (60 DEG C -75 DEG C, 3-
5min), it is then spray-dried to obtain the final product.The PURE WHEY obtained using above-mentioned technique is compared with general proteins powder, the main distinction
Be wherein functional active components (MFGM albumen, phosphatide, sphingomyelin, sialic acid, lactoferrin, Immunoglobulin IgG,
Lactadherin, gangliosides and MUC1 albumen) content it is opposite improve, and this 9 kinds of functions are living in common PURE WHEY
Property be in trace or minor levels.
Using main nutrient composition relative mass percentage composition in the PURE WHEY made from above-mentioned technique rich in MFGM
It is as follows: lactalbumin 70%-75%, total MFGM albumen 3%-7%, phosphatidase 5 %-9%, sphingomyelin 0.5%-3%, saliva
Sour 1%-3%, lactoferrin 0.5%-2%, Immunoglobulin IgG 2%-6%, lactadherin 0.5%-2%, ganglioside
Rouge 0.1%-0.5%, MUC1 albumen 1%-3%.
Other ingredients include alpha-lactoalbumin containing common PURE WHEY, lipid, fatty acid, lactose, oligosaccharides, more
Glycans, minerals, vitamin, choline, peptides, inositol, taurine, lutein, carnitine etc..
In the specific embodiment of the present invention, table 2 is added into the raw milk by solid-liquid ratio 1:46.5Kg/L
The PURE WHEY rich in MFGM.Other principal ingredients include lactose, the mixed vegetable oil containing OPO Structure grease, general
Logical PURE WHEY (containing alpha lactalbumin), galactooligosaccharide (GOS), oligofructose (FOS), polyfructosan
(Polyfructose), docosahexaenoic acid (pot algae is split in DHA, source), arachidonic acid (ARA), taurine, minerals,
Vitamin, nucleotide, l-carnitine tartrate, casein phosphopeptide (CPP), lutein etc., wherein main Macronutrient contains
Amount is shown in Table 3.
Table 2 is from cow's milk rich in functional active components relative amount in MFGM PURE WHEY
Table 3 has main magnanimity nutrient composition content table in the infant formula for promoting intestinal health
Contain in every 100 grams of infant formulas: total MFGM albumen 0.251g, phosphatidase 0 .301g, sphingomyelin
0.0688g, sialic acid 0.171g, lactoferrin 0.0344g, Immunoglobulin IgG 0.172g, lactadherin 0.043g, nerve
Glycosides rouge 0.0086g, MUC1 albumen 0.0602g is saved, alpha-lactoalbumin containing common PURE WHEY 3.7g, lactose 46.2g contain
The mixed vegetable oil 19.3g of OPO Structure grease, galactooligosaccharide 0.89g, oligofructose 0.1g, polyfructosan 0.07g, 20
Two carbon acid 0.045g, arachidonic acid 0.065g, taurine 0.038g, minerals 1.32g, vitamin 0.079g, nucleosides
Sour 0.025g, l-carnitine tartrate 0.007g, casein phosphopeptide 0.045g, lutein 0.00007g.
The infant formula of promotion intestinal health of the invention, can be prepared as follows: using wet method processing technology
(Fig. 1) carries out pre-sterilizing after net cream using raw milk as raw milk, is rich in MFGM to by addition in pre-sterilized raw milk
PURE WHEY and other ingredients, sterilized after homogeneous, then concentrated, spray drying to get.
Main technologic parameters are as follows: pre-sterilizing (85 DEG C -88 DEG C, 30s)；Homogeneous 15MPa；It sterilizes (93 DEG C -95 DEG C, 15s)；Spray
Mist is dry (150 DEG C -160 DEG C of inlet air temperature, 85 DEG C -90 DEG C of leaving air temp).
Product nutritive index, physical and chemical index, microbiological indicator and the detection of organoleptic indicator are in strict accordance with food safety country
The specified detection project of standard infant formulation (GB-10765-2010) and the method for inspection carry out.
In another embodiment of the invention, using high throughput sequencing technologies to 16S rDNA in infant faeces
Gene carries out sequencing analysis, investigates the shadow that the formula milk of PURE WHEY of the addition rich in MFGM constitutes baby intestinal flora
Ring, and combine baby's defecation situation, in intestines problem incidence and excrement immune factor content, from macroscopic perspective to being rich in
The infant formula of MFGM is given data to the facilitation of intestinal health and is supported.
It is provided by the invention that there is the prescription emulsifiable powder for promoting baby intestinal health, the lactalbumin of MFGM is rich in by adding
Powder, improve in formula with total MFGM albumen of specific function effect, lactoferrin, IgG, lactadherin, MUC1/Mucin1,
The content of 9 kinds of functional active components such as phosphatide, gangliosides, sphingomyelin and sialic acid makes it as far as possible close to breast milk,
So that the baby intestinal flora for eating the formula constitutes and prebiotic bacterial content is close to breast feeding babies；Excrement is promoted simultaneously
The content of middle sIgA is to enhance intestinal immunity；In conjunction with the baby intestinal disease for eating the formula, a situation arises, as a result table
Bright, this product has facilitation to baby intestinal health, particularly suitable suitable for the exploitation of baby and larger infant formula
It is designed in 1 section of babies ' formula milk powder.
Detailed description of the invention
Fig. 1 is the processing process figure that the present invention has the infant formula for promoting intestinal health.
Fig. 2 is that two kinds of formula milk group babies tie compared with breast milk group infant faeces character in present pre-ferred embodiments
Fruit.Wherein, 1 group of milk powder is common infant formula nursing group (FF1), and 2 groups of milk powder are infant formula of the addition rich in MFGM
Milk powder group (FF2).
Specific embodiment
The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention..Unless otherwise specified, embodiment
According to conventional laboratory conditions, such as Sambrook molecular cloning experiment handbook (Sambrook J&Russell DW,
Molecular Cloning:a Laboratory Manual, 2001), or according to the condition of manufacturer's specification suggestion.
The relative mass percentage of 9 kinds of functional active components in PURE WHEY used in the following embodiment rich in MFGM
Content is shown in Table 2.
1 section of babies ' formula milk powder of normal control group is purchased from Sanyuan Food Co., Ltd., Beijing, product name " golden clothes happiness
Intelligence is good for babies ' formula milk powder ".
Embodiment is suitable for the babies ' formula milk powder with promotion intestinal health of 0-6 month infant
1, it is suitable for the design with the formula milk for promoting baby intestinal health at 0-6 monthly age
Using raw milk as primary raw material, be especially added with the PURE WHEY rich in MFGM, other principal ingredients include lactose,
It is mixed vegetable oil containing OPO Structure grease, common PURE WHEY (contain alpha lactalbumin), galactooligosaccharide (GOS), oligomeric
Fructose (FOS), polyfructosan (Polyfructose), docosahexaenoic acid (pot algae is split in DHA, source), arachidonic acid
(ARA), taurine, minerals, vitamin, nucleotide, l-carnitine tartrate, casein phosphopeptide (CPP), lutein etc.,
Wherein main Macronutrient content is shown in Table 3.Table 4 show in 9 functional active components in breast milk, it is in inventive formulation and general
Comparision contents in logical control group, as shown in Table 4, by adding in the formula being rich in after the PURE WHEY of MFGM, 9 kinds of functions
Active component content is higher than control formula milk group, and its content for being relatively close to these functional active components in breast milk group.
Table 4 has functional active components content in the infant formula for promoting intestinal health
Contain in every 100 grams of new prescription emulsifiable powders: total MFGM albumen 0.251g, phosphatidase 0 .301g, sphingomyelin
0.0688g, sialic acid 0.171g, lactoferrin 0.0344g, Immunoglobulin IgG 0.172g, lactadherin 0.043g, nerve
Glycosides rouge 0.0086g, MUC1 albumen 0.0602g is saved, alpha-lactoalbumin containing common PURE WHEY 3.7g, lactose 46.2g contain
The mixed vegetable oil 19.3g of OPO Structure grease, galactooligosaccharide 0.89g, oligofructose 0.1g, polyfructosan 0.07g, 20
Two carbon acid 0.045g, arachidonic acid 0.065g, taurine 0.038g, minerals 1.32g, vitamin 0.079g, nucleosides
Sour 0.025g, l-carnitine tartrate 0.007g, casein phosphopeptide 0.045g, lutein 0.00007g.
Designed new formula infant milk powder uses wet method processing technology, and Fig. 1 is shown in process flow.Using raw milk as raw material
Cream carries out pre-sterilizing after cream only, to the PURE WHEY for being rich in MFGM by addition 1Kg in pre-sterilized raw milk 46.5L, and
Other ingredients are added, are sterilized after homogeneous, it is then concentrated, spray drying to get.
Main technologic parameters are as follows: pre-sterilizing (85 DEG C -88 DEG C, 30s)；Homogeneous 15mPa；It sterilizes (93 DEG C -95 DEG C, 15s)；Spray
Mist is dry (150 DEG C -160 DEG C of inlet air temperature, 85 DEG C -90 DEG C of leaving air temp).
2, product nutritional quality and safety detection
Addition after the PURE WHEY of MFGM rich in having the infant formula for promoting intestinal health according to designing
The product that is obtained after pilot scale of formula entrust Beijing Haidian Quality Supervision and Examination Institute according to food safety country
The requirement of standard infant formulation (GB-10765-2010) carries out after examining item by item, and product indices are up to state standards,
Product is qualified.
3, infant formula of the addition rich in MFGM evaluates the clinical efficacy of baby intestinal health benefit
3.1 intestinal floras constitute and the influence of changing rule
Breast-feeding group (BF), common infant formula nursing group (FF1) and addition are rich in the infant formula milk of MFGM
The baby of powder group (FF2) is as shown in table 5 from birth to intestinal flora composition changing rule 6 monthly ages.As can be seen from Table 5, exist
First three dominant microflora of the horizontal upper three groups of baby intestinal flora rankings of door is bacteroid Bacteroidetes, sclerine bacterium
Firmicutes and mycetozoan Proteobacteria, and with three kinds of bacterium relative abundance variation tendencies in three groups of the variation at monthly age
It unanimously, is Bacteroidetes in the trend gradually risen, and the trend gradually decreased is presented in Proteobacteria, but
Compare the opposite of three kinds of dominant bacterias of person in the lower three groups of baby intestinals of different time points by Cruskal-wallis rank sum test method
Abundance (table 6), as the result is shown without significant difference (p > 0.05).
The relative abundance of the upper three groups of baby intestinal dominant microfloras of 5 levels of table
Using breast milk group as standard, ranking is carried out by descending sequence in 85% flora to the horizontal relative abundance of section,
As a result as shown in 6 first row of table.To the relative abundances of this 9 kinds of bacterium in two group of formula milk powder group baby intestinal floras respectively with breast milk
Group baby is compared analysis, and acquired p value is listed in table 7.As can be seen from Table 7, baby intestinal flora in formula milk FF1 group
Unstable changing rule is presented with the growth at monthly age in difference flora between breast milk group baby, by rigid connatae 2 kinds of differences
Different flora, increasing when to 3 monthly age is 5 species diversity bacterium, and to 6 monthly age when sports indifference flora；But formula milk FF2 group
There are 3 species diversity floras compared with breast milk group when 1 monthly age of birth in although, as becoming for steady decrease is presented in the increase at monthly age
Gesture, difference flora when to 6 monthly age between the two is only a kind, thus infers the edible formula milk baby intestinal bacterium rich in MFGM
Group gradually decreases with the increase flora composition at monthly age and the difference of relative abundance and breast milk group, and flora is constituted with breast milk group gradually
It is close.
The Cruskal-wallis sum of ranks of the lower three groups of baby intestinal flora relative abundances of different time points in 6 levels of table
Examine p value
The horizontal upper two kinds of formula milk groups baby of 7 section of the table p value with breast milk group baby intestinal flora comparing difference respectively
Note: statistical method is (Mann-Whitney) U method of inspection, and wherein the use overstriking italic of p < 0.05 indicates.
The detection of immune factor in 3.2 excrement
The case where in order to investigate three groups of baby intestinal local immunities, analyzes the content of sIgA in excrement, as a result such as table 8
Shown, as can be seen from Table 8, the trend for first increasing and reducing afterwards is presented in the content of sIgA in three groups of baby intestinals, but without significant
Difference (P > 0.05), and the three groups of babies selected in the content discovery present invention of sIgA in baby intestinal under more each monthly age go out
The content of sIgA content in FF2 group is substantially less than breast-feeding group and FF1 group in green tire excrement, but after nursing in 15 days,
Content in FF2 group is close with FF1 group, but is lower than breast milk group, but when reaching for 1 monthly age in three groups of baby intestinals sIgA content without
Significant difference.This shows that addition facilitates to stimulate baby intestinal mucosal secretions immune factor sIgA rich in the formula milk of MFGM,
To improve baby intestinal immunity.
Immune factor sIgA comparision contents (μ g/mL, X ± s) in baby intestinal under 8 Different Month of table
Note: there are significant differences in the level of α=0.05 between same row difference lowercase a and b indicate different groups
The incidence of 3.3 baby's defecation situations and intestines problem
Defecation character is that the important clinical of evaluation baby formula milk powder comfort level refers to one of disease.Specific nutrition in breast milk
The Nomenclature Composition and Structure of Complexes determines the characteristics of its absorption easy to digest, a large number of studies show that breast feeding babies fecal character is compared with formula milk
Feeding infant excrement is soft.Result of the present invention is as shown in Fig. 2, figure it is seen that from 1-6 monthly age breast feeding babies excrement
Character is gradated by loose stools as half form, and formula fed infant fecal character be gradually converted into based on half form with
Based on forming.But loose stools and half form relative scale are higher than when comparing the two group of formula milk powder groups discovery FF2 group baby 1-3 monthly age
FF1 group, two group of formula fed infants are to shape based on excrement when to 6 monthly age.This result shows that, the baby of FF2 group
Fecal character is more releived compared with FF1 group baby by the process that loose stools and half form are gradually converted into forming, shows that edible addition is rich in
The formula milk of MFGM lactalbumin is higher than the baby of food sanitation standard formula powder to baby intestinal comfort level.
Intestines problem incidence is to investigate an important indicator of baby intestinal health, and the present invention utilizes Chi-square method ratio
Compared with the difference of three groups of baby intestinal disease incidences, as shown in Table 9, two kinds of formula fed infant intestines problem disease incidence
With breast feeding babies without significant difference under each time point at 1-6 monthly age.After this illustrates addition rich in the lactalbumin of MFGM
Formula milk and common standard formula milk breast-feeding group baby is not significantly higher than to the incidence of baby intestinal disease
Youngster is conducive to the healthy development of baby intestinal.
9 three groups of baby intestinal disease incidents of table compare
For the additive amount of the PURE WHEY rich in MFGM in different phase or the formula powder of different constitution baby exploitations
It need to be adjusted according to the actual situation, add the cream for being rich in MFGM into raw milk by the range of solid-liquid ratio 1-3:80Kg/L
Albumin powder, formula milk obtained have effects that similar promotion baby intestinal health.
Although above the present invention is described in detail with a general description of the specific embodiments,
On the basis of the present invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Cause
This, these modifications or improvements, fall within the scope of the claimed invention without departing from theon the basis of the spirit of the present invention.
Claims (3)
1. a kind of infant formula for promoting intestinal health, which is characterized in that the infant formula is to be with raw milk
Primary raw material is modulated by adding the PURE WHEY for being rich in milk fat ball film and other ingredients；
Wherein, other ingredients include alpha-lactoalbumin containing common PURE WHEY, lipid, fatty acid, lactose, oligosaccharide
Class, polysaccharide, minerals, vitamin, choline, peptides, inositol, taurine, lutein, carnitine；
Contain in every 100 grams of infant formulas: total milk fat ball film 0.251g, phosphatidase 0 .301g, sphingomyelin
0.0688g, sialic acid 0.171g, lactoferrin 0.0344g, Immunoglobulin IgG 0.172g, lactadherin 0.043g, nerve
Glycosides rouge 0.0086g is saved, membrane albumen 0.0602g, alpha-lactoalbumin containing common PURE WHEY 3.7g, lactose 46.2g contain
The mixed vegetable oil 19.3g of OPO Structure grease, galactooligosaccharide 0.89g, oligofructose 0.1g, polyfructosan 0.07g, 20
Two carbon acid 0.045g, arachidonic acid 0.065g, taurine 0.038g, minerals 1.32g, vitamin 0.079g, nucleosides
Sour 0.025g, l-carnitine tartrate 0.007g, casein phosphopeptide 0.045g, lutein 0.00007g.
2. the preparation method of the infant formula according to claim 1 for promoting intestinal health, which is characterized in that use
Wet method processing technology carries out pre-sterilizing after net cream using raw milk as raw milk, to by adding richness in pre-sterilized raw milk
The PURE WHEY of creaminess fat ball film and other ingredients are sterilized after homogeneous, then concentrated, spray drying to get.
3. the preparation method of the infant formula according to claim 2 for promoting intestinal health, which is characterized in that kill in advance
85 DEG C -88 DEG C of bacterium condition, 30s；Processing condition 15MPa；93 DEG C -95 DEG C of sterilization conditions, 15s；Spray drying condition: inlet air temperature
150 DEG C -160 DEG C, 85 DEG C -90 DEG C of leaving air temp.
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101484024A (en) * | 2006-06-30 | 2009-07-15 | 艾博特公司 | Enriched infant formulas |
| CN102524421A (en) * | 2011-12-31 | 2012-07-04 | 黑龙江省完达山乳业股份有限公司 | Novel acid-base balance infant formula milk powder and preparation method thereof |
| CN102665428A (en) * | 2009-12-08 | 2012-09-12 | 雀巢产品技术援助有限公司 | Infant formula with probiotics and milk fat globule membrane components |
| CN103155999A (en) * | 2011-12-16 | 2013-06-19 | 光明乳业股份有限公司 | Nutrient modularized infant milk powder and raw material composition thereof |
| CN105076484A (en) * | 2015-09-09 | 2015-11-25 | 浙江康诺邦健康产品有限公司 | Infant formula milk powder for improving intestinal absorption and preparation method thereof |
| CN105578899A (en) * | 2013-07-01 | 2016-05-11 | 英雄股份公司 | New prophylactic use for prevention of infections |
-
2016
- 2016-08-24 CN CN201610721097.4A patent/CN106359604B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101484024A (en) * | 2006-06-30 | 2009-07-15 | 艾博特公司 | Enriched infant formulas |
| CN102665428A (en) * | 2009-12-08 | 2012-09-12 | 雀巢产品技术援助有限公司 | Infant formula with probiotics and milk fat globule membrane components |
| CN103155999A (en) * | 2011-12-16 | 2013-06-19 | 光明乳业股份有限公司 | Nutrient modularized infant milk powder and raw material composition thereof |
| CN102524421A (en) * | 2011-12-31 | 2012-07-04 | 黑龙江省完达山乳业股份有限公司 | Novel acid-base balance infant formula milk powder and preparation method thereof |
| CN105578899A (en) * | 2013-07-01 | 2016-05-11 | 英雄股份公司 | New prophylactic use for prevention of infections |
| CN105076484A (en) * | 2015-09-09 | 2015-11-25 | 浙江康诺邦健康产品有限公司 | Infant formula milk powder for improving intestinal absorption and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 乳脂肪球膜的组成与应用研究进展;乔发东;《中国乳品工业》;20111231(第11期);35-38 |
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