CN106841646A - Automatic clinical chemistry analyzer and method with spininess alternating apparatus - Google Patents
Automatic clinical chemistry analyzer and method with spininess alternating apparatus Download PDFInfo
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- CN106841646A CN106841646A CN201710034211.0A CN201710034211A CN106841646A CN 106841646 A CN106841646 A CN 106841646A CN 201710034211 A CN201710034211 A CN 201710034211A CN 106841646 A CN106841646 A CN 106841646A
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- reagent
- hollow needle
- pin
- spininess
- cup
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1004—Cleaning sample transfer devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1065—Multiple transfer devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1065—Multiple transfer devices
- G01N2035/1076—Multiple transfer devices plurality or independently movable heads
Abstract
The invention discloses a kind of automatic clinical chemistry analyzer with spininess alternating apparatus and method, the instrument includes reagent disc, reaction tray, agitating unit, sample load units, detection cup cleaning unit, optical detection unit, control and Data Analysis Services unit and more than one spininess alternating apparatus；The spininess alternating apparatus include multiple hollow needles, valve, connecting line, fixed-quantity injector and pin mobile device；The hollow needle is connected by valve, pipeline and fixed-quantity injector respectively；The pin mobile device is used for the multiple hollow needles of synchronous drive between reagent bottle and detection cup, or between specimen cup and detection cup, or synchronizing moving between reagent bottle, specimen cup and detection cup.The present invention greatly reduces traditional automatic clinical chemistry analyzer because reagent/specimen pin cleans not thoroughly caused difference reagents, sample room cross pollution by spininess alternating apparatus, can improve the accuracy and reliability of testing result.
Description
Technical field
The invention belongs to medical test detection technique field, particularly a kind of full-automatic biochemical with spininess alternating apparatus
Analyzer and method.
Background technology
Automatic clinical chemistry analyzer is the conventional testing equipment of medical institutions.Subject matter in existing this quasi-instrument use
One of be exactly that various different reagents, different sample are usually needed to use in detecting, and instrument is using shared reagent pin and sample
Product pin is measured in drawing different reagents and different each detection cups of sample addition respectively.When reagent and sample is drawn, examination
Inside and outside, especially usually remaining reagent and the sample inside pin of agent pin and sample pin, and thoroughly cleaning is difficult to, medical science inspection in addition
General the requiring of instrument is tested to be run according to speed higher, therefore, often without time enough to reagent pin, sample pin inside and outside
Thoroughly cleaning is carried out, and causes the reagent or sample of residual to form interference to subsequent detection.And using many in instrument operation
Although the mode of secondary cleaning can effectively lower or avoid this kind of cross pollution, so directly result in instrument detection speed
Substantially reduce.
Also there is the method that sample or reagent are drawn using disposable tip in the prior art, but due to drawing examination every time
Agent, sample are required for abandoning a used tip, and this is accomplished by larger space and deposits substantial amounts of disposable tip just now
May insure that instrument is on duty without operating personnel, and required consumable quantity is huge during the instrument operation of the design.
The content of the invention
It is an object of the invention to provide a kind of automatic clinical chemistry analyzer with spininess alternating apparatus and method, solve
Existing automatic clinical chemistry analyzer device reagent pin, the cross-contamination issue of sample pin.
The technical scheme for realizing the object of the invention is：A kind of automatic clinical chemistry analyzer with spininess alternating apparatus, should
Instrument includes reagent disc, reaction tray, agitating unit, sample load units, detection cup cleaning unit, optical detection unit, control
And Data Analysis Services unit and more than one spininess alternating apparatus；
The reagent disc is used to place reagent, and the sample load units are used to place sample, and the reaction tray periphery is used
In detection cup is placed, the agitating unit is used to be stirred liquid in detection cup；The optical detection unit is used for inspection
Survey liquid in cup to be detected, the detection cup cleaning unit is used to clean detection cup, the control and Data Analysis Services list
Unit is analyzed treatment for controlling analyzer each unit cooperating to optical detection unit detection data；
The spininess alternating apparatus include multiple hollow needles, valve, connecting line, fixed-quantity injector and pin mobile device,
Hollow needle is connected by valve, connecting line and fixed-quantity injector respectively；The pin mobile device is used to drive multiple hollow needles
Between reagent bottle and detection cup, or between specimen cup and detection cup, or between reagent bottle, specimen cup and detection cup synchronously
It is mobile.
The present invention also provides a kind of reagent/specimen distribution method based on automatic clinical chemistry analyzer, comprises the following steps：
Step 1, by pin mobile device by multiple hollow needle synchronizing movings of spininess alternating apparatus to reagent bottle or sample
In cup；
Step 2, when multiple hollow needles are lowered into reagent bottleneck with liquid upper surface, due to the sensing of pin liquid level
Function, hollow needle is stopped in the shallow-layer of liquid surface, and one of hollow needle draws reagent or sample, and remaining hollow needle is not drawn,
In stand-by state；
Multiple hollow needles are moved to detection cup top by step 3 by pin mobile device, draw the one of reagent or sample
Individual hollow needle just to detection rim of a cup, the reagent or sample of absorption is assigned in detection cup；
Step 4, after completing reagent and sample distribution, pin mobile device drives hollow needle to return to cleaning position simultaneously and carries out clearly
Wash；
Step 5, pin mobile device drawn by multiple hollow needle synchronizing movings, again and enabled when distributing reagent it is last round of in
Hollow needle in stand-by state, the hollow needle of last round of work is in stand-by state during this；
Step 6, repeat step 1- steps 5, until instrument completes reagent distribution and Detection task.
The present invention also provides another reagent/specimen distribution method based on automatic clinical chemistry analyzer, including following step
Suddenly：
Step 1, by pin mobile device by two hollow needle synchronizing movings of spininess alternating apparatus to reagent bottle or sample
In cup；
Step 2, the 3rd motor 4M is rotated, and drives the first vertical upper arm 5L ' above to carry by regulating arm 4L so that first
Hollow needle N1 is above carried and is not stretched into liquid level, and in stand-by state, the second hollow needle N2 stretches into liquid level and draws reagent or sample；
Two hollow needles are moved to detection cup position by step 3 by pin mobile device, will be drawn in the second hollow needle N2
Reagent or sample be assigned to detection cup in；
Step 4, after completing reagent or sample distribution, two hollow needles return to cleaning position and are cleaned simultaneously；
Step 5, pin mobile device drives by two hollow needles again synchronizing moving to reagent bottle or specimen cup, when the 3rd
Motor is rotated and drives the second vertical upper arm 5L above to carry by regulating arm so that the second hollow needle N2 is above carried and do not stretched into liquid level, is in
Stand-by state, the first hollow needle N1 stretches into liquid level and draws reagent or sample.
Compared with prior art, remarkable result of the invention is：The present invention is full-automatic with new spininess alternating apparatus
Biochemical Analyzer, can not extend scavenging period, it is ensured that on the premise of instrument operating rate, inside and outside reagent pin and sample pin
The residual of reagent and sample realizes abundant and effective cleaning, substantially reduces or even eliminate other with quasi-instrument in the link
The cross pollution of formation, and for different degrees of cross pollution treatment provide multiple modes solution, therefore with compared with
Convenience well, feasibility, economy and validity.
Brief description of the drawings
Fig. 1 is that the present invention contains two analyzer structural representations of spininess alternating apparatus.
Fig. 2 is analyzer structural representation of the present invention using rail mounted specimen holder.
Fig. 3 is that reagent of the present invention one and reagent two share an analyzer structural representation for disk.
Fig. 4 is a kind of analyzer structural representation containing reagent/specimen disk of the invention.
Fig. 5 is another analyzer structural representation containing reagent/specimen disk of the invention, wherein reagent disc and sample disc
A region is shared, sample is loaded into the center of disk, and reagent bottle is then loaded into around disk.
Fig. 6 is the spininess alternating apparatus operating diagram containing a syringe and an orientation pump.
Fig. 7 is containing two spininess alternating apparatus operating diagrams of syringe.
Fig. 8 is the spininess alternating apparatus operating diagram containing two syringes and an orientation pump.
Fig. 9-1- Fig. 9-3 controls to change the schematic diagram of hollow needle horizontal range for the present invention by electronic eccentric wheel.
Figure 10-1 and Figure 10-2 is the hollow needle schematic diagram that at least one hollow needle increased insulation protective jacket 3H.
Figure 11-1, Figure 11-2 and Figure 11-3 change the schematic diagram of hollow needle upper and lower displacement for the present invention by motor control,
Wherein Figure 11-1 is front view, and Figure 11-2 and 11-3 is side view.
Figure 12-1- Figure 12-3 is pin outer wall ponding remove device schematic diagram of the present invention.
Figure 13-1 and Figure 13-2 sets the schematic diagram of the second air jet system for the present invention.
Specific embodiment
With reference to Fig. 1, a kind of automatic clinical chemistry analyzer with spininess alternating apparatus of the invention, the instrument includes reagent
Disk 1, reaction tray 5, agitating unit, sample load units, detection cup cleaning unit 2B, optical detection unit, control and data point
Analysis processing unit and more than one spininess alternating apparatus；
The reagent disc 1 is used to place reagent, and the sample load units 3A is used to place sample, the reaction tray 5 weeks
Side is used to place detection cup, and the agitating unit is used to be stirred liquid in detection cup；The optical detection unit is used for
Liquid in detection cup is detected, the detection cup cleaning unit 2B is used to clean detection cup, the control and data analysis
Processing unit is used to control analyzer each unit cooperating, and is analyzed treatment to optical detection unit detection data；
The spininess alternating apparatus include multiple hollow needles, valve, connecting line, fixed-quantity injector and pin mobile device,
Hollow needle is connected by valve, connecting line and fixed-quantity injector respectively；The pin mobile device is used to drive multiple hollow needles
Between reagent bottle and detection cup, or between specimen cup and detection cup, or between reagent bottle, specimen cup and detection cup synchronously
It is mobile.
Multiple hollow needles that same pin mobile device is driven enter only one when reagent bottle draws reagent every time
Hollow needle draws reagent, and other pins are not drawn, but when inside and outside cleaning is carried out to pin every time in each on the same reagent arm
The equal synchronous cleaning of empty needle.
Further, the spininess alternating apparatus include N number of hollow needle, valve, the first fixed-quantity injector S1, the first orientation
Pump P1 and pin mobile device；Each hollow needle is connected by setting valvular connecting line with the first fixed-quantity injector S1, institute
State the first fixed-quantity injector S1 to be connected with one end of the first orientation pump P1 by valve, the other end of the first orientation pump P1 is by the road
It is connected with cup.As N=2, the spininess alternating apparatus specifically include the first hollow needle N1, the second hollow needle N2, the first valve
Door V1, the second valve V2, the 3rd valve V3, the orientation pumps of the first fixed-quantity injector S1 and first P1；The first hollow needle N1 warps
Pipeline is connected with the 3rd valve V3, and the 3rd valve V3 is connected with the first fixed-quantity injector S1 by the road；Second hollow needle N2 is through pipe
Road is connected with the second valve V2, and the second valve V2 is connected with the first fixed-quantity injector S1 by the road；The pipeline of the first syringe is also
It is connected with the first valve V1 simultaneously, and the one end of the first valve V1 by the road with the first orientation pump P1 is connected, the first orientation pump P1
The other end be connected with cup by the road.The working method of the spininess alternating apparatus is：When pin mobile device is by two pins all bands
During in reagent bottle or specimen cup, if the first hollow needle N1 is used to draw reagent or sample, the second hollow needle N2 is not aspirated temporarily
Stand-by state in inoperative, specially closes the first valve V1, the second valve V2, opens the 3rd valve V3, and first quantifies
Syringe S1 pumpbacks, reagent or sample are sucked in the first hollow needle N1；When pin mobile device all takes two pins to detection cup position,
First fixed-quantity injector S1 pistons are advanced, and the reagent or sample drawn in the first hollow needle N1 are assigned in detection cup；Complete
After reagent distribution during cleaning needle, the first valve V1, the second valve V2, the 3rd valve V3 are opened, and orientation pump P1 works to pipeline
Water is pumped into, then two hollow needles are cleaned simultaneously.Draw again and enable the first hollow needle N2 when distributing reagent, during cleaning still
It is so that two pins are cleaned simultaneously.
Further, the spininess alternating apparatus include the movement of N number of hollow needle, valve, N number of second fixed-quantity injector and pin
Device；Each hollow needle is connected by setting valvular connecting line with corresponding second fixed-quantity injector, each second determine
Amount syringe is connected by valve with cup.As N=2, the spininess alternating apparatus specifically include the 3rd hollow needle N3,
Four hollow needle N4, the 4th valve V4, the 5th valve V5, the 6th valve V6, the 7th valve V7, the second fixed-quantity injector S2 and the 3rd
Fixed-quantity injector S3；The 3rd hollow needle N3 is connected by the 7th valve V7 and the 3rd fixed-quantity injector S3, in the described 4th
Empty needle N4 is connected by the 4th valve V4 and the second fixed-quantity injector S2；The second fixed-quantity injector S2 and the 3rd calibrated shot
Device S3 is connected by the 5th valve V5 and the 6th valve V6 with cup respectively.
Further, spininess alternating apparatus also include second orientation pump P2, each second fixed-quantity injector by valve with
One end connection of the second orientation pump P2, the other end of the second orientation pump P2 is connected with cup.As N=2, the 5th valve V5 and
Six valve V6 are connected by the second orientation pump P2 with cup, and the second orientation pump P2 is used to provide power by water along the 5th valve
V5, the path of the 4th valve V4 and the 4th hollow needle N4 are sent to the 4th hollow needle N4 to pin internal washing, and by water along the 6th
Valve V6, the path of the 7th valve V7 and the 3rd hollow needle N3 are sent to the 3rd hollow needle N3 to pin internal washing.
Further, the pin mobile device includes support frame 3L, the first motor 3F, the first driving belt 3F ', axle
Bar 3K, pin transfer arm 2A, fixed seat 3K ', the second motor 3G and the second driving belt 3G ', pin transfer arm 2A and axostylus axostyle 3K
Connection, support frame 3L is by the axostylus axostyle 3K, the first motor 3F of the fixed pin transfer arms of fixed seat 3K ' by the first transmission
The axostylus axostyle 3K of belt 3F ' control transfer arms horizontally rotates, so as to drive multiple hollow needles synchronously to rotate in the horizontal direction；Second drives
Dynamic motor 3G controls the axostylus axostyle 3K of transfer arm to move up and down by the second driving belt 3G ', so as to drive multiple hollow needle synchronizations
Move up and down.
Further, the spininess alternating apparatus also include the first air jet system 10, water cleaning head 11 and waste collection groove
2D, air jet system 10, water cleaning head 11 are arranged at pin cleaning positions, and air jet system 10, water cleaning head 11 are directed to hollow needle
The outer wall at top, and the outlet port of the first air jet system 10 is higher than the position of water cleaning head 11, and water cleaning head 11 is first passed through when using
To pin outside injection pure water, the water that subsequent first air jet system 10 is remained when pin appearance is cleaned to pin appearance gas injection is clear
Sweep, waste collection groove 2D is arranged on spininess alternating apparatus lower section, for collecting the waste water after rinsing；
The offside of first air jet system 10 is provided with collecting pipe 12, when the first air jet system 10 is to needle point outer wall jet drying gas
When, the ponding of produced gas and the pin appearance for being blown off enters in collecting pipe 12.
Further, spininess alternating apparatus include two hollow needles, and the inclined of motorized motions is provided between two hollow needles
Heart wheel 3M, spring P3, the first insulation clip P1, the second insulation clip P2 and attachment means P；The motor-driven bias
Wheel 3M is arranged on the top between two hollow needles, and the spring S is by the first insulation clip P1 and the second insulation clip
P2 connects two hollow needles, and the setting attachment means P below spring, the attachment means P are connected between two hollow needles
And attachment means P can be rotated with two hollow needle tie points respectively；Two needle points of bottom when electronic eccentric wheel 3M transverse presentation
It is close to, fits into aperture, pulls two needle points to separate automatically when electronic eccentric wheel erects position；
Spininess alternating apparatus also include that the 3rd motor 4M, regulating arm 4L, the first vertical upper arm 5L ' and second vertically hang
Arm 5L；3rd motor 4M is connected with regulating arm 4L, and the two ends of regulating arm connect the first vertical upper arm 5L ' and second and hang down respectively
The other end of direct screening arm 5L, the first vertical upper arm 5L ' connects the other end connection the of the first hollow needle N1, the second vertical upper arm 5L
Two hollow needle N2；By the position adjustment of the first hollow needle N1 and the second hollow needle N2 pins it is in turn as needed operationally one high
One is low, it is to avoid two pins are while contact liq；Two hollow needle needle points are provided with liquid level induction system, for sensing hollow needle pin
Whether point is stretched into liquid.
Further, at least one of two hollow needles pin outside has the insulation protective jacket insulation will to separate between two pins；
The second air jet system being fixed with hollow needle, pin outer surface reagent is removed for draw leave after reagent blow before reagent bottle.The
The quantity of two air jet systems is one or two.
Further, the sample disc is circular sample disk 3A or rail mounted specimen holder 3B.
Further, the reagent disc and sample load units share a disk, and reagent position is arranged on the outer ring of disk,
Sample bit is arranged on the inner ring of disk.
Further, the agitating unit includes mixing needle 2E and air pressure mixing needle 2F.
The present invention also provides a kind of reagent/specimen based on the above-mentioned automatic clinical chemistry analyzer with spininess alternating apparatus
Distribution method, comprises the following steps：
Step 1, by pin mobile device by multiple hollow needle synchronizing movings of spininess alternating apparatus to reagent bottle or sample
In cup；
Step 2, when multiple hollow needles are lowered into reagent bottleneck with liquid upper surface, due to the sensing of pin liquid level
Function, hollow needle is stopped in the shallow-layer of liquid surface, and one of hollow needle draws reagent or sample, and remaining hollow needle is not drawn,
In stand-by state；
Multiple hollow needles are moved to detection cup position, by what is drawn in a hollow needle by step 3 by pin mobile device
Reagent or sample are assigned in detection cup；
Step 4, after completing reagent and sample distribution, pin mobile device drives hollow needle to return to cleaning position simultaneously and carries out clearly
Wash；
Step 5, pin mobile device drawn by multiple hollow needle synchronizing movings, again and enabled when distributing reagent it is last round of in
Hollow needle in stand-by state, the hollow needle of last round of work is in stand-by state during this；
Step 6, repeat step 1- steps 5, until instrument completes reagent distribution and Detection task.
For the crosspointer alternating apparatus with eccentric wheel, mentioned reagent/sample distribution method is comprised the following steps：
Step 1, by pin mobile device by two hollow needle synchronizing movings of spininess alternating apparatus to reagent bottle or sample
In cup, now eccentric wheel is in perpendicular position, and the needle point of two hollow needles is in separated position；
Step 2, because pin liquid level senses when during two hollow needles lower into reagent bottleneck with liquid upper surface
Function, two pins are stopped in the shallow-layer of liquid surface, and one of hollow needle draws reagent or sample, and another hollow needle is not drawn,
In stand-by state；
Two hollow needles are moved to detection cup position by step 3 by pin mobile device, and eccentric wheel becomes transverse presentation by perpendicular position,
The needle point of two hollow needles is drawn close, and into detection rim of a cup, the reagent or sample drawn in a hollow needle is assigned into detection afterwards
In cup；
Step 4, after completing reagent and sample distribution, eccentric wheel becomes perpendicular position by transverse presentation, and two needle points of hollow needle are separated, pin
Mobile device drives two hollow needles to return to cleaning position simultaneously and is cleaned；
Step 5, pin mobile device drawn by two hollow needle synchronizing movings, again and enabled when distributing reagent it is last round of in
Hollow needle in stand-by state, the hollow needle of last round of work is in stand-by state during this.
Only one of which pin is in running order all the time in this device course of work, and another pin is in stand-by state, i.e.,
Each pin uses the preceding inside and outside cleaning for obtaining twice.
The present invention also provides another reagent/sample based on the above-mentioned automatic clinical chemistry analyzer with spininess alternating apparatus
Product distribution method, comprises the following steps：
Step 1, by pin mobile device by two hollow needle synchronizing movings of spininess alternating apparatus to reagent bottle or sample
In cup；
Step 2, the 3rd motor 4M is rotated, and drives the first vertical upper arm 5L ' above to carry by regulating arm 4L so that first
Hollow needle N1 is above carried and is not stretched into liquid level, and in stand-by state, the second hollow needle N2 stretches into liquid level and draws reagent or sample；
Two hollow needles are moved to detection cup position by step 3 by pin mobile device, will be drawn in the second hollow needle N2
Reagent or sample be assigned to detection cup in；
Step 4, after completing reagent or sample distribution, two hollow needles return to cleaning position and are cleaned simultaneously；
Step 5, pin mobile device drives by two hollow needles again synchronizing moving to reagent bottle or specimen cup, when the 3rd
Motor is rotated and drives the second vertical upper arm 5L above to carry by regulating arm so that the second hollow needle N2 is above carried and do not stretched into liquid level, is in
Stand-by state, the first hollow needle N1 stretches into liquid level and draws reagent or sample.
Only one of which pin is in low level working condition all the time in the device course of work, and another pin is in high-order standby
State so that the liquid drawn required for the tip contacts of each only one of which pin when two pins take turns to operate, and each pin
Use the preceding inside and outside cleaning for obtaining twice.
The present invention is described further with reference to the accompanying drawings and examples.
Embodiment 1
Such as accompanying drawing 1, a kind of automatic clinical chemistry analyzer with spininess alternating apparatus, the instrument include two reagent discs 1,
Sample disc 3A, reaction tray 5, agitating unit, optical detection unit, detection cup cleaning unit 2B, 2 spininess alternating apparatus and one
Sample pin；Optical detection unit includes light source 5A, monochromator 5B, optical signal detector 5C；2 spininess alternating apparatus are included respectively
First pin transfer arm 2A and the second pin transfer arm 2A ', sample is directed to and answers pin transfer arm 2C.
There are multiple reagent bottle 1-1 on described two reagent discs 1, be respectively used to place reagent one and reagent two；The sample
Disk 3A is used to place sample；The reaction tray 5 is additionally provided with multiple detection cups 6, for placing detection cup；The optical detection unit
For being detected to liquid in detection cup；The detection cup cleaning unit 2B is used to clean detection cup；The spininess wheel changes the outfit
Put for drawing reagent, each spininess alternating apparatus is made up of two hollow needles and two circuits respectively, and each pipeline is respectively connected
One fixed-quantity injector, and all of pin is fixed in a pin mobile device, each pin synchronizing moving at any time, in turn in work
When the hollow needle of state, i.e., is in running order, another hollow needle is in stand-by state；The sample pin is used to draw sample
This.
Each detection cup during detection in reaction tray 5 receives the first reagent at the first detection cup position RC1 all the time, in the second inspection
Survey at the RC2 of cup position and receive sample, first time stirring is carried out at the 3rd detection cup position RC3, portion of reagent detection project is the 4th
Receive the second reagent at detection cup position RC4, carry out second stirring at the 5th detection cup position RC5 afterwards.Instrument is anti-when running
Rotation every time should be coiled turn around and stop after+1, therefore detection cup position often rotates once just reach one, in reaction tray rotary course
According to order detect cup in add reagent one, sample, be stirred afterwards, selectively add or be added without reagent two.
After adding reagent two, agitating device is again stirring for liquid in detection cup, and all detection cup is examined when reaction tray rotates every time
Survey, each detection cup of acquisition is added after serum before and after reagent one is added, and adds reagent two to detect the extinction of liquid in cup afterwards
Angle value, finally according to the absorbance data that each detection cup is obtained to overall process detection, projects in the different samples of analysis acquisition
Biochemistry detection result.
Embodiment 2
As accompanying drawing 2, the present embodiment are distinguished as with embodiment 1, sample load mode is rail mounted sample introduction in the present embodiment
Device 3B.
Embodiment 3
Such as accompanying drawing 4, the present embodiment is distinguished as with embodiment 1, the reagent one of the present embodiment, reagent two and sample shared
Sample is placed in individual first reagent sample disk 8, outer ring, and inner ring places reagent, and only 1 spininess alternating apparatus are used to distribute reagent
And sample.
Embodiment 4
Such as accompanying drawing 5, the present embodiment is distinguished as with embodiment 3, the reagent one of the present embodiment, reagent two and sample shared
Individual second reagent sample disk 9, inner ring places sample, and reagent is placed in outer ring.
Embodiment 5
Such as accompanying drawing 6, on the basis of embodiment 1, spininess alternating apparatus are included in the first hollow needle N1, second the present embodiment
Empty needle N2, the first valve V1, the second valve V2, the 3rd valve V3, the first fixed-quantity injector S1, the first orientation pump P1 and pin movement
Device；The first orientation pump P1 is connected by the first valve V1 with the first fixed-quantity injector S1, the first hollow needle N1, the
Two hollow needle N2 are connected by the 3rd valve V3, the second valve V2 with the first fixed-quantity injector S1 respectively；The pin mobile device
For driving the first hollow needle N1 and the second hollow needle N2 to be moved between reagent position, sample position and detection cup simultaneously.
First hollow needle N1, the second hollow needle N2 synchronizing movings, but two hollow needles are in running order in turn, i.e., when
When one hollow needle N1 is in running order, the second hollow needle N2 is in standby and specially cleans state, same rather than two needle systems
The absorption distribution of Shi Zhihang samples or reagent.Its specific works mode is：When pin mobile device all takes two hollow needles to examination
When in agent bottle or specimen cup, if the first hollow needle N1 is used to draw reagent or sample, the second hollow needle N2 is not aspirated temporarily and is in
The stand-by state of inoperative, specially closes the first valve V1, the second valve V2, opens the 3rd valve V3, the first calibrated shot
Device S1 pumpbacks, reagent or sample are sucked in the first hollow needle N1；When pin mobile device all takes two pins to detection cup position, first
Fixed-quantity injector S1 pistons are advanced, and the reagent or sample drawn in the first hollow needle N1 are assigned in detection cup；
When the first hollow needle N1 work is finished takes back cleaning position in pin mobile device, two pins perform once inside and outside clear simultaneously
Wash, its internal washing is：The first valve V1 is opened, the second valve V2 and the 3rd valve V3 is closed, the first orientation pump P1 extracts water
Into syringe, the first valve V1 is then shut off, opens the second valve V2 and the 3rd valve V3, the first fixed-quantity injector S1 is pushed away
Enter, water is discharged by the road to being poured water in two hollow needles by syringe needle.Simultaneously one is additionally provided with the outside of two hollow needles
Exterior washings head above is cleaned to the outside of hollow needle with water, and then pin mobile device transports two pins according to above-mentioned flow
OK, only the second hollow needle N2 is used for the absorption distribution of reagent or sample in this flow, and the second hollow needle N2 is using finishing
When pin mobile device takes back cleaning position afterwards, two pins perform once clean again simultaneously, then reuse the first hollow needle N1, so
Each pin is all cleaned twice using preceding.
Embodiment 6
If accompanying drawing 7, the present embodiment are that the spininess alternating apparatus of the present embodiment are fixed comprising two with the difference of embodiment 5
Amount syringe, only uses one of hollow needle, the same hollow needle first to draw reagent, then pipette samples during per task, with
Reagent is together assigned in a detection cup with sample afterwards.
3rd hollow needle N3, the 4th hollow needle N4 synchronizing movings during work, its specific works mode is：When pin mobile device
When transfer arm 2A takes two pins to reagent bottle, if the 3rd hollow needle N3 is used to draw reagent, the 4th hollow needle N4 does not take out temporarily
The stand-by state in inoperative is inhaled, the 6th valve V6 is specially closed, the 7th valve V7 is opened, the 3rd fixed-quantity injector S3 is
3rd hollow needle N3 provides draw power；When pin mobile device transfer arm 2A takes two pins to detection cup position, the 3rd determines
Amount syringe S3 piston propulsions, the reagent drawn in the 3rd hollow needle N3 is assigned in detection cup；
When the 3rd hollow needle N3 work finish take back cleaning position in pin mobile device transfer arm 2A when, the 3rd hollow needle N3 and
4th hollow needle N4 performs once inside and outside cleaning simultaneously, and its internal washing is：The 4th valve V4 and the 7th valve V7 is closed, is opened
5th valve V5 and the 6th valve V6, the second fixed-quantity injector S2 and the 3rd fixed-quantity injector S3 pumpbacks, water is drawn into second to be determined
In amount syringe S2 and the 3rd fixed-quantity injector S3, the 5th valve V5 and the 6th valve V6 is closed afterwards, open the 4th valve V4
With the 7th valve V7, the second fixed-quantity injector S2 and the 3rd fixed-quantity injector S3 propulsion, water by the road to the 3rd hollow needle N3 and
Poured water in 4th hollow needle N4, and discharged by syringe needle, while being additionally provided with more than one outside in the outside of two hollow needles
Cleaning head is cleaned to the outside of hollow needle.Then pin mobile device transfer arm 2A drives the 3rd hollow needle N3 for sample
Distribution is drawn, the 3rd hollow needle N3 using when finishing rear pin mobile device transfer arm 2A and taking back cleaning position, hold simultaneously again by two pins
Row is once cleaned, and then reuses the 4th hollow needle N4, and so each pin is all cleaned twice using preceding.
Embodiment 7
Such as accompanying drawing 1 and Fig. 2, on the basis of the present embodiment 1, analyzer configures one to be used to draw and distribute the hollow of sample
Pin, and two spininess alternating apparatus for being exclusively used in drawing distribution reagent are additionally provided with simultaneously, drawn by two different reagent discs respectively
Reagent is assigned in detection cup.
Embodiment 8
In the present embodiment, analyzer configures the spininess alternating apparatus for being used to drawing and distributing sample, and also simultaneously
Two spininess alternating apparatus for being exclusively used in drawing distribution reagent are provided with, drawing reagent by two different reagent discs respectively is assigned to inspection
Survey in cup.
Embodiment 9
Such as accompanying drawing 3, in the present embodiment, the analyzer configures first spininess dedicated for drawing and distributing sample
Alternating apparatus 2A, and a second spininess alternating apparatus 2A ' dedicated for drawing and distributing reagent is additionally provided with simultaneously.
Embodiment 10
As shown in Figure 8, the present embodiment and embodiment 6 are distinguished as, and the present embodiment spininess alternating apparatus also contain second
Orientation pump P2, the second syringe S2 and the 3rd syringe S3 are pumped into for providing sufficient power by water or cleaning agent.
Embodiment 11
The present embodiment spininess alternating apparatus are also provided with eccentric wheel 3M, the spring of motorized motions between two hollow needles
P3, the first insulation clip P1, the second insulation clip P2 and attachment means P.The motor-driven eccentric wheel 3M is arranged on
Top between two pins, the spring S is connected two hollow needles by the first insulation clip P1 and the second insulation clip P2,
And hereunder also have attachment means P be connected between two hollow needles and the attachment means respectively with two hollow needle tie points
Can rotate.
Such as Fig. 9-1- Fig. 9-3, during work, electronic eccentric wheel 3M is rotated from perpendicular position to transverse presentation, is driven outside two hollow needle upper ends
Push away, two syringe needles are drawn close to centre；Work is finished, and electronic eccentric wheel 3M is rotated from transverse presentation to perpendicular position, drives two hollow needle upper ends
Interior receipts, two syringe needles are horizontally divided, continue to keep certain distance.
Embodiment 12
Such as accompanying drawing 10-1, two hollow needle N1 and N2 upper outsides respectively have an insulation protective jacket 3H '；
Or such as accompanying drawing 10-2, only have on the top of spininess and insulation protective jacket 3H is carried on the outside of a hollow needle N2.
Embodiment 13
As shown in accompanying drawing 11-1- Figure 11-3, the spininess alternating apparatus of the present embodiment also include the 3rd motor 4M, regulation
Arm 4L, the first vertical upper arm 5L ' and the second vertical upper arm 5L.3rd motor and regulating arm are joined directly together, and the two of regulating arm
End connects the first vertical upper arm and the second vertical upper arm respectively, and the other end of the first vertical upper arm connects the first hollow needle N1, the
The other end of two vertical upper arms connects the second hollow needle N2.
Operationally can as needed in turn by the position adjustment of the first hollow needle N1 and the second hollow needle N2 pins be it is one high,
One is low, it is to avoid two pins are while contact liq.3rd motor 4M is rotated, and drives the first vertical upper arm above to carry by regulating arm,
So that the first hollow needle N1 is above carried and do not stretched into liquid level, in stand-by state, the second hollow needle N2 stretches into liquid level and draws reagent or sample
Product；Two hollow needles are moved to by detection cup position, the reagent or sample that will be drawn in the second hollow needle N2 by pin mobile device
Product are assigned in detection cup；After completing reagent or sample distribution, two hollow needles return to cleaning position and are cleaned simultaneously；Pin is moved
By in two hollow needles again synchronizing moving to reagent bottle or specimen cup, the 3rd motor is rotated and driven by regulating arm device
Second vertical upper arm is above carried so that the second hollow needle N2 is above carried and do not stretched into liquid level, and in stand-by state, the first hollow needle N1 is stretched into
Liquid level draws reagent or sample.Only one of which pin is in running order all the time in this device course of work, and another pin is in
Stand-by state, i.e. each pin use the preceding inside and outside cleaning for obtaining twice.
Embodiment 14
As shown in accompanying drawing 12-1- Figure 12-3, the present embodiment cleaning position is additionally provided with the first air jet system 10, the and of water cleaning head 11
Bigbore collecting pipe 12, work hour hands outer wall ponding remove device shower nozzle points to two hollow needles with 45 degree of angles from top to bottom
Outer wall, dry gas are sprayed after the completion of pin cleaning to pin outer wall, blow the ponding of pin appearance off, it is to avoid water droplet brings reagent bottle and sample into
In product cup.Bigbore collecting pipe is used to collect due to the liquid and air-flow that are splashed when gas sprays.
Embodiment 15
As shown in Figure 13-1 and Figure 13-2, the second air jet system is fixed with the hollow needle of the present embodiment, is tried for drawing
Pin outer surface reagent is removed in air blowing before reagent bottle is left after agent.
When the quantity of the second air jet system is one, hollow needle side is arranged on；The quantity of the second air jet system is two
When, reference 13 and 14 in figure are separately positioned on the both sides of hollow needle.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.Each part being not known in the present embodiment can use prior art to be realized.
Claims (10)
1. a kind of automatic clinical chemistry analyzer with spininess alternating apparatus, it is characterised in that the instrument include reagent disc (1),
Reaction tray (5), agitating unit, sample load units, detection cup cleaning unit (2B), optical detection unit, control and data point
Analysis processing unit and more than one spininess alternating apparatus；
The reagent disc (1) is used to place sample, the reaction tray (5) for placing reagent, the sample load units (3A)
Periphery is used to place detection cup, and the agitating unit is used to be stirred liquid in detection cup；The optical detection unit is used
Liquid is detected in detection cup, and detection cup cleaning unit (2B) is used to clean detection cup, the control and data
Analysis and processing unit is used to control analyzer each unit cooperating, and is analyzed place to optical detection unit detection data
Reason；
The spininess alternating apparatus include more than one hollow needle, valve, connecting line, fixed-quantity injector and pin movement dress
Put, hollow needle is connected by valve, connecting line and fixed-quantity injector respectively；The pin mobile device is used to drive multiple hollow
Pin between reagent bottle and detection cup, or between specimen cup and detection cup, or between reagent bottle, specimen cup and detection cup it is same
Moved further.
2. the automatic clinical chemistry analyzer with spininess alternating apparatus according to claim 1, it is characterised in that same pin
Multiple hollow needles that mobile device is driven enter only one hollow needle when reagent bottle draws reagent and draw reagent every time,
And other pins are not drawn, but the equal synchronous cleaning of each hollow needle when inside and outside cleaning is carried out to pin every time on the same reagent arm.
3. the automatic clinical chemistry analyzer with spininess alternating apparatus according to claim 1, it is characterised in that described many
Pinwheel changing device includes N number of hollow needle, valve, the first fixed-quantity injector (S1), the first orientation pump (P1) and pin mobile device；Often
Individual hollow needle is connected by setting valvular connecting line with the first fixed-quantity injector (S1), first fixed-quantity injector
(S1) it is connected with one end of the first orientation pump (P1) by valve, the other end of the first orientation pump (P1) connects with cup by the road
Connect.
4. the automatic clinical chemistry analyzer with spininess alternating apparatus according to claim 1, it is characterised in that described many
Pinwheel changing device includes N number of hollow needle, valve, N number of second fixed-quantity injector and pin mobile device；Each hollow needle is by setting
Valvular connecting line is connected with corresponding second fixed-quantity injector, and each second fixed-quantity injector passes through valve and cup
Connection.
5. the automatic clinical chemistry analyzer with spininess alternating apparatus according to claim 4, it is characterised in that many pinwheels
Changing device also includes the second orientation pump (P2), and each second fixed-quantity injector is connected by one end of valve and the second orientation pump (P2)
Connect, the other end of the second orientation pump (P2) is connected with cup.
6. the automatic clinical chemistry analyzer with spininess alternating apparatus according to claim 3,4 or 5, it is characterised in that
The pin mobile device includes that support frame (3L), the first motor (3F), the first driving belt (3F '), axostylus axostyle (3K), pin are moved
Swing arm (2A), fixed seat (3K '), the second motor (3G) and the second driving belt (3G '), pin transfer arm (2A) and axostylus axostyle
(3K) is connected, the axostylus axostyle (3K) that support frame (3L) passes through the fixed pin transfer arm of fixed seat (3K '), first motor (3F)
The axostylus axostyle (3K) for controlling transfer arm by the first driving belt (3F ') horizontally rotates, so as to drive multiple hollow needles synchronous in water
Square to rotation；Second motor (3G) controls the axostylus axostyle (3K) of transfer arm to move up and down by the second driving belt (3G '),
So as to drive multiple hollow needles synchronously to move up and down.
7. the automatic clinical chemistry analyzer with spininess alternating apparatus according to claim 1, it is characterised in that described many
Pinwheel changing device also includes the first air jet system (10), water cleaning head (11) and waste collection groove (2D), air jet system (10), water
Cleaning head (11) is arranged at pin cleaning positions, and air jet system (10), water cleaning head (11) are directed to the outer wall at the top of hollow needle,
And first air jet system (10) outlet port be higher than water cleaning head (11) position, first passed through when using water cleaning head (11) to pin outside
Side spray penetrates pure water, and the water that subsequent first air jet system (10) remains when pin appearance is cleaned to pin appearance gas injection is cleaned
Fall, waste collection groove (2D) is arranged on spininess alternating apparatus lower section, for collecting the waste water after rinsing.
First air jet system (10) offside is provided with collecting pipe (12), when the first air jet system (10) is to needle point outer wall jet drying gas
During body, the ponding of produced gas and the pin appearance for being blown off enters in collecting pipe (12).
8. the automatic clinical chemistry analyzer with spininess alternating apparatus according to claim 1, it is characterised in that many pinwheels
Changing device includes two hollow needles, and the eccentric wheel (3M) of motorized motions, spring (P3), first exhausted is provided between two hollow needles
Edge clip (P1), the second insulation clip (P2) and attachment means (P)；The eccentric wheel (3M) be arranged on two hollow needles it
Between top, the spring (S) by first insulation clip (P1) and second insulation clip (P2) by two hollow needles connection,
And attachment means (P) are set below spring, the attachment means (P) are connected between two hollow needles and the attachment means
(P) rotated with two hollow needle tie points respectively and be connected；When electronic eccentric wheel (3M) transverse presentation, two needle points of bottom are close to, and work as electricity
Movable eccentric wheel pulls two needle points to separate automatically when erecting position；
Spininess alternating apparatus also include that the 3rd motor (4M), regulating arm (4L), the first vertical upper arm (5L ') and second are vertical
Upper arm (5L)；3rd motor (4M) is connected with regulating arm (4L), and the two ends of regulating arm connect the first vertical upper arm respectively
(5L ') and the second vertical upper arm (5L), the other end of the first vertical upper arm (5L ') connects the first hollow needle (N1), and second is vertical
The other end of upper arm (5L) connects the second hollow needle (N2)；Operationally as needed in turn by the first hollow needle (N1) and second
The position adjustment of hollow needle (N2) pin is one high and one low, it is to avoid two pins are while contact liq；Two hollow needle needle points are provided with
Liquid level induction system, for sensing whether hollow needle needle point is stretched into liquid.
9. a kind of reagent/specimen distribution based on the automatic clinical chemistry analyzer with spininess alternating apparatus described in claim 1
Method, it is characterised in that comprise the following steps：
Step 1, in multiple hollow needle synchronizing movings to the reagent bottle or specimen cup by pin mobile device by spininess alternating apparatus；
Step 2, when multiple hollow needles are lowered into reagent bottleneck with liquid upper surface, because pin liquid level senses work(
Can, hollow needle is stopped in the shallow-layer of liquid surface, and one of hollow needle draws reagent or sample, and remaining hollow needle is not drawn, and is located
In stand-by state；
Multiple hollow needles are moved to detection cup top by step 3 by pin mobile device, in drawing of reagent or sample
Empty needle just to detection rim of a cup, the reagent or sample of absorption is assigned in detection cup；
Step 4, after completing reagent and sample distribution, pin mobile device drives hollow needle to return to cleaning position simultaneously and is cleaned；
Step 5, pin mobile device drawn by multiple hollow needle synchronizing movings, again and enabled when distributing reagent it is last round of in be in
The hollow needle of stand-by state, the hollow needle of last round of work is in stand-by state during this；
Step 6, repeat step 1- steps 5, until instrument completes reagent distribution and Detection task.
10. a kind of reagent/specimen distribution based on the automatic clinical chemistry analyzer with spininess alternating apparatus described in claim 8
Method, it is characterised in that comprise the following steps：
Step 1, in two hollow needle synchronizing movings to the reagent bottle or specimen cup by pin mobile device by spininess alternating apparatus；
Step 2, the 3rd motor 4M is rotated, and drives the first vertical upper arm 5L ' above to carry by regulating arm 4L so that first is hollow
Pin N1 is above carried and is not stretched into liquid level, and in stand-by state, the second hollow needle N2 stretches into liquid level and draws reagent or sample；
Two hollow needles are moved to detection cup position, the examination that will be drawn in the second hollow needle N2 by step 3 by pin mobile device
Agent or sample are assigned in detection cup；
Step 4, after completing reagent or sample distribution, two hollow needles return to cleaning position and are cleaned simultaneously；
Step 5, pin mobile device by two hollow needles again synchronizing moving to reagent bottle or specimen cup, when the 3rd motor
Rotate and drive the second vertical upper arm 5L above to carry by regulating arm so that the second hollow needle N2 is above carried and do not stretched into liquid level, in standby
State, the first hollow needle N1 stretches into liquid level and draws reagent or sample.
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| CN109507440A (en) * | 2018-10-22 | 2019-03-22 | 迪瑞医疗科技股份有限公司 | A kind of probe assembly, test sample device and its test sample method |
| CN111796078A (en) * | 2020-08-10 | 2020-10-20 | 淄博纳瑞仪器有限公司 | Petroleum anti-emulsification performance tester |
| US20210011046A1 (en) * | 2018-04-04 | 2021-01-14 | Merlin Biomedical (Xiamen) Co., Ltd. | Sample processing and detecting kit with a material transfer structure |
| CN112378887A (en) * | 2020-11-16 | 2021-02-19 | 深圳传世生物医疗有限公司 | Analysis method of blood coagulation analyzer and blood coagulation analyzer |
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