CN106831454A - A kind of ephedrine extraction method - Google Patents
A kind of ephedrine extraction method Download PDFInfo
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- CN106831454A CN106831454A CN201510876975.5A CN201510876975A CN106831454A CN 106831454 A CN106831454 A CN 106831454A CN 201510876975 A CN201510876975 A CN 201510876975A CN 106831454 A CN106831454 A CN 106831454A
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- ephedrine
- extraction method
- filter
- ephedra
- distilled water
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention discloses a kind of ephedrine extraction method, using half bionical-biological enzyme extracting method, the shortcomings of overcoming half biomimetic method Extracting temperature be high at ambient pressure, be difficult to separating-purifying, the addition of enzyme is conducive to leaching and the bioconversion of active material, on the premise of original composition is not destroyed, the ephedrine inside Chinese ephedra is more effectively extracted.
Description
Technical field
The invention belongs to pharmaceutical technology field, and in particular to be a kind of ephedrine extraction method.
Background technology
Chinese ephedra, Latin literary fame：Ephedra sinica Stapf, Ephedraceae, Ephedra herbaceous plant.For diseases caused by external factors wind
Cold, fever with aversion to cold is opened facilitaing lung gas, dispersing wind and cold and is relievingd asthma.Alkaloid enriches, and is the Main Resources for extracting ephedrine.Chinese ephedra
Alkali, 1. can prevent bronchial asthma attack and alleviate mild asthma breaking-out, not good to acute severe asthma breaking-out effect.2. it is used for
Low blood pressure and chronic hypotension disease that subarachnoid anesthesia or caudal anaesthesia cause.3. the nose that treatment a variety of causes causes is sticked
The nasal obstruction that film is congested, swelling causes.
There are patent literature, a kind of extraction process of ephedrine（CN201210489938）Carried using alkalization, dimethylbenzene
Take, oxalic acid extraction technique, extract high-purity ephedrine.Wherein the organic solvent pollution such as dimethylbenzene weight, high cost.The present invention
The environment absorbed through gastrointestinal transit using half bionical-biological enzyme extraction method simulation oral drugs, selects Suitable cellulases pair
Chinese medicine is pre-processed, and destroys vegetable drug cell membrane, and energy is more environmentally friendly, more effectively extract ephedrine.
Semi-bionic extraction (abbreviation SBE) is the new method for proposing in recent years.It is the angle from biopharmacy, will be whole
Body drug research method is combined with molecular medicine organon, the environment that simulation oral drugs absorb through gastrointestinal transit, using work
Property instruct under guiding separation method；It is a kind of new extraction process of the formulation design being administered orally through alimentary canal.Half bionical-
Biological enzyme extraction method is that first selection Suitable cellulases are pre-processed to Chinese medicine, to destroy vegetable drug cell membrane.The method gram
The shortcomings of having taken half biomimetic method Extracting temperature is high at ambient pressure, be difficult to separating-purifying, the addition of enzyme is conducive to the leaching of active material
Go out and bioconversion, be conducive to human body to absorb active material.
The content of the invention
The invention provides a kind of accurate, reliable, stabilization ephedrine extraction method.
For achieving the above object, a kind of ephedrine extraction method of the invention, concrete scheme is：
A kind of ephedrine extraction method of the present invention, it is characterised in that its extracting method is：
1. extract for the first time：Ephedra is placed in flask, plus 4 ~ 8 times of distilled water（pH=1.5~2.5）, 1 ~ 2h is heated to reflux,
Filtering；
2. extract for second：To being added in filter residue, biology enzyme is appropriate, 40 ~ 50 DEG C of 1 ~ 2h of hydrolysis, filtering；
3. third time is extracted：Added plus 2 ~ 6 times of distilled water in filter residue（pH=7.0~8.5）, 1 ~ 2h is heated to reflux, filter；Merge
Three filtrates of extraction, are drying to obtain.
A kind of ephedrine extraction method of the present invention, step 2. the biology enzyme species be cellulase, alphalise starch
One or more combination in enzyme, pectase, 1,4 beta-glucanase, lipase.
A kind of ephedrine extraction method of the present invention, 3. the drying temperature is 70 ~ 105 DEG C to step.
Specific embodiment
Example below is only to further illustrate the present invention, scope that the invention is not limited in any way.
Embodiment 1
Ephedra is placed in flask, plus 5 times of distilled water（pH=2.0）, 1.5h is heated to reflux, filter；To adding 1% in filter residue
Cellulase（In terms of Chinese ephedra quality）, 45 DEG C of hydrolysis 2h, filtering；Added plus 4 times of distilled water in filter residue（pH=7.5）, heat back
Stream 1.5h, filtering；Merging filtrate, is drying to obtain.
Embodiment 2
Ephedra is placed in flask, plus 6 times of distilled water（pH=2.0）, 1.5h is heated to reflux, filter；To adding 1% in filter residue
AMS（In terms of Chinese ephedra quality）, 50 DEG C of hydrolysis 2h, filtering；Added plus 6 times of distilled water in filter residue（pH=7.5）, heat back
Stream 1.5h, filtering；Merging filtrate, is drying to obtain.
Embodiment 3
Ephedra is placed in flask, plus 7 times of distilled water（pH=2.5）, 1.5h is heated to reflux, filter；To adding 1% in filter residue
Cellulase and 1% AMS 1:1 mixing（In terms of Chinese ephedra quality）, 45 DEG C of hydrolysis 2h, filtering；Add plus distill in filter residue
4 times of water（pH=8.0）, 1h is heated to reflux, filter；Merging filtrate, is drying to obtain.
Embodiment 4
The purity and yield of the ephedrine that the extraction process of comparative example 1,2,3 is extracted, as a result show what embodiment 1,2,3 was extracted
Ephedrine purity and yield are higher, but the ephedrine purity and yield of the extraction of mixed biologic enzyme are optimal, as a result see the table below.
。
Claims (3)
1. a kind of ephedrine extraction method, it is characterised in that the ephedrine extraction method and step is：
1. Ephedra is placed in flask, plus 4 ~ 8 times of distilled water（pH=1.5~2.5）, 1 ~ 2h is heated to reflux, filter；
2. to adding biology enzyme appropriate in filter residue, 40 ~ 50 DEG C of 1 ~ 2h of hydrolysis are filtered；
3. added plus 2 ~ 6 times of distilled water in filter residue（pH=7.0~8.5）, 1 ~ 2h is heated to reflux, filter；
Merge 1. 2. 3. filtrate, be drying to obtain.
2. a kind of ephedrine extraction method according to claim 1, it is characterised in that the species of the step 2. biology enzyme
It is one or more combination in cellulase, AMS, pectase, 1,4 beta-glucanase, lipase.
3. a kind of ephedrine extraction method according to claim 1, it is characterised in that 3. the drying temperature is 70 to step
~105℃。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510876975.5A CN106831454A (en) | 2015-12-03 | 2015-12-03 | A kind of ephedrine extraction method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510876975.5A CN106831454A (en) | 2015-12-03 | 2015-12-03 | A kind of ephedrine extraction method |
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| Publication Number | Publication Date |
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| CN106831454A true CN106831454A (en) | 2017-06-13 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510876975.5A Pending CN106831454A (en) | 2015-12-03 | 2015-12-03 | A kind of ephedrine extraction method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107892652A (en) * | 2017-11-07 | 2018-04-10 | 何本科 | A kind of extracting method of ephedrine |
| CN109692248A (en) * | 2017-10-24 | 2019-04-30 | 汉寿康运医药科技有限公司 | A kind of vine tea total flavone extracting method |
| CN109692232A (en) * | 2017-10-23 | 2019-04-30 | 康普药业股份有限公司 | A kind of extracting method of Aguiyangxue granules |
-
2015
- 2015-12-03 CN CN201510876975.5A patent/CN106831454A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109692232A (en) * | 2017-10-23 | 2019-04-30 | 康普药业股份有限公司 | A kind of extracting method of Aguiyangxue granules |
| CN109692248A (en) * | 2017-10-24 | 2019-04-30 | 汉寿康运医药科技有限公司 | A kind of vine tea total flavone extracting method |
| CN107892652A (en) * | 2017-11-07 | 2018-04-10 | 何本科 | A kind of extracting method of ephedrine |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170613 |
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| WD01 | Invention patent application deemed withdrawn after publication |