CN106823134B - A kind of integral intelligent oral administration patch instrument and its manufacture craft - Google Patents
A kind of integral intelligent oral administration patch instrument and its manufacture craft Download PDFInfo
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- CN106823134B CN106823134B CN201710025612.XA CN201710025612A CN106823134B CN 106823134 B CN106823134 B CN 106823134B CN 201710025612 A CN201710025612 A CN 201710025612A CN 106823134 B CN106823134 B CN 106823134B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
- A61N1/303—Constructional details
- A61N1/306—Arrangements where at least part of the apparatus is introduced into the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0625—Mouth
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
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- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses integral intelligent oral administration patch instrument and its manufacture crafts, are made of patch and quantity of electricity controller, and patch is fixedly mounted on the lower end of quantity of electricity controller, and patch is an integral molding structure with quantity of electricity controller；By the preparation containing medicine plaster, the preparation without medicine plaster, electrode installation, with microcontroller dock and be administered starting step, the manufacture craft of completion integral intelligent oral administration patch instrument；The present invention is directly controlled drug by the infiltration in oral cavity by electricity, the dosage of administration can be precisely controlled by adjusting electricity, the increase of electricity can control the oral osmotic speed and dosage of drug with reduction, the control of electricity can be carried out by current strength and conduction time, the control of electricity can be by the control of current strength and conduction time by microcontroller implementation, using the present invention compared to traditional mouth paster, injection speed and dosage are substantially increased.Harmless to mucous membrane of mouth when being administered using the present invention, administration process is painless.
Description
Technical field
The invention belongs to oral administration patch fields, and in particular to a kind of integral intelligent oral administration patch instrument.
Background technology
The traditional approach for taking medicine is injection or takes orally that injection can bring pain and inconvenience, patient to need to go to patient
Hospital is completed by nurse；Medicine needs that finally blood circulation could be entered by stomach and liver when oral, can hold thus to patient
It includes the first pass effect of liver easily to bring many effects of paying, and mucous membrane of mouth drug delivery system can avoid liver first-pass effect due to it
With to gastrointestinal tract stimulation, facilitate patient to take, maintain the advantages that stable administration transmission system and opened by more and more people
Hair application.
The dissection of mucous membrane of mouth and physilogical characteristics：Oral cavity mucous membrane tissue structure divides squamous epithelial, base from shallow to deep
Counterdie and connective tissue layer.Its arterial blood supplies to derive from external carotid artery, and venous return to jugular vein enters body through superior vena cava and follows
Ring.Mucous membrane of mouth has following characteristics：1, rete vasculosum is abundant；2, it repairs and is exceedingly fast after wound；3, substantially thin without Langerhans
Born of the same parents lack such as just because of Langerhans cells, and mucous membrane of mouth administration just has good immunological tolerance basis.Different mouths
Anatomical cavity region mucosa structure is different：It is barrier action that hard palate mucous membrane, gum mucosal epithelium, which have cuticular layer, major function,；Cheek
Mucous membrane, sublingual mucosa, mouth bottom mucous membrane and soft palate mucous membrane lack cuticular layer, since cuticular layer lacks in the region epithelium layer
It is weary, there is preferable permeability to water, permeability to weak from being followed successively by cheek mucous membrane, sublingual mucosa, mouth bottom mucous membrane by force.Drug penetrates
There are two types of the modes of mucous membrane of mouth：Across cell and by way of space between cells.Its main mechanism is Passive intake, in spite of
Epithelial cell endocytosis phenomenon, but this effect can not possibly pass through holostrome, it is also not possible to pass through active transport.To sum up, glutinous from oral cavity
The dissection of film and physilogical characteristics see that sublingual mucosa has the condition as drug systemic administration route with cheek mucous membrane.Mucous membrane of mouth is administered
Approach advantage：1, mucous membrane of mouth administration route is essentially parenteral approach, can avoid the first pass effect of liver and breaking for gastrointestinal tract
Bad and degradation.2, mucous membrane of mouth administration route is simple and practicable.The approach plays low dose of big effect there is a possibility that dosage is more accurate
The effect answered；Local directed complete set can be carried out according to optical clearing implementations；Convenient for promptly removing.3, it is single into internal approach
To only passing through buccal absorption.4, area research progress is rapid, has had the achievement in research that can be provided utilize accordingly.Such as
Mucosal absorption accelerating agent, slow controlled-release technology and the device etc. for preventing mucus influence disperse.5, mucous membrane of mouth administration route has good
Good compliance.6, compared with bronchia mucosal approach, mucous membrane of mouth approach is not easy to cause mucosa lesions.Mucous membrane of mouth is to medical instrument
Have the advantages that absorption is rapid, avoid the destruction of pipe intestinal digesting enzyme and bypasses liver first-pass effect, but current mucous membrane of mouth
Administration has very various deficiencies：1, since the space for being can absorb mucous membrane by oral cavity is limited, drug delivery system is unable to volume
It is excessive.2, involuntary salivary secretion and swallow influence mucous membrane of mouth approach efficiency.3, the taste stimulation of drug influences to be somebody's turn to do
The compliance of approach.4, not every substance can be transferred through mucous membrane of mouth, absorb by fat-soluble, pH value, molecular weight etc.
It influences.5, it needs to use mucous membrane permeability enhancing agent under certain condition.And mucous membrane of mouth permeability is poor, cannot generally provide fast
Speed absorbs the bioavilability become reconciled, that is, in cheek oromucosal route, many drugs need mucosal absorption reinforcing agent, and absorb and increase
Strong agent would generally generate mucous membrane of mouth in certain side effect such as oral cavity and itch, redness etc..6, the administering mode of oral anesthestia medicine
It is typically injection oral cavity of having an injection, pain is brought to patient.Therefore the application of the approach is subject to certain restrictions, which is only limitted to certain
A little drugs.Currently used have nitroglycerin, certain sex steroid hormones, analgesic etc., and the dosage of drug and
It is precisely to be improved.
Invention content
It may be implemented precisely to be administered in view of the above-mentioned deficiencies in the prior art, it is an object of the present invention to now provide one kind, improve and use
In the dosage and bioavilability of the medicament categories of mucous membrane of mouth administration, while the integral intelligent oral administration without any pain
Patch instrument and its manufacture craft.
In order to solve the above technical problems, the technical solution adopted by the present invention is：A kind of integral intelligent oral administration patch
Instrument, innovative point are：It is made of patch and quantity of electricity controller, the patch is fixedly mounted on the lower end of quantity of electricity controller
Portion, the patch are an integral molding structure with quantity of electricity controller；
The quantity of electricity controller is switched by instrument, minicell and microcontroller form, the instrument switch, minicell
It is electrically connected with microcontroller, the instrument switch is digitlization button；
The patch includes containing medicine plaster and being free of medicine plaster, described containing medicine plaster and without being divided between medicine plaster
0.01-5mm, preferably 0.1-0.3mm.
Further, it is described containing medicine plaster be the patch containing water-soluble drug.
Further, the electric current of the quantity of electricity controller is 0.01-2.0mA, preferably 0.1-0.3mA, the electricity time
Voltage for 0.1-24h, the minicell is 1V-30V, preferably 3-6V.
Another object of the present invention is to disclose a kind of manufacture craft of integral intelligent oral administration patch instrument, wound
New point is：By the preparation containing medicine plaster, the preparation without medicine plaster, electrode installation, with microcontroller dock and administration
Starting step completes the manufacture craft of integral intelligent oral administration patch instrument；The step is specific as follows：
(1) preparation containing medicine plaster：The liquid medicine being prepared is injected into medical husky cotton middle section, the sand cotton periphery
The parts 0.2mm are affixed on medical adhesive tape, and the middle section of the sand cotton is attached on protection sheet, completes the preparation containing medicine plaster；
(2) preparation of medicine plaster is free of：By water or lotion, gel, lipid, microballoon is injected into medical husky cotton middle section,
The part of husky cotton periphery 0.2mm wide is affixed on medical adhesive tape, the middle section 1.0cm of the sand cotton2Place is attached on protection sheet, so
Protection sheet is attached on medical adhesive tape afterwards, completes the preparation without medicine plaster；
(3) electrode is installed：According to the charged characteristic of the object of Chinese medicine containing medicine plaster, metal electrode and corresponding metal salt electrode are carried out
Insertion, the preferred Ag of metal, the preferred AgCl of metal salt；
(4) it is docked with microcontroller：The anode of microcontroller will be docked with the patch portion of Ag electrodes, it will be with AgCl electricity
The cathode of the patch portion docking microcontroller of pole；
(5) administration starts：Electricity, electric current and conduction time are set on the display screen of microcontroller, press instrument switch,
It carries out starting to be administered.
Further, the preparation method of the liquid medicine in the preparation process containing medicine plaster is：By cellulose gum：
Water：Tri- kinds of materials of hydrochloric acid Li Kaduoyin press 2：95.5：2.5 weight ratio is mixed to the aqueous solution jelly of 9000CPS,
Li Kaduoyin will be free in the form of cation in aqueous solution.
Further, the preparation method of the liquid medicine in the preparation process containing medicine plaster is：Non-ionic macromolecular medicine
Object needs the package that non-ionic macromolecular drug is carried out using carrier, then by wrapped non-ionic macromolecular drug
It is dissolved in aqueous solution and forms suspension or jelly, the mass ratio of the carrier and non-ionic macromolecular drug is 50-70:
30-60, preferential 65:35.
Further, the carrier is one in chitosan lactate, other macroion surfactants, liposome
Kind.
Further, the method for the preparation without medicine plaster is：Two kinds of materials of cellulose gum and water are pressed 2：
98 weight ratio is mixed to the aqueous solution jelly of 10000CPS, and aqueous solution jelly is then injected into medical husky cotton
The part of middle section, husky cotton periphery 0.2mm wide is affixed on medical adhesive tape, the middle section 1.0cm of the sand cotton2Place is attached to guarantor
It protects on paper, then protection sheet is attached on medical adhesive tape, complete the preparation without medicine plaster.
Beneficial effects of the present invention are as follows：
(1) present invention is directly controlled drug by the infiltration in oral cavity by electricity, and the dosage of administration can be by adjusting electricity
It measures and is precisely controlled, increase and the reduction of electricity can control the oral osmotic speed and dosage of drug, and the control of electricity can
It is carried out by current strength and conduction time, the control of electricity can be by the control of current strength and conduction time by microcontroller reality
It is existing, using the present invention compared to traditional mouth paster, substantially increase injection speed and dosage.
(2) using present invention administration harmless to mucous membrane of mouth when, administration process is painless, while can be effective right
The dosage of oral administration carries out control accurate.
Description of the drawings
Fig. 1 is the overall structure diagram of the present invention；
Fig. 2 is the pig mucous membrane of mouth figure without electricity processing of the present invention；
Fig. 3 is that the electricity of the present invention passes through 8 hours 0.3mA treated pig mucous membrane of mouth figures.
Specific implementation mode
Illustrate that embodiments of the present invention, those skilled in the art can be by this explanations by particular specific embodiment below
Content disclosed by book understands other advantages and effect of the present invention easily.
It is as shown in Figure 1 the overall structure diagram of the present invention, a kind of integral intelligent oral administration patch instrument, by pasting
Piece and quantity of electricity controller 1 form, and patch is fixedly mounted on the lower end of quantity of electricity controller 1, and patch is integrated with quantity of electricity controller 1
Molding structure；
Quantity of electricity controller 1 is made of instrument switch 11, minicell 12 and microcontroller 13, instrument switch 11, micro electric
Pond 12 and microcontroller 13 are electrically connected, and instrument switch 11 is digitlization button；The electric current of quantity of electricity controller 1 is 0.01-
2.0mA, preferably 0.1-0.3mA, electricity time are 0.1-24h, and the voltage of minicell 12 is 1V-30V, preferably 3-6V, miniature
Battery 12 is preferably button cell or paper battery.
Patch includes containing medicine plaster 2 and being free of medicine plaster 3, containing medicine plaster 2 and without being divided between medicine plaster 3
0.01-5mm, preferably 0.1-0.3mm are the patch containing water-soluble drug containing medicine plaster 2.
The manufacture craft of integral intelligent oral administration patch instrument, by containing medicine plaster 2 preparation, be free of medicine plaster 3
Preparation, electrode installation, with microcontroller 13 dock and be administered starting step, completion integral intelligent oral administration patch device
The manufacture craft of tool；Step is specific as follows：
(1) preparation containing medicine plaster 2：The liquid medicine being prepared is injected into medical husky cotton middle section, husky cotton periphery
The parts 0.2mm are affixed on medical adhesive tape, and the middle section of husky cotton is attached on protection sheet, complete the preparation containing medicine plaster；
(2) preparation of medicine plaster 3 is free of：By water or lotion, gel, lipid, microballoon is injected into medical husky cotton middle section,
The part of husky cotton periphery 0.2mm wide is affixed on medical adhesive tape, the middle section 1.0cm of husky cotton2Place is attached on protection sheet, then will
Protection sheet is attached on medical adhesive tape, completes the preparation without medicine plaster；
(3) electrode is installed：According to the charged characteristic of the object of Chinese medicine containing medicine plaster, metal electrode and corresponding metal salt electrode are carried out
Insertion, the preferred Ag of metal, the preferred AgCl of metal salt；
(4) it is docked with microcontroller：The anode of microcontroller will be docked with the patch portion of Ag electrodes, it will be with AgCl electricity
The cathode of the patch portion docking microcontroller of pole；
(5) administration starts：Electricity, electric current and conduction time are set on the display screen of microcontroller, press instrument switch,
It carries out starting to be administered.
Preferably, the preparation method of the liquid medicine in the preparation process containing medicine plaster is：By cellulose gum：Water：Hydrochloric acid
Tri- kinds of materials of Li Kaduoyin press 2：95.5：2.5 weight ratio is mixed to the aqueous solution jelly of 9000CPS, Li Kaduo
Because will be free in aqueous solution in the form of cation.
Preferably, the preparation method of the liquid medicine in preparation process containing medicine plaster 2 is：Non-ionic macromolecular drug needs
It to use carrier to carry out the package of non-ionic macromolecular drug, then be dissolved in wrapped non-ionic macromolecular drug
The mass ratio of formation suspension or jelly in aqueous solution, carrier and non-ionic macromolecular drug is 50-70:30-60, preferentially
65:35。
Preferably, carrier is one kind in chitosan lactate, other macroion surfactants, liposome.
Preferably, the method for the preparation without medicine plaster 3 is：Two kinds of materials of cellulose gum and water are pressed 2：98 weight
Amount ratio is mixed to the aqueous solution jelly of 10000CPS, and aqueous solution jelly is then injected into medical husky cotton middle part
Point, the part of husky cotton periphery 0.2mm wide is affixed on medical adhesive tape, the middle section 1.0cm of husky cotton2Place is attached on protection sheet, so
Protection sheet is attached on medical adhesive tape afterwards, completes the preparation without medicine plaster 3.
Embodiment 1
The external oral administration simulated experiment of pig mucous membrane of mouth：
(1) mucous membrane of mouth is obtained from pig buccal portion, mucous membrane of mouth thickness is 300-500 μm, and the area of mucous membrane of mouth is
1.0cm2, it is placed between Franz diffusion cell supply pool pieces and Franz diffusion cell acceptance pools, the epithelial tissue direction of mucous membrane of mouth
Then dosing paster instrument is placed in supply pool and is attached on mucous membrane of mouth, phosphate-buffered is filled it up in acceptance pool by supply pool
Brine is to simulate blood circulation, and the temperature in acceptance pool is maintained at 37 DEG C, for simulating body temperature.
(2) electricity is set：0.3mA, 8 hours conduction time press 11 power-on switch of instrument switch.
After (3) 8 hours, sample is taken from acceptance pool, Pharmaceutical Analysis is carried out with high pressure liquid phase analysis instrument, is recorded, as a result such as
Shown in Fig. 2 and Fig. 3.
The hydrochloric acid Li Kaduoyin mouth pasters injection speed and dosage of the tradition that table 1 is 8 hours and this method compare table：
Table 1
The nicotine hydrochloride mouth paster injection speed and dosage of the tradition that table 2 is 8 hours and this method compare table：
Table 2
The present invention is directly controlled drug by the infiltration in oral cavity by electricity, and the dosage of administration can be obtained by adjusting electricity
To being precisely controlled, increase and the reduction of electricity can control the oral osmotic speed and dosage of drug, and the control of electricity can be by electricity
Intensity of flow and conduction time carry out, the control of electricity can by the control of current strength and conduction time by microcontroller implementation,
Using the present invention compared to traditional mouth paster, injection speed and dosage are substantially increased.Counterpart when being administered using the present invention
Chamber mucous membrane is harmless, and administration process is painless, while effectively can carry out control accurate to the dosage of oral administration.
Above-described embodiment is presently preferred embodiments of the present invention, is not the limitation to technical solution of the present invention, as long as
Without the technical solution that creative work can be realized on the basis of the above embodiments, it is regarded as falling into patent of the present invention
Rights protection scope in.
Claims (5)
1. a kind of manufacture craft of integral intelligent oral administration patch instrument, the integral intelligent oral administration patch instrument
It is made of patch and quantity of electricity controller, the patch is fixedly mounted on the lower end of quantity of electricity controller, the patch and electricity control
Device processed is an integral molding structure；The quantity of electricity controller is switched by instrument, minicell and microcontroller form, and the instrument is opened
Pass, minicell and microcontroller are electrically connected, and the instrument switch is digitlization button；The patch includes containing medicine plaster
With without medicine plaster, it is described containing medicine plaster and without being divided into 0.1-0.3mm between medicine plaster, it is characterised in that：By containing
Starting step is docked and be administered to the preparation of medicine plaster, electrode installation, with microcontroller at the preparation without medicine plaster, completion one
The manufacture craft of body intelligence oral administration patch instrument；The step is specific as follows：
(1) preparation containing medicine plaster：The liquid medicine being prepared is injected into medical husky cotton middle section, medical adhesive tape is affixed on institute
The medical husky cotton periphery parts 0.2mm are stated, protection sheet is attached to the middle section of the medical husky cotton, completes the system containing medicine plaster
It is standby；
(2) preparation of medicine plaster is free of：By water or lotion, gel, lipid, microballoon is injected into medical husky cotton middle section, will cure
The medical husky cotton periphery parts 0.2mm are affixed on adhesive tape, protection sheet is attached to the middle section 1.0mm of the medical husky cotton2Place, so
Protection sheet is attached on medical adhesive tape afterwards, completes the preparation without medicine plaster；
(3) electrode is installed：According to the charged characteristic of the object of Chinese medicine containing medicine plaster, progress metal electrode is inserted with corresponding metal salt electrode
Enter, the metal is Ag, metal salt AgCl；
(4) it is docked with microcontroller：The anode of microcontroller will be docked with the patch portion of Ag electrodes, it will be with AgCl electrodes
Patch portion docks the cathode of microcontroller；
(5) administration starts：Electricity, electric current and conduction time are set on the display screen of microcontroller, presses instrument switch, carries out
Start to be administered.
2. a kind of manufacture craft of integral intelligent oral administration patch instrument according to claim 1, it is characterised in that：
The preparation method of liquid medicine in the preparation process containing medicine plaster is：By cellulose gum：Water：Tri- kinds of hydrochloric acid Li Kaduoyin
Material presses 2：95.5：2.5 weight ratio is mixed to the aqueous solution jelly of 9000CPS, and Li Kaduoyin is with cation
Form is free in aqueous solution.
3. a kind of manufacture craft of integral intelligent oral administration patch instrument according to claim 1, it is characterised in that：
The preparation method of liquid medicine in the preparation process containing medicine plaster is：Non-ionic macromolecular drug is wrapped using carrier
It wraps up in, then wrapped non-ionic macromolecular drug is dissolved in aqueous solution and forms suspension or jelly, the carrier
Mass ratio with non-ionic macromolecular drug is 50-70:30-60.
4. a kind of manufacture craft of integral intelligent oral administration patch instrument according to claim 3, it is characterised in that：
The carrier is one kind in chitosan lactate, other macroion surfactants, liposome.
5. a kind of manufacture craft of integral intelligent oral administration patch instrument according to claim 1, it is characterised in that：
The method of the preparation without medicine plaster is：Two kinds of materials of cellulose gum and water are pressed 2：98 weight ratio mixing and
As the aqueous solution jelly of 10000CPS, aqueous solution jelly is then injected into medical husky cotton middle section, by medical adhesive
Band is affixed on the medical husky cotton periphery parts 0.2mm, and protection sheet is attached to the middle section 1.0cm of the medical husky cotton2Then place will
Protection sheet is attached on medical adhesive tape, completes the preparation without medicine plaster.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710025612.XA CN106823134B (en) | 2017-01-13 | 2017-01-13 | A kind of integral intelligent oral administration patch instrument and its manufacture craft |
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| CN201710025612.XA CN106823134B (en) | 2017-01-13 | 2017-01-13 | A kind of integral intelligent oral administration patch instrument and its manufacture craft |
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| CN106823134B true CN106823134B (en) | 2018-08-21 |
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| CN108106971A (en) * | 2018-02-13 | 2018-06-01 | 常州华佳医疗器械有限公司 | A kind of novel intelligent is transdermal and oral administration device and method |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN204219363U (en) * | 2014-11-17 | 2015-03-25 | 王丽婷 | A kind of physiotherapy table and physical therapy heating plate |
| CN204469019U (en) * | 2015-03-13 | 2015-07-15 | 河南中医学院 | Function instrument is pasted in a kind of type talus needle magnetic therapy cave |
| CN105381543A (en) * | 2015-11-18 | 2016-03-09 | 马燕 | Multifunctional endocrine therapeutic apparatus |
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| CN204335849U (en) * | 2014-12-24 | 2015-05-20 | 葛银林 | For the siRNA cutaneous penetration brassiere of mastocarcinoma gene treatment |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN204219363U (en) * | 2014-11-17 | 2015-03-25 | 王丽婷 | A kind of physiotherapy table and physical therapy heating plate |
| CN204469019U (en) * | 2015-03-13 | 2015-07-15 | 河南中医学院 | Function instrument is pasted in a kind of type talus needle magnetic therapy cave |
| CN105381543A (en) * | 2015-11-18 | 2016-03-09 | 马燕 | Multifunctional endocrine therapeutic apparatus |
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Address after: 213003 Jiangsu province Changzhou City Zhonglou District Zou Hui Ling Road No. 65 Co-patentee after: Changzhou Hualian medical device group Co.,Ltd. Patentee after: CHANGZHOU HUAJIA MEDICAL DEVICE Ltd. Address before: 213003 Jiangsu province Changzhou City Zhonglou District Zou Hui Ling Road No. 65 Co-patentee before: Changzhou Hualian Medical Equipment Group Co.,Ltd. Patentee before: CHANGZHOU HUAJIA MEDICAL DEVICE Ltd. Address after: 213003 Jiangsu province Changzhou City Zhonglou District Zou Hui Ling Road No. 65 Co-patentee after: Changzhou Hualian Medical Equipment Group Co.,Ltd. Patentee after: CHANGZHOU HUAJIA MEDICAL DEVICE Ltd. Address before: 213003 Jiangsu province Changzhou City Zhonglou District Zou Hui Ling Road No. 65 Co-patentee before: Changzhou Hualian Medical Equipment Co.,Ltd. Patentee before: CHANGZHOU HUAJIA MEDICAL DEVICE Ltd. Address after: 213003 Jiangsu province Changzhou City Zhonglou District Zou Hui Ling Road No. 65 Co-patentee after: Changzhou Hualian Medical Equipment Co.,Ltd. Patentee after: CHANGZHOU HUAJIA MEDICAL DEVICE Ltd. Address before: 213003 Jiangsu province Changzhou City Zhonglou District Zou Hui Ling Road No. 65 Co-patentee before: CHANGZHOU HUALIAN HEALTH DRESSING Co.,Ltd. Patentee before: CHANGZHOU HUAJIA MEDICAL DEVICE Ltd. |