CN206434601U - A kind of new capsaicine hydrogel patch - Google Patents
A kind of new capsaicine hydrogel patch Download PDFInfo
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- CN206434601U CN206434601U CN201621031254.0U CN201621031254U CN206434601U CN 206434601 U CN206434601 U CN 206434601U CN 201621031254 U CN201621031254 U CN 201621031254U CN 206434601 U CN206434601 U CN 206434601U
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- capsaicine
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- hydrogel
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Abstract
The utility model provides a kind of new capsaicine hydrogel patch, belongs to emplastrum field.The patch include the first back sheet, be arranged in the middle of the first back sheet magnetic sheet, be arranged on magnetic sheet the second back sheet, be arranged in the middle of the second back sheet capsaicine hydrogel layer, be arranged on the adhered layer of the second back sheet surrounding, the laminating adhesive being arranged on capsaicine hydrogel layer layer and be arranged on laminating adhesive layer on protective layer.The medicine layer of the patch is capsaicine hydrogel, the gel can effectively mitigate the threshold of pain and inflammation, simultaneously, magnetic sheet is arranged in the middle of the first back sheet and the second back sheet, using the magnetic action in magnetic field, has the effect of calm, analgesic and anti-inflammatory to affected part, laminating adhesive layer is arranged on capsaicine hydrogel layer, permeability is good, makes medicine not only not in contact with skin but also can play good action, mitigates the excitant or nonirritant to skin.The back sheet of the patch enables patch to be preferably pasted onto joint using unique designed arc-shaped appearance, difficult for drop-off.
Description
Technical field
The utility model belongs to emplastrum field, and in particular to a kind of new capsaicine hydrogel patch.
Background technology
Capsaicine (Capsaicin, CAP) is also known as capsaicine, and 1876, Thres et al. was separated from capsicum
And name.It is a kind of vanilla amide alkaloid, its chemical name is：N- [(4- hydroxy-3-methoxies-phenyl)-methyl]-
8- methyl-(anti-) -6- nonenamides.Its molecular formula is C18H27NO3, sterling be white plates or acicular crystal or white powder,
Fusing point is 65~66 DEG C.It is soluble in methanol, ethanol, acetone, chloroform and ether, also dissolves in alkaline aqueous solution, at high temperature
Irritative gas can be produced.Structure is as follows：
Capsaicine has the physiology and pharmacological activity of Various Complex, including anti-inflammatory, analgesia, antibacterial, desinsection, antipruritic, anti-
Control angiocardiopathy, promote the effect such as fat metabolism, mediate tumor cell apoptosis, radioresistance, anti-mutagenesis, be widely used in doctor
In terms of medicine health care, field of food, biological pesticide, wherein more unique is the effect of its long-acting analgesic and new analgesic mechanism.
It mainly plays analgesia and itching-relieving action by the release, synthesis and the storage that influence neuropeptide substance p, so as to be different from tradition
Central analgesia medicine (opiates) and analgesic-antipyretic (non-steroid).Its analgesic activity is suitable and more longlasting with morphine, after use
Additive and NSAIDs the gastrointestinal reaction of opium kind analgesicses will not be produced.
Show according to the study:Capsaicine to the body pain as caused by chemical stimulation is morphine hydrochloride analgesic effect 80 times
More than, moreover, capsaicine Syndrome of Morphine Dependent mouse has good Withdrawal Effect.Planted simultaneously, because capsaicine is one kind from green
The natural materials extracted in thing, than drug rehabilitation medicine such as methadone of other chemical syntheses etc., to body in itself without additive,
This is also it as one of the reason for morphine abstinence syndrome specific drug.
With capsaicine extraction purification technology raising and application it is increasingly extensive, to the development and application of capsaicine into
For international study hotspot, clinically it is used to treat arthralgia, postoperative neuralgia, postherpetic neuralgia, itch, art at present
Nausea and vomiting and it is used as gastric mucosa protectant etc. afterwards.Capsaicine has the first pass effect of hepar of height, and half-life period is too short, at present
Mainly based on local be administered.But excitant is locally administered substantially in it, still there are burn feeling, thorn in external application starting stage some patientss
Bitterly, itch and flush, regional area hyperemia and the inflammatory reaction of neurogenic, these side effects of continuation medication can just disappear
Lose.Thus clinically it is subject to certain restrictions using capsaicine external preparation.Capsaicine is prepared into different formulations to drop
Its low side effect, reduces excitant, changes method of administration, and it is Recent study using waiting and expanding its clinical practice to facilitate patient
Focus.
At present, the preparation such as existing capsaicin cream agent, paster, and these external application capsaicin preparations directly contact skin presence
Skin irritatin sex chromosome mosaicism.And existing patch is attached to some joint positions, it is impossible to effectively permanent to be pasted onto on skin, curative effect
It is not notable.
Utility model content
The purpose of this utility model is directly to contact skin in the presence of stimulation sex chromosome mosaicism to solve existing capsaicin preparation,
And the problem of patch adhesion difference, and a kind of new capsaicine hydrogel patch is provided.
The utility model provides a kind of new capsaicine hydrogel patch, and the patch includes the first back sheet, is arranged on the
Magnetic sheet in the middle of one back sheet, the second back sheet being arranged on magnetic sheet, the capsaicine water-setting being arranged in the middle of the second back sheet
Glue-line, the adhered layer for being arranged on the second back sheet surrounding, the laminating adhesive being arranged on capsaicine hydrogel layer layer and it is arranged on laminating adhesive
Protective layer on layer.
Preferably, the first described back sheet and the second back sheet are made up of polyvinyl chloride.
Preferably, described magnetic sheet is circle, a diameter of 12mm.
Preferably, described capsaicine hydrogel layer is using the polymer of soybean protein, chitosan and Geniposide as controlled release
Gel layer, coating medicine capsaicine is prepared from.
Preferably, described adhered layer is made up of the sub- quick glue of acrylic acid.
Preferably, described laminating adhesive layer is made up of plain weave spun laced fabric.
Preferably, described protective layer is made up of white silica gel paper.
Preferably, the length of described protective layer is 10-15cm, and width is 5-8cm；Described capsaicine hydrogel layer
Length is 5-8cm, and width is 2-4cm.
The beneficial effects of the utility model
The utility model provides a kind of new capsaicine hydrogel patch, and the patch includes the first back sheet, is arranged on the
Magnetic sheet in the middle of one back sheet, the second back sheet being arranged on magnetic sheet, the capsaicine water-setting being arranged in the middle of the second back sheet
Glue-line, the adhered layer for being arranged on the second back sheet surrounding, the laminating adhesive being arranged on capsaicine hydrogel layer layer and it is arranged on laminating adhesive
Protective layer on layer.The medicine layer of the patch is capsaicine hydrogel, and the gel can effectively mitigate the threshold of pain and inflammation, and soybean
Protein/chitosan reduces the stimulation to skin, capsaicine is slowly discharged, and reduces its first pass effect of hepar, realizes sustained release
Effect improves the compliance of patient to reduce administration number of times, more safety and stability, while the aqueogel can also keep capsicum
The biological activity of alkali.Meanwhile, magnetic sheet is arranged in the middle of the first back sheet and the second back sheet, using the magnetic action in magnetic field,
There is the effect of calm, analgesic and anti-inflammatory to affected part, laminating adhesive layer is arranged on capsaicine hydrogel layer, and permeability is good, makes medicine
Thing not only not in contact with skin but also can play good action, mitigate the excitant or nonirritant to skin.The back sheet of the patch
Using unique designed arc-shaped appearance, patch is set preferably to be pasted onto joint, it is difficult for drop-off.
Brief description of the drawings
Fig. 1 is a kind of side structure sectional view of new capsaicine hydrogel patch of the utility model；
Fig. 2 is a kind of top view of new capsaicine hydrogel patch of the utility model；
In figure, the 1, first back sheet, 2, adhered layer, 3, magnetic sheet, 4, capsaicine hydrogel layer, 5, laminating adhesive layer, 6, protective layer,
7th, the second back sheet.
Embodiment
Illustrate present embodiment, a kind of new capsaicine hydrogel patch with reference to Fig. 1 and Fig. 2, the patch includes first back of the body
Lining 1, it is arranged on 1 magnetic sheet 3 in the middle of the first back sheet, the second back sheet 7 being arranged on magnetic sheet 3, is arranged on the second backing
Layer 7 in the middle of capsaicine hydrogel layer 4, be arranged on the adhered layer 2 of the surrounding of the second back sheet 7, be arranged on capsaicine hydrogel layer
Laminating adhesive layer 5 and the protective layer 6 being arranged in laminating adhesive layer 5 on 4.
The first back sheet 1 and the second back sheet 7 described in present embodiment are made up of polyvinyl chloride, described adhered layer 2
It is made up of the sub- quick glue of acrylic acid.Magnetic sheet 3 is that magnetic grain is using warm into magnetic grain by bonding ferromagnetic oxide powder and synthetic rubber Compound Machining
Pressure technique is processed into magnetic sheet, and the magnetic field intensity of magnetic sheet is 500-800 Gausses.Described capsaicine hydrogel layer 4 is with soybean egg
In vain, the polymer of chitosan and Geniposide is controlled-release gel layer, and coating medicine capsaicine is prepared from；Described laminating adhesive layer 5
It is made up of plain weave spun laced fabric；Described protective layer 6 is made up of white silica gel paper.
The first back sheet 1 and the second back sheet 7 described in present embodiment enable patch more using unique designed arc-shaped appearance
It is good to be pasted onto joint, it is difficult for drop-off.First back sheet 1 is identical with the size and dimension of the second back sheet 7；Magnetic sheet 3 is preferred
For circle, a diameter of 12mm is arranged on the centre of the first back sheet 1 and the second back sheet 7, and capsaicine hydrogel layer 4 is arranged on
On second back sheet 7, the surrounding of the second back sheet 7 sets adhered layer 2, and the length of described capsaicine hydrogel layer 4 is preferably 5-
8cm, width is 2-4cm, and the size of capsaicine hydrogel layer 4 and adhered layer 2 is covered on whole second back sheet 7, laminating adhesive layer 5
Size it is identical with capsaicine hydrogel layer 3, the length of described protective layer 6 is preferably 10-15cm, and width is 5-8cm；Make
Used time, protective layer 6 is peeled off, the alignment of laminating adhesive layer 5 is affixed on affected part, and whole patch is affixed at skin.
Above-described embodiment is not constituted to limitation of the present utility model, and all use equivalent substitution or equivalent form are obtained
Technical scheme, the utility model protection within the scope of.
Claims (8)
1. a kind of new capsaicine hydrogel patch, it is characterised in that the patch includes the first back sheet (1), is arranged on first
Magnetic sheet (3) in the middle of back sheet (1), the second back sheet (7) being arranged on magnetic sheet (3), it is arranged in the middle of the second back sheet (7)
Capsaicine hydrogel layer (4), be arranged on the adhered layer (2) of the second back sheet (7) surrounding, be arranged on capsaicine hydrogel layer
(4) laminating adhesive layer (5) on and the protective layer (6) being arranged in laminating adhesive layer (5).
2. a kind of new capsaicine hydrogel patch according to claim 1, it is characterised in that the first described back sheet
(1) it is made up of with the second back sheet (7) polyvinyl chloride.
3. a kind of new capsaicine hydrogel patch according to claim 1, it is characterised in that described capsaicine water-setting
Glue-line (4) is layer by controlled-release gel of the polymer of soybean protein, chitosan and Geniposide, and coating medicine capsaicine is prepared from
's.
4. a kind of new capsaicine hydrogel patch according to claim 1, it is characterised in that described adhered layer (2)
It is made up of the sub- quick glue of acrylic acid.
5. a kind of new capsaicine hydrogel patch according to claim 1, it is characterised in that described laminating adhesive layer (5)
It is made up of plain weave spun laced fabric.
6. a kind of new capsaicine hydrogel patch according to claim 1, it is characterised in that described protective layer (6)
It is made up of white silica gel paper.
7. a kind of new capsaicine hydrogel patch according to claim 1, it is characterised in that described protective layer (6)
Length be 10-15cm, width is 5-8cm；The length of described capsaicine hydrogel layer (4) is 5-8cm, and width is 2-4cm.
8. a kind of new capsaicine hydrogel patch according to claim 1, it is characterised in that described magnetic sheet (3) is
Circle, a diameter of 12mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621031254.0U CN206434601U (en) | 2016-08-31 | 2016-08-31 | A kind of new capsaicine hydrogel patch |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621031254.0U CN206434601U (en) | 2016-08-31 | 2016-08-31 | A kind of new capsaicine hydrogel patch |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206434601U true CN206434601U (en) | 2017-08-25 |
Family
ID=59644797
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201621031254.0U Expired - Fee Related CN206434601U (en) | 2016-08-31 | 2016-08-31 | A kind of new capsaicine hydrogel patch |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206434601U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111297834A (en) * | 2020-04-19 | 2020-06-19 | 田文超 | Cooling paste |
-
2016
- 2016-08-31 CN CN201621031254.0U patent/CN206434601U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111297834A (en) * | 2020-04-19 | 2020-06-19 | 田文超 | Cooling paste |
| CN111297834B (en) * | 2020-04-19 | 2023-05-26 | 田文超 | Defervescing plaster |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20170825 Termination date: 20190831 |