CN106823134A - A kind of integral intelligent oral administration paster apparatus and its manufacture craft - Google Patents
A kind of integral intelligent oral administration paster apparatus and its manufacture craft Download PDFInfo
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- CN106823134A CN106823134A CN201710025612.XA CN201710025612A CN106823134A CN 106823134 A CN106823134 A CN 106823134A CN 201710025612 A CN201710025612 A CN 201710025612A CN 106823134 A CN106823134 A CN 106823134A
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- paster
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
- A61N1/303—Constructional details
- A61N1/306—Arrangements where at least part of the apparatus is introduced into the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0625—Mouth
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
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- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Dermatology (AREA)
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Abstract
The invention discloses integral intelligent oral administration paster apparatus and its manufacture craft, it is made up of paster and quantity of electricity controller, paster is fixedly mounted on the bottom of quantity of electricity controller, paster and quantity of electricity controller are formed in one structure；Installed by the preparation containing medicine plaster, the preparation without medicine plaster, electrode and dock and starting step be administered with microcontroller, the manufacture craft of completion integral intelligent oral administration paster apparatus；The present invention is directly controlled medicine by the infiltration in oral cavity by electricity, the dosage of administration can be precisely controlled by adjusting electricity, the increase of electricity can control the oral osmotic speed and dosage of medicine with reducing, the control of electricity can be carried out by current strength and conduction time, the control of electricity can be by the control of current strength and conduction time by microcontroller implementation, using the present invention compared to traditional mouth paster, injection speed and dosage are substantially increased.Harmless to mucous membrane of mouth during using present invention administration, administration process is painless.
Description
Technical field
The invention belongs to oral administration paster field, and in particular to a kind of integral intelligent oral administration paster apparatus.
Background technology
The traditional approach for taking medicine is injection or oral, and injection can bring pain and inconvenience to patient, and patient needs to go
Hospital is completed by nurse；Medicine needs that finally blood circulation could be entered by stomach and liver when oral, can hold to patient for this
Easily bringing many effects of paying includes the first pass effect of liver, and mucous membrane of mouth delivery system can avoid liver first-pass effect due to it
With the stimulation to intestines and stomach, facilitate patient to take, maintain stabilization administration transmission system the advantages of and opened by increasing people
Hair application.
The dissection of mucous membrane of mouth and physilogical characteristics：Oral cavity mucous membrane tissue structure divides squamous epithelial, base from shallow to deep
Counterdie and connective tissue layer.Its arterial blood is followed through superior vena cava for deriving from external carotid artery, venous return to jugular vein into body
Ring.Mucous membrane of mouth has following characteristics：1st, rete vasculosum enriches；2nd, repaired after wound and be exceedingly fast；3rd, it is substantially thin without Langerhans
Born of the same parents, lack such as just because of Langerhans cells, and mucous membrane of mouth administration just has good immunological tolerance basis.Different mouths
Anatomical cavity region mucosa structure is different：Hard palate mucous membrane, gum mucosal epithelium have cuticular layer, and its major function is barrier action；Cheek
Mucous membrane, sublingual mucosa, mouth bottom mucous membrane and soft palate mucous membrane lack cuticular layer, because cuticular layer lacks in the region epithelium layer
It is weary, there is preferable permeability to water, permeability to weak from being followed successively by cheek mucous membrane, sublingual mucosa, mouth bottom mucous membrane by force.Medicine is passed through
The mode of mucous membrane of mouth has two kinds：Through cell and by way of space between cells.Its main mechanism is Passive intake, in spite of
Epithelial cell endocytosis phenomenon, but this effect can not possibly be by holostrome, it is also not possible to by active transport.To sum up, it is glutinous from oral cavity
The dissection of film and physilogical characteristics see that sublingual mucosa possesses as the condition of drug systemic administration route with cheek mucous membrane.Mucous membrane of mouth is administered
Approach advantage：1st, mucous membrane of mouth method of administration is essentially parenteral approach, can avoid the first pass effect of liver and breaking for intestines and stomach
Bad and degraded.2nd, mucous membrane of mouth method of administration is simple and easy to apply.The approach plays low dose of big effect there is a possibility that dosage is more accurate
The effect answered；Local directed complete set can be carried out according to optical clearing implementations；It is easy to urgent removing.3rd, it is single into internal approach
To only by buccal absorption.4th, area research progress is rapid, has possessed the achievement in research that can be provided utilize accordingly.Such as
Mucosal absorption accelerator, the device for delaying controlled-release technology and preventing mucus influence disperse etc..5th, mucous membrane of mouth method of administration has good
Good compliance.6th, compared with bronchia mucosal approach, mucous membrane of mouth approach is not easy to cause mucosa lesions.Mucous membrane of mouth is to medical instrument
Have the advantages that absorption is rapid, avoid the destruction of pipe intestinal digesting enzyme and bypass liver first-pass effect, but current mucous membrane of mouth
What is be administered has very many deficiencies：1st, due to being limited by the space of the absorbable mucous membrane in oral cavity, drug delivery system is unable to volume
It is excessive.2nd, involuntary salivary secretion and swallow influence mucous membrane of mouth approach efficiency.3rd, the taste stimulation influence of medicine should
The compliance of approach.4th, not every material can be transferred through mucous membrane of mouth, and it is absorbed by fat-soluble, pH value, molecular weight etc.
Influence.5th, mucous membrane permeability enhancing agent is needed to use under certain condition.And mucous membrane of mouth permeability is poor, can not typically provide fast
Speed absorbs the bioavilability become reconciled, that is, in cheek oromucosal route, many medicines need mucosal absorption reinforcing agent, and absorb and increase
Strong agent would generally produce certain side effect such as oral cavity to itch mucous membrane of mouth, redness etc..6th, the administering mode of oral anesthestia medicine
Typically have an injection and inject oral cavity, pain is brought to patient.Therefore the application of the approach is subject to a definite limitation, the approach to be only limitted to certain
A little medicines.Conventional at present have nitroglycerin, some sex steroid hormones, analgesic etc., and the dosage of medicine and
Precisely have much room for improvement.
The content of the invention
The purpose of the present invention is to solve the shortcomings of the prior art, now providing one kind can realize precisely administration, improve and use
In the dosage and bioavilability of the medicament categories of mucous membrane of mouth administration, while the integral intelligent oral administration without any pain
Paster apparatus and its manufacture craft.
In order to solve the above technical problems, the technical solution adopted by the present invention is：A kind of integral intelligent oral administration paster
Apparatus, its innovative point is：It is made up of paster and quantity of electricity controller, the paster is fixedly mounted on the lower end of quantity of electricity controller
Portion, the paster and quantity of electricity controller are formed in one structure；
The quantity of electricity controller is switched by apparatus, minicell and microcontroller are constituted, the apparatus switch, minicell
It is electrically connected with microcontroller, the apparatus switch is digitlization button；
The paster includes containing medicine plaster and without medicine plaster, it is described containing medicine plaster and without between medicine plaster at intervals of
0.01-5mm, preferably 0.1-0.3mm.
Further, described is the paster containing water-soluble medicine containing medicine plaster.
Further, the electric current of the quantity of electricity controller is 0.01-2.0mA, preferably 0.1-0.3mA, the electricity time
It is 0.1-24h, the voltage of the minicell is 1V-30V, preferably 3-6V.
Another object of the present invention is to disclose a kind of manufacture craft of integral intelligent oral administration paster apparatus, its wound
Newly point is：Docked and administration with microcontroller by the preparation containing medicine plaster, the preparation without medicine plaster, electrode installation
Starting step, completes the manufacture craft of integral intelligent oral administration paster apparatus；The step is specific as follows：
(1) preparation containing medicine plaster：The liquid medicine that will be prepared is injected into medical husky cotton center section, the husky cotton periphery
0.2mm parts are affixed on medical adhesive tape, and the center section of the husky cotton is attached on protection sheet, complete the preparation containing medicine plaster；
(2) preparation without medicine plaster：Water or emulsion, gel, lipid, microballoon are injected into medical husky cotton center section,
Part husky cotton periphery 0.2mm wide is affixed on medical adhesive tape, the center section 1.0cm of the husky cotton2Place is attached on protection sheet, so
Protection sheet is attached on medical adhesive tape afterwards, completes the preparation without medicine plaster；
(3) electrode is installed：According to the charged characteristic of the thing of Chinese medicine containing medicine plaster, metal electrode is carried out with corresponding metal salt electrode
Insertion, the preferred Ag of metal, the preferred AgCl of slaine；
(4) docked with microcontroller：The patch portion of band Ag electrodes is docked the positive pole of microcontroller, will be with AgCl electricity
The patch portion of pole docks the negative pole of microcontroller；
(5) administration starts：Electricity, electric current and conduction time are set on the display screen of microcontroller, apparatus switch is pressed,
Carry out starting administration.
Further, the preparation method of the liquid medicine in the preparation process containing medicine plaster is：By cellulose gum：
Water：Tri- kinds of materials of hydrochloric acid Li Kaduoyin press 2：95.5：2.5 part by weight is mixed to the aqueous solution jelly of 9000CPS,
Li Kaduoyin will be free in the aqueous solution with the form of cation.
Further, the preparation method of the liquid medicine in the preparation process containing medicine plaster is：Non-ionic macromolecular medicine
Thing, it is necessary to carry out the parcel of non-ionic macromolecular drug using carrier, then by wrapped non-ionic macromolecular drug
Formation suspension or jelly in the aqueous solution are dissolved in, the carrier is 50-70 with the mass ratio of non-ionic macromolecular drug:
30-60, preferential 65:35.
Further, the carrier is in chitosan lactate, other macroion surfactant, liposomes
Kind.
Further, the method for the preparation without medicine plaster is：Two kinds of materials of cellulose gum and water are pressed 2：
98 part by weight is mixed to the aqueous solution jelly of 10000CPS, and aqueous solution jelly then is injected into medical husky cotton
Center section, part husky cotton periphery 0.2mm wide is affixed on medical adhesive tape, the center section 1.0cm of the husky cotton2Place is attached to guarantor
On shield paper, then protection sheet is attached on medical adhesive tape, completes the preparation without medicine plaster.
Beneficial effects of the present invention are as follows：
(1) present invention is directly controlled medicine by the infiltration in oral cavity by electricity, and the dosage of administration can be by adjusting electricity
Measure and be precisely controlled, the increase of electricity can control the oral osmotic speed and dosage of medicine with reducing, and the control of electricity can
Carried out by current strength and conduction time, the control of electricity can be by the control of current strength and conduction time by microcontroller reality
It is existing, using the present invention compared to traditional mouth paster, substantially increase injection speed and dosage.
(2) harmless to mucous membrane of mouth when using present invention administration, administration process is painless, while can be effectively right
The dosage of oral administration carries out control accurate.
Brief description of the drawings
Fig. 1 is overall structure diagram of the invention；
Fig. 2 is the pig mucous membrane of mouth figure without electricity treatment of the invention；
Fig. 3 is pig mucous membrane of mouth figure of the electricity of the invention after 8 hours 0.3mA are processed.
Specific embodiment
Embodiments of the present invention are illustrated by particular specific embodiment below, those skilled in the art can be by this explanation
Content disclosed by book understands other advantages of the invention and effect easily.
It is as shown in Figure 1 overall structure diagram of the invention, a kind of integral intelligent oral administration paster apparatus, by pasting
Piece and quantity of electricity controller 1 are constituted, and paster is fixedly mounted on the bottom of quantity of electricity controller 1, and paster is integrated with quantity of electricity controller 1
Molding structure；
Quantity of electricity controller 1 is made up of apparatus switch 11, minicell 12 and microcontroller 13, apparatus switch 11, micro electric
Pond 12 and microcontroller 13 are electrically connected, and apparatus switch 11 is digitlization button；The electric current of quantity of electricity controller 1 is 0.01-
2.0mA, preferably 0.1-0.3mA, the electricity time is 0.1-24h, and the voltage of minicell 12 is 1V-30V, preferably 3-6V, miniature
Battery 12 is preferably button cell or paper battery.
Paster includes containing medicine plaster 2 and without medicine plaster 3, containing medicine plaster 2 and without between medicine plaster 3 at intervals of
0.01-5mm, preferably 0.1-0.3mm, are the paster containing water-soluble medicine containing medicine plaster 2.
The manufacture craft of integral intelligent oral administration paster apparatus, by the preparation containing medicine plaster 2, without medicine plaster 3
Preparation, electrode install and dock and starting step be administered with microcontroller 13, completion integral intelligent oral administration paster device
The manufacture craft of tool；Step is specific as follows：
(1) containing the preparation of medicine plaster 2：The liquid medicine that will be prepared is injected into medical husky cotton center section, husky cotton periphery
0.2mm parts are affixed on medical adhesive tape, and the center section of husky cotton is attached on protection sheet, complete the preparation containing medicine plaster；
(2) without the preparation of medicine plaster 3：Water or emulsion, gel, lipid, microballoon are injected into medical husky cotton center section,
Part husky cotton periphery 0.2mm wide is affixed on medical adhesive tape, the center section 1.0cm of husky cotton2Place is attached on protection sheet, then will
Protection sheet is attached on medical adhesive tape, completes the preparation without medicine plaster；
(3) electrode is installed：According to the charged characteristic of the thing of Chinese medicine containing medicine plaster, metal electrode is carried out with corresponding metal salt electrode
Insertion, the preferred Ag of metal, the preferred AgCl of slaine；
(4) docked with microcontroller：The patch portion of band Ag electrodes is docked the positive pole of microcontroller, will be with AgCl electricity
The patch portion of pole docks the negative pole of microcontroller；
(5) administration starts：Electricity, electric current and conduction time are set on the display screen of microcontroller, apparatus switch is pressed,
Carry out starting administration.
Preferably, the preparation method of the liquid medicine in the preparation process containing medicine plaster is：By cellulose gum：Water：Hydrochloric acid
Tri- kinds of materials of Li Kaduoyin press 2：95.5：2.5 part by weight is mixed to the aqueous solution jelly of 9000CPS, Li Kaduo
Because will be free in the aqueous solution with the form of cation.
Preferably, the preparation method of the liquid medicine in preparation process containing medicine plaster 2 is：Non-ionic macromolecular drug, needs
The parcel of non-ionic macromolecular drug is carried out using carrier, then wrapped non-ionic macromolecular drug is dissolved in
Suspension or jelly are formed in the aqueous solution, carrier is 50-70 with the mass ratio of non-ionic macromolecular drug:30-60, preferentially
65:35。
Preferably, carrier is the one kind in chitosan lactate, other macroion surfactant, liposomes.
Preferably, the method for the preparation without medicine plaster 3 is：Two kinds of materials of cellulose gum and water are pressed 2：98 weight
Amount ratio is mixed to the aqueous solution jelly of 10000CPS, and aqueous solution jelly then is injected into medical husky cotton pars intermedia
Point, part husky cotton periphery 0.2mm wide is affixed on medical adhesive tape, the center section 1.0cm of husky cotton2Place is attached on protection sheet, so
Protection sheet is attached on medical adhesive tape afterwards, completes the preparation without medicine plaster 3.
Embodiment 1
The external oral administration simulated experiment of pig mucous membrane of mouth：
(1) mucous membrane of mouth is obtained from pig buccal portion, mucous membrane of mouth thickness is 300-500 μm, and the area of mucous membrane of mouth is
1.0cm2, it is placed between Franz diffusion cell supply pool pieces and Franz diffusion cell acceptance pools, the epithelial tissue direction of mucous membrane of mouth
Supply pool, dosing paster apparatus then be placed in supply pool and be attached on mucous membrane of mouth, and phosphate-buffered is filled it up with acceptance pool
To simulate blood circulation, the temperature in acceptance pool is maintained at 37 DEG C to salt solution, for simulating body temperature.
(2) electricity is set：0.3mA, 8 hours conduction time, presses apparatus and switchs 11 power-on switch.
After (3) 8 hours, sample is taken from acceptance pool, Pharmaceutical Analysis is carried out with high pressure liquid phase analysis instrument, recorded, as a result such as
Shown in Fig. 2 and Fig. 3.
Table 1 is the tradition of 8 hours and hydrochloric acid Li Kaduoyin mouth pasters injection speed and dosage the contrast form of this method：
Table 1
Table 2 is the tradition of 8 hours and nicotine hydrochloride mouth paster injection speed and dosage the contrast form of this method：
Table 2
The present invention is directly controlled medicine by the infiltration in oral cavity by electricity, and the dosage of administration can be obtained by adjusting electricity
To being precisely controlled, the increase of electricity can control the oral osmotic speed and dosage of medicine with reducing, and the control of electricity can be by electricity
Intensity of flow and conduction time are carried out, the control of electricity can by the control of current strength and conduction time by microcontroller implementation,
Using the present invention compared to traditional mouth paster, injection speed and dosage are substantially increased.Counterpart during using present invention administration
Chamber mucous membrane is harmless, and administration process is painless, while dosage that can be effectively to oral administration carries out control accurate.
Above-described embodiment is presently preferred embodiments of the present invention, is not the limitation to technical solution of the present invention, as long as
Without the technical scheme that creative work can be realized on the basis of above-described embodiment, it is regarded as falling into patent of the present invention
Rights protection scope in.
Claims (8)
1. a kind of integral intelligent oral administration paster apparatus, it is characterised in that：It is made up of paster and quantity of electricity controller, the patch
Piece is fixedly mounted on the bottom of quantity of electricity controller, and the paster and quantity of electricity controller are formed in one structure；
The quantity of electricity controller is switched by apparatus, minicell and microcontroller are constituted, the apparatus switch, minicell and micro-
Controller is electrically connected, and the apparatus switch is digitlization button；
The paster includes containing medicine plaster and without medicine plaster, it is described containing medicine plaster and without between medicine plaster at intervals of
0.01-5mm, preferably 0.1-0.3mm.
2. a kind of integral intelligent oral administration paster apparatus according to claim 1, it is characterised in that：It is described containing drug paste
Piece is the paster containing water-soluble medicine.
3. a kind of integral intelligent oral administration paster apparatus according to claim 1, it is characterised in that：The electricity control
The electric current of device processed is 0.01-2.0mA, preferably 0.1-0.3mA, and the electricity time is 0.1-24h, the voltage of the minicell
It is 1V-30V, preferably 3-6V.
4. a kind of manufacture craft of integral intelligent oral administration paster apparatus as claimed in claim 1, it is characterised in that：Through
Cross to be installed containing the preparation of medicine plaster, the preparation without medicine plaster, electrode and dock and starting step is administered with microcontroller, it is complete
The manufacture craft of integralization intelligence oral administration paster apparatus；The step is specific as follows：
(1) preparation containing medicine plaster：The liquid medicine that will be prepared is injected into medical husky cotton center section, the husky cotton periphery
0.2mm parts are affixed on medical adhesive tape, and the center section of the husky cotton is attached on protection sheet, complete the preparation containing medicine plaster；
(2) preparation without medicine plaster：Water or emulsion, gel, lipid, microballoon are injected into medical husky cotton center section, Sha Mian
Part periphery 0.2mm wide is affixed on medical adhesive tape, the center section 1.0cm of the husky cotton2Place is attached on protection sheet, then will
Protection sheet is attached on medical adhesive tape, completes the preparation without medicine plaster；
(3) electrode is installed：According to the charged characteristic of the thing of Chinese medicine containing medicine plaster, metal electrode is carried out slotting with corresponding metal salt electrode
Enter, the preferred Ag of metal, the preferred AgCl of slaine；
(4) docked with microcontroller：The patch portion of band Ag electrodes is docked the positive pole of microcontroller, by band AgCl electrodes
Patch portion docks the negative pole of microcontroller；
(5) administration starts：Electricity, electric current and conduction time are set on the display screen of microcontroller, apparatus switch is pressed, are carried out
Start administration.
5. the manufacture craft of a kind of integral intelligent oral administration paster apparatus according to claim 4, it is characterised in that：
The preparation method of the liquid medicine in the preparation process containing medicine plaster is：By cellulose gum：Water：Tri- kinds of hydrochloric acid Li Kaduoyin
Material presses 2：95.5：2.5 part by weight is mixed to the aqueous solution jelly of 9000CPS, and Li Kaduoyin will be with cation
Form be free in the aqueous solution.
6. the manufacture craft of a kind of integral intelligent oral administration paster apparatus according to claim 4, it is characterised in that：
The preparation method of the liquid medicine in the preparation process containing medicine plaster is：Non-ionic macromolecular drug using carrier, it is necessary to be entered
, then be dissolved in wrapped non-ionic macromolecular drug in the aqueous solution and formed by the parcel of the non-ionic macromolecular drug of row
Suspension or jelly, the carrier are 50-70 with the mass ratio of non-ionic macromolecular drug:30-60, preferential 65:35.
7. the manufacture craft of a kind of integral intelligent oral administration paster apparatus according to claim 4, it is characterised in that：
The carrier is the one kind in chitosan lactate, other macroion surfactant, liposomes.
8. the manufacture craft of a kind of integral intelligent oral administration paster apparatus according to claim 4, it is characterised in that：
The method of the preparation without medicine plaster is：Two kinds of materials of cellulose gum and water are pressed 2：98 part by weight mixing and
Aqueous solution jelly as 10000CPS, is then injected into medical husky cotton center section, husky cotton periphery by aqueous solution jelly
Part 0.2mm wide is affixed on medical adhesive tape, the center section 1.0cm of the husky cotton2Place is attached on protection sheet, then will protection
Paper is attached on medical adhesive tape, completes the preparation without medicine plaster.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710025612.XA CN106823134B (en) | 2017-01-13 | 2017-01-13 | A kind of integral intelligent oral administration patch instrument and its manufacture craft |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710025612.XA CN106823134B (en) | 2017-01-13 | 2017-01-13 | A kind of integral intelligent oral administration patch instrument and its manufacture craft |
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| Publication Number | Publication Date |
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| CN106823134A true CN106823134A (en) | 2017-06-13 |
| CN106823134B CN106823134B (en) | 2018-08-21 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108106971A (en) * | 2018-02-13 | 2018-06-01 | 常州华佳医疗器械有限公司 | A kind of novel intelligent is transdermal and oral administration device and method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN204219363U (en) * | 2014-11-17 | 2015-03-25 | 王丽婷 | A kind of physiotherapy table and physical therapy heating plate |
| CN204335849U (en) * | 2014-12-24 | 2015-05-20 | 葛银林 | For the siRNA cutaneous penetration brassiere of mastocarcinoma gene treatment |
| CN204469019U (en) * | 2015-03-13 | 2015-07-15 | 河南中医学院 | Function instrument is pasted in a kind of type talus needle magnetic therapy cave |
| CN105381543A (en) * | 2015-11-18 | 2016-03-09 | 马燕 | Multifunctional endocrine therapeutic apparatus |
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2017
- 2017-01-13 CN CN201710025612.XA patent/CN106823134B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN204219363U (en) * | 2014-11-17 | 2015-03-25 | 王丽婷 | A kind of physiotherapy table and physical therapy heating plate |
| CN204335849U (en) * | 2014-12-24 | 2015-05-20 | 葛银林 | For the siRNA cutaneous penetration brassiere of mastocarcinoma gene treatment |
| CN204469019U (en) * | 2015-03-13 | 2015-07-15 | 河南中医学院 | Function instrument is pasted in a kind of type talus needle magnetic therapy cave |
| CN105381543A (en) * | 2015-11-18 | 2016-03-09 | 马燕 | Multifunctional endocrine therapeutic apparatus |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108106971A (en) * | 2018-02-13 | 2018-06-01 | 常州华佳医疗器械有限公司 | A kind of novel intelligent is transdermal and oral administration device and method |
| WO2019157833A1 (en) * | 2018-02-13 | 2019-08-22 | 常州华佳医疗器械有限公司 | Novel smart transdermal and oral administration equipment and method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106823134B (en) | 2018-08-21 |
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Address after: 213003 Jiangsu province Changzhou City Zhonglou District Zou Hui Ling Road No. 65 Co-patentee after: Changzhou Hualian medical device group Co.,Ltd. Patentee after: CHANGZHOU HUAJIA MEDICAL DEVICE Ltd. Address before: 213003 Jiangsu province Changzhou City Zhonglou District Zou Hui Ling Road No. 65 Co-patentee before: Changzhou Hualian Medical Equipment Group Co.,Ltd. Patentee before: CHANGZHOU HUAJIA MEDICAL DEVICE Ltd. Address after: 213003 Jiangsu province Changzhou City Zhonglou District Zou Hui Ling Road No. 65 Co-patentee after: Changzhou Hualian Medical Equipment Group Co.,Ltd. Patentee after: CHANGZHOU HUAJIA MEDICAL DEVICE Ltd. Address before: 213003 Jiangsu province Changzhou City Zhonglou District Zou Hui Ling Road No. 65 Co-patentee before: Changzhou Hualian Medical Equipment Co.,Ltd. Patentee before: CHANGZHOU HUAJIA MEDICAL DEVICE Ltd. Address after: 213003 Jiangsu province Changzhou City Zhonglou District Zou Hui Ling Road No. 65 Co-patentee after: Changzhou Hualian Medical Equipment Co.,Ltd. Patentee after: CHANGZHOU HUAJIA MEDICAL DEVICE Ltd. Address before: 213003 Jiangsu province Changzhou City Zhonglou District Zou Hui Ling Road No. 65 Co-patentee before: CHANGZHOU HUALIAN HEALTH DRESSING Co.,Ltd. Patentee before: CHANGZHOU HUAJIA MEDICAL DEVICE Ltd. |