CN106823019A - 一种自修复超声穿刺用聚乙烯醇水凝胶仿生材料及其制备方法和应用 - Google Patents
一种自修复超声穿刺用聚乙烯醇水凝胶仿生材料及其制备方法和应用 Download PDFInfo
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Abstract
本发明公开了一种自修复超声穿刺用聚乙烯醇水凝胶仿生材料及其制备方法和应用,所述仿生材料以聚乙烯醇为主要原料,辅以硼砂的甘油溶液和碱溶液。本发明所述自修复超声穿刺用聚乙烯醇水凝胶仿生材料高度均一、易于成型,具有与生物组织相近的力学属性,透超声,可自修复,能够循环使用;本发明所述自修复超声穿刺用聚乙烯醇水凝胶仿生材料在超声引导下实现穿刺练习,假体材料制备简单、成本低,可用于教学指导和练习操作。
Description
技术领域
本发明属于生物医疗领域,涉及一种能够代替生物软组织的假体组织,具体为一种自修复超声穿刺用聚乙烯醇水凝胶仿生材料及其制备方法和应用。
背景技术
癌症是人类的一大克星,它至今仍是全球性的医学难题,每年有几百万人因它而失去生命。近年来,恶性肿瘤的发病率和死亡率均有逐渐增加的趋势,已成为威胁人类生命健康的主要杀手。
细胞病理学检查是诊断癌症的主要方法,该检查首先需要获取目标器官的组织样本。由于具有花费低,创伤小,并发症少,愈合较快等优点,目前临床上提取组织标本的首选方法是穿刺活检法。穿刺活检就是利用中空取样针剌入目标软组织,切下少量组织样本并保存在针芯空腔中一并取出的方法。在实际临床中,穿刺活检的取样精度及取样效率一直不尽人意,原因在于穿刺过程中,穿剌距离不定,再加上人体内环境复杂,活检针在穿刺过程中极易与不相关的器官接触产生弯曲变形而导致穿刺的失败。实际操作中,医生通常借助超声(B超)图像引导操作穿刺活检,穿刺过程中通过不断手动调整活检针柄以提高穿刺精度。但该方法要求医生具有一定的实操经验,并且需要多人配合操作,耗时费力,并且会加剧患者的痛苦和继发症。由此可见,行之有效的手段是通过对软组织进行研究,降低穿刺活检过程中针与组织的相互作用力,减少针与组织的变形,同时,制备与人体组织相近的假体材料供医学者模拟练习穿刺技术,最终达到提高活检取样精度和效率的目的。
高分子水凝胶是由网状结构的高聚物和水组成。它是通过化学共价键相交联和氢键、范德华力相互联接形成网状结构,才使水凝胶具有强的吸水性、溶胀性、触变性、脱水收缩性、弹性和生物相容性。由于水凝胶具有这些特性使其可作人体软组织的替代物,才引起许多科学工作者广泛的重视并进行了研究,特别是在医学和生物学方面的基础与应用研究更引人瞩目。目前通过化学合成的医用水凝胶,已经在生物细胞的培养、蛋白酶的活性控制、药物释放载体、酶、抗原、抗体的分离、人体软组织填充以及组织工程等方面得到应用,在智能材料方面具有潜在的应用价值。它将成为生物材料学科最活跃、最引人注目、发展最快的研究领域之一。
聚乙烯醇(polyvinyl alcohol,简称PVA)是一种线性水溶性聚合物,白色颗粒状树脂,主要以1,3-二醇键(头-尾)的化学结构形式存在,并含有少量(约2%)的1,2-二醇键(头-头)以及微量的其他多种形式的链结构,是一种含有大量侧羟基的聚合物。羟基是强亲水性基团,因此聚乙烯醇是水溶性高分子化合物。完全醇解型聚乙烯醇是含乙酸根很少而结晶度颇高的聚乙烯醇,由于大分子链间的强烈相互作用,水溶性较差。所以通常聚乙烯醇需要在90℃至95℃的热水中才可完全溶解。同时,聚乙烯醇还可溶于二甲基亚砜、酞胺及脂肪族多羟基化合物,除此之外,几乎不溶于其它有机溶剂。由于PVA水凝胶除了具备一般水凝胶的性能外,特别具有毒性低、机械性能优良(高弹性模量和高的机械强度)、吸水量高和生物相容性好等优点,因而倍受青睐,目前已成为世界上产量最大的水溶性聚合物。PVA水凝胶在生物医学和实验方面的用途非常广泛,可以做为人造皮肤,人造肌肉等人工代用品。
目前常用的穿刺假体材料有仿肌肉弹道测试材料、塑料溶胶、PVC(聚氯乙稀)、琼脂等,然而一些材料的力学属性与真实组织相比有一定差距,作为穿刺假体并不可靠,并且一次或多次穿刺后留下的针道将严重导致B超成像质量下降。PVA水溶液与硼砂可以迅速形成水凝胶,但是由于硼砂与PVA反应过于迅速,从而导致形成的水凝胶不均匀,不适合倒入模具成型。
发明内容
解决的技术问题:为了克服现有技术的缺陷,获得一种高度均一、易于成型,具有与生物组织相近的力学属性,透超声,可自修复,能够循环使用的水凝胶仿生材料,本发明提供了一种自修复超声穿刺用聚乙烯醇水凝胶仿生材料及其制备方法和应用。
技术方案:一种自修复超声穿刺用聚乙烯醇水凝胶仿生材料的制备方法,包含以下步骤:
(1)将聚乙烯醇溶于水中,配制质量分数为5~10%的聚乙烯醇水溶液,室温保存;
(2)将硼砂溶于甘油中,硼砂的浓度为0.01~0.02g/mL,加入蒸馏水助溶,室温条件下完全溶解;
(3)将步骤(2)获得的硼砂的甘油溶液加入步骤(1)的聚乙烯醇水溶液中混合体积比为1:20~1:10,混合均匀后静置,溶液呈无色透明状;
(4)向步骤(3)获得的溶液中加入碱溶液,至形成水凝胶;
(5)步骤(4)中的凝胶用于超声穿刺后,将其加热至溶解,再冷却成型,实现循环使用。
优选的,步骤(1)中聚乙烯醇水溶液中聚乙烯醇的质量分数为10%。
优选的,步骤(2)中硼砂的浓度为0.02g/mL。
优选的,步骤(3)中硼砂的甘油溶液与聚乙烯醇水溶液的混合体积比为1:10。
优选的,步骤(4)中碱溶液使用的终浓度为10%。
任一所述方法制备获得的自修复超声穿刺用聚乙烯醇水凝胶仿生材料。
所述的自修复超声穿刺用聚乙烯醇水凝胶仿生材料在B型超声引导穿刺活检中的应用。
有益效果:(1)本发明所述自修复超声穿刺用聚乙烯醇水凝胶仿生材料高度均一、易于成型,具有与生物组织相近的力学属性,透超声,可自修复,能够循环使用;(2)本发明所述自修复超声穿刺用聚乙烯醇水凝胶仿生材料在超声引导下实现穿刺练习,假体材料制备简单、成本低,可用于教学指导和联系操作。
具体实施方式
以下实施例进一步说明本发明的内容,但不应理解为对本发明的限制。在不背离本发明精神和实质的情况下,对本发明方法、步骤或条件所作的修改和替换,均属于本发明的范围。若未特别指明,实施例中所用的技术手段为本领域技术人员所熟知的常规手段。
实施例1
一种自修复超声穿刺用聚乙烯醇水凝胶仿生材料的制备方法,包含以下步骤:
(1)95℃恒温水浴,将聚乙烯醇溶于水中,配制质量分数为5%的聚乙烯醇水溶液,完全溶解后降至室温保存;
(2)将硼砂溶于甘油中,硼砂的浓度为0.02g/mL,加入蒸馏水助溶,室温条件下搅拌至完全溶解;
(3)将步骤(2)获得的硼砂的甘油溶液加入步骤(1)的聚乙烯醇水溶液中,混合体积比为1:20,高速搅拌至混合均匀后静置2小时,溶液呈无色透明状;
(4)向步骤(3)获得的溶液中加入10%NaOH水溶液,至形成水凝胶;
(5)步骤(4)中的凝胶用于超声穿刺后,将其加热至100℃溶解,再降温至20℃冷却成型,实现循环使用。
由所述方法制备获得的自修复超声穿刺用聚乙烯醇水凝胶仿生材料。
将上述自修复超声穿刺用聚乙烯醇水凝胶仿生材料用于B型超声引导穿刺活检中,活检针柄能比较精确的到达指定位置,且针与凝胶的变形较小。并且可对多次进行穿刺实验的凝胶进行回收,并进行步骤(5)从而达到PVA材料的回收再利用。
实施例2
一种自修复超声穿刺用聚乙烯醇水凝胶仿生材料的制备方法,包含以下步骤:
(1)95℃恒温水浴,将聚乙烯醇溶于水中,配制质量分数为7%的聚乙烯醇水溶液,完全溶解后降至室温保存;
(2)将硼砂溶于甘油中,硼砂的浓度为0.0125g/mL,加入蒸馏水助溶,室温条件下搅拌至完全溶解;
(3)将步骤(2)获得的硼砂的甘油溶液加入步骤(1)的聚乙烯醇水溶液中,混合体积比为2:10,高速搅拌至混合均匀后静置2小时,溶液呈无色透明状;
(4)向步骤(3)获得的溶液中加入10%NaOH水溶液,至形成水凝胶;
(5)步骤(4)中的凝胶用于超声穿刺后,将其加热至100℃溶解,再降温至20℃冷却成型,实现循环使用。
由所述方法制备获得的自修复超声穿刺用聚乙烯醇水凝胶仿生材料。
将上述自修复超声穿刺用聚乙烯醇水凝胶仿生材料用于B型超声引导穿刺活检中,活检针柄能比较精确的到达指定位置,且针与凝胶的变形较小。并且可对多次进行穿刺实验的凝胶进行回收,并进行步骤(5)从而达到PVA材料的回收再利用。
实施例3
一种自修复超声穿刺用聚乙烯醇水凝胶仿生材料的制备方法,包含以下步骤:
(1)95℃恒温水浴,将聚乙烯醇溶于水中,配制质量分数为10%的聚乙烯醇水溶液,完全溶解后降至室温保存;
(2)将硼砂溶于甘油中,硼砂的浓度为0.01g/mL,加入蒸馏水助溶,室温条件下搅拌至完全溶解;
(3)将步骤(2)获得的硼砂的甘油溶液加入步骤(1)的聚乙烯醇水溶液中,混合体积比为1:10,高速搅拌至混合均匀后静置2小时,溶液呈无色透明状;
(4)向步骤(3)获得的溶液中加入10%NaOH水溶液,至形成水凝胶;
(5)步骤(4)中的凝胶用于超声穿刺后,将其加热至100℃溶解,再降温至20℃冷却成型,实现循环使用。
由所述方法制备获得的自修复超声穿刺用聚乙烯醇水凝胶仿生材料。
将上述自修复超声穿刺用聚乙烯醇水凝胶仿生材料用于B型超声引导穿刺活检中,活检针柄能比较精确的到达指定位置,且针与凝胶的变形较小。并且可对多次进行穿刺实验的凝胶进行回收,并进行步骤(5)从而达到PVA材料的回收再利用。
Claims (7)
1.一种自修复超声穿刺用聚乙烯醇水凝胶仿生材料的制备方法,其特征在于,包含以下步骤:
(1)将聚乙烯醇溶于水中,配制质量分数为5~10%的聚乙烯醇水溶液,室温保存;
(2)将硼砂溶于甘油中,硼砂的浓度为0.01~0.02g/mL,加入蒸馏水助溶,室温条件下完全溶解;
(3)将步骤(2)获得的硼砂的甘油溶液加入步骤(1)的聚乙烯醇水溶液中混合体积比为1:20~1:10,混合均匀后静置,溶液呈无色透明状;
(4)向步骤(3)获得的溶液中加入碱溶液,至形成水凝胶;
(5)步骤(4)中的凝胶用于超声穿刺后,将其加热至溶解,再冷却成型,实现循环使用。
2.根据权利要求1所述的一种自修复超声穿刺用聚乙烯醇水凝胶仿生材料的制备方法,其特征在于,步骤(1)中聚乙烯醇水溶液中聚乙烯醇的质量分数为10%。
3.根据权利要求1所述的一种自修复超声穿刺用聚乙烯醇水凝胶仿生材料的制备方法,其特征在于,步骤(2)中硼砂的浓度为0.02g/mL。
4.根据权利要求1所述的一种自修复超声穿刺用聚乙烯醇水凝胶仿生材料的制备方法,其特征在于,步骤(3)中硼砂的甘油溶液与聚乙烯醇水溶液的混合体积比为1:10。
5.根据权利要求1所述的一种自修复超声穿刺用聚乙烯醇水凝胶仿生材料的制备方法,其特征在于,步骤(4)中碱溶液使用的终浓度为10%。
6.权利要求1~5任一所述方法制备获得的自修复超声穿刺用聚乙烯醇水凝胶仿生材料。
7.权利要求6所述的自修复超声穿刺用聚乙烯醇水凝胶仿生材料在B型超声引导穿刺活检中的应用。
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