CN106822311A - A kind of Chinese medicine composition and its application with Portugal leaf as primary raw material - Google Patents
A kind of Chinese medicine composition and its application with Portugal leaf as primary raw material Download PDFInfo
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- CN106822311A CN106822311A CN201710038899.XA CN201710038899A CN106822311A CN 106822311 A CN106822311 A CN 106822311A CN 201710038899 A CN201710038899 A CN 201710038899A CN 106822311 A CN106822311 A CN 106822311A
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- chinese medicine
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- orange peel
- dried orange
- portugal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The present invention relates to Natural Medicine Chemistry technical field, a kind of Chinese medicine composition with Portugal leaf as primary raw material and its application are specifically disclosed.Described Chinese medicine composition includes Chinese medicine material Portugal leaf, dried orange peel and Common Camptotheca Fruit, and is prepared via a method which to obtain：(1) Portugal leaf, dried orange peel and Common Camptotheca Fruit are mixed, is then extracted with ethanol, concentrated extracting solution obtains ethanol extract；(2) ethanol extract that step (1) is prepared is dissolved in water, is then extracted with organic solvent A and organic solvent B successively, the partial concentration that organic solvent B is obtained by extraction posts to obtain described Chinese medicine composition after drying.The liver protection function of described Chinese medicine composition and treatment hepatic injury effect are better than positive control drug legalon.
Description
Technical field
The present invention relates to Natural Medicine Chemistry technical field, and in particular to a kind of Chinese medicine group with Portugal leaf as primary raw material
Compound and its application.
Background technology
Liver is intraperitoneal maximum parenchymatous organ, undertakes the important physiological function of human body.Liver damage disease is a class
Common disease.And in liver damage disease, wherein being much as the hepatic injury as caused by chemically Hepatoxic substance, referred to as
Chemical damage.These chemical substances include the chemical toxic substances and some drugses in alcohol, environment.As the weight of human body
Detoxify organ --- liver, with arteria hepatica and vena hepatica double blood supply.Chemical substance can be by intestines and stomach portal vein
Or body circulation is converted into liver, therefore liver is easily subject to the toxicant infringement in chemicals.The Nature and the mankind
There are some in industrial processes to the virose material of liver, referred to as " hepatotropic poison ", these poisonous substances are general in crowd
All over susceptible, incubation period is short, and the process of lesion is directly related with the dosage for infecting, and the different degrees of liver cell of liver can be caused bad
Extremely, fat deformation, cirrhosis and liver cancer.Therefore, a kind of medicine or health products that can treat hepatic injury of exploitation has important
Meaning.
Portugal leaf, Chinese medicine name.It is the leaf of myrtle Portugal Syzygiumjambos (L.) Alston.It is distributed in good fortune
Build, Guangdong, Guangxi, Hainan, Guizhou, Yunnan, the ground such as Taiwan.With it is clearing heat and detoxicating the effect of.It is usually used in aphthae, sore,
Variola.
Dried orange peel, Chinese medicine name.It is rutaceae orange Citrus reticulata Blanco and its drying of variety
Ripe pericarp.With regulating qi-flowing for strengthening spleen, the effect of eliminating dampness and eliminating phlegm.For abdominal fullness and distention, deficiency of food is vomited and diarrhoea, coughing with a lot of sputum.
Common Camptotheca Fruit, is the fruit of Nyssaceae plant camptotheca acuminata CamptothecaacuminataDecne..For anticancer, dissipate
Knot, blood-breaking stagnation resolvation.
Prior art does not report that the combination of Portugal leaf, dried orange peel and Common Camptotheca Fruit has the effect for the treatment of hepatic injury.
The content of the invention
The technical problems to be solved by the invention are to provide a kind of effect Chinese medicine with treatment hepatic injury of brand-new combination
Composition.
Above-mentioned technical problem to be solved by this invention, is achieved by the following technical programs：
A kind of Chinese medicine composition with Portugal leaf as primary raw material, comprising Chinese medicine material Portugal leaf, dried orange peel and Common Camptotheca Fruit.
Preferably, described Chinese medicine composition, the Chinese medicine material comprising following weight portion：80~120 parts of Portugal leaf；Dried orange peel
50~70 parts；20~40 parts of Common Camptotheca Fruit.
Most preferably, described Chinese medicine composition, the Chinese medicine material comprising following weight portion：100 parts of Portugal leaf；Dried orange peel 60
Part；30 parts of Common Camptotheca Fruit.
Preferably, described Portugal leaf, dried orange peel and Common Camptotheca Fruit are dry Portugal leaf, dried orange peel and Common Camptotheca Fruit.
Preferably, the Chinese medicine composition is prepared via a method which to obtain：
(1) Portugal leaf, dried orange peel and Common Camptotheca Fruit are mixed, is then extracted with ethanol, concentrated extracting solution obtains ethanol extract；
(2) ethanol extract that step (1) is prepared is dissolved in water, then successively with organic solvent A and organic molten
Agent B is extracted, and the partial concentration that organic solvent B is obtained by extraction posts to obtain described Chinese medicine composition after drying.
Preferably, the ethanol described in step (1) is ethanol that volume fraction is 50%~70%.
Preferably, the extracting method described in step (1) is heating and refluxing extraction method；The addition of ethanol be Portugal leaf,
5~10 times of dried orange peel and Common Camptotheca Fruit gross weight；Extraction time is 1~3h, and extraction time is 1~3 time.
Preferably, organic solvent A is petroleum ether, hexamethylene or chloroform.
Preferably, organic solvent B is ethyl acetate.
Above-mentioned Chinese medicine composition as liver protecting or treatment hepatic injury medicine or health products application.
Beneficial effect：(1) the invention provides a kind of brand-new composition is with liver protecting or treats hepatic injury effect
Chinese medicine composition；(2) Chinese medicine composition described in possesses very excellent liver protection function and treatment hepatic injury effect, described
Liver protecting and the treatment hepatic injury of collaboration are produced between the chemical composition extracted after the mixing of Portugal leaf, dried orange peel and Common Camptotheca Fruit
Effect；Embodiment data display, its liver protection function and treatment hepatic injury effect are better than positive control drug legalon.
Specific embodiment
The present invention is explained further below in conjunction with specific embodiment, but embodiment does not do any type of limit to the present invention
It is fixed.
The preparation of the Chinese medicine composition of embodiment 1
Chinese medicine material：100 parts of Portugal leaf；60 parts of dried orange peel；30 parts of Common Camptotheca Fruit；Described Portugal leaf, dried orange peel and Common Camptotheca Fruit are
Dry Portugal leaf, dried orange peel and Common Camptotheca Fruit.
Preparation method：
(1) Portugal leaf, dried orange peel and Common Camptotheca Fruit are mixed according to the above ratio, is subsequently adding Portugal leaf, dried orange peel and Common Camptotheca Fruit total
The ethanol (volume fraction of ethanol is 60%) of 8 times of weight, carries out heating and refluxing extraction, and extraction time is 2h, extraction time
It is 3 times；Merge each extract solution, concentrated extracting solution obtains ethanol extract into paste；
(2) ethanol extract that step (1) is prepared is dissolved in water into suspension, then with isometric with suspension
Petroleum ether extraction 3 times, then extracted 3 times with the ethyl acetate isometric with suspension, combined ethyl acetate extract, concentration is dry
Described Chinese medicine composition is obtained final product after dry.
The preparation of the Chinese medicine composition of embodiment 2
Chinese medicine material：80 parts of Portugal leaf；50 parts of dried orange peel；40 parts of Common Camptotheca Fruit；Described Portugal leaf, dried orange peel and Common Camptotheca Fruit are dry
Dry Portugal leaf, dried orange peel and Common Camptotheca Fruit.
Preparation method：
(1) Portugal leaf, dried orange peel and Common Camptotheca Fruit are mixed according to the above ratio, is subsequently adding Portugal leaf, dried orange peel and Common Camptotheca Fruit total
The ethanol (volume fraction of ethanol is 60%) of 8 times of weight, carries out heating and refluxing extraction, and extraction time is 2h, extraction time
It is 3 times；Merge each extract solution, concentrated extracting solution obtains ethanol extract into paste；
(2) ethanol extract that step (1) is prepared is dissolved in water into suspension, then with isometric with suspension
Petroleum ether extraction 3 times, then extracted 3 times with the ethyl acetate isometric with suspension, combined ethyl acetate extract, concentration is dry
Described Chinese medicine composition is obtained final product after dry.
The preparation of the Chinese medicine composition of embodiment 3
Chinese medicine material：120 parts of Portugal leaf；70 parts of dried orange peel；20 parts of Common Camptotheca Fruit；Described Portugal leaf, dried orange peel and Common Camptotheca Fruit are
Dry Portugal leaf, dried orange peel and Common Camptotheca Fruit.
Preparation method：
(1) Portugal leaf, dried orange peel and Common Camptotheca Fruit are mixed according to the above ratio, is subsequently adding Portugal leaf, dried orange peel and Common Camptotheca Fruit total
The ethanol (volume fraction of ethanol is 60%) of 8 times of weight, carries out heating and refluxing extraction, and extraction time is 2h, extraction time
It is 3 times；Merge each extract solution, concentrated extracting solution obtains ethanol extract into paste；
(2) ethanol extract that step (1) is prepared is dissolved in water into suspension, then with isometric with suspension
Petroleum ether extraction 3 times, then extracted 3 times with the ethyl acetate isometric with suspension, combined ethyl acetate extract, concentration is dry
Described Chinese medicine composition is obtained final product after dry.
Organic solvent A and organic solvent B are extracted, and the partial concentration that organic solvent B is obtained by extraction is posted described after drying
Chinese medicine composition.
The Portugal leaf extract of comparative example 1
The dry Portugal leaves of 1kg are taken, Portugal leaf extract is prepared according to the preparation method described in embodiment 1.
The dried orange peel extracts of comparative example 2
1kg dried orange peels are taken, dried orange peel extracts are prepared according to the preparation method described in embodiment 1.
The camplotheca acuminata berry extract of comparative example 3
The dry Common Camptotheca Fruits of 1kg are taken, camplotheca acuminata berry extract is prepared according to the preparation method described in embodiment 1.
Protection of the Chinese medicine composition that the test example embodiment of the present invention 1~3 is prepared to alcohol induced mice hepatic injury
Effect
Kunming mouse (18-22g) is randomly divided into 9 groups, and every group 20, specific packet is shown in Table 1.Embodiment 1 is given respectively
Extract, legalon positive drug that~3 Chinese medicine compositions for preparing, comparative example 1~3 are prepared, dosage are equal
It is 100mg/kg.Continuous gavage is administered 5 days, and blank control group, model group are with isometric distilled water gavage.
2h after 5th day most single administration, blank control group presses body weight intraperitoneal injection 20ml/kg physiological saline, and remaining group is pressed
20ml/kg gavage volume fractions are 95% edible alcohol, cause mouse alcoholic hepatic injury model.Adopted after 24 hours to alcohol
Blood, 3000r/min centrifugation 15min, separates serum, determines ALT, AST activity in mice serum.Test result is shown in Table 1.
Influence of the Chinese medicine composition of the present invention of table 1 to ALT, AST activity in hepatic injury mice serum caused by alcohol
Note：△Compare P ＜ 0.05 with blank control group；※ compares P ＜ 0.05 with model group；
From table 1, continuously to after alcohol, ALT, AST activity of model group are significantly raised, with blank pair for experiment mice
According to group compared to there is significant difference (P ＜ 0.05), modeling success is illustrated.
ALT, AST activity given in the mice serum of Chinese medicine composition described in embodiment 1~3 are bright compared with model group
It is aobvious to reduce, and it reduces degree more than positive control drug；Illustrate that it has extraordinary liver protection function and treatment hepatic injury
Effect, and liver protection function and treatment hepatic injury effect are better than positive control drug legalon.
Additionally, can be seen that being administered alone the extraction of Portugal leaf from ALT, AST activity data of the extract of comparative example 1~3
Thing, dried orange peel extracts or camplotheca acuminata berry extract, ALT, AST activity in mice serum reduce unobvious, and this explanation individually makes
Excellent liver protection function or treatment hepatic injury is not had with Portugal leaf extract, dried orange peel extracts or camplotheca acuminata berry extract
Effect.And the Chinese medicine composition obtained in steps such as heated refluxing extraction, extractions after mixing Portugal, dried orange peel and Common Camptotheca Fruit,
Its liver protection function and treatment hepatic injury effect are greatly enhanced, and are better than any comparative example extract.This is illustrated Pu
Chemical composition in the Chinese medicine composition obtained after heating extraction and extraction after the mixing of peach, dried orange peel and Common Camptotheca Fruit there occurs association
Acted on liver protection function and treatment hepatic injury.
Claims (10)
1. a kind of Chinese medicine composition with Portugal leaf as primary raw material, it is characterised in that comprising Chinese medicine material Portugal leaf, dried orange peel and
Common Camptotheca Fruit.
2. Chinese medicine composition according to claim 1, it is characterised in that the Chinese medicine material comprising following weight portion：Portugal
80~120 parts of leaf；50~70 parts of dried orange peel；20~40 parts of Common Camptotheca Fruit.
3. Chinese medicine composition according to claim 1, it is characterised in that the Chinese medicine material comprising following weight portion：Portugal
100 parts of leaf；60 parts of dried orange peel；30 parts of Common Camptotheca Fruit.
4. Chinese medicine composition according to claim 1, it is characterised in that described Portugal leaf, dried orange peel and Common Camptotheca Fruit are dry
Dry Portugal leaf, dried orange peel and Common Camptotheca Fruit.
5. the Chinese medicine composition according to any one of Claims 1 to 4, it is characterised in that the Chinese medicine composition is by such as
Lower section method is prepared：
(1) Portugal leaf, dried orange peel and Common Camptotheca Fruit are mixed, is then extracted with ethanol, concentrated extracting solution obtains ethanol extract；
(2) ethanol extract that step (1) is prepared is dissolved in water, is then extracted with organic solvent A and organic solvent B successively
Take, the partial concentration that organic solvent B is obtained by extraction posts to obtain described Chinese medicine composition after drying.
6. Chinese medicine composition according to claim 5, it is characterised in that the ethanol described in step (1) is volume fraction
It is 50%~70% ethanol.
7. Chinese medicine composition according to claim 5, it is characterised in that the extracting method described in step (1) is heating
Reflux extraction；The addition of ethanol is 5~10 times of Portugal leaf, dried orange peel and Common Camptotheca Fruit gross weight；Extraction time is 1~3h,
Extraction time is 1~3 time.
8. Chinese medicine composition according to claim 5, it is characterised in that organic solvent A is petroleum ether, ring in step (2)
Hexane or chloroform.
9. Chinese medicine composition according to claim 5, it is characterised in that organic solvent B is ethyl acetate in step (2).
10. the Chinese medicine composition described in any one of claim 1~9 as liver protecting or treatment hepatic injury medicine or health care
The application of product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710038899.XA CN106822311B (en) | 2017-01-19 | 2017-01-19 | Traditional Chinese medicine composition with syzygium jambos leaves as main raw materials and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710038899.XA CN106822311B (en) | 2017-01-19 | 2017-01-19 | Traditional Chinese medicine composition with syzygium jambos leaves as main raw materials and application thereof |
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| Publication Number | Publication Date |
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| CN106822311A true CN106822311A (en) | 2017-06-13 |
| CN106822311B CN106822311B (en) | 2021-04-16 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107441110A (en) * | 2017-08-02 | 2017-12-08 | 广东医科大学附属医院 | A kind of Exocarpium Citri Grandis extract and its application in cancer therapy drug is prepared |
| CN113826808A (en) * | 2021-09-27 | 2021-12-24 | 佛山科学技术学院 | Method for removing 5-hydroxymethylfurfural and application of method in food processing |
| CN114209641A (en) * | 2021-12-23 | 2022-03-22 | 广州远想生物科技股份有限公司 | Plant compound composition for fading pigments and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105481878A (en) * | 2015-12-31 | 2016-04-13 | 胡文杰 | Novel limonin compound and preparation method and medical application thereof |
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2017
- 2017-01-19 CN CN201710038899.XA patent/CN106822311B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105481878A (en) * | 2015-12-31 | 2016-04-13 | 胡文杰 | Novel limonin compound and preparation method and medical application thereof |
Non-Patent Citations (5)
| Title |
|---|
| MD RAFIKUL ISLAM等: "Antioxidant and hepatoprotective activity of an ethanol extract of Syzygium jambos (L.) leaves", 《DRUG DISCOVERIES & THERAPEUTICS》 * |
| QIN LI等: "A study of antioxidant activity about extracts with different solvents from four Chinese herbal medicines in Enshi", 《ADVANCED MATERIALS RESEARCH》 * |
| 정성제等: "Screening for Antioxidant Activity of Plant Medicinal Extracts", 《JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY》 * |
| 谢平等: "《天然药物化学实验技术》", 31 December 1993, 江西科学技术出版社 * |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107441110A (en) * | 2017-08-02 | 2017-12-08 | 广东医科大学附属医院 | A kind of Exocarpium Citri Grandis extract and its application in cancer therapy drug is prepared |
| CN113826808A (en) * | 2021-09-27 | 2021-12-24 | 佛山科学技术学院 | Method for removing 5-hydroxymethylfurfural and application of method in food processing |
| CN113826808B (en) * | 2021-09-27 | 2024-02-06 | 佛山科学技术学院 | Method for removing 5-hydroxymethylfurfural and application of method in food processing |
| CN114209641A (en) * | 2021-12-23 | 2022-03-22 | 广州远想生物科技股份有限公司 | Plant compound composition for fading pigments and preparation method thereof |
| CN114209641B (en) * | 2021-12-23 | 2023-05-12 | 广州远想生物科技股份有限公司 | Plant compound composition for fading pigment and preparation method thereof |
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