CN106818792A - A kind of Pesticidal combination of and macrolides compound compounding - Google Patents
A kind of Pesticidal combination of and macrolides compound compounding Download PDFInfo
- Publication number
- CN106818792A CN106818792A CN201611257712.7A CN201611257712A CN106818792A CN 106818792 A CN106818792 A CN 106818792A CN 201611257712 A CN201611257712 A CN 201611257712A CN 106818792 A CN106818792 A CN 106818792A
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- CN
- China
- Prior art keywords
- pesticidal combination
- effective active
- ketek
- macrolides compound
- component
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
Abstract
The present invention relates to a kind of feed, more particularly, to a kind of Pesticidal combination of and macrolides compound compounding.Specifically contain two kinds of effective active components of A, B, remaining component auxiliary agent, constituent and complementary component for needed for preparing during the related formulations of pesticide in the Pesticidal combination.Wherein, effective active component A is selected from new Ketek, and effective active component B is selected from emamectin benzoate.Found in combine experiment, obvious synergistic effect can be produced between two kinds of effective active compositions, substantially increase insecticide efficiency, 10% 15% or so are generally improved compared to single dose to the preventive effect of insect, and quick-acting has large increase, the lasting period is long, the Reusability number of times and dosage of less agricultural chemicals, agricultural cost is reduced, the pollution to environment is alleviated.
Description
Technical field
The present invention relates to disease control composition, more particularly, to a kind of desinsection group of and macrolides compound compounding
Compound.
Background technology
Macrolide antibiotics is played an important role in the treatment of clinical departments infectious diseases.Our times model
Enclose interior drug-fast bacteria problem increasingly serious, carrying out structural modification to Macrocyclic lactone compounds using chemical method has been obtained for several classes
There are the compound of good antibacterial activity, such as ketolide, acyl lactone class and 4- carbamate compounds to drug-fast bacteria.
For the severe infections for solving the problems, such as to be caused by antibody-resistant bacterium, it is badly in need of the new antibiosis effective to drug-fast bacteria of exploitation
Element.It has been generally acknowledged that 3 cladinoses of Erythromycin A are the necessary groups of antibacterial activity, being hydrolyzed can cause activity decrease.It is early
20 century 70s just have been reported that 3 be carbonyl erythromycin A analogPikromycinWithNarbomycinDo not induce gold
Portugal bacterium is to erythromycin series resistance, and the macrolides for having cladinose can trigger drug resistance, and thinks 3 of Erythromycin A
Cladinose is relevant with inducible resistance.At that time due toPikromycinWithNarbomyciIt is several without antibacterial activity, therefore this structure
Feature does not cause enough attention.To the mid-90 in 20th century, HoechstMarrionRoussel companies are by red mould
The further investigation of plain A structure-activity relationships and resistance mechanism, will cause 3 cladinoses of bacteria-induction drug resistance on Erythromycin A ring
Ketone carbonyl is transformed into, while 11, an aryl side chains are introduced on 12 cyclic carbramates, so as to obtain first ketone lactone
Class antibiotic --- Ketek, the latter is considered as the representative product of the third generation macrolide antibiotics effective to drug-fast bacteria
Kind.Ketek is sensitive to macrolide, resistance respiratory tract pathogenic bacteria have excellent activity, in 2001 first in Germany
City, so far in 12 countries and regions listings.Inspired by it, many international large-scale medical enterprises put into huge fund in ketone one after another
Esters carry out system research, and the ABT-773 chemical constitutions that aryl side chains are connected with the 6- hydroxyls that wherein Abbott companies develop are only
Spy, the antibacterial activity to part bacterium is better than Ketek, is now in registering the last stage, and it will turn into Ketek after listing
Contenders.The antibacterial activity of this kind of new macrolide antibiotics-- ketone lactone antibiotic has following several respects special
Point：One is to overcome the in-ductive drug -tolerance common to 14 membered macrolides, has stronger antibacterial to live to macrolide drug-fast bacteria
Property；Two is to Methicillin-resistant Staphylococcus aureus（MRSA）, multidrug resistant streptococcus pneumonia and respiratory tract pathogenic bacteria have excellent antibacterial
Activity；Three is also have remarkable activity to enterococcus and hemophilus.Ketolide remains the antibacterial activity to sensitive bacteria, together
When also have good activity to drug-fast bacteria, therefore its successfully develop be considered as macrolide antibiotics research new mileage
Upright stone tablet.
Now for macrolides material utilization all in body field of antibiotics, and do not go out in insecticide
A kind of good mode of existing worming effect.
The content of the invention
The technical problems to be solved by the invention be to provide a kind of prevention effect it is good and macrolides compound compounding
Pesticidal combination.
The present invention solves its technology:
Specifically contain two kinds of effective active components of A, B in the Pesticidal combination, remaining component is the related formulations of pesticide of preparation
Shi Suoxu auxiliary agents, constituent and complementary component.Wherein, effective active component A is selected from new Ketek, effective active group
B is divided to be selected from emamectin benzoate.
Ketek is first antibacterial that the woods of semi-synthetic macrolide one can be in phthalein amine one streptogramine B (MLSB) family
Medicine, belong to ketolide antibiotics, with broad spectrum antibiotic activity, relatively low selective drug resistance and with other ketone antibiotics
Cross resistance.
Emamectin benzoate full name emamectin-benzoate, is synthesized since fermented product emamectin benzoate or indoxacarb B1
A kind of new and effective semisynthetic antibiotics insecticide, it has ultra high efficiency, and low toxicity (preparation is closely nontoxic), low-residual is nuisanceless
Deng biological pesticide the characteristics of, to the active high of the larva of lepidopterous insects and other many insects, existing stomach poison function again and
Action of contace poison, and beneficial insect is not injured during pest control, be conducive to the integrated control to insect, expand in addition
Insecticidal spectrum, reduces the toxicity to people and animals.
Found in combine experiment, obvious synergistic effect can be produced between two kinds of effective active compositions, greatly improved
Insecticide efficiency, the preventive effect to insect generally improves 10%-15% or so compared to single dose, and quick-acting has large increase,
Lasting period is long, the Reusability number of times and dosage of less agricultural chemicals, reduces agricultural cost, alleviates the pollution to environment.
In addition, another key factor for compounding being met between two kinds of farm chemical ingredients is, the compatibility between two kinds of active ingredients
Preferably, the formulations of pesticide being applicable in agricultural can be prepared into, be easy to the concrete application of agricultural chemicals, the performance of drug effect, and agriculture after medicine
The decomposition of medicine.
Combinations of the above thing, it is characterised in that the optimal weight hundred of active ingredient Ketek and emamectin benzoate in composition
Divide than being 5: 1-1：30.
Combinations of the above thing, it is characterised in that active ingredient accounts for the 10-36% of composition total weight.
Combinations of the above thing, it is characterised in that said composition can be made into suspending agent, aqueous emulsion, microemulsion, missible oil, wettable
Pulvis or water dispersible granules, and corresponding solvent, carrier and auxiliary agent can be needed to use according to exploitation.
The Representative Cultivars of the Ketek of the invention third generation macrolides effective to drug-fast bacteria, beneficial aspect exists
In：
1. one is to overcome the in-ductive drug -tolerance common to macrolides, has stronger antibacterial activity to macrolide drug-fast bacteria；
2. two is to Methicillin-resistant Staphylococcus aureus（MRSA）, multidrug resistant streptococcus pneumonia and respiratory tract pathogenic bacteria have excellent anti-
Bacterium activity；
3. three is also have remarkable activity to enterococcus and hemophilus
A kind of and macrolides compound compounding Pesticidal combination of the present invention, by the combination of Ketek and emamectin benzoate,
Combined with the compounding of traditional insecticide by antibiotic, can effectively be prevented and treated MRSE, staphylococcus albus, pneumonia
Diplococcus and γ-streptococcus have stronger antibacterial activity, can effectively prevent and treat graw mold of tomato, can prevent and treat paddy rice, wheat, corn,
The various pests of vegetables, tobacco, tea tree, fruit tree and sugarcane, with the lasting period it is long, work efficiency is high, target is not likely to produce the resistance to the action of a drug, ring
Border pollution it is low, save medicine water-saving the characteristics of.
Specific embodiment
Embodiment 1
A kind of suspending agent of the Pesticidal combination of and macrolides compound compounding：
Ketek 5g, emamectin benzoate 1g, butyl hydroxybenzoate 3g, ethylene glycol 2g, xanthans 6g, silicone oil 1g, water surplus complement to 100g,
Other auxiliary agents are mixed, it is well mixed through high speed shear, Ketek and emamectin benzoate are added, abrading-ball 2-3 hours in ball crusher,
Make a diameter in below 5mm, the suspending agent of the above-mentioned Pesticidal combination containing Ketek and emamectin benzoate of the present invention is obtained
Preparation.Butyl hydroxybenzoate can strengthen the insecticidal effect of Ketek and emamectin benzoate, while drug-fast generation can be delayed.
Ketek 15g, emamectin benzoate 2g, butyl hydroxybenzoate 6g, ethylene glycol 3g, xanthans 8g, silicone oil 1g, water surplus are complemented to
100g, other auxiliary agents are mixed, well mixed through high speed shear, add Ketek and emamectin benzoate, the abrading-ball 2-3 in ball crusher
Hour, make a diameter in below 5mm, the outstanding of the above-mentioned Pesticidal combination containing Ketek and emamectin benzoate of the present invention is obtained
Floating agent formulation.
Embodiment 2
A kind of Pesticidal combination aqueous emulsion of and macrolides compound compounding：
Ketek 10g, emamectin benzoate 1g, polyoxyethylene aliphatic alcohol ether 4g, dichloromethane 3g, sodium citrate 4g, ethylene glycol 3g, silicon
Oily 1g, xanthans 5g, water complements to 100g.Active compound Ketek and emamectin benzoate, solvent and emulsifying agent, cosolvent are added in one
Rise, make to be dissolved into uniform oil phase；By part water, antifreeze, other insecticides adjuvants such as antimicrobial are mixed into
Uniform water phase；Oil phase is added into water phase while high-speed stirred in a kettle., is slowly added water up to reaching phase inversion point, opened
Cutter carries out high speed shear, and adds remaining water, shearing about half an hour, forms the aqueous emulsion of oil-in-water type.It is obtained and contains
There is the aqueous emulsion of the Pesticidal combination of Ketek and emamectin benzoate.
Embodiment 3
A kind of water dispersible granules of the Pesticidal combination of and macrolides compound compounding：
Ketek 2g, emamectin benzoate 10g, butyl hydroxybenzoate 6g, spaonin powder 6g, citric acid 2g, white carbon 74g.By Ketek, first
Dimension salt and butyl hydroxybenzoate, spaonin powder, citric acid and white carbon are well mixed, are crushed with micro jet, through mediating, so
Add afterwards granulated in fluidized-bed granulation dryer, dry, sieve after through sampling analysis, it is prepared of the invention above-mentioned to contain Thailand
The water dispersible granules of the Pesticidal combination of Citropten and emamectin benzoate.
It will be apparent to those skilled in the art that technical scheme that can be as described above and design, make other various
It is corresponding to change and deformation, and all these change and deformation should all belong to the protection domain of the claims in the present invention
Within.
Claims (5)
1. a kind of Pesticidal combination of and macrolides compound compounding, it is characterised in that：Contain A, B in the Pesticidal combination
Two kinds of effective active components, remaining component auxiliary agent, constituent and complementary component for needed for preparing during the related formulations of pesticide；Its
In, effective active component A is selected from new Ketek, and effective active component B is selected from emamectin benzoate.
2. the Pesticidal combination that according to claim 1 a kind of and macrolides compound is compounded, it is characterised in that：Institute
The composition stated, it is characterised in that the optimal percentage by weight of active ingredient Ketek and emamectin benzoate is 5: 1- in composition
1：30.
3. the Pesticidal combination that according to claim 1 a kind of and macrolides compound is compounded, it is characterised in that：Institute
The composition stated, it is characterised in that active ingredient accounts for the 10-36% of composition total weight.
4. the Pesticidal combination that according to claim 1 a kind of and macrolides compound is compounded, it is characterised in that：Institute
The composition stated, it is characterised in that said composition can be made into suspending agent, aqueous emulsion, microemulsion, missible oil, wettable powder or moisture
Shot agent, and corresponding solvent, carrier and auxiliary agent can be needed to use according to exploitation.
5. what the formula described in any one of claim 1-4 was obtained is all a kind of and the desinsection group of macrolides compound compounding
Compound.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611257712.7A CN106818792A (en) | 2016-12-30 | 2016-12-30 | A kind of Pesticidal combination of and macrolides compound compounding |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611257712.7A CN106818792A (en) | 2016-12-30 | 2016-12-30 | A kind of Pesticidal combination of and macrolides compound compounding |
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|---|---|
| CN106818792A true CN106818792A (en) | 2017-06-13 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611257712.7A Pending CN106818792A (en) | 2016-12-30 | 2016-12-30 | A kind of Pesticidal combination of and macrolides compound compounding |
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101322493A (en) * | 2008-07-05 | 2008-12-17 | 惠州市中迅化工有限公司 | Insecticidal composition containing spinosad and emamectin-benzoate |
| CN101669489A (en) * | 2009-09-24 | 2010-03-17 | 江苏东宝农药化工有限公司 | Biological pesticidal and sterilizing composition and production method thereof |
| CN102550561A (en) * | 2010-12-21 | 2012-07-11 | 南京农业大学 | Pesticide composition |
| CN103704224A (en) * | 2012-10-08 | 2014-04-09 | 上海农乐生物制品股份有限公司 | Shenqinmycin-avermectins suspoemulsion used for controlling plant nematodes and preparation method of the suspoemulsion |
| CN103960292A (en) * | 2013-01-25 | 2014-08-06 | 陕西汤普森生物科技有限公司 | Insect disinfestation composition containing conidioblous thromboides and biological source |
| CN104996439A (en) * | 2015-01-12 | 2015-10-28 | 四川利尔作物科学有限公司 | Pesticide composition and application thereof |
| US20160067179A1 (en) * | 2008-07-21 | 2016-03-10 | Otonomy, Inc. | Controlled release antimicrobial compositions and methods for the treatment of otic disorders |
| US20160355487A1 (en) * | 2013-12-24 | 2016-12-08 | University Of Florida Research Foundation, Incorporated | Phenazine derivatives as antimicrobial agents |
-
2016
- 2016-12-30 CN CN201611257712.7A patent/CN106818792A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101322493A (en) * | 2008-07-05 | 2008-12-17 | 惠州市中迅化工有限公司 | Insecticidal composition containing spinosad and emamectin-benzoate |
| US20160067179A1 (en) * | 2008-07-21 | 2016-03-10 | Otonomy, Inc. | Controlled release antimicrobial compositions and methods for the treatment of otic disorders |
| CN101669489A (en) * | 2009-09-24 | 2010-03-17 | 江苏东宝农药化工有限公司 | Biological pesticidal and sterilizing composition and production method thereof |
| CN102550561A (en) * | 2010-12-21 | 2012-07-11 | 南京农业大学 | Pesticide composition |
| CN103704224A (en) * | 2012-10-08 | 2014-04-09 | 上海农乐生物制品股份有限公司 | Shenqinmycin-avermectins suspoemulsion used for controlling plant nematodes and preparation method of the suspoemulsion |
| CN103960292A (en) * | 2013-01-25 | 2014-08-06 | 陕西汤普森生物科技有限公司 | Insect disinfestation composition containing conidioblous thromboides and biological source |
| US20160355487A1 (en) * | 2013-12-24 | 2016-12-08 | University Of Florida Research Foundation, Incorporated | Phenazine derivatives as antimicrobial agents |
| CN104996439A (en) * | 2015-01-12 | 2015-10-28 | 四川利尔作物科学有限公司 | Pesticide composition and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| Н.А.克拉西立尼科夫: "《微生物在植物生活中的作用》", 31 July 1955 * |
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Application publication date: 20170613 |