CN106807106A - Crystal system and method for crystallising - Google Patents
Crystal system and method for crystallising Download PDFInfo
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- CN106807106A CN106807106A CN201510855068.2A CN201510855068A CN106807106A CN 106807106 A CN106807106 A CN 106807106A CN 201510855068 A CN201510855068 A CN 201510855068A CN 106807106 A CN106807106 A CN 106807106A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0004—Crystallisation cooling by heat exchange
- B01D9/0013—Crystallisation cooling by heat exchange by indirect heat exchange
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0077—Screening for crystallisation conditions or for crystal forms
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- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The present invention discloses crystal system and method for crystallising, wherein, method for crystallising is comprised the following steps：(1) in sample to be crystallized being deposited in into sample storage device, in making it into crystallization apparatus tank body by first charging aperture；(2) the first solvent in the first solvent storage device is added in tank body by second charging aperture, opens the heater in temperature control component, tank body heated so that the sample to be crystallized in tank body is completely dissolved；(3) the second solvent in the second solvent storage device is added in tank body by the 3rd charging aperture, opens the cooler in temperature control component, tank body cooled down so that the sample solution cooling crystallization to be crystallized in tank body；(4) after the completion of crystallization, by the two-layer filter of tank bottom, the crystal of appropriate particle size is obtained.Thus, using the method, quantitative, constant speed, efficient crystallization and screening can be carried out to sample, it is easy to operate, and crystalline quality is can guarantee that, on the other hand, also allow for determining crystallization processes parameter.
Description
Technical field
The invention belongs to medicine synthesis technique apparatus field, specifically, being related to a kind of crystal system and method for crystallising.
Background technology
Crystallization belongs to the conventional operating procedure of pharmaceutical synthesis field, and the product of high-purity is can obtain by crystallization, and medicine is special
Determining crystal formation can directly affect follow-up preparation process and be played a crucial role for drug effect performance.However, laboratory rank conventional at present
The crystallization operation of section is generally carried out in uncovered beaker, focuses on screening recrystallisation solvent, and for Crystallization Process parameter control simultaneously
It is very not strict.And it is well known by those skilled in the art that be process that solute is separated out from solution based on crystallization, can be divided into
Nucleus generates (nucleation) and two stages of crystal growth, it is necessary to the regular hour, right in addition to having screening to recrystallisation solvent
It is required to be controlled in the procedure parameter of operations step, this is also beneficial to obtain target crystal formation.
Therefore, it is existing be suitable to screen the crystal system and method for crystallising that obtain specific products crystal formation be further improved.
The content of the invention
It is contemplated that at least solving one of technical problem present in prior art to a certain extent or providing at one kind to have
Business is selected.Therefore, it is an object of the present invention to provide a kind of crystallization for being suitable to screen and obtaining specific products crystal formation
System and method for crystallising, using the system, quantitative, constant speed, efficient crystallization can be carried out to sample and are screened, operation ten
Divide convenient, and can guarantee that crystalline quality, on the other hand, also allow for determining crystallization processes parameter.
Therefore, in invention in a first aspect, the present invention proposes a kind of crystal system.Embodiments in accordance with the present invention, this is
System includes：
Crystallization apparatus, the crystallization apparatus are made up of tank body, tank deck and tank bottom, and the tank wall has temperature control component,
The tank deck is offered at least one charging aperture, the tank body and is provided with two-layer filter, the tank at tank bottom
Bottom offers at least one discharging opening；
Sample storage device, the sample storage device is connected by the first charging aperture of the tank deck with the crystallization apparatus；
First solvent storage device, first solvent storage device is filled by the second charging aperture of the tank deck and the crystallization
Put connected, the first solvent storage device has first flow control device；
Second solvent storage device, the 3rd charging aperture and the crystallization apparatus phase that second solvent storage device passes through tank deck
Even, the second solvent storage device has second flow control device；And
Motor, the motor connection has faciola shape propeller blade, and the faciola shape propeller blade is arranged at the crystallization apparatus
In tank body, and can be moved up and down along tank body.
It is surprisingly found by the inventors that, crystal system of the invention is suitable to screening and obtains specific products crystal formation, thus, using the knot
Crystallographic system is united, and can be quantified, constant speed, efficiently be realized treating the treatment of crystallized sample, and by crystal system of the invention
It is easy to the influence of the species, addition groping, determine different recrystallisation solvents to crystalline product.Formed in crystal system tank body
Product, processed via faciola shape propeller blade, can avoid producing excessive crystal block, and to the tiny crystalline substance for the treatment of of doing over again
Body is crushed, and so as to proceed Crystallization Process, thus can improve crystalline product yield.
In addition, crystal system according to embodiments of the present invention, can also have following additional technical feature：
Embodiments in accordance with the present invention,
The temperature control component includes：
Temperature control chuck, the temperature control chuck is arranged on the outer wall of the tank body；
Cooling/heating apparatus, the cooling/heating apparatus are arranged in the temperature control chuck, and the cooling/heating apparatus include single
Only controllable heating coil and cooling coil, the heating coil have heating medium inlet and Crude product input, described to add
Hot coil has the first valve control device and the first temperature controller；The cooling coil has cooling medium entrance and cooling
Media outlet, the cooling coil has the second valve control device and second temperature controller；
Heater, the heater is arranged on outside the crystallization apparatus and is connected with the heating coil；
Cooler, the cooler is arranged on outside the crystallization apparatus and is connected with the cooling coil.
Thus, it is possible to meet crystallization process, the demand of dissolving and cooling crystallization to sample.By the first temperature controller
With second temperature controller, it is possible to achieve the regulation to temperature parameter in crystallization.
The conventional method for carrying out crystal screening is common slow cooling, is primarily due to easily cause crystal not using fast cooling
Can successfully separate out, or product quality is not high.However, for specific products crystal formation, using the fast cooling of certain amplitude,
Can be conducive to obtaining product.Therefore, state modulator is carried out for temperature-fall period to be conducive to obtaining specific products crystal formation.
Embodiments in accordance with the present invention,
The crystallization apparatus tank deck further offers crystal seed and adds mouth.Thus, it is easy to difficult crystalline product quickly to obtain target brilliant
Type.
Embodiments in accordance with the present invention, the crystallization apparatus tank deck is provided with visual windows.Thus, it is easy to observe crystal system
Middle Product Status.When excessive crystal block is found, motor, regulation faciola shape propeller blade position can be opened, and smash it
Excessive crystal block.
Embodiments in accordance with the present invention, the crystallization apparatus tank body is provided with temperature indicating device.Thus, it is easy to monitoring different
Temperature in state lower tank, to accumulate the temperature parameter in crystallization processes.
Embodiments in accordance with the present invention, the two-layer filter is removably provided with the particle diameter choosing of large and small two kinds of different meshes
Select module.The selection of mesh number can be adjusted according to the actual requirements.By two-layer filter, make to meet the crystalline substance of Particle size requirements
Between body is contained therein.And particle diameter is excessive remains in tank body, processed by faciola shape propeller blade；Particle diameter is too small
Crystal, can unify take out, return tank body recrystallize.Thus the yield of target crystal can be improved.
Embodiments in accordance with the present invention, the tank body specification of the crystallization apparatus is 1L, 2L, 5L, 10L, 20L, 50L, 100L,
One of 200L and 500L.Thus crystal system of the invention goes for the medicine synthesising process of different scales.
Embodiments in accordance with the present invention, the heating coil and the cooling coil are coiled in the temperature control folder in the shape of a spiral side by side
In set.
Embodiments in accordance with the present invention, the heating coil and the cooling coil are separately Stainless Steel Coil or glass
Coil pipe.When crystallization apparatus specification is smaller, glass material can be selected, with reduces cost.When crystallization apparatus specification is larger,
Stainless steel can be selected, to extend life of product, and can be with pressure-resistant.
In the second aspect of the present invention, the present invention proposes a kind of method using above-mentioned crystal system crystallized sample.According to this
Inventive embodiment, the method is comprised the following steps：
(1) in sample to be crystallized being deposited in into the sample storage device, crystallization apparatus tank is made it into by first charging aperture
In body；
(2) the first solvent in the first solvent storage device is added in tank body by second charging aperture, opens temperature control component
In heater, tank body is heated so that the sample to be crystallized in tank body is completely dissolved；
(3) the second solvent in the second solvent storage device is added in tank body by the 3rd charging aperture, opens temperature control component
In cooler, tank body is cooled down so that the sample solution cooling crystallization to be crystallized in tank body；
(4) after the completion of crystallization, by the two-layer filter of tank bottom, the crystal of appropriate particle size is obtained.
According to a particular embodiment of the invention, the first solvent is added to enter into tank via the first solvent storage device in step (2)
While in body, the first valve control device is opened, heating medium is entered heating coil, so that sample to be crystallized is complete
CL.
According to a particular embodiment of the invention, heating medium is released after step (2) terminates, and closes the first valve control device
11-3。
According to a particular embodiment of the invention, step (3) is via the second solvent storage device, and quantitative, constant speed addition second is molten
Agent is entered into tank body, while opening the second valve control device, cooling medium is entered cooling coil.
According to a particular embodiment of the invention, by second temperature controller, constant speed regulation cooldown rate makes sample to be crystallized
Solution cooling crystallization.
The method of the present invention is suitable to screening and obtains specific products crystal formation, thus, using the method for crystallising, can be to sample
Product carry out quantitative, constant speed, efficient crystallization and screen, easy to operate, and can guarantee that crystalline quality, on the other hand,
Also allow for determining crystallization processes parameter.
Additional aspect of the invention and advantage will be set forth in part in the description, and partly will from the following description become bright
It is aobvious, or recognized by practice of the invention.
Brief description of the drawings
Of the invention above-mentioned and/or additional aspect and advantage will be apparent from description of the accompanying drawings below to embodiment is combined
Be readily appreciated that, wherein：
Fig. 1 is crystal system structural representation according to an embodiment of the invention；
Fig. 2 is the jacket structured schematic diagram of temperature control in crystal system according to an embodiment of the invention；
Fig. 3 is two-layer filter apparatus configuration schematic diagram in crystal system according to an embodiment of the invention.
Specific embodiment
Embodiments of the invention are described below in detail, the example of the embodiment is shown in the drawings, wherein identical from start to finish
Or similar label represents same or similar element or the element with same or like function.Retouched below with reference to accompanying drawing
The embodiment stated is exemplary, it is intended to for explaining the present invention, and be not considered as limiting the invention.
In the description of the invention, it is to be understood that term " " center ", " longitudinal direction ", " transverse direction ", " length ", " width ",
" thickness ", " on ", D score, "front", "rear", "left", "right", " vertical ", " level ", " top ", " bottom ", " interior ", " outward ",
The orientation or position relationship of the instruction such as " clockwise ", " counterclockwise ", " axial direction ", " radial direction ", " circumference " are based on shown in the drawings
Orientation or position relationship, are for only for ease of the description present invention and simplify and describe, rather than indicate or imply signified device or
Element with specific orientation, with specific azimuth configuration and operation, therefore must be not considered as limiting the invention.
Additionally, term " first ", " second " be only used for describe purpose, and it is not intended that indicate or imply relative importance or
Person implies the quantity of the technical characteristic for indicating indicated.Thus, define " first ", the feature of " second " can express or
Implicitly include at least one this feature.In the description of the invention, " multiple " is meant that at least two, such as two,
Three etc., unless otherwise expressly limited specifically.
In the present invention, unless otherwise clearly defined and limited, the art such as term " installation ", " connected ", " connection ", " fixation "
Language should be interpreted broadly, for example, it may be fixedly connected, or be detachably connected, or integrally；Can be machinery
Connection, or electrical connection；Can be joined directly together, it is also possible to be indirectly connected to by intermediary, can be two units
Connection or two interaction relationships of element inside part, unless otherwise clearly restriction.For the ordinary skill of this area
For personnel, above-mentioned term concrete meaning in the present invention can be as the case may be understood.
In the present invention, unless otherwise clearly defined and limited, fisrt feature second feature " on " or D score can be first
Pass through intermediary mediate contact with second feature directly contact, or the first and second features.And, fisrt feature is second
Feature " on ", " top " and " above " but fisrt feature directly over second feature or oblique upper, or to be merely representative of first special
Level height is levied higher than second feature.Fisrt feature second feature " under ", " lower section " and " below " can be that fisrt feature exists
Immediately below second feature or obliquely downward, or fisrt feature level height is merely representative of less than second feature.
In the first aspect of the present invention, the present invention proposes a kind of crystal system.Crystal system screening of the invention obtains specific
The crystal system and method for crystallising of product crystal formation, using the system, can carry out quantitative, constant speed, efficient crystallization to sample
And screening, it is easy to operate, and crystalline quality is can guarantee that, on the other hand, also allow for determining crystallization processes parameter.
For convenience of understanding, referring to Fig. 1-3, crystal system of the invention is described in detail.
Embodiments in accordance with the present invention, crystal system of the invention 1000 includes：Crystallization apparatus 100, sample storage device 200,
First solvent storage device 300, the second solvent storage device 400 and motor 500.
Embodiments in accordance with the present invention, crystallization apparatus 100 are made up of tank body 110, tank deck 120 and tank bottom 130, and described
The outer wall of tank body 110 has temperature control component, and the tank deck 120 is offered at least one charging aperture, the tank body and near tank
Two-layer filter 131 is provided with bottom 130, the tank bottom offers at least one discharging opening 132.Thus, it is possible to according to
The need for sample to be separated, at least one solvent storage device is set.Generally use 2.
Embodiments in accordance with the present invention, first charging aperture 121 and crystallization apparatus that sample storage device 200 passes through tank deck 120
100 are connected.
Embodiments in accordance with the present invention, second charging aperture 122 and crystallization of first solvent storage device 300 by tank deck 120
Device 100 is connected, and the first solvent storage device 300 has first flow control device 310.Thus, it is possible to pass through second
Volume control device 310 adjusts the flow velocity of solvent in the first solvent storage device 300.
Embodiments in accordance with the present invention, the 3rd charging aperture 123 and crystallization apparatus that the second solvent storage device 400 passes through tank deck
100 are connected, and the second solvent storage device 400 has second flow control device 410.Thus, it is possible to pass through the 3rd flow control
Device processed 410 adjusts the flow velocity of solvent in the second solvent storage device 400.
Embodiments in accordance with the present invention, motor 500 is connected with faciola shape propeller blade 510, the faciola shape propeller blade 510
It is arranged in the tank body 110 of crystallization apparatus 100, and can be moved up and down along tank body 110.
Thus, crystal system of the invention 1000 is suitable to screening and obtains specific products crystal formation, using the crystal system 1000,
Can quantify, constant speed, efficiently realize treating the treatment of crystallized sample, and be easy to by crystal system of the invention 1000
Influence of the species, addition for grope, determining different recrystallisation solvents to crystalline product.In the tank body 100 of crystal system 1000
The product of formation, is processed via faciola shape propeller blade 510, can avoid producing excessive crystal block, and to treatment of doing over again
Fine crystals crushed, so as to proceed Crystallization Process, thus can improve crystalline product yield.
Some embodiments of the invention, as shown in Fig. 2 temperature control component includes：Temperature control chuck 111, cooling/heating apparatus,
Heater 11-5 and cooler 12-5.Wherein, temperature control chuck 111 is arranged on the outer wall of the tank body 110；Cooling heating dress
Put and be arranged in temperature control chuck 111, cooling/heating apparatus include individually controllable heating coil 11 and cooling coil 12；Heating
Coil pipe 11 has heating medium inlet 11-1 and Crude product input 11-2, and heating coil 11 has the first valve control device
11-3 and the first temperature controller 11-4；Cooling coil 12 has cooling medium entrance 12-1 and cooling medium outlet 12-2,
The cooling coil 12 has the second valve control device 12-3 and second temperature controller 12-4；Heater 11-5 is arranged on
Crystallization apparatus are outer and are connected with heating coil 11；Cooler 12-5 is arranged on outside crystallization apparatus and is connected with cooling coil 12.
Thus, it is possible to the dissolving of sample and the demand of cooling crystallization in meeting crystallization process.By the first temperature controller 11-4 and
Second temperature controller 12-4, it is possible to achieve the regulation to temperature parameter in crystallization.
Some embodiments of the invention, the tank deck 120 of crystallization apparatus 100 further offers crystal seed and adds mouth 124.By
This, is easy to difficult crystalline product quickly to obtain target crystal formation.
Some embodiments of the invention, crystallization apparatus tank deck 120 is provided with visual windows 125.Thus, it is easy to observation
Product Status in crystal system.When excessive crystal block is found, motor 500, regulation faciola shape propeller blade 510 can be opened
Position, and it is smashed excessive crystal block.
Some embodiments of the invention, crystallization apparatus tank body 110 is provided with temperature indicating device 13.Thus, it is easy to prison
The temperature surveyed in different conditions lower tank 110, to accumulate the temperature parameter in crystallization processes.
Some embodiments of the invention, as shown in figure 3, two-layer filter 131 is removably provided with large and small two kinds
Particle diameter the selecting module 131-1 and 131-2 of different meshes.The selection of mesh number can be adjusted according to the actual requirements.By two-layer
Filter 131, makes the crystal for meeting Particle size requirements be present in the middle of particle diameter selecting module 131-1 and 131-2.And particle diameter mistake
Big remains in tank body, is processed by faciola shape propeller blade 510；The too small crystal of particle diameter, can unify to take out,
Tank body 110 is returned to recrystallize.Thus the yield of target crystal can be improved.
Some embodiments of the invention, the specification of tank body 110 of crystallization apparatus is 1L, 2L, 5L, 10L, 20L, 50L,
One of 100L, 200L and 500L.Thus crystal system of the invention goes for the medicine synthesising process of different scales.
According to a particular embodiment of the invention, heating coil 11 and cooling coil 12 are coiled in temperature control chuck in the shape of a spiral side by side
In 111.
Some embodiments of the invention, heating coil 11 and cooling coil 12 are separately Stainless Steel Coil or glass
Glass coil pipe.When the specification of crystallization apparatus 100 is smaller, glass material can be selected, with reduces cost.When crystallization apparatus 100
When specification is larger, stainless steel can be selected, to extend life of product, and can be with pressure-resistant.
In the second aspect of the present invention, the present invention proposes a kind of method using the above-mentioned crystallized sample of crystal system 1000.Root
According to embodiments of the invention, the method is comprised the following steps：
(1) in sample to be crystallized being deposited in into the sample storage device 200, knot is made it into by first charging aperture 121
In brilliant device tank body 110；
(2) the first solvent in the first solvent storage device is added in tank body by second charging aperture, opens temperature control component
In heater, tank body is heated so that the sample to be crystallized in tank body is completely dissolved；
(3) the second solvent in the second solvent storage device is added in tank body by the 3rd charging aperture, opens temperature control component
In cooler, tank body is cooled down so that the sample solution cooling crystallization to be crystallized in tank body；
(4) after the completion of crystallization, by the two-layer filter 131 of tank bottom, the crystal of appropriate particle size is obtained.
According to a particular embodiment of the invention, the first solvent is added to enter via the first solvent storage device 300 in step (2)
While in tank body 110, the first valve control device 11-3 is opened, heating medium is entered heating coil 11, so that
Sample to be crystallized is obtained to be completely dissolved.
According to a particular embodiment of the invention, heating medium is released after step (2) terminates, and closes the first valve control device
11-3。
According to a particular embodiment of the invention, step (3) is via the second solvent storage device 400, and quantitative, constant speed adds the
Two solvents are entered into tank body 110, while opening the second valve control device 12-3, cooling medium is entered cooling coil.
According to a particular embodiment of the invention, by second temperature controller 12-4, constant speed regulation cooldown rate makes to be crystallized
Sample solution cooling crystallization.
The method of the present invention is suitable to screening and obtains specific products crystal formation, thus, using the method for crystallising, can be to sample
Product carry out quantitative, constant speed, efficient crystallization and screen, easy to operate, and can guarantee that crystalline quality, on the other hand,
Also allow for determining crystallization processes parameter.
It should be noted that the above-mentioned feature and advantage for described by crystal system 1000 are equally applicable to crystallization of the invention
Method, here is omitted.
In the description of this specification, reference term " one embodiment ", " some embodiments ", " example ", " specific example ",
Or the description of " some examples " etc. means to combine specific features, structure, material or feature bag that the embodiment or example are described
It is contained at least one embodiment of the invention or example.In this manual, to the schematic representation of above-mentioned term necessarily
It is directed to identical embodiment or example.And, the specific features of description, structure, material or feature can be any
Combined in an appropriate manner in individual or multiple embodiments or example.Additionally, in the case of not conflicting, the skill of this area
Can be combined for the feature of the different embodiments or example described in this specification and different embodiments or example by art personnel
And combination.
Although embodiments of the invention have been shown and described above, it is to be understood that above-described embodiment be it is exemplary,
It is not considered as limiting the invention, one of ordinary skill in the art within the scope of the invention can be to above-described embodiment
It is changed, changes, replacing and modification.
Claims (10)
1. a kind of crystal system, it is characterised in that including：
Crystallization apparatus, the crystallization apparatus are made up of tank body, tank deck and tank bottom, and the tank wall has temperature control component,
The tank deck is offered at least one charging aperture, the tank body and is provided with two-layer filter, the tank at tank bottom
Bottom offers at least one discharging opening；
Sample storage device, the sample storage device is connected by the first charging aperture of the tank deck with the crystallization apparatus；
First solvent storage device, first solvent storage device is filled by the second charging aperture of the tank deck and the crystallization
Put connected, the first solvent storage device has first flow control device；
Second solvent storage device, the 3rd charging aperture and the crystallization apparatus phase that second solvent storage device passes through tank deck
Even, the second solvent storage device has second flow control device；And
Motor, the motor connection has faciola shape propeller blade, and the faciola shape propeller blade is arranged at the crystallization apparatus
In tank body, and can be moved up and down along tank body.
2. crystal system according to claim 1, it is characterised in that the temperature control component includes：
Temperature control chuck, the temperature control chuck is arranged on the outer wall of the tank body；
Cooling/heating apparatus, the cooling/heating apparatus are arranged in the temperature control chuck, and the cooling/heating apparatus include single
Only controllable heating coil and cooling coil, the heating coil have heating medium inlet and Crude product input, described to add
Hot coil has the first valve control device and the first temperature controller；The cooling coil has cooling medium entrance and cooling
Media outlet, the cooling coil has the second valve control device and second temperature controller；
Heater, the heater is arranged on outside the crystallization apparatus and is connected with the heating coil；
Cooler, the cooler is arranged on outside the crystallization apparatus and is connected with the cooling coil.
3. crystal system according to claim 1, it is characterised in that the crystallization apparatus tank deck further offers crystalline substance
Plant and add mouth.
4. crystal system according to claim 1, it is characterised in that the crystallization apparatus tank deck is provided with visual windows.
5. crystal system according to claim 1, it is characterised in that the crystallization apparatus tank body is provided with temperature and shows
Device.
6. crystal system according to claim 1, it is characterised in that the two-layer filter be removably provided with it is big,
The particle diameter selecting module of small two kinds of different meshes.
7. crystal system according to claim 2, it is characterised in that the tank body specification of the crystallization apparatus be 1L,
One of 2L, 5L, 10L, 20L, 50L, 100L, 200L and 500L.
8. crystal system according to claim 2, it is characterised in that the heating coil and the cooling coil are side by side
It is coiled in the shape of a spiral in the temperature control chuck.
9. crystal system according to claim 8, it is characterised in that the heating coil and the cooling coil are distinguished
It independently is Stainless Steel Coil or glass coil pipe.
10. a kind of method of the crystal system crystallized sample described in utilization claim any one of 1-9, it is characterised in that bag
Include following steps：
(1) in sample to be crystallized being deposited in into the sample storage device, crystallization apparatus tank is made it into by first charging aperture
In body；
(2) the first solvent in the first solvent storage device is added in tank body by second charging aperture, opens temperature control component
In heater, tank body is heated so that the sample to be crystallized in tank body is completely dissolved；
(3) the second solvent in the second solvent storage device is added in tank body by the 3rd charging aperture, opens temperature control component
In cooler, tank body is cooled down so that the sample solution cooling crystallization to be crystallized in tank body；
(4) after the completion of crystallization, by the two-layer filter of tank bottom, the crystal of appropriate particle size is obtained.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510855068.2A CN106807106A (en) | 2015-11-30 | 2015-11-30 | Crystal system and method for crystallising |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510855068.2A CN106807106A (en) | 2015-11-30 | 2015-11-30 | Crystal system and method for crystallising |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106807106A true CN106807106A (en) | 2017-06-09 |
Family
ID=59155576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510855068.2A Pending CN106807106A (en) | 2015-11-30 | 2015-11-30 | Crystal system and method for crystallising |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106807106A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005087087A (en) * | 2003-09-17 | 2005-04-07 | Tsukishima Kikai Co Ltd | Method and system for cooling crystallization of sugar |
| CN102423543A (en) * | 2011-09-02 | 2012-04-25 | 江苏斯威森生物医药工程研究中心有限公司 | Vinpocetine special-purpose crystallization pot |
| CN204352951U (en) * | 2014-12-19 | 2015-05-27 | 青岛科技大学 | A kind of miniature high-speed pulverizer that can make the direct classification of material |
| CN205182237U (en) * | 2015-11-30 | 2016-04-27 | 中美华世通生物医药科技（武汉）有限公司 | Crystal system |
-
2015
- 2015-11-30 CN CN201510855068.2A patent/CN106807106A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005087087A (en) * | 2003-09-17 | 2005-04-07 | Tsukishima Kikai Co Ltd | Method and system for cooling crystallization of sugar |
| CN102423543A (en) * | 2011-09-02 | 2012-04-25 | 江苏斯威森生物医药工程研究中心有限公司 | Vinpocetine special-purpose crystallization pot |
| CN204352951U (en) * | 2014-12-19 | 2015-05-27 | 青岛科技大学 | A kind of miniature high-speed pulverizer that can make the direct classification of material |
| CN205182237U (en) * | 2015-11-30 | 2016-04-27 | 中美华世通生物医药科技（武汉）有限公司 | Crystal system |
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