CN206666421U - A kind of refined device for refining - Google Patents
A kind of refined device for refining Download PDFInfo
- Publication number
- CN206666421U CN206666421U CN201720271719.8U CN201720271719U CN206666421U CN 206666421 U CN206666421 U CN 206666421U CN 201720271719 U CN201720271719 U CN 201720271719U CN 206666421 U CN206666421 U CN 206666421U
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- CN
- China
- Prior art keywords
- bleacher
- dissolving
- crystallizing tank
- temperature
- drain hole
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
Abstract
The utility model is a kind of refined device for refining.Including dissolving bleacher, reflux condenser, distiller condenser, filter, crystallizing tank, pans, temperature controlling instruments, dissolve and charge door is provided with the top of bleacher and provided with the port that can insert the first temperature detector and the first agitator, and provided with dissolving bleacher set by the reflux condenser that communicates of cavity, the bottom of dissolving bleacher is provided with the first drain hole, first drain hole communicates with the entrance of filter, filtrate inlet connection set by the outlet of filter and crystallizing tank, the second temperature detector and the second agitator are equiped with crystallizing tank cavity, set outlet is connected with distiller condenser at the top of crystallizing tank, the set outlet in distiller condenser bottom is connected with pans, temperature controlling instruments is connected with dissolving bleacher and crystallizing tank respectively.The utility model can accurately control dissolving, bleaching temperature and the time of refined material, efficiently the quality of production can stablize and meet the pranoprofen bulk drug of medicinal requirements.
Description
Technical field
A kind of refined device for refining is the utility model is related to, it is particularly a kind of to be refined for medical material pranoprofen is refined
Device.
Background technology
Pranoprofen is a kind of NSAIDs of synthesis, and its refined refining technique directly affects drug quality.The product
Pharmacological activity is stronger, and clinical dosage is relatively low, therefore smaller, the generally only several hectograms of the general production of pranoprofen bulk drug batch
, should not be with other kind shared devices of industrialization production to several kilograms.Because product quality requires higher, it refines and refined
Journey need to strictly control charge ratio, solvent distillation amount, crystallization temperature, crystallization time etc..For the uniform continuous production pledge of energy
Amount is stable simultaneously to meet the pranoprofen bulk drug of medicinal requirements, objectively needs to develop and a kind of is applied to that pranoprofen is refined to be carried
The device of refining.
The content of the invention
Technical problem to be solved in the utility model is to provide a kind of refined device for refining.Suitable for medical material pula
Ibuprofen bulk drug refines the device of refinement.The utility model can control exactly the dissolving of refined material, bleaching temperature and when
Between；Distillation amount, crystallization temperature and the time of accurate control solvent, produce steady quality beneficial to high-efficiency and continuous and meet medicinal want
The pranoprofen bulk drug asked.
To solve the above problems, refined device for refining of the present utility model, include dissolving bleacher, the first temperature detector,
Second temperature detector, charge door, the first agitator, the second agitator, reflux condenser, distiller condenser, filter, the first blowing
Mouth, filtrate inlet, crystallizing tank, pans, temperature controlling instruments, wherein the top of dissolving bleacher is provided with charge door, and it is respectively equipped with
The first temperature detector can be inserted and insert the port of the first agitator, and provided with dissolving bleacher set by the returned cold that communicates of cavity
Condenser, the bottom for dissolving bleacher are provided with the first drain hole, and the first drain hole communicates with the entrance of filter, the outlet of filter
It is connected with the filtrate inlet set by crystallizing tank, the second temperature detector and the second agitator is equiped with crystallizing tank cavity, crystallizes tank deck
The set outlet in portion be connected with distiller condenser, is exported set by distiller condenser bottom and is connected with pans, temperature controlling instruments respectively with
Dissolve bleacher and crystallizing tank connection.
Refined device for refining of the present utility model can control dissolving, bleaching temperature and the time of refined material exactly；It is accurate
Really distillation amount, crystallization temperature and the time of control solvent, produce steady quality beneficial to high-efficiency and continuous and meet medicinal requirements
Pranoprofen bulk drug.In addition, the utility model dissolving bleacher, crystallizing tank are transparent glass reaction kettle, production process
It is convenient that material in kettle is observed at any time.The utility model is a kind of heating, refrigeration community installations, and equipment, pipeline take up an area empty
Between small, the refined device for refining of convenient layout.
Brief description of the drawings
Fig. 1 is schematic diagram of the present utility model.
Embodiment
Embodiment：
Schematic diagram of the present utility model includes dissolving bleacher as shown in figure 1, refined device for refining of the present utility model
1st, the first temperature detector 2, the second temperature detector 3, charge door 4, the first agitator 5, the second agitator 6, reflux condenser 7, distillation are cold
Condenser 8, filter 9, the first drain hole 10, filtrate inlet 12, crystallizing tank 13, pans 14, temperature controlling instruments 15, wherein dissolving is de-
The top of color tank 1 is provided with charge door 4, and is respectively equipped with the port that can be inserted the first temperature detector 2 and insert the first agitator 5, the
One temperature detector 2 and the first agitator 5 of insertion are inserted by port in the cavity of dissolving bleacher 1, and provided with dissolving bleacher 1
The reflux condenser 7 that set cavity communicates, the bottom of dissolving bleacher 1 are provided with the first drain hole 10, the first drain hole 10 and mistake
The entrance of filter 9 is communicated, and the outlet of filter 9 is connected with the filtrate inlet 12 set by crystallizing tank 13, and the cavity of crystallizing tank 13 is built-in
Provided with the second temperature detector 3 and the second agitator 6, the set outlet in the top of crystallizing tank 13 is connected with distiller condenser 8, distiller condenser
The set outlet in 8 bottoms is connected with pans 14, and temperature controlling instruments 15 is connected with dissolving bleacher 1 and crystallizing tank 13 respectively.Crystallizing tank
13 major function is heating solvent distillation and stirring crystallisation by cooling.
In the present embodiment, pans 14 are pans with a scale.Convenient accurate read of pans 14 with a scale is distilled
Quantity of solvent.
In the present embodiment, the pipeline that the set outlet in the above-mentioned bottom of distiller condenser 8 is connected with pans 14 is provided with distillation
Valve 16.Distillation valve 16 can close distillation procedure in time after conveniently distilling out ormal weight solvent.
In the present embodiment, the bottom of above-mentioned crystallizing tank 13 is provided with the second drain hole 11.
In the present embodiment, above-mentioned second drain hole 11 is connected with centrifuge.
In the present embodiment, above-mentioned temperature controlling instruments 15 is the device with two kinds of functions of heating and refrigeration, and temperature control scope is -40
DEG C~100 DEG C.When dissolving bleacher 1, the heating of the needs of crystallizing tank 13 or freezing, temperature controlling instruments 15 is conveyed medium by pipeline
In to the interlayer of dissolving bleacher 1 or crystallizing tank 13.When the function switch that need to be heated and cooled down, bleacher will be first dissolved
1 or crystallizing tank 13 set by mediator depletion in interlayer, then lead to another medium, to save time and the energy.
In the present embodiment, above-mentioned dissolving bleacher 1, crystallizing tank 13 are transparent glass reaction kettle.Production process is convenient
Material in kettle is observed at any time.
Operation principle of the present utility model is as follows：Refined solvent for use, pranoprofen crude product, activated carbon are passed through into charge door
4 are placed in dissolving bleacher 1, open the first agitator 5 and stir, and being heated in dissolving bleacher 1 dissolves pranoprofen, opens simultaneously
Cooling water in reflux condenser 7 is opened, bleaching temperature is monitored by the first temperature detector 2.It is incubated back under the conditions of technological temperature is provided
The stipulated time is flow to, through the first drain hole 10, the pranoprofen decoction after decolouring is filtered by filter 9, filtrate is through filter
Liquid entrance 12, which is delivered in crystallizing tank 13, carries out distillation and concentration, is accurately distilled through distiller condenser 8 and pans 14 with a scale
After going out ormal weight solvent, distillation valve 16 to be closed, opens temperature controlling instruments 15, remaining decoction is cooled to set point of temperature by coolant,
And crystallization temperature is monitored by the second temperature detector 3, periodically turn on the second agitator 6 and stir, placing to setting time makes crystallization complete
Entirely, discharged through the second drain hole 11, leaching crystallization, dry, produce medicinal pranoprofen.
Claims (7)
1. a kind of refined device for refining, it is characterised in that include dissolving bleacher, the first temperature detector, the second temperature detector, charging
Mouth, the first agitator, the second agitator, reflux condenser, distiller condenser, filter, the first drain hole, filtrate inlet, knot
Brilliant tank, pans, temperature controlling instruments, wherein the top of dissolving bleacher is provided with charge door, and it is respectively equipped with and can inserts the first temperature detection
Device and the port for inserting the first agitator, and provided with dissolving bleacher set by the reflux condenser that communicates of cavity, dissolving decolourizes
The bottom of tank is provided with the first drain hole, and the first drain hole communicates with the entrance of filter, set by the outlet of filter and crystallizing tank
Filtrate inlet connection, be equiped with the second temperature detector and the second agitator in crystallizing tank cavity, at the top of crystallizing tank set outlet with
Distiller condenser is connected, and the set outlet in distiller condenser bottom is connected with pans, temperature controlling instruments respectively with dissolve bleacher and
Crystallizing tank connects.
2. refined device for refining according to claim 1, it is characterised in that above-mentioned pans are pans with a scale.
3. refined device for refining according to claim 1, it is characterised in that the set outlet in above-mentioned distiller condenser bottom with
Receive tank connected pipeline and be provided with distillation valve.
4. the refined device for refining according to any one of claims 1 to 3, it is characterised in that the bottom of above-mentioned crystallizing tank is provided with
Second drain hole.
5. refined device for refining according to claim 4, it is characterised in that above-mentioned second drain hole is connected with centrifuge.
6. refined device for refining according to claim 5, it is characterised in that the temperature control scope of above-mentioned temperature controlling instruments is -40 DEG C
~100 DEG C.
7. refined device for refining according to claim 6, it is characterised in that above-mentioned dissolving bleacher, crystallizing tank are transparent
Glass reaction kettle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720271719.8U CN206666421U (en) | 2017-03-20 | 2017-03-20 | A kind of refined device for refining |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720271719.8U CN206666421U (en) | 2017-03-20 | 2017-03-20 | A kind of refined device for refining |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206666421U true CN206666421U (en) | 2017-11-24 |
Family
ID=60377806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720271719.8U Expired - Fee Related CN206666421U (en) | 2017-03-20 | 2017-03-20 | A kind of refined device for refining |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206666421U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110372713A (en) * | 2019-08-15 | 2019-10-25 | 广州市汉普医药有限公司 | A kind of polishing purification method of pranoprofen |
| CN114053978A (en) * | 2021-11-25 | 2022-02-18 | 上海师范大学 | Metal-containing waste purification device |
-
2017
- 2017-03-20 CN CN201720271719.8U patent/CN206666421U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110372713A (en) * | 2019-08-15 | 2019-10-25 | 广州市汉普医药有限公司 | A kind of polishing purification method of pranoprofen |
| CN110372713B (en) * | 2019-08-15 | 2022-05-17 | 广州市汉普医药有限公司 | Refining and purifying method of pranoprofen |
| CN114053978A (en) * | 2021-11-25 | 2022-02-18 | 上海师范大学 | Metal-containing waste purification device |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20171124 Termination date: 20190320 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |