CN207412792U - A kind of valaciclovir hydrochlordide production crystallizing tank - Google Patents
A kind of valaciclovir hydrochlordide production crystallizing tank Download PDFInfo
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- CN207412792U CN207412792U CN201721487991.6U CN201721487991U CN207412792U CN 207412792 U CN207412792 U CN 207412792U CN 201721487991 U CN201721487991 U CN 201721487991U CN 207412792 U CN207412792 U CN 207412792U
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- rotation axis
- vane
- tank body
- cooling coil
- valaciclovir hydrochlordide
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Abstract
The utility model provides a kind of valaciclovir hydrochlordide production crystallizing tank, including tank body, tank body upper end is equipped with feed inlet, lower end is equipped with conical discharge port, cooling coil is equipped with outside tank body, the lower part of cooling coil is equipped with refrigerant inlet, the top of cooling coil is equipped with refrigerant exit, motor is equipped with above tank body, the shaft of motor and the first rotation axis connection, first rotation axis is arranged on tank interior, in first rotation axis at least three layers of agitating vane are equipped with along vertical axis direction, each layer of agitating vane quantity is multiple, agitating vane includes the vertical vane of the bottom and the dihedral vane of other layers, the vertical vane and horizontal plane, dihedral vane favours horizontal plane setting.Temperature reaches unanimity in the crystallizing tank, and Flow of Goods and Materials is uniform, and crystal grain, which suspends, to be uniformly mixed, and the crystal size of crystallization is uniform, and quality is preferable.Scraper plate is set to be rotated simultaneously with rotation axis, ensures that material and Binding in inner tank wall, prevent fouling, beneficial to heat transfer.
Description
Technical field
The utility model belongs to a kind of crystallization apparatus, more particularly to a kind of valaciclovir hydrochlordide production crystallizing tank.
Background technology
In chemical industry, crystallization is an important operating procedure, and the technique and equipment of crystallization directly affect crystal
Purity and particle size distribution, in drug production process, have an effect on solubility, fusing point, the validity of biology of drug
Deng.
Solution crystallization process is the process that substance is changed into crystalline state from liquid, to undergo two steps：Crystallization nucleation and
Crystal growth.Crystallization nucleation is that a certain number of nucleus are generated in supersaturated solution；And crystalline substance is grown on the basis of nucleus
Body is then crystal growth.In valaciclovir hydrochlordide production, because valaciclovir hydrochlordide molecular weight is larger, crystallization has certain difficulty,
Crystallization time up to 12 it is small when more than.Method for crystallising of the prior art is mainly by introducing valaciclovir hydrochlordide crystal seed and raising
Valaciclovir hydrochlordide solution concentration improves the production capacity of equipment, so allows for part valaciclovir hydrochlordide in crystallizing tank
It is precipitated and fouling on wall, it is therefore desirable to which stirring makes the temperature spread of each point in container narrow down to certain value, and stirring makes
Grain suspends, and the particle otherwise accumulated makes internal solute concentration different, causes oversaturated difference, poor crystal quality.But it stirs
When shearing force it is excessively high, can cause crystallization when secondary nucleation.Existing crystallizing tank is since the shearing force of agitating device is stronger, easily
Make crystal fracture, be unfavorable for the generation of a large amount of nucleus.
The content of the invention
The technical problem to be solved by the utility model is to provide a kind of valaciclovir hydrochlordide production crystallizing tanks, make material
Flowing is uniform, and temperature reaches unanimity in crystallizing tank, and crystal grain, which suspends, to be uniformly mixed, and the crystal size of crystallization is uniform, quality compared with
It is good.
In order to solve the above technical problems, technical solution is used by this：A kind of valaciclovir hydrochlordide production crystallizing tank,
Including tank body, the tank body upper end is equipped with feed inlet, and lower end is equipped with conical discharge port, and cooling coil is equipped with outside tank body, described
The lower part of cooling coil is equipped with refrigerant inlet, and the top of cooling coil is equipped with refrigerant exit, motor, the electricity are equipped with above tank body
The shaft of machine and the first rotation axis connection, first rotation axis is arranged on tank interior, along vertical in first rotation axis
Axis direction is equipped at least three layers of agitating vane, and each layer of agitating vane quantity is multiple, and the agitating vane includes most bottom
The vertical vane of layer and the dihedral vane of other layers, the vertical vane and horizontal plane, dihedral vane favour horizontal plane
It sets.
In preferred scheme, the angle of the dihedral vane and horizontal plane is 45 ~ 60 °.
In preferred scheme, scraper plate is connected by connecting rod in first rotation axis, scraper plate is close to inner tank wall.
In preferred scheme, the lower end of first rotation axis connects the second rotation axis, and the second rotation axis is equipped with spiral
Blade.
In preferred scheme, the tank base is equipped with ultrasonic probe, the ultrasonic probe and supersonic generator
Connection.
In preferred scheme, cladding insulating layer outside the cooling coil.
In preferred scheme, the dihedral vane is equipped with anti-turbulent flow hole.
A kind of valaciclovir hydrochlordide production crystallizing tank provided by the utility model, has the advantages that：
1st, axially distributed multiple layers of stirring blades piece, dihedral vane make dihedral vane due to having certain angle with horizontal plane
There is axis stream, be used cooperatively with vertical vane, material is made to circulate up and down, is conducive to the suspension of crystal, makes on material
Lower flowing is uniform, and temperature and concentration reach unanimity, and is conducive to control crystal quality.
2nd, the scraper plate set rotates simultaneously with rotation axis, ensures that material and Binding in inner tank wall, prevent fouling, profit
In heat transfer.
3rd, the helical blade set, makes material easily be delivered to conical discharge port downwards, prevents conical discharge port from blocking.
4th, the supersonic generator set, the saturated concentration required by making crystallization reduces, the crystal form of crystallization is good.
5th, cladding insulating layer outside cooling coil prevents the heat losses of cooling coil.
The 6th, anti-turbulent flow hole on dihedral vane is set, whole system during stirring is avoided to generate turbulent phenomenon and influence crystal quality
The problem of.
Description of the drawings
The utility model is described in further detail with reference to the accompanying drawings and examples：
Fig. 1 is the overall structure diagram of the utility model.
Fig. 2 is the distribution map of the agitating vane of the utility model.
In figure：Tank body 1, cooling coil 2, motor 3, the first rotation axis 4, the second rotation axis 5, agitating vane 6, connecting rod 7,
Scraper plate 8, helical blade 9, ultrasonic probe 10, supersonic generator 11, insulating layer 12, feed inlet 101, conical discharge port 102,
Refrigerant inlet 201, refrigerant exit 202, vertical vane 601, dihedral vane 602, anti-turbulent flow hole 603.
Specific embodiment
In Fig. 1 ~ 2, a kind of valaciclovir hydrochlordide production crystallizing tank, including tank body 1,1 upper end of tank body be equipped with into
Material mouth 101, lower end are equipped with conical discharge port 102, and 1 outside of tank body is equipped with cooling coil 2, and the lower part of the cooling coil 2 is equipped with
Refrigerant inlet 201, the top of cooling coil 2 are equipped with refrigerant exit 202, and 1 top of tank body is equipped with motor 3, and the shaft of motor 3 passes through
Retarder is connected with the first rotation axis 4, and first rotation axis 4 is arranged on inside tank body 1, along perpendicular in first rotation axis 4
Straight axis direction is equipped with three layers of agitating vane 6, and each layer of 6 quantity of agitating vane is two, and agitating vane 6 is along the first rotation axis
4 is symmetrical, and agitating vane 6 between layers is interspersed, the vertical vane 601 of agitating vane 6 including the bottom and its
The dihedral vane 602 of his layer, the vertical vane 601 and horizontal plane, the angle of dihedral vane 602 and horizontal plane is 45 ° ~
Arbitrary value between 60 °.1 outer wall of tank body facilitates the temperature of monitoring 1 internal solution of tank body also in terms of set temperature.
Scraper plate 8 is connected by connecting rod 7 in first rotation axis 4, scraper plate 8 is close to 1 inner wall of tank body.
The lower end of first rotation axis 4 connects the second rotation axis 5, and the second rotation axis 5 is equipped with helical blade 9.
1 bottom of tank body is equipped with ultrasonic probe 10, and the ultrasonic probe 10 is connected with supersonic generator 11.
2 outside cladding insulating layer 12 of cooling coil.12 material of insulating layer for asbestic blanket or polystyrol plastic foam plate or
Phenol formaldehyde foam.
Dihedral vane 602 is equipped with anti-turbulent flow hole 603.
The device is in use, first put into valaciclovir hydrochlordide solution in tank body 1, in the refrigerant inlet 201 of cooling coil 2
Chilled brine cooling material is injected, with the temperature of 1 outer wall of thermometer measure tank body, after temperature is reduced to below 5 DEG C, is intermittently opened
It opens supersonic generator 11 and motor 3 is stirred, the crystallization that valaciclovir hydrochlordide solution can be completed when small by 4 ~ 8.
The above embodiments are only the optimal technical scheme of the utility model, and are not construed as the limit for the utility model
System, the technical solution that the scope of protection of the utility model should be recorded with claim, the technical solution recorded including claim
The equivalents of middle technical characteristic are protection domain.Equivalent substitution i.e. within this range is improved, also in the utility model
Protection domain within.
Claims (7)
1. a kind of valaciclovir hydrochlordide production crystallizing tank, including tank body（1）, the tank body（1）Upper end is equipped with feed inlet
（101）, lower end is equipped with conical discharge port（102）, tank body（1）Outside is equipped with cooling coil（2）, the cooling coil（2）Under
Portion is equipped with refrigerant inlet（201）, cooling coil（2）Top be equipped with refrigerant exit（202）, tank body（1）Top is equipped with motor
（3）, the motor（3）Shaft and the first rotation axis（4）Connection, first rotation axis（4）It is arranged on tank body（1）Inside,
It is characterized in that：First rotation axis（4）On along vertical axis direction be equipped at least three layers of agitating vane（6）, each layer
Agitating vane（6）Quantity is multiple, the agitating vane（6）Vertical vane including the bottom（601）With the inclination of other layers
Blade（602）, the vertical vane（601）With horizontal plane, dihedral vane（602）Favour horizontal plane setting.
2. a kind of valaciclovir hydrochlordide production crystallizing tank according to claim 1, it is characterised in that：The dihedral vane
（602）Angle with horizontal plane is 45 ~ 60 °.
3. a kind of valaciclovir hydrochlordide production crystallizing tank according to claim 1, it is characterised in that：First rotation
Axis（4）On pass through connecting rod（7）Connect scraper plate（8）, scraper plate（8）With tank body（1）Inner wall is close to.
4. a kind of valaciclovir hydrochlordide production crystallizing tank according to claim 1, it is characterised in that：First rotation
Axis（4）Lower end connect the second rotation axis（5）, the second rotation axis（5）It is equipped with helical blade（9）.
5. a kind of valaciclovir hydrochlordide production crystallizing tank according to claim 1, it is characterised in that：The tank body（1）
Bottom is equipped with ultrasonic probe（10）, the ultrasonic probe（10）With supersonic generator（11）Connection.
6. a kind of valaciclovir hydrochlordide production crystallizing tank according to claim 1, it is characterised in that：The cooling coil
（2）Outside cladding insulating layer（12）.
7. a kind of valaciclovir hydrochlordide production crystallizing tank according to claim 1, it is characterised in that：The dihedral vane
（602）It is equipped with anti-turbulent flow hole（603）.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721487991.6U CN207412792U (en) | 2017-11-09 | 2017-11-09 | A kind of valaciclovir hydrochlordide production crystallizing tank |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721487991.6U CN207412792U (en) | 2017-11-09 | 2017-11-09 | A kind of valaciclovir hydrochlordide production crystallizing tank |
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| Publication Number | Publication Date |
|---|---|
| CN207412792U true CN207412792U (en) | 2018-05-29 |
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ID=62308416
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201721487991.6U Active CN207412792U (en) | 2017-11-09 | 2017-11-09 | A kind of valaciclovir hydrochlordide production crystallizing tank |
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| CN (1) | CN207412792U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112454598A (en) * | 2020-11-14 | 2021-03-09 | 太湖县金伊都狐服饰有限公司 | Manufacturing process and device of environment-friendly board |
| CN112774244A (en) * | 2020-12-30 | 2021-05-11 | 江苏楷益智能科技有限公司 | Scraper type surface crystallizer |
-
2017
- 2017-11-09 CN CN201721487991.6U patent/CN207412792U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112454598A (en) * | 2020-11-14 | 2021-03-09 | 太湖县金伊都狐服饰有限公司 | Manufacturing process and device of environment-friendly board |
| CN112774244A (en) * | 2020-12-30 | 2021-05-11 | 江苏楷益智能科技有限公司 | Scraper type surface crystallizer |
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