CN202122849U - Stirring propeller for pravastatin sodium salt crystallization process - Google Patents
Stirring propeller for pravastatin sodium salt crystallization process Download PDFInfo
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- CN202122849U CN202122849U CN2011202092616U CN201120209261U CN202122849U CN 202122849 U CN202122849 U CN 202122849U CN 2011202092616 U CN2011202092616 U CN 2011202092616U CN 201120209261 U CN201120209261 U CN 201120209261U CN 202122849 U CN202122849 U CN 202122849U
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- blade
- paddle
- sodium salt
- pravastatin
- pravastatin sodium
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Abstract
The utility model belongs to field of bulk drug production equipment and relates to a stirring device of a crystallization tank for bulk drug production process, in particular to a stirring propeller for a pravastatin sodium salt crystallization process. Aiming at increasing crystallization success ratio of pravastatin sodium and reducing production cost of pravastatin sodium, the utility model provides the stirring propeller for the pravastatin sodium salt crystallization process and comprises an upper-grade stirring propeller and a lower-grade stirring propeller; compared with the prior art, the tail end of each stirring propeller main body is provided with a blade group. The stirring propeller can meet requirements of the pravastatin sodium salt crystallization process; the pravastatin sodium salt crystallization failure caused by fierce stirring can be effectively avoided when the purpose of heat and mass transfer is achieved, the success ratio of pravastatin sodium salt crystallization and the production quality of pravastatin sodium are increased, and the production cost is reduced.
Description
Technical field
The utility model belongs to the production of raw medicine apparatus field, is specifically related to the agitating device of the crystallizing tank that a kind of production of raw medicine technology uses, particularly a kind of paddle that is used for the sodium salt of pravastatin crystallization processes.
Background technology
Pravastatin sodium is a kind of HMG-CoA reductase inhibitor, has good lipidemia function, belongs to high fat of blood and regulates a line medication, and it suppresses the HMG-CoA reductase through invertibity ground, thereby suppresses the biosynthesis of cholesterol.Therefore, it is mainly used in the treatment of hyperlipidemia, familial hypercholesterolemia.
Pravastatin sodium is that the microorganism biological through Kang Baiting transforms and obtains; Its production technology is: the zymotic fluid that contains pravastatin sodium obtains containing the concentrate of high concentration pravastatin sodium after operations such as filtering fermentation liquor, extraction, charcoal take off, concentrate, concentrate obtains the pravastatin sodium finished product after low temperature crystallization, filtration and drying.
The pravastatin sodium crystallization process adopts the saturated solution of pravastatin sodium to carry out the mode of crystallisation by cooling; The required cold of crystallisation by cooling process is supplied with by chuck or external heat exchanger; Need improve through the mode that stirs and conduct heat and mass-transfer efficiency, spare with density unevenness to avoid in the crystallizing tank solution temperature.The pravastatin sodium crystallization need be experienced two stages, i.e. formation of pravastatin sodium nucleus and pravastatin sodium crystal growth stage.At first, in the formation stage of pravastatin sodium nucleus, need the control speed of agitator reach 100 rev/mins or more than, reaching the purpose of sufficient heat transfer and mass transfer, and make interior solution temperature of crystallizing tank and concentration reach uniform purpose.Secondly; In the stage of growth of Pravastatin sodium crystal; Then need under lower stir speed (S.S.) degree, accomplish, speed of agitator is generally 30 rev/mins or following, and too high mixing speed can make product separate out fast and form cotton-shaped product; Granular crystal can not be obtained, and follow-up isolated by filtration operation can't be carried out.Yet speed of agitator is crossed and low can be caused conducting heat not enough with mass transfer again, and solution temperature and CONCENTRATION DISTRIBUTION are inhomogeneous in the crystallizing tank, cause the crystal of having separated out at last under low temperature environment, sink at the bottom of the crystallizing tank, forms jelly gradually and causes crystallization to be failed.
The crystallizing tank agitating device that the production pravastatin sodium technology of using is at present used comprises motor, cycloidal planetary gear speed reducer, mechanical seal, shaft and two-stage paddle.Existing crystallizing tank paddle is the pusher stirring of the oblique sheet of double leaf, is divided into two-stage up and down, lays respectively at the middle part and the bottom of shaft; Every grade of paddle by about two paddle bodies and an axle sleeve form; Paddle body and axle sleeve are fixedly connected, and the paddle body becomes miter angle to tilt with shaft, and axle sleeve is fixed on the shaft through lock screw; About two paddle bodies be the left and right sides that symmetrical line is symmetrically distributed in shaft with the straight line at shaft place; The length of single paddle body is about 1/4 of retort diameter, and width is 5-15cm, and thickness is 2-8mm.This crystallizing tank paddle makes the low viscosity fluid of pravastatin sodium be in turbulence state easily; But because it when rotated; Main produce to the pravastatin sodium flow axis to thrust; The shearing force that the pravastatin sodium fluid is acted on is very little, is difficult to make high viscosity pravastatin sodium fluid to be in turbulence state, also is difficult to make high viscosity pravastatin sodium fluid to stir.Therefore, though this agitating device can satisfy the requirement that pravastatin sodium crystallization nucleus forms the stage, in crystal growth during the stage; Along with increasing of Pravastatin sodium crystal; The increase of fluid viscosity, this agitating device can not produce effectively the Pravastatin sodium crystal of having separated out and fully stir, cause these Pravastatin sodium crystals to sink to jar at the bottom of after form jelly gradually and the crystallization failure; Reduce the power that crystallizes into of pravastatin sodium, increased the production cost of pravastatin sodium.
The utility model content
The purpose of the utility model is, improves the power that crystallizes into of pravastatin sodium, reduces the production cost of pravastatin sodium.The utility model is set about from the crystallization processes of pravastatin sodium; The final discovery; Dynamics that stirs and uniformity coefficient have very significant effects for the crystallization processes of pravastatin sodium; Therefore, the utility model provides a kind of agitating device that is applicable to the whole crystallization processes of pravastatin sodium, and a kind of paddle that is used for the whole crystallization processes of pravastatin sodium especially is provided.
A kind of paddle that is used for the sodium salt of pravastatin crystallization processes that the utility model provides, it comprises higher level's paddle and subordinate's paddle composition, lays respectively at the middle part and the bottom of shaft; Higher level's paddle and subordinate's paddle respectively by about two paddle bodies and an axle sleeve form, paddle body and axle sleeve are fixedly connected, the paddle body becomes miter angle to tilt with shaft; Axle sleeve is fixed on the shaft through lock screw, and the length of single paddle body is about 1/4 of retort diameter, and width is 5-15cm; Thickness is 2-8mm; Different with prior art is, above-mentioned each paddle body tip is provided with vane group, and the vane group of the utility model can be made up of a blade, two blades, three blades or four blades; Preferably, the vane group of the utility model is made up of three blades.
Stirring efficiency for unit interval of improving the utility model agitating device; The inventor has carried out preferred from shape, size and the position relation of vane group respectively; Enable greatly to satisfy mass transfer and heat transfer requirement in the pravastatin sodium crystallization process, play stirring action more equably.
At first; This vane group is made up of first blade, second blade and the 3rd blade; First blade connects with second vanes fixed, and second blade connects with the 3rd vanes fixed, and first blade and the 3rd blade are parallel to each other; The paddle body connects with second vanes fixed, and the paddle body is perpendicular to the plane at second blade place.
Secondly, the inventor has carried out preferably the shape and size size of the vane group of the utility model.First blade 11, second blade 12 and the 3rd blade 13 thickness are the stainless steel substrates of 0.8cm, and wherein first blade 11 and the 3rd blade 13 shapes are cuboid, and the length of cuboid * wide * height is 15cm * 10cm * 0.8cm, highly is the thickness of blade; Second blade is that the bottom surface is the right pyramid of rhombus, and the rib of right prism is long to be 0.8cm, and rib length is the thickness of second blade, and the length of side of rhombus is 10cm, and an angle of rhombus is 45 degree.
Further preferably, first blade of above-mentioned a kind of paddle that is used for the sodium salt of pravastatin crystallization processes is vertical each other with second blade, and the 3rd blade is vertical each other with second blade, and first blade and the 3rd blade all are positioned at the same side of second blade.
At last; Consider that the paddle body of the utility model and the position of vane group concern the influence to the degree of stirring; The inventor has carried out preferably the paddle body of the utility model and the position relation of vane group, and preferably, described paddle body becomes miter angle with shaft; First blade and the 3rd blade are parallel to each other; And first blade is vertical each other with second blade, and the 3rd blade is vertical each other with second blade, and first blade and the 3rd blade all are positioned at the same side of second blade.
A kind of paddle that is used for the sodium salt of pravastatin crystallization processes that the utility model provides; It compared with prior art; Have following technical advantage: it can meet the requirement of sodium salt of pravastatin crystallization processes; In the purpose that reaches abundant heat transfer and mass transfer simultaneously, can effectively avoid causing sodium salt of pravastatin crystallization failure because of stirring fierceness.A kind of paddle that is used for the sodium salt of pravastatin crystallization processes that the utility model provides also is particularly useful for the product of those crystal growth stages need to carry out crystallization under the very low stirring (below 30 rev/mins).Can either improve the success rate of sodium salt of pravastatin crystallization, can improve the quality of production of pravastatin sodium again, reduce production costs.
Description of drawings
Fig. 1 is the structural representation of prior art pravastatin sodium crystallizing tank and agitating device thereof.In Fig. 1,1 is motor and cycloidal planetary gear speed reducer, and 2 is mechanical sealing linkage ring, and 3 is mechanical sealing static ring, and 4 is crystallizing tank tank deck flange, and 5 is shaft, and 6 is crystallizing tank, and 7 is higher level's paddle, and 8 is subordinate's paddle.
Fig. 2 is a kind of structural representation that is used for an embodiment of paddle of sodium salt of pravastatin crystallization processes in this prior art.81 for stirring axle sleeve in Fig. 2, and 82 is the paddle body.
Fig. 3 is a kind of structural representation that is used for an embodiment of paddle of sodium salt of pravastatin crystallization processes of the utility model.In Fig. 3,9 for stirring axle sleeve, and 10 is the paddle body, and 11 is first blade, and 12 is second blade, and 13 is the 3rd blade, and 14 is subordinate's paddle, and 15 is higher level's paddle.
The specific embodiment
Below in conjunction with accompanying drawing, further describe the utility model through specific embodiment, but the utility model is not limited only to following examples.In the scope of the utility model or in the content that does not break away from the utility model, spirit and scope; The described a kind of paddle that is used for the sodium salt of pravastatin crystallization processes of the utility model and building block thereof are carried out to reduced scale or expansion, a kind of material and/or building block that is used for the paddle of sodium salt of pravastatin crystallization processes of replacement; Will become apparent to those skilled in the art that they all are regarded as is included within the utility model scope.
Fig. 1 is the structural representation of prior art pravastatin sodium crystallizing tank and agitating device thereof.In Fig. 1,1 is motor and cycloidal planetary gear speed reducer, and 2 is mechanical sealing linkage ring, and 3 is mechanical sealing static ring, and 4 is crystallizing tank tank deck flange, and 5 is shaft, and 6 is crystallizing tank, and 7 is higher level's paddle, and 8 is subordinate's paddle.Fig. 2 is a kind of structural representation that is used for an embodiment of paddle of sodium salt of pravastatin crystallization processes in this prior art.81 for stirring axle sleeve in Fig. 2, and 82 is the paddle body.
Fig. 3 is a kind of structural representation that is used for an embodiment of paddle of sodium salt of pravastatin crystallization processes of the utility model.Can find out by Fig. 3; A kind of paddle that is used for the sodium salt of pravastatin crystallization processes is made up of higher level's paddle 15 and subordinate's paddle 14 in the present embodiment; Higher level's paddle 15 includes with subordinate's paddle 14 and stirs axle sleeve 9, paddle body 10 and vane group, and wherein vane group is made up of first blade 11, second blade 12 and the 3rd blade 13.
More specifically, a kind of paddle that is used for the sodium salt of pravastatin crystallization processes of the utility model, it comprises higher level's paddle 15 and subordinate's paddle 14; Be individually fixed in the middle part and the bottom of shaft 5; Two paddle bodies 10 and a stirring axle sleeve 9 were formed about higher level's paddle 15 comprised respectively with subordinate's paddle 14, and paddle body 10 is fixedly connected with stirring axle sleeve 9, and 5 one-tenth miter angles of paddle body 10 and shaft tilt; Stirring axle sleeve 9 is fixed on the shaft 5 through lock screw; The length of single paddle body 10 is 1/4 of crystallizing tank diameter, and width is 5～15cm, and thickness is 2～8mm; And paddle body 10 ends are provided with vane group; Described vane group is made up of first blade 11, second blade 12 and the 3rd blade 13, and first blade 11, second blade 12 and the 3rd blade 13 thickness are the stainless steel substrates of 0.8cm, and wherein first blade 11 and the 3rd blade 13 shapes are cuboid; The length of cuboid * wide * height is 15cm * 10cm * 0.8cm, highly is the thickness of blade; Second blade is that the bottom surface is the right pyramid of rhombus, and the rib of right prism is long to be 0.8cm, and rib length is the thickness of second blade, and the length of side of rhombus is 10cm, and an angle of rhombus is 45 degree.
In the present embodiment, first blade 11 is vertical each other with second blade 12, and the 3rd blade 13 is mutual vertical with second blade 12, and first blade 11 and the 3rd blade 13 all are positioned at the same side of second blade 12.
A kind of paddle that is used for the sodium salt of pravastatin crystallization processes that the utility model provides; Meet the requirement of sodium salt of pravastatin crystallization processes fully; The purpose of abundant heat transfer and mass transfer can be avoided causing sodium salt of pravastatin crystallization failure because of stirring fierceness simultaneously effectively in reaching crystallization process.A kind of paddle that is used for the sodium salt of pravastatin crystallization processes that the utility model provides also is particularly useful for the product of those crystal growth stages need to carry out crystallization under the very low stirring (below 30 rev/mins).Can either improve the success rate of sodium salt of pravastatin crystallization, can improve the quality of production of pravastatin sodium again, reduce production costs.
Claims (4)
1. paddle that is used for the sodium salt of pravastatin crystallization processes, it comprises higher level's paddle and subordinate's paddle, is individually fixed in the middle part and the bottom of shaft; Two paddle bodies and an axle sleeve were formed about higher level's paddle and subordinate's paddle comprised respectively; Paddle body and axle sleeve are fixedly connected, and the paddle body becomes miter angle to tilt with shaft, and axle sleeve is fixed on the shaft through lock screw; The length of single paddle body is 1/4 of crystallizing tank diameter; Width is 5～15cm, and thickness is 2～8mm, it is characterized in that; Described paddle body tip is provided with vane group, and described vane group is made up of 1 blade, 2 blades, 3 blades or 4 blades.
2. a kind of paddle that is used for the sodium salt of pravastatin crystallization processes as claimed in claim 1; It is characterized in that, described vane group by first blade, second blade and the 3rd blade totally 3 blades form, first blade connects with second vanes fixed; Second blade connects with the 3rd vanes fixed; First blade and the 3rd blade are parallel to each other, and the paddle body connects with second vanes fixed, and the paddle body is perpendicular to the plane at second blade place.
3. a kind of paddle that is used for the sodium salt of pravastatin crystallization processes as claimed in claim 2; It is characterized in that; Described first blade, second blade and the 3rd vane thickness are the stainless steel substrates of 0.8cm; Wherein first blade and the 3rd blade shape are cuboid, and the length of cuboid * wide * height is 15cm * 10cm * 0.8cm; Second blade is that the bottom surface is the right pyramid of rhombus, and the rib of right prism is long to be 0.8cm, and the length of side of rhombus is 10cm, and an angle of rhombus is 45 degree.
4. like claim 2 or 3 described a kind of paddles that are used for the sodium salt of pravastatin crystallization processes; It is characterized in that; Described first blade is vertical each other with second blade, and the 3rd blade is vertical each other with second blade, and first blade and the 3rd blade all are positioned at the same side of second blade.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011202092616U CN202122849U (en) | 2011-06-20 | 2011-06-20 | Stirring propeller for pravastatin sodium salt crystallization process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011202092616U CN202122849U (en) | 2011-06-20 | 2011-06-20 | Stirring propeller for pravastatin sodium salt crystallization process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202122849U true CN202122849U (en) | 2012-01-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011202092616U Expired - Fee Related CN202122849U (en) | 2011-06-20 | 2011-06-20 | Stirring propeller for pravastatin sodium salt crystallization process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202122849U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103239887A (en) * | 2013-05-20 | 2013-08-14 | 无锡市华立石化工程有限公司 | Mixing and stirring device of crystallization kettle |
| CN110723353A (en) * | 2019-10-23 | 2020-01-24 | 殷震花 | Dispersion filling integrated water-based paint process system, process method and paint formula |
-
2011
- 2011-06-20 CN CN2011202092616U patent/CN202122849U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103239887A (en) * | 2013-05-20 | 2013-08-14 | 无锡市华立石化工程有限公司 | Mixing and stirring device of crystallization kettle |
| CN110723353A (en) * | 2019-10-23 | 2020-01-24 | 殷震花 | Dispersion filling integrated water-based paint process system, process method and paint formula |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120125 Termination date: 20130620 |