CN106798815A - 一种降低复方氟米松软膏副作用的药剂 - Google Patents
一种降低复方氟米松软膏副作用的药剂 Download PDFInfo
- Publication number
- CN106798815A CN106798815A CN201710140492.8A CN201710140492A CN106798815A CN 106798815 A CN106798815 A CN 106798815A CN 201710140492 A CN201710140492 A CN 201710140492A CN 106798815 A CN106798815 A CN 106798815A
- Authority
- CN
- China
- Prior art keywords
- medicament
- component
- side effect
- parts
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/37—Celastraceae (Staff-tree or Bittersweet family), e.g. tripterygium or spindletree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
本发明公开了一种降低复方氟米松软膏副作用的药剂,属于药物技术领域,该药剂包括组份A和组份B,组份A为复方氟米松软膏,组份B为中草药提取物,组份A与组份B按照重量比1∶2的比例充分混合搅匀即得本发明所述的药剂。经临床试验证明,能显著的降低复方氟米松软膏在治疗银屑病时的副作用,而且无复发。
Description
技术领域
本发明涉及药物技术领域,尤其涉及一种降低复方氟米松软膏临床治疗银屑病复发副作用的药剂。
背景技术
牛皮癣又叫做寻常型银屑病,是一种临床上十分常见的炎症性皮肤病,多由人体内部因素及外界因素共同作用所致。此病患者的主要临床表现是存在特征性皮损,初起时可呈炎性红色丘疹,如绿豆般大小,而后可发展为棕红色的斑块,周围有红晕,边界清晰,表面覆盖有多层白色鳞屑,刮去鳞屑,下面是一层淡红色发亮的薄膜,再刮去薄膜,下面是许多细小的出血点。目前,复方氟米松软膏是临床上治疗牛皮癣的首选药物之一,但研究表明会使患者用药部位偶发皮肤发红,瘙痒感、接触性过敏、皮肤色素沉着、掩蔽感染、烧灼感、刺激感、干燥等不良反应,严重影响了患者的正常生活。为解决复方氟米松软膏在使用中存在的问题,发明人在多年的临床治疗实践中,对复方氟米松软膏进行改进,降低临床使用中的副作用,经临床验证,取得了较好的效果。
发明内容
本发明的目的是提供一种降低复方氟米松软膏副作用的药剂。
本发明的目的是通过以下技术方案实现的,该降低复方氟米松软膏副作用的药剂包括组份A和组份B,所述组份A为复方氟米松软膏,所述组份B为中草药提取物。
所述中草药提取物由以下中草药制成:吊干麻180-200份、竹节七160-180份、血满草120-140份、合子草80-90份、灯笼草90-100份、羊蹄草40-60份。
优选的:吊干麻190份、竹节七170份、血满草130份、合子草85份、灯笼草95份、羊蹄草50份。
制备方法:取各原料药粉碎混匀,加入8倍量(重量倍数)75%~95%(体积百分数)乙醇,回流提取1.5~2.5h滤过,药渣再加入4倍量(重量倍数)同等浓度的乙醇,回流提取1~3h滤过,合并两次醇提取液,减压回收乙醇,并浓缩至相对密度为1.20~1.30(50℃测)的稠膏,加入甘油(每1克稠膏加入0.4~0.6ml的甘油),制成膏剂即得。
使用时,将组份A与组份B按照重量比1∶2的比例充分混合搅匀即得本发明所述的药剂。
方中:吊干麻清热透疹、舒筋活络;竹节七清热解毒、活血止痛、利水消肿;血满草祛风利水、散瘀通络;合子草治水肿、蛇咬伤;灯笼草清热行气、止痛消肿;羊蹄草清热利水、凉血解毒。
临床资料
1、一般资料 选取我院自2010年1月至2013年3月收治的银屑病患者150例,男80例,年龄为22-50岁,平均年龄为32岁,病程为4个月-10年,平均病程为5年;女70例,年龄为22-48岁,平均年龄为33岁,病程为3个月-10年,平均病程为5年;随机将其分为对照组、治疗组、中药组,每组50例;各组患者的临床表现及各项检查结果均符合银屑病的临床诊断标准。只使用组份A治疗的为对照组,使用本发明药剂治疗的为治疗组,单独使用本发明所述的组份B治疗的为中药组。各组在年龄、性别等一般资料比较无统计学意义,具有可比性。
2、纳入和排除标准 纳入:年龄在18岁以上的患者;无肝、肾或其他系统性疾病的患者;皮损面积占个体表面的30%以内;无实验药物过敏史的患者;能遵循医嘱用药,同意本实验的患者;排除:有肝、肾或其他系统性疾病的患者;在妊娠或哺乳期的妇女;对实验药物有过敏的患者。
3、治疗方法 用药前,先清洗患处;待皮肤干爽后,将药物均匀涂布于皮损上,形成一层薄膜;涂药后应轻轻揉擦,以促进药物吸收。各组每天搽涂1-3次,用药6周后观察疗效。
3、疗效评定标准 显效:用药4-5周后,患者皮肤瘙痒、斑块、鳞屑等症状基本消失,皮损恢复正常的面积达90%以上。有效:用药6-8周后,患者皮肤瘙痒、斑块、鳞屑等症状明显改善,皮损恢复正常的面积达80%-90%。无效:用药6周后,患者皮肤瘙痒斑块、鳞屑等症状无任何改善,甚至加重。治疗的总有效率=(显效+有效)/总例数×100%。
4、治疗结果 如下表所示。
组别 | 例数 | 日搽次数 | 显效 | 有效 | 无效 | 副作用 | 复发率 | 总有效率 |
治疗组 | 50 | 1 | 30 | 14 | 1 | 0 | 0 | 98% |
对照组 | 50 | 3 | 20 | 15 | 15 | 9 | 17 | 70% |
中药组 | 50 | 3 | 15 | 15 | 15 | 2 | 8 | 60% |
通过以上临床资料可知,治疗组虽然日搽次数较少,但是取得了理想的治疗效果,总有效率高于对照组和中药组,而且无副作用,无复发率。而对照组使用组份A治疗,有8例出现皮肤发红,4例出现瘙痒刺痛,2例出现皮肤干燥,3例有烧灼感;中药组有1例伴发痒痛症状,1例有干燥感。由此可知,治疗组中各成份配伍后发生了协同增效作用,值得临床推广应用。
在对以上治疗组患者进行随访时,其中有3例自述“使用本发明的膏剂后,不但银屑病得到了有效治疗,而且膝骨性关节炎也有所好转。得到这一消息后,我们随即对30例患有不同程度膝骨性关节炎患者,采用本发明膏剂进行搽涂治疗。
疗效评定标:痊愈:膝关节肿胀、疼痛完全消失,关节活动恢复正常;显效:关节疼痛明显减轻,肿胀基本消失,膝关节功能明显改善;有效:疼痛、肿胀有所减轻,膝关节功能有所改善;无效:疼痛、肿胀无减轻,膝关节功能无改变。
治疗结果 30例患者中,痊愈15例(50%),显效12例(40%),有效2例(6.67%),无效1例(3.33%)总有效率为96.67%。由此可知,使用本发明的膏剂,不但治疗银屑病疗效显著,而且对膝骨性关节炎患者具有很好的治疗效果,值得临床推广应用。
具体实施方式
实施方式一:该降低复方氟米松软膏副作用的药剂包括组份A和组份B,所述组份A为复方氟米松软膏,所述组份B为中草药提取物,所述中草药提取物由吊干麻180g、竹节七160g、血满草120g、合子草80g、灯笼草90g、羊蹄草40g粉碎混匀,加入8倍量(重量倍数)80%(体积百分数)乙醇,回流提取2h滤过,药渣再加入4倍量(重量倍数)同等浓度的乙醇,回流提取2h滤过,合并两次醇提取液,减压回收乙醇,并浓缩至相对密度为1.25(50℃测)的稠膏,加入甘油(每1克稠膏加入0.5ml的甘油),制成的膏剂;使用时,将组份A与组份B按照重量比1∶2的比例充分混合搅匀即得本发明所述的药剂。
实施方式二:该降低复方氟米松软膏副作用的药剂包括组份A和组份B,所述组份A为复方氟米松软膏,所述组份B为中草药提取物;所述中草药提取物由吊干麻190g、竹节七170g、血满草130g、合子草85g、灯笼草95g、羊蹄草50g粉碎制成,制备使用方法同实施方式一。
实施方式三:该降低复方氟米松软膏副作用的药剂包括组份A和组份B,所述组份A为复方氟米松软膏,所述组份B为中草药提取物;所述中草药提取物由吊干麻200g、竹节七180g、血满草140g、合子草90g、灯笼草100g、羊蹄草60g制成,制备使用方法同实施方式一。
Claims (4)
1.一种降低复方氟米松软膏副作用的药剂,其特征在于该药剂包括组份A和组份B,所述组份A为复方氟米松软膏,所述组份B为中草药提取物。
2.如权利要求1所述的一种降低复方氟米松软膏副作用的药剂,其特征在于所述中草药提取物由以下中草药制成:吊干麻180-200份、竹节七160-180份、血满草120-140份、合子草80-90份、灯笼草90-100份、羊蹄草40-60份。
3.如权利要求2所述的一种降低复方氟米松软膏副作用的药剂,其特征在于所述中草药提取物的制备方法:取各原料药粉碎混匀,加入8倍量(重量倍数)75%~95%(体积百分数)乙醇,回流提取1.5~2.5h滤过,药渣再加入4倍量(重量倍数)同等浓度的乙醇,回流提取1~3h滤过,合并两次醇提取液,减压回收乙醇,并浓缩至相对密度为1.20~1.30(50℃测)的稠膏,加入甘油(每1克稠膏加入0.4~0.6ml的甘油),制成膏剂即得。
4.如权利要求1所述的一种降低复方氟米松软膏副作用的药剂,其特征在于将组份A与组份B按照重量比1∶2的比例充分混合搅匀即得本发明所述的药剂。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710140492.8A CN106798815A (zh) | 2017-03-02 | 2017-03-02 | 一种降低复方氟米松软膏副作用的药剂 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710140492.8A CN106798815A (zh) | 2017-03-02 | 2017-03-02 | 一种降低复方氟米松软膏副作用的药剂 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN106798815A true CN106798815A (zh) | 2017-06-06 |
Family
ID=58988843
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201710140492.8A Pending CN106798815A (zh) | 2017-03-02 | 2017-03-02 | 一种降低复方氟米松软膏副作用的药剂 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN106798815A (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106728489A (zh) * | 2017-03-21 | 2017-05-31 | 宋祥义 | 一种在治疗骨折后肿胀中降低七叶皂苷钠搽剂副作用的药物 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104510911A (zh) * | 2014-12-25 | 2015-04-15 | 四川天联药业有限公司 | 治疗非感染性炎症性皮肤病的药物组合物及其制备方法 |
-
2017
- 2017-03-02 CN CN201710140492.8A patent/CN106798815A/zh active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104510911A (zh) * | 2014-12-25 | 2015-04-15 | 四川天联药业有限公司 | 治疗非感染性炎症性皮肤病的药物组合物及其制备方法 |
Non-Patent Citations (2)
Title |
---|
丰靓等: "普连膏联合复方氟米松软膏治疗寻常型银屑病疗效观察", 《医药前沿》 * |
杜品: "《青藏高原甘南藏药植物志》", 31 December 2006, 甘肃科学技术出版社 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106728489A (zh) * | 2017-03-21 | 2017-05-31 | 宋祥义 | 一种在治疗骨折后肿胀中降低七叶皂苷钠搽剂副作用的药物 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103463539B (zh) | 一种治疗湿疹的药物及其制备方法和用途 | |
CN102552809B (zh) | 用于通经活络的外用药酒 | |
CN101961449B (zh) | 一种治疗体癣病的中药 | |
CN102178817B (zh) | 一种治疗多发性脂肪瘤的中药组合物 | |
CN106798815A (zh) | 一种降低复方氟米松软膏副作用的药剂 | |
CN101120949B (zh) | 治疗痔疮的中药 | |
CN102755515B (zh) | 治疗乳腺增生的中药汤剂 | |
CN101983652A (zh) | 一种治疗肩周炎的中药 | |
CN101904998B (zh) | 一种治疗脚气的药物及其制备方法 | |
CN103393783B (zh) | 一种含有白藜芦醇的组合物及用途 | |
CN105148150A (zh) | 一种保健茶及其制备方法 | |
CN106581147A (zh) | 一种降低喷昔洛韦乳膏副作用的膏剂 | |
CN103536745A (zh) | 一种治疗乳腺增生的中药水丸 | |
CN105343423B (zh) | 一种治疗湿疹的药物及其制备方法 | |
CN106860454A (zh) | 一种降低他扎罗汀临床使用副作用的膏剂 | |
CN103933426B (zh) | 一种皮肤病治疗外用制剂、制备及应用 | |
CN115025187B (zh) | 一种治疗腰痛的中药组合物、穴位贴及其制备方法和应用 | |
CN106822271A (zh) | 一种治疗风湿痹症的药物组合物及其制备方法和用途 | |
CN102228538A (zh) | 一种治疗白癜风的中药制剂 | |
CN101979073A (zh) | 一种疏肝理气药剂 | |
CN106822390A (zh) | 一种降低联苯苄唑临床使用副作用的膏剂 | |
CN105343741A (zh) | 一种治疗甲状腺肿瘤的中药及其制备方法 | |
CN104740543A (zh) | 一种治疗扁平疣的药物及其制备方法 | |
CN104524133A (zh) | 一种补肾固胞养颜的中药组合物 | |
CN104096170A (zh) | 一种超微粉中药减肥的外用配方及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WD01 | Invention patent application deemed withdrawn after publication | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170606 |