CN106794229B - 工程化嵌合聚乙二醇化adi和使用方法 - Google Patents

工程化嵌合聚乙二醇化adi和使用方法 Download PDF

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CN106794229B
CN106794229B CN201580022377.XA CN201580022377A CN106794229B CN 106794229 B CN106794229 B CN 106794229B CN 201580022377 A CN201580022377 A CN 201580022377A CN 106794229 B CN106794229 B CN 106794229B
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CN106794229A (zh
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B-W·吴
R·阿尔玛西
何玮
R·E·肖沃尔特
何娇娟
郭云云
J·A·汤姆森
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Polaris Pharmaceutical Group Co ltd
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Tdw Group
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/03—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amidines (3.5.3)
    • C12Y305/03006—Arginine deiminase (3.5.3.6)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201580022377.XA 2014-03-18 2015-03-18 工程化嵌合聚乙二醇化adi和使用方法 Active CN106794229B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461954929P 2014-03-18 2014-03-18
US61/954,929 2014-03-18
PCT/US2015/021189 WO2015143006A1 (en) 2014-03-18 2015-03-18 Engineered chimeric pegylated adi and methods of use

Publications (2)

Publication Number Publication Date
CN106794229A CN106794229A (zh) 2017-05-31
CN106794229B true CN106794229B (zh) 2020-12-18

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US (1) US10463721B2 (enExample)
EP (1) EP3119421B1 (enExample)
JP (1) JP6612316B2 (enExample)
KR (2) KR102523031B1 (enExample)
CN (1) CN106794229B (enExample)
SG (1) SG11201607736UA (enExample)
WO (1) WO2015143006A1 (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2015141932A (ru) 2013-03-15 2017-04-26 Поларис Груп Аргининдеиминаза с пониженной перекрестной реактивностью к антителам adi-peg 20 для лечения рака
US10463721B2 (en) 2014-03-18 2019-11-05 Tdw Group Engineered chimeric pegylated ADI and methods of use
CA2961602A1 (en) * 2014-09-16 2016-03-24 Polaris Group Arginine deiminase with reduced cross-reactivity toward adi - peg 20 antibodies for cancer treatment
TW202440153A (zh) 2016-07-05 2024-10-16 開曼群島商北極星藥業集團股份有限公司 用精胺酸耗盡劑進行之組合癌症免疫療法
CN116407644A (zh) * 2016-11-02 2023-07-11 波拉里集团 聚乙二醇化精氨酸脱亚氨酶的调配物
CN106591270B (zh) * 2017-01-23 2018-09-21 江南大学 一株定点突变改造的基因工程精氨酸脱亚胺酶
CN110461354A (zh) 2017-03-29 2019-11-15 瑞华药业集团 蛋白质缀合物
WO2022063178A1 (en) * 2020-09-23 2022-03-31 The Hong Kong Polytechnic University Fluorescent biosensor for rapid determination of l-arginine
KR102640230B1 (ko) * 2021-09-24 2024-02-22 가천대학교 산학협력단 C-peptide를 처리한 자궁내막 기질세포의 이동성 변화 기작을 이용한 자궁내막 관련질환의 진단 방법 및 자궁내막 관련질환 치료제의 스크리닝 방법
US20240084282A1 (en) * 2022-09-02 2024-03-14 Polaris Group Modified arginine deiminases

Citations (4)

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US6132713A (en) * 1997-01-31 2000-10-17 Enzon, Inc. Arginine deiminase derived from mycoplasma arthritidis and polymer conjugates containing the same
CN1518595A (zh) * 2000-11-28 2004-08-04 凤凰药理学公司 修饰的精氨酸脱亚胺酶
WO2005052145A2 (en) * 2003-10-07 2005-06-09 University Of Florida Recombinant alkaliizing bacteria
US20140348814A1 (en) * 2013-03-15 2014-11-27 Polaris Group Arginne deiminase with reduced cross-reactivity toward adi - peg 20 antibodies for cancer treatment

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JP2900279B2 (ja) 1989-08-02 1999-06-02 株式会社ジャパンエナジー 新規なアルギニンデイミナーゼ、その製造法及び該酵素を有効成分とする制癌剤
US5372942A (en) 1992-02-10 1994-12-13 Coriell Institute For Medical Research Protease K resistant arginine deiminase, its method of preparation and its use as an anti-neoplastic agent
US6635462B1 (en) 1997-05-12 2003-10-21 Phoenix Pharmacologies, Inc. Mutated form of arginine deiminase
US6183738B1 (en) 1997-05-12 2001-02-06 Phoenix Pharamacologics, Inc. Modified arginine deiminase
US6180387B1 (en) * 1997-08-11 2001-01-30 Smithkline Beecham Corporation Arginine deiminase
IT1298918B1 (it) 1998-02-20 2000-02-07 Mendes Srl Uso di batteri dotati di arginina deiminasi per indurre apoptosi e/o ridurre una reazione infiammatoria e composizioni farmaceutiche
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Patent Citations (4)

* Cited by examiner, † Cited by third party
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US6132713A (en) * 1997-01-31 2000-10-17 Enzon, Inc. Arginine deiminase derived from mycoplasma arthritidis and polymer conjugates containing the same
CN1518595A (zh) * 2000-11-28 2004-08-04 凤凰药理学公司 修饰的精氨酸脱亚胺酶
WO2005052145A2 (en) * 2003-10-07 2005-06-09 University Of Florida Recombinant alkaliizing bacteria
US20140348814A1 (en) * 2013-03-15 2014-11-27 Polaris Group Arginne deiminase with reduced cross-reactivity toward adi - peg 20 antibodies for cancer treatment

Non-Patent Citations (2)

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Crystal Structures of Arginine Deiminase with Covalent Reaction Intermediates: Implications for Catalytic Mechanism;Kalyan Das,et al;《Structure》;20040430;第12卷;657-667页 *
Structure-Informed Design of an Enzymatically Inactive Vaccine Component for Group A Streptococcus;Anna Henningham,et al;《mBio》;20130806;第4卷(第4期);1-9页 *

Also Published As

Publication number Publication date
KR102353046B1 (ko) 2022-01-19
WO2015143006A1 (en) 2015-09-24
KR20220011806A (ko) 2022-01-28
US10463721B2 (en) 2019-11-05
KR20160134789A (ko) 2016-11-23
EP3119421A1 (en) 2017-01-25
JP6612316B2 (ja) 2019-11-27
JP2017513516A (ja) 2017-06-01
SG11201607736UA (en) 2016-10-28
US20170000862A1 (en) 2017-01-05
CN106794229A (zh) 2017-05-31
EP3119421A4 (en) 2017-11-29
EP3119421B1 (en) 2019-10-02
KR102523031B1 (ko) 2023-04-19

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