CN106729644A - A kind of gentle multiple-effect ectylotic and preparation method thereof - Google Patents

A kind of gentle multiple-effect ectylotic and preparation method thereof Download PDF

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Publication number
CN106729644A
CN106729644A CN201611023607.7A CN201611023607A CN106729644A CN 106729644 A CN106729644 A CN 106729644A CN 201611023607 A CN201611023607 A CN 201611023607A CN 106729644 A CN106729644 A CN 106729644A
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acid
ectylotic
wart
composition
solvent
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王卫国
赵永亮
王冠轶
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Zhengzhou Bio Engineering Co Ltd
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Zhengzhou Bio Engineering Co Ltd
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/723—Xanthans
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
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Abstract

The invention discloses one kind existing disappear wart effect, also ectylotic of skin makeup skin care effect and preparation method thereof.The ectylotic is by skin care composition, disappears wart composition and solvent is constituted, both containing various nutrients such as the collagen needed for normal skin nutrition, vitamins, and the health components such as the DPN needed for the Maintenance Of Skin Health, DPN I, niacinamide, Co-Q10 are contained；Existing sterilization anti-corrosive antibacterial antipathogenic composition, dispels aging cutin composition again, and the efficient combination of various ingredients can produce the gentle wart that disappears to act on；And with safe, it is easy to use, it is widely applicable, the advantages of excellent effect.Ectylotic of the present invention is nontoxic, non-stimulated, painless, without allergy, it is adaptable to nearly all crowd；The preparation method mild condition of ectylotic of the present invention, low without intensification, energy consumption, technological process is brief, and non-environmental-pollution, is a kind of green manufacture technology being worthy to be popularized.

Description

A kind of gentle multiple-effect ectylotic and preparation method thereof
Technical field
The invention belongs to cosmetics and technical field of medicine, relate in particular to a kind of gentle multiple-effect ectylotic and its Preparation method.
Background technology
Everybody has a love of beauty, and fashion health is even more everyone yearning.The health of skin ceases with the health breath of whole body It is related.Modern scientific research shows that skin is and our the maximum organs of life-critical area.Skin is both to protect our bodies First barrier of body health, is again to the beautiful main carriers of people's displaying.However, with the quickening of people's rhythm of life, work Make the increasing of pressure, and aggravation the problems such as environmental pollution and the reason, increasing people such as self health status are not good enough It is more vulnerable to invasion and attack or infection from various pathogen in environment or microorganism.Wart（wart）It is commonly called as " wart " or " hard head Meat ", it is by human papilloma virus（HPV）A kind of skin surface neoplasm that infection causes, can betide any of body surface Position.Traditionally this disease is a kind of chronic benign disease not very sick in other words, but modern medicine study finds that wart not only can The daily life that wart does harm to patient is had influence on, being such as born in the wart of face will directly influence the cleaning of face, scrape palpus, fearful , it is all that canceration, human papilloma virus can be caused by disease caused by " human papilloma virus " infection（HPV）Have Infectiousness, but not only itself spread of infection, can also infect other people, be passed especially easily between the family and friends for having close contact Dye, such as treats not in time, and some patient also results in malignant tumour, such as cutaneum carcinoma, tongue cancer and cervical carcinoma after HPV infection Deng.It is generally believed that wart is more common in children and youth, in fact, wart can result from multiple age brackets, the raw wart on the body of the elderly Also it is extremely common.The incubation period of HPV is 1~3 month, can autoinoculation diffusive transport.HPV viruse is normally present in acantholysis cell In, hyperplasia can be promoted, form excipuliform infringement.Wart has polytype, common are verruca vulgaris, flat wart, condyloma acuminatum etc.. If common verruca vulgaris is from the beginning of being the big papule of needle point, cumulative big or bigger to pea, circular or polygonal, rough surface is in thorn Shape, matter is hard, sallow, dirty yellow or dirty brown, and it is in papillary hyperplasia to continue to develop.Easy bleeding when friction or shock.Initial is often 1 It is individual, remain unchanged for a long period of time or be on the increase, neighbor is merged into each other, sometimes can autoinoculation propagation.For another example flat wart, is also wart disease One kind in disease, is also called " verruca plana ", is common skin vegetations, is apt to occur in young people's face, the back of the hand and forearm in needle point To the big flat papule of soya bean, general no conscious sympton has slight scratchiness sometimes, and fash gradually increases, and the course of disease is slow, itself Infect.Flat wart is all by human papilloma virus as verruca vulgaris（HPV）The lesion of projection is formed on the skin for causing, is faced The bed performance initial stage is the flat papule of color of the leather or pink, and later stage color can deepen to become taupe, be more common in face and the back of the hand, Without obvious subjective symptoms, the course of disease is chronic.Can be by direct or indirect contagion.
At present, for the treatment method of wart, common drug therapy and operative treatment.In operative treatment with laser ablation method most For common.Because the growth and breeding of verrucosis poison is that laser can only remove body surface excipuliform in below the epidermis and with diffusivity Protrusion, and virus cannot be rooted out in subcutaneous deep tissue, the virus for diffusing into normal skin cannot more be touched, so being difficult to To basic therapeutic action, even if eliminating raised wart at that time, often having crossed a period of time verrucosis poison can also grow again, and And dermal tissue can typically be injured so permanent scar, and surgery cost often can be left in body surface due to laser ablation art Height is not said, if not anaesthetizing can also allow patient pain unbearably.Medicinal treatment can be divided into 2 major classes by method of administration：Interior use and external application. Innerlich anwenden is divided into oral solid preparations and liquid formulation again, in addition, also injection such as interferon（Mostly ancillary drug）Deng.Press Drug type can be divided into Chinese medicine and Western medicine again.Because innerlich anwenden reaches skin focus again from oral cavity to internal organ Absorption And Metabolism, be through A very long process is gone through, the effective dose for reaching target position is substantially reduced with drug effect, so effect is difficult ideal.Externally applied drug also may be used It is divided into Chinese medicine and Western medicine, commonly uses 80% phenol solution or 33% trichloroacetic acid solution, or 10% potassium hydroxide aqueous solution, or apply 10% outward The tincture of iodine or Betagen Solution are in skin damaged, otherwise it is to be made vina using virose kinds of traditional Chinese medicines material that Chinese medicine is then mostly Coating affected part, otherwise making, water decoction is smoked to wash affected part.These processing modes, though there is certain effect, otherwise excitant is too strong, Containing toxic component, when in use, should not be coated onto liquid medicine point on normal skin in order to avoid injured skin by mostly alerting, If medicine for oral administration, patient is also reminded simultaneously, intermittent use in order to avoid producing adverse consequences.Therefore, how one kind is provided for people What not only safe but also easy to use and effect significantly disappeared that wart method or preparation always skin care scientific domain is badly in need of solving important asking One of topic.
The content of the invention
To solve the defect or deficiency of above-mentioned technology or product, the invention provides a kind of gentle multiple-effect ectylotic and its system Preparation Method.
Basic ideas of the invention are first on the premise of drug safety and skin safe is ensured, by common various The parsing of wart class thing Producing reason and wart body structure, protection had both been needed based on patient skin, with greater need for wart of dispelling, dispel wart and protection Or the theory laid equal stress on is repaired, screening there are nutrition and health care to act on to skin and belongs to biogenic or biochemical class, food-borne , component based on the component of clear efficacy, to generally acknowledge salicylic acid and its salt or esters with broad-spectrum high efficacy safety etc. Derivative, sorbic acid and its salt, enoxolone, glycyrrhizic acid or/and its esters, urea etc. are used as main disinfection and exfoliating Composition, absorbs or the understanding through rule characteristic and analysis according to skin histology and cell to different material, has without tradition In the case of toxic and side effect or dripping of irritant drugs, will have to skin nutrition and health care act on and the wart effect that disappears biogenic or Biochemical class component carries out science and assembles one group of optimization can not only having protected with skin nutrition but also gentle group of the safe multiple-effect of the wart that can dispel Compound, then disappeared wart product formulation using the skin care that certain technology method is made into Energy and comfort.
It is an object of the invention to provide a kind of gentle multiple-effect ectylotic and preparation method thereof.Ectylotic of the invention is existing The obvious wart effect that disappears, and the nutritious effect with protection skin.The ectylotic be by skin care composition, disappear wart composition Constituted with solvent.The ectylotic contains hyaluronic acid or/and hyaluronate, the senior middle school of high, normal, basic three kinds of different molecular weight sizes The polyglutamic acid or/and polyglutamate of low three kinds of different molecular weight sizes, glutamic acid or/and glutamate, collagen, glue Former protein peptides, Vc, Ve, Vb5, nicotinic acid, niacinamide, DPN, DPN I, chondroitin sulfate, taurine, liquaemin, L- Vitamin Cs Sour 2- glucosides, ubiquinone10, trehalose, sodium alginate, xanthans, sorbic acid and its esters, enoxolone, glycyrrhizic acid or/and Its esters, salicylic acid or/and salt or esters, acetylsalicylic acid, smart ammonia acetylsalicylic acid, lysine acetylsalicylate, A Si Woods calcium urea, urea, allantoin, lactic acid, lactate, malic acid, tartaric acid, citric acid, polyethylene glycol, grape-kernel oil, glycerine, Ethanol, water.Ectylotic of the present invention is easy to use comfortable, effect is significant, and the easy simultaneously environmental sound of fabricating technology method.
What the present invention was realized in：
The present invention provides a kind of gentle multiple-effect ectylotic.Ectylotic of the invention be by skin care composition, disappear wart composition Constituted with solvent, wherein, described skin care composition include the hyaluronic acid of high, normal, basic three kinds of different molecular weight sizes or/ With hyaluronate, the polyglutamic acid or/and polyglutamate of high, normal, basic three kinds of different molecular weight sizes, glutamic acid or/and paddy Propylhomoserin salt, collagen, collagen peptide, Vc, Ve, Vb5, nicotinic acid, niacinamide, DPN, DPN I, chondroitin sulfate, ox sulphur Acid, liquaemin, AA 2G, ubiquinone10, trehalose, sodium alginate, xanthans；The described wart composition bag that disappears Include sorbic acid and its esters, enoxolone, glycyrrhizic acid or/and its esters, urea, allantoin, lactic acid, lactate, malic acid, wine Stone acid, citric acid and salicylic acid or/and salt or esters, acetylsalicylic acid, Arginine Acetylsalicylate, lysine acetyl salicylic Any or its combination in acid, calcium acetylsalicylate urea；Described solvent contain grape wine, polyethylene glycol, lactic acid, grape-kernel oil, Glycerine, second alcohol and water；Without tradition tool toxic and side effect or dripping of irritant drugs in the case of, by above-mentioned skin care composition, Disappear wart composition and solvent carries out science and assembles and optimize, then Energy and comfort is made into using certain technology method Ectylotic formulation.Ectylotic of the present invention is easy to use comfortable, effect is significant, and fabricating technology method it is simple and to environment without Evil.
Skin care composition of the present invention, the quality proportioning of disappear wart composition and solvent three are：0.1~98.00: 0.2 ~99.00: 0.1~99.70；
Wherein, described skin care composition is by following mass percent（%）Raw material composition：The hyalomitome of HMW Acid or/and hyaluronate 0.1-5.0, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 0.1-8.0, low-molecular-weight Hyaluronic acid or/and hyaluronate 0.1-10.0, the polyglutamic acid of HMW or/and polyglutamate 0.1-4.0, in point The polyglutamic acid or/and polyglutamate 0.1-6.0, the polyglutamic acid of low-molecular-weight or/and polyglutamate 0.1- of son amount 12.0th, collagen 0.01-10.0, collagen peptide 0.01-8.0, Vc 0.01-5.0, Ve 0.01-5.0, Vb5 0.01- 8.0th, nicotinic acid 0.01-5.0, niacinamide 0.01-5.0, DPN 0.01-2.0, DPN I 0.01-2.0, chondroitin sulfate 0.01-5.0, taurine 0.01-5.0, liquaemin 0.01-5.0, AA 2G 0.01-8.0, ubiquinone10 0.01-5.0, trehalose 0.01-9.0, sodium alginate 0.01-9.0, xanthans 0.01-9.0；
The described wart composition that disappears includes following mass fraction（Part）Raw material：It is sorbic acid or/and its esters 0.001-4.0, sweet Careless hypo acid 0.001-4.0, glycyrrhizic acid or/and its esters 0.001-4.0, urea 0.01-15.0, allantoin 0.01-15.0, lactic acid Salt 0.01-5.0, citric acid 0.01-5.0, malic acid 0.01-8.0, tartaric acid 0.01-8.0 and salicylic acid or/and its esters or Esters 0.001-35.0, acetylsalicylic acid 0.001-25.0, Arginine Acetylsalicylate 0.002-30.0, lysine acetyl salicylic Any or its combination in sour 0.002-40.0, calcium acetylsalicylate urea 0.002-40.0；
Solvent of the present invention is by following mass percent（%）Raw material constitute：Grape wine 0.0001-40.0, polyethylene glycol 0.0001-15.0, lactic acid 0.01-5.0, grape-kernel oil 0.01-8.0, glycerine 0.0001-10.0, ethanol 0.0001-50.0 and water 0.01-99.9。
Used as a kind of preferred embodiment of the ectylotic, skin care composition in the ectylotic, disappear wart composition and molten The quality proportioning of agent three is：0.2~98.00: 0.3~99.00: 0.1~99.50；Wherein, described skin care composition By following mass percent（%）Raw material composition：The hyaluronic acid or/and hyaluronate 0.1-3.0 of HMW, middle molecule The hyaluronic acid or/and hyaluronate 0.1-6.0 of amount, the hyaluronic acid of low-molecular-weight or/and hyaluronate 0.1-8.0, The polyglutamic acid or/and polyglutamate 0.1-3.0 of HMW, the polyglutamic acid or/and polyglutamate of middle-molecular-weihydroxyethyl 0.1-5.0, the polyglutamic acid of low-molecular-weight or/and polyglutamate 0.1-6.0, collagen 0.1-8.0, collagen peptide 0.1-6.0、Vc 0.1-4.0、Ve 0.1-4.0、Vb50.1-6.0, nicotinic acid 0.05-3.0, niacinamide 0.05-3.0, DPN 0.05-1.0, DPN I 0.05-1.0, chondroitin sulfate 0.1-3.0, taurine 0.1-2.0, liquaemin 0.1-2.0, L- are anti-bad Hematic acid 2- glucosides 0.1-5.0, ubiquinone100.1-3.0, trehalose 0.1-5.0, sodium alginate 0.1-5.0, xanthans 0.1- 5.0；
The described wart composition that disappears includes following mass fraction（Part）Raw material：Sorbic acid or/and its salt 0. 01-2.0, Radix Glycyrrhizae Hypo acid 0.001-3.0, glycyrrhizic acid or/and its esters 0.01-3.0, urea 0.1-10.0, allantoin 0.1-8.0, lactate 0.1- 3.0th, citric acid 0.1-3.0, malic acid 0.1-5.0, tartaric acid 0.1-5.0 and salicylic acid or/and its esters or esters 0.01- 20.0th, acetylsalicylic acid 0.01-19.0, Arginine Acetylsalicylate 0.02-25.0, lysine acetylsalicylate 0.02-30.0, Any or its combination in calcium acetylsalicylate urea 0.02-30.0；
Described solvent is by following mass percent（%）Raw material constitute：Grape wine 0.01-25.0, polyethylene glycol 0.01- 10.0th, lactic acid 0.1-3.0, grape-kernel oil 0.1-4.0, glycerine 0.01-5.0, ethanol 0.01-30.0 and water 0.1-98.5.
Except a small number of biological endogenous property of category or the derivative beyond the region of objective existence of biochemical class component in ectylotic component of the invention, other are Biological endogenous property, food-borne, clear efficacy component, wherein, some still constitute skin histology and cell it is basic into Point, and, most components have various physiology/pharmacological functions or effect.As hyaluronic acid, polyglutamic acid, collagen, Collagen peptide, Vc, Ve, Vb5, nicotinic acid, niacinamide, DPN, DPN I, chondroitin sulfate, taurine, heparin, lactic acid, breast Hydrochlorate, ubiquinone10The basis that constitutes skin histology and cell is with water or maintains normal skin tissue and the cell to carry out Biogenic physiologically active ingredient, meanwhile, also there is anti-aging to be immunized with moisturizing, anti-oxidant and raising skin for they Power, antiallergy etc. are acted on；Enoxolone, glycyrrhizic acid or/and its esters, urea, allantoin, lactate, citric acid, malic acid, Tartaric acid and salicylic acid or/and salt or esters, acetylsalicylic acid, smart ammonia acetylsalicylic acid, lysine acetylsalicylate, A Si Woods calcium urea, then in anti-corrosion, sterilize, the wart that disappears, cutin-softening, dispel the aspects such as cutin and work well, each component uses cooperatively it The wart effect that disappears is more significantly and rapid；Trehalose and sodium alginate protect Skin Cell and radiation-resistant function under having adverse circumstance； Xanthans then has good thickening, attachment and lubrication；Sorbic acid and its esters are that the food-level antibacterial of generally recognized as safe is prevented Rotten agent, is conducive to keeping the long-time stability and quality of product.Said components are carried out into science to assemble and optimize, using the present invention Described solvent, can be prepared using certain technology method can eliminate in the case of without any wound and pain The preparation of stupid wart.
The hyaluronic acid or/and hyalomitome of the high, normal, basic three kinds of different molecular weight sizes in ectylotic of the present invention Hydrochlorate refers to the molecular weight of polymer hyaluronic acid or hyaluronate more than 1,800,000 dalton, middle molecular weight hyaluronic acid Or the molecular weight of hyaluronate is between 1,000,000-1, between 800,000 dalton, low molecular weight hyaluronic acid or hyalomitome The molecular weight of hydrochlorate is less than 600,000 dalton.
The polyglutamic acid or/and polyglutamate of high, normal, basic three kinds of different molecular weight sizes refer to macromolecule polyglutamic The molecular weight of acid or polyglutamate is more than the molecular weight of 1,000,000 dalton, middle molecule polyglutamic acid or polyglutamate Between 600,000-1, between 000,000 dalton, the molecular weight of low molecular weight polycaprolactone glutamic acid or polyglutamate is less than 100,000 Dalton.
Grape wine in the solvent includes red wine and white wine；Preferably, it is that extra dry red wine, half extra dry red wine and half are sweet red And extra dry white wine, medium dry white wine and half are sweet white；Polyethylene glycol refers to that molecular weight more than food-grade is appointing in 200-20000 dalton A kind of or its combination；Lactic acid, grape-kernel oil, glycerine and ethanol are more than food-grade；Water be counter-infiltration level above pure water or Its distilled water.
In ectylotic of the invention, all components are product more than commercially available food-grade or medical grade；Except above-mentioned Outside composition and solvent, can allow in skin care item to use using tradition as suitably desired without potential safety hazard composition or Additive or carrier or auxiliary material.For example, the material such as other whitening agents, NMF, antioxidant, surfactant, alcohols, water Material.
The ectylotic formulation of Energy and comfort of the present invention includes liquid formulation and solid formulation, preferably half fluidised form system Agent, more preferably water gelling agent；In practical application, can be disappeared with described as needed and the Energy and comfort that uses Composition in wart agent in addition to the solvents is base-material, then mixes ectylotic acceptable carrier of the present invention or auxiliary material, using corresponding Preparation technique is made convenient applicable various formulations, can be aqua, vina, tincture, suspension, emulsion, creme, paste, solidifying Jelly, coagulant liquid, finish, film, spray or patch etc..
Present invention also offers the preparation method of above-mentioned ectylotic, comprise the following steps：
（1）Formula and formula ratio as described in this patent weigh skin care and each component of the wart composition that disappears respectively, standby；
（2）Formula and formula ratio as described in this patent weigh each component of the ectylotic solvent for use, normal temperature or low temperature respectively Under stir and evenly mix it is rear standby；
（3）The each component of the skin care composition of formula ratio is added the solvent of part formulation amount, normal temperature or low temperature Mix, obtain mixture A；
（4）The each component of the wart composition that disappears of formula ratio is added the solvent of part formulation amount, normal temperature or low temperature mix, Obtain mixture B；
（5）Mixture B is slowly added into mixture A, then residual solvent is added thereto, normal temperature or low temperature are equal It is even, obtain final product the ectylotic.
Step（2）（3）（4）（5）Described in normal temperature or cryogenic conditions be preferably less than 42 DEG C, again more preferably less than 21 DEG C But more than 10 DEG C.
Step（2）（3）（4）（5）Described in the operating condition that stirs and evenly mixs be preferably in medical stainless steel blender Two dimension is mixed, the stirring of three-dimensional hybrid more preferably in glass reactor or 316L stainless steel blenders, further preferably for Emulsifying mode under vacuum is realized.
In practical operation, with above-mentioned ectylotic as base-material, then can match somebody with somebody as needed and the Energy and comfort that uses Upper ectylotic acceptable carrier of the present invention or auxiliary material, convenient applicable various formulations are made using corresponding preparations technology.
The present invention compared with tradition disappears wart method or technique, with following features：
（1）Chemical composition, skin biochemistry and the physiology such as skin physiology characteristic and verruca vulgaris, flat wart according to skin The biochemical characteristic and theory based on the wart skin care again that should dispel carries out comprehensive prescription design；
（2）In the selection of ectylotic raw material components, based on the consideration of the principle of security first, present invention skin care raw material used Except the biological endogenous property of minority category or the derivative beyond the region of objective existence of biochemical class component, other are biological endogenous property, biochemical class, food-borne , the component of clear efficacy, these compositions are natively had in skin histology or body, only because with the age Increase or other reasons cause its content deficiency or scarcity and skin or body immunity is declined and is turned into the susceptible of pathogen Person, wherein, some still constitute the basis of skin histology and cell, and, most components have various physiology/medicines Reason function simultaneously has good protective effect to skin.So, both be skin tissue cell provide enough nutrition needed for group Point, there is the function of multiple protective skin again；
（3）Also want skin friendly based on the wart that should disappear or toxic and side effect or irritating principle are not produced to body or skin, In the wart raw material components that disappear selection, existing sterilization anti-corrosive antibacterial antipathogenic composition dispels aging cutin composition, the two effective group again Conjunction can produce the gentle wart that disappears to act on；Especially used cooperatively with skin care composition, the wart that gently disappears effect is more notable；
（4）Solvent of the invention is unique, is various by grape wine, polyethylene glycol, lactic acid, grape-kernel oil, glycerine, second alcohol and water etc. Component is constituted, and both can dissolve water-soluble component, also can dissolve alcohol-soluble or oil-soluble or fat-soluble ingredient, and such solvent is constituted Can ensure raw materials used wherein with good dissolubility；
（5）The preparation method mild condition of ectylotic of the present invention, process is simple, non-environmental-pollution.Because the present invention is raw materials used Mostly biochemical class component, it is more sensitive to physical and chemical factors such as high temperature and illumination, so, by component preferably and process optimization, build A kind of process is simple, non-environmental-pollution technical method that ectylotic of the present invention can be prepared under normal temperature or low temperature is found；
（6）In this patent prescription not only being successfully solved by the optimum organization and the use of gentle process of preparing that are formulated Labile active ingredient such as Vc etc. is easily decomposed, problem oxidizable, easy to change, is also solved various active composition and is mixed The various stability problems being likely to occur, such as light are stable, thermally-stabilised, and allow each component to produce collaboration or synergistic effect；
（7）The existing wart effect of dispelling of ectylotic of the present invention, also skin makeup skin care effect, can also be attached to verruca vulgaris, plantar wart and flat wart Near skin carries out prophylactic disinfection in case its further diffusive transport, its core feature is that have protectiveness to normal skin, And then there is depth sterilization and the property dispelled to " wart " or " hard head meat ", and larger wart can be shown to become apparent from and more Rapid effect.This ectylotic is primarily adapted for use in the sterilization of verruca vulgaris, flat wart and plantar wart and dispels；
（8）This ectylotic can quickly penetrate into wart body bottom and its surrounding skin tissue, thoroughly kill or suppress epidermis, corium and skin Virus in undertissue's cell, and efficient protective layer is formed in skin surface, the invasion and attack again and infection of virus are prevented, and can be deep Layer nourishes rough skin.
A large amount of long-term result of practical application show that the present invention has the advantages that：
（1）The wart that disappears is gentle, hurtless measure no pain.In the formula of this ectylotic, containing various foster skin skin care ingredient such as hyaluronic acids, Collagen, vitamin etc., it is ensured that skin friendly while wart is disappeared；
（2）It is easy to use, excellent effect.Only wart body is smeared daily 1-3 times, 1-2 weeks takes effect, be within 4 weeks a treatment with this ectylotic Journey, the 3-5 course for the treatment of can thoroughly eliminate stupid wart, and not stay scar, also user's fitness skin；
（3）It is safe, it is widely applicable.Ectylotic of the present invention is nontoxic, non-stimulated, without allergy, it is adaptable to nearly all crowd；
（4）Simple production process, production cost is relatively low；
（5）The preparation method mild condition of ectylotic of the present invention, low without intensification, energy consumption, technological process is short, and dirty without environment Dye, is a kind of green manufacture technology being worthy to be popularized.
The trial effect of people volunteer is as follows：
（1）Case selection：68 patients of random selection, wherein, male 28, women 40, age 18-65 Sui, average age 38 years old, course of disease 2-300 month, average 18 months.Wart body is located at face person 44, face, the equal originator in the back of the hand face 14, up/down Limb and other positions person 10.Selected wart body size has from needle point to pea size person.
（2）Diagnostic criteria：With reference to nineteen ninety-five《People's Republic of China's traditional Chinese medicine industry standard》Judge.Verruca vulgaris from the beginning of for The big papule of needle point, cumulative greatly or bigger to pea, circular or polygonal, rough surface is in thorn-like, and matter is hard, and sallow, dirt are yellow or dirty Brown, it is in papillary hyperplasia to continue to develop.Easy bleeding when friction or shock.Initial is often 1, remains unchanged for a long period of time or is on the increase, Neighbor is merged into each other, sometimes can autoinoculation propagation.The Clinical Manifestations of Plane Warts initial stage is the flat papule of color of the leather or pink, Later stage color can deepen to become taupe, be more common in face and the back of the hand, and without obvious subjective symptoms, the course of disease is chronic.Can be by straight Connect or indirectly contagion.
（3）Treatment method：Use ectylotic spot printing wart body 2-3 times daily, it is at least sooner or later each 1 time, if middle washing with water needs 1 time is added to ensure having ectylotic on wart body all the time, 1-3 minutes can be massaged after smearing for the first time to promote to absorb, Ran Houzai Once to increase dose, 1-2 weeks takes effect spot printing, is within 4 weeks a course for the treatment of, and according to the state of an illness, wart body bigot can continuously use 3-5 The course for the treatment of.
（4）Criterion of therapeutical effect：It is recovery from illness to be disappeared substantially without obvious projection person with wart body, and wart body regression 60-70% is effective, wart Body regression 40-50% is effective, and fash is unchanged or regression is invalid less than 10%.
（5）Treatment results：In 68, fully recover 46, effective 14, effective 7, invalid 1, cure rate 67.6% is effective Rate 20.6%, efficient 10.3%, inefficiency 1.5%, total effective rate 98.5%.
Specific embodiment
With reference to embodiment, the present invention is described in detail：
Embodiment l：
Formula：
Skin care composition in the ectylotic, the quality proportioning of disappear wart composition and solvent three are：0.10∶0.20∶ 99.70；
Wherein, described skin care composition is by following mass percent（%）Raw material composition：The hyalomitome of HMW Acid or/and the hyaluronic acid or/and the hyaluronic acid of hyaluronate 8.0, low-molecular-weight of hyaluronate 0.1, middle-molecular-weihydroxyethyl Or/and the polyglutamic acid of hyaluronate 0.1, HMW or/and the polyglutamic acid of polyglutamate 0.1, middle-molecular-weihydroxyethyl or/ With polyglutamic acid or/and polyglutamate 0.1, the collagen 0.01, collagen peptide of polyglutamate 6.0, low-molecular-weight 8.0、Vc 0.01、Ve 0.01、Vb50.01st, nicotinic acid 0.01, niacinamide 5.0, DPN 2.0, DPN I 0.01, sulfuric acid are soft Ossein 0.01, taurine 0.01, liquaemin 5.0, AA 2G 0.01, ubiquinone100.01st, trehalose 0.01, Sodium alginate 0.01；Xanthans 9.0；
The described wart composition that disappears includes following mass fraction（Part）Raw material：Sorbic acid or/and its salt 0.001, glycyrrhizic acid or/ With its esters 4.0, urea 0.01, allantoin 0.01, lactate 5.0, citric acid 0.01, malic acid 0.01, the and of tartaric acid 0.01 Salicylic acid 0.001；
Described solvent is by following mass percent（%）Raw material constitute：Grape wine 0.0001, PEG 20000 0.0001st, lactic acid 5.0, grape-kernel oil 0.01, glycerine 0.0001, ethanol 5.0 and water 90.0；
Preparation method：Comprise the steps of：
（1）Formula and formula ratio as described in this patent weigh skin care and each component of the wart composition that disappears respectively, standby；
（2）Formula and formula ratio as described in this patent weigh each component of the ectylotic solvent for use, normal temperature or low temperature respectively Under stir and evenly mix it is rear standby；
（3）The each component of the skin care composition of formula ratio is added the solvent of part formulation amount, normal temperature or low temperature Mix, obtain mixture A；
（4）The each component of the wart composition that disappears of formula ratio is added the solvent of part formulation amount, normal temperature or low temperature mix, Obtain mixture B；
（5）Mixture B is slowly added into mixture A, then residual solvent is added thereto, normal temperature or low temperature are equal It is even, obtain final product the ectylotic；
Embodiment 2：
Formula：
Skin care composition in the ectylotic, the quality proportioning of disappear wart composition and solvent three are：8.00∶9.00∶ 83.00；
Wherein, described skin care composition is by following mass percent（%）Raw material composition：The hyalomitome of HMW Acid or/and the hyaluronic acid or/and the hyaluronic acid of hyaluronate 0.1, low-molecular-weight of hyaluronate 5.0, middle-molecular-weihydroxyethyl Or/and the polyglutamic acid or/and the polyglutamic acid of polyglutamate 4.0, middle-molecular-weihydroxyethyl of hyaluronate 10.0, HMW Or/and polyglutamic acid or/and polyglutamate 12.0, collagen 10.0, the collagen egg of polyglutamate 0.1, low-molecular-weight White peptide 0.01, Vc 5.0, Ve 5.0, Vb58.0th, nicotinic acid 5.0, niacinamide 0.01, DPN 0.01, DPN I 2.0, sulfuric acid Chondroitin 5.0, taurine 5.0, liquaemin 0.01, AA 2G 8.0, ubiquinone105.0th, trehalose 9.0, sea Mosanom 9.0；Xanthans 0.01；
The described wart composition that disappears includes following mass fraction（Part）Raw material：Sorbic acid or/and its salt 4.0, glycyrrhizic acid or/and Its esters 0.0 01, urea 15.0, allantoin 15.0, lactate 0.01, citric acid 5.0, malic acid 8.0, tartaric acid 8.0 and water Poplar acid or/and its esters or esters 35.0；
Described solvent is by following mass percent（%）Raw material constitute：Grape wine 40.0, polyethylene glycol 2000 15.0, lactic acid 0.01st, grape-kernel oil 8.0, glycerine 0.0001, ethanol 10.0 and water 27.0；
Preparation method：With embodiment 1.
Embodiment 3：
Formula：
Skin care composition in the ectylotic, the quality proportioning of disappear wart composition and solvent three are：15.00∶15.00∶ 70.00；
Wherein, described skin care composition is by following mass percent（%）Raw material composition：The hyalomitome of HMW Acid or/and the hyaluronic acid or/and the hyaluronic acid of hyaluronate 1.0, low-molecular-weight of hyaluronate 1.0, middle-molecular-weihydroxyethyl Or/and the polyglutamic acid of hyaluronate 1.0, HMW or/and the polyglutamic acid of polyglutamate 2.0, middle-molecular-weihydroxyethyl or/ With polyglutamic acid or/and polyglutamate 2.0, the collagen 5.0, collagen peptide of polyglutamate 2.0, low-molecular-weight 4.0、Vc 3.0、Ve 2.50、Vb54.0th, nicotinic acid 2.0, niacinamide 3.0, DPN 1.0, DPN I 1.0, chondroitin sulfate 2.0th, taurine 3.0, liquaemin 2.0, AA 2G 4.0, ubiquinone103.0th, trehalose 5.0, sodium alginate 5.0th, xanthans 4.0；
The described wart composition that disappears includes following mass fraction（Part）Raw material：Sorbic acid or/and its salt 2.0, glycyrrhizic acid or/and Its esters 0.1, urea 8.0, allantoin 7.0, lactate 3.0, citric acid 3.0, malic acid 4.0, tartaric acid 4.0 and salicylic acid Or/and its esters or esters 18.0, acetylsalicylic acid 12.50；
Described solvent is by following mass percent（%）Raw material constitute：Grape wine 20.0, PEG400 8.0, lactic acid 3.0th, grape-kernel oil 4.0, glycerine 10.0, ethanol 5.0 and water 55.0；
Preparation method：With embodiment 1.
Embodiment 4：
Formula：
Skin care composition in the ectylotic, the quality proportioning of disappear wart composition and solvent three are：98.00∶1.90∶ 0.10；
Wherein, described skin care composition is by following mass percent（%）Raw material composition：The hyalomitome of HMW Acid or/and the hyaluronic acid or/and the hyaluronic acid of hyaluronate 4.0, low-molecular-weight of hyaluronate 2.50, middle-molecular-weihydroxyethyl Or/and the polyglutamic acid of hyaluronate 5.0, HMW or/and the polyglutamic acid of polyglutamate 2.0, middle-molecular-weihydroxyethyl or/ With polyglutamic acid or/and polyglutamate 6.0, the collagen 2.0, collagen peptide of polyglutamate 3.0, low-molecular-weight 1.0、Vc 1.0、Ve 4.0、Vb51.0th, nicotinic acid 0.5, niacinamide 1.0, DPN 0.1, DPN I 0.2, chondroitin sulfate 2.50th, taurine 1.0, liquaemin 0.5, AA 2G 0.1, ubiquinone100.2nd, trehalose 3.0, sodium alginate 2.0th, xanthans 2.0；
The described wart composition that disappears includes following mass fraction（Part）Raw material：Sorbic acid or/and its salt 1.0, glycyrrhizic acid or/and Its esters 0.5, urea 5.0, allantoin 1.0, lactate 0.1, citric acid 1.0, malic acid 1.0, tartaric acid 1.0 and salicylic acid Or/and its esters or esters 10.0, acetylsalicylic acid 0.50, Arginine Acetylsalicylate 2.0；
Described solvent is by following mass percent（%）Raw material constitute：Grape wine 0.1, PEG 8000 0.1, lactic acid 0.1st, grape-kernel oil 0.1, glycerine 0.1, ethanol 0.1 and water 99.40；
Preparation method：With embodiment 1.
Embodiment 5：
Formula：
Skin care composition in the ectylotic, the quality proportioning of disappear wart composition and solvent three are：3.00∶5.00∶ 92.00；
Wherein, described skin care composition is by following mass percent（%）Raw material composition：The hyalomitome of HMW Acid or/and the hyaluronic acid or/and the hyaluronic acid of hyaluronate 3.0, low-molecular-weight of hyaluronate 2.0, middle-molecular-weihydroxyethyl Or/and the polyglutamic acid of hyaluronate 2.0, HMW or/and the polyglutamic acid of polyglutamate 2.0, middle-molecular-weihydroxyethyl or/ With polyglutamic acid or/and polyglutamate 3.0, the collagen 3.0, collagen peptide of polyglutamate 4.0, low-molecular-weight 3.0、Vc 2.0、Ve 1.0、Vb52.0th, nicotinic acid 1.0, niacinamide 2.0, DPN 0.5, DPN I 0.5, chondroitin sulfate 3.0th, taurine 4.0, liquaemin 1.0, AA 2G 2.0, ubiquinone100.5th, trehalose 6.0, sodium alginate 6.0th, xanthans 6.0；
The described wart composition that disappears includes following mass fraction（Part）Raw material：Sorbic acid or/and its salt 0.5, glycyrrhizic acid or/and Its esters 1.0, urea 2.0, allantoin 2.0, lactate 2.0, citric acid 2.0, malic acid 2.0, tartaric acid 2.0 and salicylic acid Or/and its esters or esters 4.0, acetylsalicylic acid 5.0, Arginine Acetylsalicylate 10.0, lysine acetylsalicylate 8.0；
Described solvent is by following mass percent（%）Raw material constitute：Grape wine 0.1, Macrogol 4000 5, lactic acid 5, Portugal Grape seed oil 0.1, glycerine 3, ethanol 15 and water 71.8；
Preparation method：With embodiment 1.
Embodiment 6：
Formula：
Skin care composition in the ectylotic, the quality proportioning of disappear wart composition and solvent three are：0.50∶99.00∶ 0.50；
Wherein, described skin care composition is by following mass percent（%）Raw material composition：The hyalomitome of HMW Acid or/and the hyaluronic acid or/and the hyaluronic acid of hyaluronate 4.0, low-molecular-weight of hyaluronate 2.50, middle-molecular-weihydroxyethyl Or/and the polyglutamic acid of hyaluronate 5.0, HMW or/and the polyglutamic acid of polyglutamate 2.0, middle-molecular-weihydroxyethyl or/ With polyglutamic acid or/and polyglutamate 6.0, the collagen 5.0, collagen peptide of polyglutamate 3.0, low-molecular-weight 4.0、Vc 2.5、Ve 2.5、Vb54.0th, nicotinic acid 2.5, niacinamide 2.5, DPN 1.0, DPN I 1.0, chondroitin sulfate 2.5th, taurine 2.5, liquaemin 2.5, AA 2G 4.0, ubiquinone102.5th, trehalose 4.5, sodium alginate 4.5th, xanthans 4.5；
The described wart composition that disappears includes following mass fraction（Part）Raw material：Sorbic acid or/and its salt 0.1, glycyrrhizic acid or/and Its esters 1.5, urea 10.0, allantoin 4.0, lactate 3.0, citric acid 4.0, malic acid 4.0, tartaric acid 4.0 and salicylic acid Or/and its esters or esters 20.0, acetylsalicylic acid 10.0, Arginine Acetylsalicylate 8.0, lysine acetylsalicylate 0.8, Calcium acetylsalicylate urea 0.5；
Described solvent is by following mass percent（%）Raw material constitute：Grape wine 0.01, PEG20000 0.05, breast Acid 0.3, grape-kernel oil 0.5, glycerine 0.01, ethanol 50.0 and water 49.1；
Preparation method：With embodiment 1.
Embodiment 7：
Formula：
Skin care composition in the ectylotic, the quality proportioning of disappear wart composition and solvent three are：6.00∶6.00∶ 88.00；
Wherein, described skin care composition is by following mass percent（%）Raw material composition：The hyalomitome of HMW Acid or/and the hyaluronic acid or/and the hyaluronic acid of hyaluronate 6.0, low-molecular-weight of hyaluronate 4.0, middle-molecular-weihydroxyethyl Or/and the polyglutamic acid of hyaluronate 8.0, HMW or/and the polyglutamic acid of polyglutamate 0.5, middle-molecular-weihydroxyethyl or/ With polyglutamic acid or/and polyglutamate 1.2, the collagen 8.0, collagen peptide of polyglutamate 0.6, low-molecular-weight 6.0、Vc 4.0、Ve 3.0、Vb54.0th, nicotinic acid 2.0, niacinamide 4.0, DPN 0.8, DPN I 0.6, chondroitin sulfate 4.0th, taurine 4.0, liquaemin 4.0, AA 2G 6.0, ubiquinone104.0th, trehalose 8.0, sodium alginate 8.0th, xanthans 6.0；
The described wart composition that disappears includes following mass fraction（Part）Raw material：Sorbic acid or/and its salt 3.0, glycyrrhizic acid or/and Its esters 2.5, urea 12.0, allantoin 8.0, lactate 4.0, citric acid 0.5, malic acid 1.5, tartaric acid 1.5 and salicylic acid Salt 0.5；
Described solvent is by following mass percent（%）Raw material constitute：Grape wine 1.0, Macrogol 6000 1.0, lactic acid 1.0th, grape-kernel oil 2.0, glycerine 1.0, ethanol 2.0 and water 92.0；
Preparation method：With embodiment 1.
The invention is not restricted to case study on implementation described above.

Claims (10)

1. a kind of gentle multiple-effect ectylotic, it is characterised in that：The ectylotic be by skin care composition, disappear wart composition and molten Agent is constituted, wherein, described skin care composition includes the hyaluronic acid of high, normal, basic three kinds of different molecular weight sizes or/and thoroughly Bright matter hydrochlorate, the polyglutamic acid or/and polyglutamate of high, normal, basic three kinds of different molecular weight sizes, glutamic acid or/and glutamic acid Salt, collagen, collagen peptide, Vc, Ve, Vb5, nicotinic acid, niacinamide, DPN, DPN I, chondroitin sulfate, taurine, Liquaemin, AA 2G, ubiquinone10, trehalose, sodium alginate, xanthans；The described wart composition that disappears includes Sorbic acid and its esters, enoxolone, glycyrrhizic acid or/and its esters, urea, allantoin, lactic acid, lactate, malic acid, winestone Acid, citric acid and salicylic acid or/and salt or esters, acetylsalicylic acid, smart ammonia acetylsalicylic acid, lysine acetylsalicylate, Any or its combination of calcium acetylsalicylate urea；Described solvent contain grape wine, lactic acid, polyethylene glycol, grape-kernel oil, glycerine, Second alcohol and water；
The skin care composition, the quality proportioning of disappear wart composition and solvent three are：0.1~98.00: 0.2~99.00 : 0.1~99.70；Wherein, described skin care composition is by following mass percent（%）Raw material composition：HMW Hyaluronic acid or/and hyaluronate 0.1-5.0, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 0.1-8.0, low The hyaluronic acid or/and hyaluronate 0.1-10.0 of molecular weight, the polyglutamic acid of HMW or/and polyglutamate 0.1- 4.0th, the polyglutamic acid of middle-molecular-weihydroxyethyl or/and polyglutamate 0.1-6.0, the polyglutamic acid or/and polyglutamic acid of low-molecular-weight Salt 0.1-12.0, collagen 0.01-10.0, collagen peptide 0.01-8.0, Vc 0.01-5.0, Ve 0.01-5.0, Vb5 0.01-8.0, nicotinic acid 0.01-5.0, niacinamide 0.01-5.0, DPN 0.01-2.0, DPN I 0.01-2.0, chondroitin sulfate Plain 0.01-5.0, taurine 0.01-5.0, liquaemin 0.01-5.0, AA 2G 0.01-8.0, ubiquinone10 0.01-5.0, trehalose 0.01-9.0, sodium alginate 0.01-9.0, xanthans 0.01-9.0；
The described wart composition that disappears includes following mass fraction（Part）Raw material：It is sorbic acid or/and its esters 0.001-4.0, sweet Careless hypo acid 0.001-4.0, glycyrrhizic acid or/and its esters 0.001-4.0, urea 0.01-15.0, allantoin 0.01-15.0, lactic acid Salt 0.01-5.0, citric acid 0.01-5.0, malic acid 0.01-8.0, tartaric acid 0.01-8.0 and salicylic acid or/and its esters or Esters 0.001-35.0, acetylsalicylic acid 0.001-25.0, Arginine Acetylsalicylate 0.002-30.0, lysine acetyl salicylic Any or its combination in sour 0.002-40.0, calcium acetylsalicylate urea 0.002-40.0；
Solvent of the present invention is by following mass percent（%）Raw material constitute：Grape wine 0.0001-40.0, polyethylene glycol 0.0001-15.0, lactic acid 0.01-5.0, grape-kernel oil 0.01-8.0, glycerine 0.0001-10.0, ethanol 0.0001-50.0 and water 0.01-99.9；
By above-mentioned skin care composition, disappear wart composition and solvent carries out science and assembles and optimize, then using certain technique Technical method is made into the ectylotic formulation of Energy and comfort.
2. ectylotic according to claim 1, it is characterised in that：The ectylotic is skin care composition, the wart that disappears combination Thing and solvent carry out science and assemble and optimize, then are prepared from using certain technology method, the skin care combination Thing, the more high quality proportioning of disappear wart composition and solvent three are：0.2~98.00: 0.3~99.00: 0.1~99.50；Its In, described skin care composition presses following mass percent（%）Raw material composition：The hyaluronic acid of HMW or/and Hyaluronate 0.1-3.0, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 0.1-6.0, the hyaluronic acid of low-molecular-weight Or/and the polyglutamic acid or/and polyglutamate 0.1-3.0 of hyaluronate 0.1-8.0, HMW, middle-molecular-weihydroxyethyl it is poly- Glutamic acid or/and polyglutamate 0.1-5.0, the polyglutamic acid of low-molecular-weight or/and polyglutamate 0.1-6.0, collagen egg White 0.1-8.0, collagen peptide 0.1-6.0, Vc 0.1-4.0, Ve 0.1-4.0, Vb50.1-6.0, nicotinic acid 0.05-3.0, cigarette Acid amides 0.05-3.0, DPN 0.05-1.0, DPN I 0.05-1.0, chondroitin sulfate 0.1-3.0, taurine 0.1-2.0, Liquaemin 0.1-2.0, AA 2G 0.1-5.0, ubiquinone100.1-3.0, trehalose 0.01-9.0, alginic acid Sodium 0.01-9.0, xanthans 0.1-5.0；
The described wart composition that disappears includes following mass fraction（Part）Raw material：Sorbic acid or/and its salt 0. 01-2.0, Radix Glycyrrhizae Hypo acid 0.001-3.0, glycyrrhizic acid or/and the 01-3.0 of its esters 0., the 1-10.0 of urea 0., the 1-8.0 of allantoin 0., lactate 0.1-3.0, citric acid 0.1-3.0, malic acid 0.1-5.0, tartaric acid 0.1-5.0 and salicylic acid or/and its esters or esters 0.01-20.0, acetylsalicylic acid 0.01-19.0, Arginine Acetylsalicylate 0.02-25.0, lysine acetylsalicylate 0.02- 30.0th, any or its combination in calcium acetylsalicylate urea 0.02-30.0；
Described solvent is by following mass percent（%）Raw material constitute：Grape wine 0.01-25.0, polyethylene glycol 0.01- 10.0th, lactic acid 0.1-3.0, grape-kernel oil 0.1-4.0, glycerine 0.01-5.0, ethanol 0.01-30.0 and water 0.1-98.5.
3. ectylotic according to claim 1, it is characterised in that：High, normal, basic three kinds of different moleculars in described ectylotic The hyaluronic acid or/and hyaluronate for measuring size refer to the molecular weight of polymer hyaluronic acid or hyaluronate more than 1, The molecular weight of 800,000 dalton, middle molecular weight hyaluronic acid or hyaluronate between 1,000,000-1 800 000 dalton Between, the molecular weight of low molecular weight hyaluronic acid or hyaluronate is less than 600,000 dalton.
4. ectylotic according to claim 1, it is characterised in that：The poly- paddy of high, normal, basic three kinds of different molecular weight sizes Propylhomoserin or/and polyglutamate refer to the molecular weight of polyphosphazene polymer glutamic acid or polyglutamate more than 1,000,000 dalton, The molecular weight of middle molecule polyglutamic acid or polyglutamate between 600,000-1, between 000,000 dalton, low molecular weight polycaprolactone paddy The molecular weight of propylhomoserin or polyglutamate is less than 100,000 dalton.
5. the ectylotic according to claim 1 and 2, it is characterised in that：Grape wine in the solvent includes red wine And white wine, the polyethylene glycol in solvent refers to that molecular weight more than food-grade is any one in 400-20000 dalton Or it is combined, lactic acid, grape-kernel oil, glycerine and ethanol in solvent are more than food-grade, and water is more than counter-infiltration level pure Water or its distilled water.
6. the ectylotic formulation of Energy and comfort according to claim 1, it is characterised in that：The ectylotic of the Energy and comfort Formulation means aqua, vina, tincture, suspension, emulsion, creme, paste, gel, coagulant liquid, finish, film, spray or patch Agent.
7. a kind of preparation method of ectylotic according to claim 1, it is characterised in that comprise the steps of：
（1）Formula and formula ratio as described in this patent weigh skin care and each component of the wart composition that disappears respectively, standby；
（2）Formula and formula ratio as described in this patent weigh each component of the ectylotic solvent for use, normal temperature or low temperature respectively Under stir and evenly mix it is rear standby；
（3）The each component of the skin care composition of formula ratio is added the solvent of part formulation amount, normal temperature or low temperature Mix, obtain mixture A；
（4）The each component of the wart composition that disappears of formula ratio is added the solvent of part formulation amount, normal temperature or low temperature mix, Obtain mixture B；
（5）Mixture B is slowly added into mixture A, then residual solvent is added thereto, normal temperature or low temperature are equal It is even, obtain final product the ectylotic.
8. the preparation method of ectylotic according to claim 7, it is characterised in that：The step（2）（3）（4）（5）In Normal temperature or cryogenic conditions are preferably less than 42 DEG C, again more preferably less than 21 DEG C but more than 10 DEG C.
9. the preparation method of ectylotic according to claim 7, it is characterised in that：The step（2）（3）（4）（5）In The two dimension mixing that operating condition is preferably in medical stainless steel blender is stirred and evenly mixed, more preferably in glass reactor Or the three-dimensional hybrid stirring in 316L stainless steel blenders, further preferably for emulsifying mode under vacuum is realized.
10. the ectylotic formulation of Energy and comfort according to claim 1, it is characterised in that：The wart that disappears of the Energy and comfort Agent formulation includes liquid formulation and solid formulation, preferably half fluidised form preparation, more preferably water gelling agent；In practical application When, can as needed and the Energy and comfort that uses, the composition with the ectylotic in addition to the solvents is as base-material, then mixes Ectylotic acceptable carrier of the present invention or auxiliary material, convenient applicable aqua, vina, tincture are made using corresponding preparations technology Agent, suspension, emulsion, creme, paste, gel, coagulant liquid, finish, film, spray or patch.
CN201611023607.7A 2016-11-22 2016-11-22 A kind of gentle multiple-effect ectylotic and preparation method thereof Pending CN106729644A (en)

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Publication number Priority date Publication date Assignee Title
CN1078388A (en) * 1992-02-20 1993-11-17 诺法姆康公司 Use hyaluronic acid and NSAIDS treatment disease
CN1761450A (en) * 2003-02-13 2006-04-19 株式会社林原生物化学研究所 Skin preparation for external use characterized by containing sugar derivative of a,a-trehalose
CN1803124A (en) * 2005-01-12 2006-07-19 东海生物科技股份有限公司 Gama-poly glutamic acid, gama-poly glutamic acid salt and use of hydrogel thereof
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1078388A (en) * 1992-02-20 1993-11-17 诺法姆康公司 Use hyaluronic acid and NSAIDS treatment disease
CN1761450A (en) * 2003-02-13 2006-04-19 株式会社林原生物化学研究所 Skin preparation for external use characterized by containing sugar derivative of a,a-trehalose
CN1803124A (en) * 2005-01-12 2006-07-19 东海生物科技股份有限公司 Gama-poly glutamic acid, gama-poly glutamic acid salt and use of hydrogel thereof
CN105963204A (en) * 2016-06-27 2016-09-28 中国人民解放军总医院 Anti-allergic mask with moisturizing and repairing functions and preparation method of anti-allergic mask

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