CN106729398B - 一种具有治疗痤疮作用的药物组合物 - Google Patents
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Abstract
本发明公开了一种具有治疗痤疮作用的药物组合物，按重量计由下述组分制成：积雪草1‑10份、当归根1‑10份、甘草根1‑10份、地榆根1‑10份、紫草1‑10份、三棱1‑10份、凤尾草1‑10份、广西莪术1‑10份、白花蛇舌草1‑10份和黄芩根1‑10份。实验证明，本发明的组合物有良好的治疗痤疮的作用，疗效确切，无刺激性，无不良反应。
Description
技术领域
本发明涉及一种护肤组合物，特别是涉及一种具有治疗痤疮作用的药物组合物。
背景技术
痤疮是一种临床常见的毛囊皮脂腺的慢性炎症性疾病。痤疮的发生与雄激素过高、皮质腺分泌增多，同时使毛囊、皮脂腺异角化过度,角质层脱落的扁平的死细胞落下毛囊漏斗部,与皮脂结合,产生混合物。如果这些混合物不能自由排出皮肤表面,而淤积于毛囊内形成脂栓。当这些异常角化细胞聚集,下部漏斗膨胀时就形成成熟的粉刺。皮脂被毛囊中存在的细菌分解,产生脂肪酸,后者刺激毛囊引起炎症,致使毛囊壁损伤破裂,毛囊内容物进入真皮,从而,引起毛囊周围程度不等的炎症反应。
随着人们消费观念的日益成熟，消费者对治疗痤疮的产品的关注重点不仅仅在于其功效性，同时也更注重其安全性。相比具有如刺激性等安全风险的化妆品而言，中药来源的天然制剂具有安全、温和、持久、高效等优点，已成为现在治疗痤疮化妆品研究开发的一大趋势。
发明内容
本发明的目的是提供一种具有治疗痤疮作用的药物组合物。
本发明的技术方案概述如下：
一种具有治疗痤疮作用的药物组合物，按重量包括下述组分：积雪草1-10份、当归根1-10份、甘草根1-10份、地榆根1-10份、紫草1-10份、三棱1-10份、凤尾草1-10份、广西莪术1-10份、白花蛇舌草1-10份和黄芩根1-10份。
优选地，所述积雪草1份、当归根3份、甘草根3份、地榆根3份、紫草8份、三棱2份、凤尾草3份、广西莪术3份、白花蛇舌草6份和黄芩根6份。
实验证明，本发明的组合物有良好的治疗痤疮的作用，疗效确切，无刺激性，无不良反应。
具体实施方式
下面结合具体实施例对本发明作进一步的说明。
实施例1
一种具有治疗痤疮作用的药物组合物，按重量包括下述组分：积雪草1份、当归根3份、甘草根3份、地榆根3份、紫草8份、三棱2份、凤尾草3份、广西莪术3份、白花蛇舌草6份和黄芩根6份；
实施例2
一种具有治疗痤疮作用的药物组合物，按重量包括下述组分：积雪草1份、当归根10份、甘草根5份、地榆根1份、紫草1份、三棱10份、凤尾草5份、广西莪术10份、白花蛇舌草5份和黄芩根1份；
实施例3
一种具有治疗痤疮作用的药物组合物，按重量包括下述组分：积雪草10份、当归根5份、甘草根1份、地榆根5份、紫草5份、三棱1份、凤尾草1份、广西莪术5份、白花蛇舌草1份和黄芩根10份；
实施例4
一种具有治疗痤疮作用的药物组合物，按重量包括下述组分：积雪草5份、当归根1份、甘草根10份、地榆根10份、紫草10份、三棱5份、凤尾草10份、广西莪术1份、白花蛇舌草10份和黄芩根5份；
实施例5
一种具有治疗痤疮作用的药物组合物软膏制备
按照实施例1的药物组合物的各重量组分：积雪草、当归根、甘草根、地榆根、三棱、凤尾草、广西莪术、白花蛇舌草和黄芩根混合，得混合物，加入混合物重量20倍的纯净水，浸泡2小时，煎煮2小时，滤过，滤液浓缩至60℃时相对密度为1.02，得到药物组合物水提浓缩液；
向紫草中加入10重量倍的橄榄油，浸泡48h，滤过，得到紫草油；
取药物组合物水提浓缩液，加入1/5倍质量的甘油，混匀为A相；取紫草油，加入3/5倍质量的硬脂酸，1/5倍质量的单硬脂酸甘油酯，1/20倍质量的三乙醇胺，混匀为B相。
A相与B相分别加热至80℃，混合，搅拌均匀，得到一种具有治疗痤疮作用的药物组合物软膏。
实施例2、3、4的组合物采用上述方法制备出相应的软膏。
实验
(1)选择100例痤疮患者，年龄16-20岁36例；20-30岁30例,30-40岁34例。
(2)方法：100例患者随机分为5组。1、2、3、4治疗组分别使用实施例1、2、3、4的组合物按实施例5的方法制备的软膏。
使用方法为：每日早晚用清水清洁面部后，将组合物均匀涂抹于患处。每天2次，治疗28天。对照组使用空白基质(以纯净水代替药物组合物水提浓缩液，以橄榄油代替紫草油，其它同实施例5的制备方法)。治疗期间患者忌食辛辣刺激食品。
(3)疗效判定标准：根据《中医病症诊断疗效标准》结合临床拟定。
治愈:皮肤损害消退,自觉症状消失好转；
好转:自觉症状明显减轻,皮损消退30％以上；
未愈:皮损及症状均无变化或消退不及30％。
(4)结果
临床疗效见表1。
4组治疗组疗效分别于对照组比较差异有统计学意义(P＜0.01)，治疗组疗效均优于对照组。实验结果表明，本发明药物组合物具有治疗痤疮的作用，治疗效果明显。
表1治疗效果比较
**：P<0.01。
Claims (2)
1.一种具有治疗痤疮作用的药物组合物软膏，其特征是用下述方法制成：
1)按重量取：积雪草1-10份、当归根1-10份、甘草根1-10份、地榆根1-10份、紫草1-10份、三棱1-10份、凤尾草1-10份、广西莪术1-10份、白花蛇舌草1-10份和黄芩根1-10份；
2)将所述积雪草、当归根、甘草根、地榆根、三棱、凤尾草、广西莪术、白花蛇舌草和黄芩根混合，得混合物，加入混合物重量20倍的纯净水，浸泡2小时，煎煮2小时，滤过，滤液浓缩至60℃时相对密度为1.02，得到药物组合物水提浓缩液；向紫草中加入10重量倍的橄榄油，浸泡48h，滤过，得到紫草油；
3)取药物组合物水提浓缩液，加入1/5倍质量的甘油，混匀为A相；取紫草油，加入3/5倍质量的硬脂酸，1/5倍质量的单硬脂酸甘油酯，1/20倍质量的三乙醇胺，混匀为B相；
4)A相与B相分别加热至80℃，混合，搅拌均匀，得到一种具有治疗痤疮作用的药物组合物软膏。
2.根据权利要求1所述的一种具有治疗痤疮作用的药物组合物软膏，其特征是所述积雪草1份、当归根3份、甘草根3份、地榆根3份、紫草8份、三棱2份、凤尾草3份、广西莪术3份、白花蛇舌草6份和黄芩根6份。
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