CN106728462A - A kind of fragrant plant mentioned in ancient texts heat-clearing lozenge and its production method - Google Patents

A kind of fragrant plant mentioned in ancient texts heat-clearing lozenge and its production method Download PDF

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CN106728462A
CN106728462A CN201510820389.9A CN201510820389A CN106728462A CN 106728462 A CN106728462 A CN 106728462A CN 201510820389 A CN201510820389 A CN 201510820389A CN 106728462 A CN106728462 A CN 106728462A
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fragrant plant
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戴路
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Harbin Moyi Biotechnology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/27Asclepiadaceae (Milkweed family), e.g. hoya
    • AHUMAN NECESSITIES
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482Cassia, e.g. golden shower tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/87Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
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    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
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    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

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Abstract

A kind of fragrant plant mentioned in ancient texts heat-clearing lozenge and its production method.By fragrant plant mentioned in ancient texts, cyperus awns, drop smell good, pear skin, largeleaf dogwood wood, corniculate cayratia root, trailing plants Japonica, caper seed, carboxymethylcellulose calcium, Water soluble starch, Glucose Constituted Deng raw material, finished product is made by sorting, drying, decoction, mixing, powder processed, compressing tablet, packaging. Active ingredient in Chinese medicine is decocted and is made extract solution by the present invention, active ingredient is combined with lozenge, the nutriment in the Chinese medicine being effectively kept;By the proportioning of science, when product of the present invention is nourished human body, with mending without dry, trophic structure rationally, strengthens effect of human body constitution.The present invention Have Health care, heat-clearing, pure natural, pollution-free, no side effectses, the advantages of conveniently take and nourish the body.

Description

A kind of fragrant plant mentioned in ancient texts heat-clearing lozenge and its production method
Technical field:
The present invention relates to field of food health care, and in particular to a kind of fragrant plant mentioned in ancient texts heat-clearing lozenge and its production method.
Background technology
Buccal tablet refers to the compressed tablets for being contained in slow mechanism dissolved in oral cavity, and lozenge will have tempting color from inside to outside, so that the mouthfeel that user has had.Therefore, the figuration composition in lozenge, such as sugar, pigment additive often " a presumptuous guest usurps the role of the host " so that some by mistake lozenge is regarded as " sugar ".
At present, most of lozenge of in the market is all medicine, and most of medicines for being to treat Throat diseases, and narrow application range, therapeutic effect is general.And it is few using the utilization rate for being processed into health products containing chip technology, it is few to body-care effect, it is impossible to meet the market demand.
The content of the invention:
It is an object of the invention to provide one kind collection heat-clearing, it is pure natural, pollution-free, No side effectses are conveniently taken and are nourished the body in one Fragrant plant mentioned in ancient texts heat-clearing lozenge and production method.
The object of the present invention is achieved like this.It is that the raw material matched somebody with somebody by following weight is made, Fragrant plant mentioned in ancient texts 15-30 Part, cyperus awns 10-20 Part, drop smell good 5-15 Part, pear skin 3-15 Part, largeleaf dogwood wood 3-15 Part, corniculate cayratia root 3-10 Part, trailing plants Japonica 4-12 Part, caper seed 6-9 Part, carboxymethylcellulose calcium 7-10 Part, water soluble starch 4-8 Part, glucose 10-15 Part.
Preparing fragrant plant mentioned in ancient texts heat-clearing lozenge preferred weight ratio range of the present invention is, Fragrant plant mentioned in ancient texts 15-25 Part, cyperus awns 10-15 Part, drop smell good 5-12 Part, pear skin 3-10 Part, largeleaf dogwood wood 3-10 Part, corniculate cayratia root 3-8 Part, trailing plants Japonica 4-10 Part, caper seed 6-8 Part, carboxymethylcellulose calcium 7-9 Part, water soluble starch 4-7 Part, glucose 10-14 Part.
Preparing fragrant plant mentioned in ancient texts heat-clearing lozenge best weight ratio scope of the present invention is, Fragrant plant mentioned in ancient texts 20 Part, cyperus awns 12 Part, drop smell good 10 Part, pear skin 8 Part, largeleaf dogwood wood 8 Part, corniculate cayratia root 5 Part, trailing plants Japonica 8 Part, caper seed 7 Part, carboxymethylcellulose calcium 8 Part, water soluble starch 6 Part, glucose 12 Part.
Above-mentioned each component is made the production method of fragrant plant mentioned in ancient texts heat-clearing lozenge of the present invention, technical process is:Sorting, drying, decoction, mixing, powder processed, compressing tablet, packaging, concrete operation method follow these steps to successively:
A , sorting, by raw material weight proportioning of soup processed, select meet the fragrant plant mentioned in ancient texts of national health and quality standard, cyperus awns, drop smell good, pear skin, largeleaf dogwood wood, corniculate cayratia root, trailing plants Japonica, caper seed, carboxymethylcellulose calcium, Water soluble starch, Glucose feed is standby;
B , drying, except carboxymethylcellulose calcium, Water soluble starch, Outside glucose, other raw materials are cut into block or sheet and are placed in desiccation in drying baker respectively, and temperature control exists 80-100 DEG C, the time 45 Minute, raw material moisture is evaporated to water content 18% , compressing tablet;
C , decoct, by above-mentioned ratio of weight and number, decocted during the raw material addition after drying is put into decocting device 2 It is secondary, add for the first time 7 Times water is decocted 1.5 Hour, second frame 5 Times water is decocted 1 Hour, filtrate is extracted in filtering respectively, will filtrate merging twice, the secondary filter dregs of a decoction and impurity, prepared extract solution;
D , mixing, by above-mentioned ratio of weight and number, carboxymethylcellulose calcium, water soluble starch, glucose will be added to be sufficiently mixed uniformly in extract solution, prepared mixed liquor;
E , powder processed, the filtrate of above-mentioned mixed liquor is cooled to room temperature, filtrate is made mixed powder using spray drying process, it is standby;
F , compressing tablet, by above-mentioned mixed powder remove production process in generation impurity, then using the mode and ultraviolet compressing tablet mode compressing tablet for radiating compressing tablet;Tablet press machine direct tablet compressing is utilized after compressing tablet;
G , packaging, by the good tablet of above-mentioned pressing according to specification for sale pack.
With lozenge be combined the traditional Chinese medicine ingredients for having good tonic effect to human body by the present invention, there is more preferable assimilation effect compared to existing lozenge, it is convenient for people to usually take, conditioning health, increase metabolism balance in vivo, regulation human body homeostasis is softer, and lifting constitution is gentler, effective for a long time can increase human body power and work endurance.
Active ingredient in Chinese medicine is decocted and is made extract solution by the present invention, active ingredient is combined with lozenge, the nutriment in the Chinese medicine being effectively kept;By the proportioning of science, when product of the present invention is nourished human body, with mending without dry, trophic structure rationally, strengthens effect of human body constitution.
In inventive formulation, fragrant plant mentioned in ancient texts heat-clearing;Resolving phlegm and softening hard masses;Li Shui;Heat in main;Phlegm knot goiter and tumor;Difficult urination;Cyperus awns clears liver and improve vision, during stomach invigorating is adjusted, ease constipation removing toxic substances;Main red eye, swell pain, dizzy alliteration, oral cavity anabrosis, habitual constipation, infantile malnutrition, dysentery, malaria; Qi-regulating of smelling good, hemostasis, the row stasis of blood, analgesic therapy are dropped;Haematemesis is controlled, is spat blood, metal-inflicted wound bleeding, traumatic injury, ulcer sore swells, lumbago, skelalgia of rheumatism, heart peratodynia;Pear skin heart clearing, lung moistening, fall fire is promoted the production of body fluid;Hot summer weather polydipsia is controlled, is coughed, spitted blood, carbuncle on the back, furunculosis;Largeleaf dogwood wood promoting blood circulation and stopping pain;Nourishing blood and preventing abortion;Main injury and bone fracture;Blood stasis and swelling pain;Blood deficiency chlorosis;Fetal irritability;Corniculate cayratia root moistens the lung and relieve the cough;Hemostasis;Main pulmonary tuberculosis cough;Blood-stained sputum;Uterine bleeding;Trailing plants Japonica nourishing the essence and strengthening QI, leads to breast, removing toxic substances;Governance wasting internal lesion caused by overexertion, impotence, under band, alactation, erysipelas sore swells; Caper seed heat-clearing is quenched one's thirst, and is hastened parturition;It is thirsty for pyreticosis, sphagitis, malignant sore swollen drug, difficult labour
The present invention is summarized and perfect in taking and clinical verification by many cases patient, constantly, and recipe ratio is more complete, determined curative effect, internally heat, phlegm knot goiter and tumor Deng master Disease Card:Degree difference is served Heat-clearing, resolving phlegm and softening hard masses, Li Shui Effect, Have The advantages of health care, heat-clearing, pure natural, pollution-free, no side effectses.
The present invention through two groups of clinical verifications, for treatment group take lozenge of the present invention, take once a day by one of which, and 7 days is a course for the treatment of, and " Amway " is taken in another group of control, Take once a day, be within 7 days a course for the treatment of, every group selection outpatient 200, wherein man 100, female 100, measure the big age 70 It is year, minimum Age 25 Year, Clinical manifestation be interior heat, phlegm knot goiter and tumor, difficult urination, red eye, swell pain, dizzy alliteration, oral cavity anabrosis, habitual constipation, Traumatic injury , dysentery, malaria , table one is to take the contrasting data after a course for the treatment of:
Table 1 Front and rear two groups of courses for the treatment of are taken to compare ( Unit : People )
There were significant differences for treatment group and control group, it will thus be seen that present invention application clinically has significant curative effect.
Technological advantage of the invention is:1st, raw material and scientific formulation are selected, production technology is advanced, its product produces taste well, convenient storage;2nd, without harmful components such as preservatives in product, nourishing and nutrition of the raw material to human body are kept, is easily absorbed by the body;3rd, raw material sources are extensive, plus process line is short, the manufacture of product easy processing.
Specific embodiment
With reference to specific embodiment, the present invention is further illustrated
Embodiment 1:Suitable for interior heat, phlegm knot goiter and tumor, difficult urination Crowd
Fragrant plant mentioned in ancient texts heat-clearing lozenge of the present invention is prepared to be made up of following component raw material(Consumption is weight portion), Fragrant plant mentioned in ancient texts 15-30 Part, cyperus awns 10-20 Part, drop smell good 5-15 Part, pear skin 3-15 Part, largeleaf dogwood wood 3-15 Part, corniculate cayratia root 3-10 Part, trailing plants Japonica 4-12 Part, caper seed 6-9 Part, carboxymethylcellulose calcium 7-10 Part, water soluble starch 4-8 Part, glucose 10-15 Part.
Embodiment 2:Suitable for red eye, swell pain, dizzy alliteration, oral cavity anabrosis, habitual constipation Crowd
Preparing fragrant plant mentioned in ancient texts heat-clearing lozenge preferred weight ratio range of the present invention is: Fragrant plant mentioned in ancient texts 15-25 Part, cyperus awns 10-15 Part, drop smell good 5-12 Part, pear skin 3-10 Part, largeleaf dogwood wood 3-10 Part, corniculate cayratia root 3-8 Part, trailing plants Japonica 4-10 Part, caper seed 6-8 Part, carboxymethylcellulose calcium 7-9 Part, water soluble starch 4-7 Part, glucose 10-14 Part.
Embodiment 3 :It is applied to Traumatic injury , dysentery, malaria Crowd
Preparing fragrant plant mentioned in ancient texts heat-clearing lozenge best weight ratio scope of the present invention is, 20 parts of fragrant plant mentioned in ancient texts, 12 parts of cyperus awns, drop smell good 10 parts, 8 parts of pear skin, 8 parts of largeleaf dogwood wood, 5 parts of corniculate cayratia root, 8 parts of trailing plants Japonica, 7 parts of caper seed, 8 parts of carboxymethylcellulose calcium, 6 parts of water soluble starch, 12 parts of glucose.
Embodiment 4
Above-mentioned each component is made the production method of fragrant plant mentioned in ancient texts heat-clearing lozenge of the present invention, technical process is:Sorting, drying, decoction, mixing, powder processed, compressing tablet, packaging, concrete operation method follow these steps to successively:
A , sorting, by raw material weight proportioning of soup processed, select meet the fragrant plant mentioned in ancient texts of national health and quality standard, cyperus awns, drop smell good, pear skin, largeleaf dogwood wood, corniculate cayratia root, trailing plants Japonica, caper seed, carboxymethylcellulose calcium, Water soluble starch, Glucose feed is standby;
B , drying, except carboxymethylcellulose calcium, Water soluble starch, Outside glucose, other raw materials are cut into block or sheet and are placed in desiccation in drying baker respectively, and temperature control exists 80-100 DEG C, the time 45 Minute, raw material moisture is evaporated to water content 18% , compressing tablet;
C , decoct, by above-mentioned ratio of weight and number, decocted during the raw material addition after drying is put into decocting device 2 It is secondary, add for the first time 7 Times water is decocted 1.5 Hour, second frame 5 Times water is decocted 1 Hour, filtrate is extracted in filtering respectively, will filtrate merging twice, the secondary filter dregs of a decoction and impurity, prepared extract solution;
D , mixing, by above-mentioned ratio of weight and number, carboxymethylcellulose calcium, water soluble starch, glucose will be added to be sufficiently mixed uniformly in extract solution, prepared mixed liquor;
E , powder processed, the filtrate of above-mentioned mixed liquor is cooled to room temperature, filtrate is made mixed powder using spray drying process, it is standby;
F , compressing tablet, by above-mentioned mixed powder remove production process in generation impurity, then using the mode and ultraviolet compressing tablet mode compressing tablet for radiating compressing tablet;Tablet press machine direct tablet compressing is utilized after compressing tablet;
G , packaging, by the good tablet of above-mentioned pressing according to specification for sale pack.
Embodiment 2
If adding appropriate disintegrant such as in the prescription of lozenge CMS-Na Improve and contain tablet stability, or add the mediation mouthfeel such as cane sugar powder, mannitol, sorbierite, various sweeteners, essence.

Claims (4)

1. a kind of fragrant plant mentioned in ancient texts heat-clearing lozenge, it is characterised in that:It is that the raw material matched by following weight is made, fragrant plant mentioned in ancient texts 15-30 part, 10-20 parts of cyperus awns, drop and smell good 5-15 parts, pear skin 3-15 parts, largeleaf dogwood wood 3-15 parts, corniculate cayratia root 3-10 parts, 4-12 parts, caper seed 6-9 parts, carboxymethylcellulose calcium 7-10 parts, water soluble starch 4-8 parts, glucose 10-15 parts of trailing plants Japonica.
2. a kind of fragrant plant mentioned in ancient texts heat-clearing lozenge according to claim 1, it is characterised in that:The weight proportion of wherein various raw materials is, fragrant plant mentioned in ancient texts 15-25 parts, 10-15 parts of cyperus awns, drop smell good 5-12 parts, pear skin 3-10 parts, largeleaf dogwood wood 3-10 parts, corniculate cayratia root 3-8 parts, 4-10 parts, caper seed 6-8 parts, carboxymethylcellulose calcium 7-9 parts, water soluble starch 4-7 parts, glucose 10-14 parts of trailing plants Japonica.
3. a kind of fragrant plant mentioned in ancient texts heat-clearing lozenge according to claim 1, it is characterised in that:The weight proportion of wherein various raw materials is, 20 parts of fragrant plant mentioned in ancient texts, 12 parts of cyperus awns, drop smell good 10 parts, 8 parts of pear skin, 8 parts of largeleaf dogwood wood, 5 parts of corniculate cayratia root, 8 parts of trailing plants Japonica, 7 parts of caper seed, 8 parts of carboxymethylcellulose calcium, 6 parts of water soluble starch, 12 parts of glucose.
4. the production method of the fragrant plant mentioned in ancient texts heat-clearing lozenge according to claim 1-3, it is characterised in that:Technical process is:Sorting, drying, decoction, mixing, powder processed, compressing tablet, packaging, concrete operation method follow these steps to successively:
A, sorting, by raw material weight proportioning of soup processed, select meet the fragrant plant mentioned in ancient texts of national health and quality standard, cyperus awns, drop smell good, pear skin, largeleaf dogwood wood, corniculate cayratia root, trailing plants Japonica, caper seed, carboxymethylcellulose calcium, water soluble starch, glucose feed it is standby;
B, drying, in addition to carboxymethylcellulose calcium, water soluble starch, glucose, other raw materials are cut into block or sheet and are placed in desiccation in drying baker respectively, and temperature control 45 minutes time, makes raw material moisture be evaporated to water content 18%, compressing tablet at 80-100 DEG C;
C, decoction, by above-mentioned ratio of weight and number, decocted 2 times during the raw material addition after drying is put into decocting device, for the first time plus 7 times of waters are decocted 1.5 hours, second frame, 5 times of waters are decocted 1 hour, and filtrate is extracted in filtering respectively, filtrate will be merged twice, the secondary filter dregs of a decoction and impurity, are obtained extract solution;
D, mixing, by above-mentioned ratio of weight and number, carboxymethylcellulose calcium, water soluble starch, glucose will be added to be sufficiently mixed uniformly in extract solution, prepared mixed liquor;
E, powder processed, the filtrate of above-mentioned mixed liquor is cooled to room temperature, filtrate is made mixed powder using spray drying process, it is standby;
F, compressing tablet, the impurity that above-mentioned mixed powder is removed the generation in production process, then using the mode and ultraviolet compressing tablet mode compressing tablet for radiating compressing tablet;Tablet press machine direct tablet compressing is utilized after compressing tablet;
G, packaging, by the good tablet of above-mentioned pressing according to specification for sale pack.
CN201510820389.9A 2015-11-24 2015-11-24 A kind of fragrant plant mentioned in ancient texts heat-clearing lozenge and its production method Pending CN106728462A (en)

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CN104940660A (en) * 2014-03-27 2015-09-30 哈尔滨浩拓生物科技开发有限公司 Pleurotus sajor-caju dissolved granules capable of clearing heat and relieving cough and production method thereof

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