CN106728287A - A kind of Chinese and Western medicine combination for treating hylactic pneumonia and preparation method thereof - Google Patents
A kind of Chinese and Western medicine combination for treating hylactic pneumonia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Chinese and Western medicine combination for treating hylactic pneumonia, the Chinese and Western medicine combination of the treatment hylactic pneumonia is according to the primary raw material of weight portion：8 15 parts of perillaseed, 17 26 parts of the fruit of Chinese magnoliavine, 8 15 parts of radish seed, 11 16 parts of the Fen, fraxinellones of panax japonicus saponin IVa 6 10,15 20 parts of ethyl palmitate, 6 10 parts of Irinotecan, 30 40 parts of yejuhua lactone, silver-colored 58 parts of linden glucoside, 7 16 parts of purpurin, 26 parts of karanjin, 59 parts of Tetrahydrocoptisine.Medicine of the present invention is strictly selected material composition according to the understanding mechanism of hylactic pneumonia, so as to reach the purpose of comprehensive rehabilitation, with rapid-action, effect stabilization, carry convenient to take, long-term taking and have no toxic side effect the characteristics of.
Description
Technical field
The present invention relates to a kind of field of medicine preparation, specifically a kind of Chinese and Western medicine combination for treating hylactic pneumonia.
Background technology
Hylactic pneumonia refers to various with antigenic organic dust, low-molecular-weight chemistry material etc. by sucking repeatedly
Other anaphylactogens, so as to the swollen property tuberculosis of the one group of diffusivity interstitial granulomatous dermatitis for causing.The generation of hylactic pneumonia is mainly and season
Property atmosphere pollution, indoor microorganism pollution it is relevant, the environment of etiology must be departed from before patient's treatment, make its breathing smooth simultaneously
And cause the material of pulmonary abnormalities reaction in air without other.Common anaphylactogen be mainly containing fungal spore, bacterial product,
The organic matter dust granules of animal protein or insect antigen, after suction anaphylactogen small number of patients occur pant, before runny nose etc.
Phase symptom, starts reaction symptom occur after 3~6 hours, be usually expressed as heating, dry cough, be short of breath, pectoralgia and anoxic, mouth
Lip, refer to toe end cyanosis etc., above-mentioned symptom reaches peak within 6~8 hours, and symptom disappears substantially within 24 hours, during breaking-out physical signs of lung with
Different during asthma attack, more without sound of stridulating, what is mainly heard is moist rales.Acute allergic pneumonia is often behind contact allergy source
4~8 hours fall ill, performance symptom be heating, chilly, cough, expiratory dyspnea, apocleisis, nausea and vomiting, disengaging anaphylactogen it
Afterwards, symptom improves typically within a few houres, but recovers to need several weeks completely, and recurrent exerbation can cause pulmonary fibrosis；Subacute allergy
Property symptoms of pneumonia breaking-out it is slow, to several weeks, the state of an illness person of continuing to develop needs hospitalization for cough and expiratory dyspnea last for days；Slowly
Property hylactic pneumonia patient, generally after sexuality is carried out occur expiratory dyspnea, cough, weak and Body weight loss up to the several months extremely
Several years, severe patient can develop into respiratory failure, therefore early diagnose and depart from the crucial institute that anaphylactogen is treated in time.Current medicine
Thing treatment is mainly long-term steroid, can alleviate and eliminate Acute Exacerbation Period symptom, and can prevent permanent lesion such as bronchus
The generation of expansion, irreversibility airway obstruction and pulmonary fibrosis.But more importantly treated and prevented since the initial stage, therefore
Needing a kind of medicine can play a part of the infringement that prevent and treat hylactic pneumonia and can reduce for human body PFT.
The content of the invention
It is an object of the invention to provide a kind of Chinese and Western medicine combination for treating hylactic pneumonia, to solve above-mentioned background technology
The problem of middle proposition.
To achieve the above object, the present invention provides following technical scheme：
A kind of Chinese and Western medicine combination for treating hylactic pneumonia, be according to the primary raw material of weight portion：Perillaseed 8-15 parts, the five tastes
It is sub- 17-26 parts, radish seed 8-15 parts, 11-16 parts of panax japonicus saponin IVa 6-10 Fen, fraxinellones, ethyl palmitate 15-20 parts, she
It is vertical for health 6-10 part, yejuhua lactone 30-40 parts, 5-8 parts of linden glucoside of silver, purpurin 7-16 parts, karanjin 2-6 parts, four
5-9 parts of hydrogen coptisine.
As further scheme of the invention：The Chinese and Western medicine combination of the treatment hylactic pneumonia, according to the master of weight portion
The raw material is wanted to be：Perillaseed 9-13 parts, fruit of Chinese magnoliavine 19-22 parts, radish seed 10-12 parts, panax japonicus saponin IVa 7-9 Fen, fraxinellones 12-14
Part, ethyl palmitate 15-20 part, Irinotecan 6-10 parts, yejuhua lactone 34-37 parts, silver 5-8 parts of linden glucoside, purpurin
7-16 parts, karanjin 3-4 parts, Tetrahydrocoptisine 5-9 parts.
As further scheme of the invention：The Chinese and Western medicine combination of the treatment hylactic pneumonia, according to the master of weight portion
The raw material is wanted to be：11 parts of perillaseed, 21 parts of the fruit of Chinese magnoliavine, 11 parts of radish seed, 13 parts of the Fen, fraxinellones of panax japonicus saponin IVa 8, ethyl palmitate
18 parts, 8 parts of Irinotecan, 36 parts of yejuhua lactone, silver-colored 7 parts of linden glucoside, 12 parts of purpurin, 4 parts of karanjin, the tetrahydrochysene coptis
8 parts of alkali.
A kind of preparation method of the Chinese and Western medicine combination for treating hylactic pneumonia, concretely comprises the following steps：
First, in pharmaceutical grade clean area, perillaseed, the fruit of Chinese magnoliavine, radish seed, panax japonicus saponin are weighed by above-mentioned metering ratio
IVa, fraxinellones, ethyl palmitate, Irinotecan, yejuhua lactone, silver-colored linden glucoside, purpurin, karanjin, the tetrahydrochysene coptis
Alkali, sieving, machinery adds ultra-pure water after mixing, place in pharmacy mixer, mixes 4-8min, RSD≤5% is controlled, after mixing
Compressing tablet and low temperature drying, at 4-8 DEG C, packaging obtains final product the Chinese and Western medicine combination for the treatment of hylactic pneumonia to temperature control.
As further scheme of the invention：Mix 6min in specific steps.
Compared with prior art, the beneficial effects of the invention are as follows：
Medicine of the present invention is strictly selected material composition according to the understanding mechanism of hylactic pneumonia, so as to reach comprehensively
The purpose of rehabilitation, with rapid-action, effect stabilization, carry convenient to take, long-term taking and have no toxic side effect the characteristics of.
Specific embodiment
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment is only a part of embodiment of the invention, rather than whole embodiments.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made, all
Belong to the scope of protection of the invention.
Embodiment 1
A kind of Chinese and Western medicine combination for treating hylactic pneumonia, be according to the primary raw material of weight portion：8 parts of perillaseed, the fruit of Chinese magnoliavine
17 parts, 8 parts of radish seed, 11 parts of the Fen, fraxinellones of panax japonicus saponin IVa 6,15 parts of ethyl palmitate, 6 parts of Irinotecan, in chrysanthemum indicum
30 parts of ester, silver-colored 5 parts of linden glucoside, 7 parts of purpurin, 2 parts of karanjin, 5 parts of Tetrahydrocoptisine.
A kind of preparation method of the Chinese and Western medicine combination for treating hylactic pneumonia, concretely comprises the following steps：
First, in pharmaceutical grade clean area, perillaseed, the fruit of Chinese magnoliavine, radish seed, panax japonicus saponin are weighed by above-mentioned metering ratio
IVa, fraxinellones, ethyl palmitate, Irinotecan, yejuhua lactone, silver-colored linden glucoside, purpurin, karanjin, the tetrahydrochysene coptis
Alkali, sieving, machinery adds ultra-pure water after mixing, place in pharmacy mixer, mixes 4min, controls RSD≤5%, is pressed after mixing
Piece and low temperature drying, at 4 DEG C, packaging obtains final product the Chinese and Western medicine combination for the treatment of hylactic pneumonia to temperature control.
Embodiment 2
A kind of Chinese and Western medicine combination for treating hylactic pneumonia, be according to the primary raw material of weight portion：9 parts of perillaseed, the fruit of Chinese magnoliavine
19 parts, 10 parts of radish seed, 12 parts of the Fen, fraxinellones of panax japonicus saponin IVa 7,15 parts of ethyl palmitate, 6 parts of Irinotecan, chrysanthemum indicum
34 parts of lactone, silver-colored 5 parts of linden glucoside, 7 parts of purpurin, 3 parts of karanjin, 5 parts of Tetrahydrocoptisine.
A kind of preparation method of the Chinese and Western medicine combination for treating hylactic pneumonia, concretely comprises the following steps：
First, in pharmaceutical grade clean area, perillaseed, the fruit of Chinese magnoliavine, radish seed, panax japonicus saponin are weighed by above-mentioned metering ratio
IVa, fraxinellones, ethyl palmitate, Irinotecan, yejuhua lactone, silver-colored linden glucoside, purpurin, karanjin, the tetrahydrochysene coptis
Alkali, sieving, machinery adds ultra-pure water after mixing, place in pharmacy mixer, mixes 4min, controls RSD≤5%, is pressed after mixing
Piece and low temperature drying, at 4 DEG C, packaging obtains final product the Chinese and Western medicine combination for the treatment of hylactic pneumonia to temperature control.
Embodiment 3
A kind of Chinese and Western medicine combination for treating hylactic pneumonia, be according to the primary raw material of weight portion：11 parts of perillaseed, the fruit of Chinese magnoliavine
21 parts, 11 parts of radish seed, 13 parts of the Fen, fraxinellones of panax japonicus saponin IVa 8,18 parts of ethyl palmitate, 8 parts of Irinotecan, chrysanthemum indicum
36 parts of lactone, silver-colored 7 parts of linden glucoside, 12 parts of purpurin, 4 parts of karanjin, 8 parts of Tetrahydrocoptisine.
A kind of preparation method of the Chinese and Western medicine combination for treating hylactic pneumonia, concretely comprises the following steps：
First, in pharmaceutical grade clean area, perillaseed, the fruit of Chinese magnoliavine, radish seed, panax japonicus saponin are weighed by above-mentioned metering ratio
IVa, fraxinellones, ethyl palmitate, Irinotecan, yejuhua lactone, silver-colored linden glucoside, purpurin, karanjin, the tetrahydrochysene coptis
Alkali, sieving, machinery adds ultra-pure water after mixing, place in pharmacy mixer, mixes 6min, controls RSD≤5%, is pressed after mixing
Piece and low temperature drying, at 6 DEG C, packaging obtains final product the Chinese and Western medicine combination for the treatment of hylactic pneumonia to temperature control.
Embodiment 4
A kind of Chinese and Western medicine combination for treating hylactic pneumonia, be according to the primary raw material of weight portion：13 parts of perillaseed, the fruit of Chinese magnoliavine
22 parts, 12 parts of radish seed, 14 parts of the Fen, fraxinellones of panax japonicus saponin IVa 9,20 parts of ethyl palmitate, 10 parts of Irinotecan, chrysanthemum indicum
37 parts of lactone, silver-colored 8 parts of linden glucoside, 16 parts of purpurin, 4 parts of karanjin, 9 parts of Tetrahydrocoptisine.
A kind of preparation method of the Chinese and Western medicine combination for treating hylactic pneumonia, concretely comprises the following steps：
First, in pharmaceutical grade clean area, perillaseed, the fruit of Chinese magnoliavine, radish seed, panax japonicus saponin are weighed by above-mentioned metering ratio
IVa, fraxinellones, ethyl palmitate, Irinotecan, yejuhua lactone, silver-colored linden glucoside, purpurin, karanjin, the tetrahydrochysene coptis
Alkali, sieving, machinery adds ultra-pure water after mixing, place in pharmacy mixer, mixes 8min, controls RSD≤5%, is pressed after mixing
Piece and low temperature drying, at 8 DEG C, packaging obtains final product the Chinese and Western medicine combination for the treatment of hylactic pneumonia to temperature control.
Embodiment 5
A kind of Chinese and Western medicine combination for treating hylactic pneumonia, be according to the primary raw material of weight portion：15 parts of perillaseed, the fruit of Chinese magnoliavine
26 parts, 15 parts of radish seed, 16 parts of the Fen, fraxinellones of panax japonicus saponin IVa 10,20 parts of ethyl palmitate, 10 parts of Irinotecan, mother chrysanthemum
40 parts of flower lactone, silver-colored 8 parts of linden glucoside, 16 parts of purpurin, 6 parts of karanjin, 9 parts of Tetrahydrocoptisine.
A kind of preparation method of the Chinese and Western medicine combination for treating hylactic pneumonia, concretely comprises the following steps：
First, in pharmaceutical grade clean area, perillaseed, the fruit of Chinese magnoliavine, radish seed, panax japonicus saponin are weighed by above-mentioned metering ratio
IVa, fraxinellones, ethyl palmitate, Irinotecan, yejuhua lactone, silver-colored linden glucoside, purpurin, karanjin, the tetrahydrochysene coptis
Alkali, sieving, machinery adds ultra-pure water after mixing, place in pharmacy mixer, mixes 8min, controls RSD≤5%, is pressed after mixing
Piece and low temperature drying, at 8 DEG C, packaging obtains final product the Chinese and Western medicine combination for the treatment of hylactic pneumonia to temperature control.
Pharmacology test
1st, chronic toxicity test
Experiment is combined as with Chinese and Western medicine obtained in the embodiment of the present invention 3, using gastric infusion mode, is continuously given in 24h
Medicine 2 times, per minor tick 8h, is administered 400mg/kg doses every time, and daily accumulation medicine total amount reaches 800mg medicines/kg, equivalent to people
100 times of quantity.After administration in 7d, mouse activity, feed, excretion are normal, well-grown, hair color light, and its is average
Body weight increases with the extension of experimental period.Every mouse of post mortem at 8d, visually observe the heart, liver, spleen, lung, kidney,
Brain, thymus gland, stomach, intestines etc. do not find color and paramophia, fail to measure median lethal dose (LD50).Result shows：This hair
Bright Chinese and Western medicine combination is without chronic toxicity.
2nd, long term toxicity test
Experiment is combined as with Chinese and Western medicine obtained in the embodiment of the present invention 3, using gastric infusion mode, by Chinese and Western medicine of the present invention
Combination is divided into low dosage, middle dosage, three groups of high dose, the drug dose of each group is respectively 80,160,240mg medicines/kg/d, phase
When in 10,20,30 times of clinical dosage.After gastric infusion 24 weeks, medicine of the present invention refers to the general status of animal, hematology
Mark, blood parameters without obvious influence, Systematic anatomy, organ coefficient and histopathological examination also no abnormal disease
Reason changes.It is discontinued 2 weeks and also has no substantially change.Result shows：Chinese and Western medicine combination of the present invention does not find in long term toxicity test
Overt toxicity reacts and delayed toxicity reaction.It can be seen that, Chinese and Western medicine of the present invention combines non-toxic reaction, and long-term prescription is safe and reliable.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be in other specific forms realized.Therefore, no matter
From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit requires to be limited rather than described above, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the present invention.
Moreover, it will be appreciated that although the present specification is described in terms of embodiments, not each implementation method is only wrapped
Containing an independent technical scheme, this narrating mode of specification is only that for clarity, those skilled in the art should
Specification an as entirety, the technical scheme in each embodiment can also be formed into those skilled in the art through appropriately combined
May be appreciated other embodiment.
Claims (5)
1. a kind of Chinese and Western medicine combination for treating hylactic pneumonia, it is characterised in that the primary raw material according to weight portion is：Perillaseed 8-
15 parts, fruit of Chinese magnoliavine 17-26 parts, radish seed 8-15 parts, 11-16 parts of panax japonicus saponin IVa 6-10 Fen, fraxinellones, ethyl palmitate
15-20 parts, Irinotecan 6-10 parts, yejuhua lactone 30-40 parts, silver-colored 5-8 parts of linden glucoside, purpurin 7-16 parts, Indian beech
It is plain 2-6 parts, Tetrahydrocoptisine 5-9 parts.
2. the Chinese and Western medicine combination for the treatment of hylactic pneumonia according to claim 1, it is characterised in that the treatment anaphylaxis
The Chinese and Western medicine combination of pneumonia, be according to the primary raw material of weight portion：Perillaseed 9-13 parts, fruit of Chinese magnoliavine 19-22 parts, radish seed 10-12
Part, 12-14 parts of panax japonicus saponin IVa 7-9 Fen, fraxinellones, ethyl palmitate 15-20 parts, Irinotecan 6-10 parts, in chrysanthemum indicum
Ester 34-37 parts, silver-colored 5-8 parts, purpurin 7-16 parts, karanjin 3-4 parts, Tetrahydrocoptisine 5-9 parts of linden glucoside.
3. the Chinese and Western medicine combination for the treatment of hylactic pneumonia according to claim 1 and 2, it is characterised in that described to treat
The Chinese and Western medicine combination of quick property pneumonia, be according to the primary raw material of weight portion：11 parts of perillaseed, 21 parts of the fruit of Chinese magnoliavine, 11 parts of radish seed, bamboo
13 parts of the Fen, fraxinellones of section ginseng saponin I Va 8,18 parts of ethyl palmitate, 8 parts of Irinotecan, 36 parts of yejuhua lactone, silver-colored 7 parts of linden glucoside,
12 parts of purpurin, 4 parts of karanjin, 8 parts of Tetrahydrocoptisine.
4. the preparation method that a kind of Chinese and Western medicine for the treatment of hylactic pneumonia as described in claim 1-3 is any is combined, its feature
It is to concretely comprise the following steps：
First, in pharmaceutical grade clean area, perillaseed, the fruit of Chinese magnoliavine, radish seed, panax japonicus saponin IVa, Ash are weighed by above-mentioned metering ratio
Ketone, ethyl palmitate, Irinotecan, yejuhua lactone, silver-colored linden glucoside, purpurin, karanjin, Tetrahydrocoptisine, sieving,
Machinery adds ultra-pure water after mixing, and places in pharmacy mixer, mixes 4-8min, controls RSD≤5%, compressing tablet and low after mixing
Temperature is dried, and at 4-8 DEG C, packaging obtains final product the Chinese and Western medicine combination for the treatment of hylactic pneumonia to temperature control.
5. the preparation method that the Chinese and Western medicine for the treatment of hylactic pneumonia according to claim 4 is combined, it is characterised in that specific
Mix 6min in step.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611189082.4A CN106728287A (en) | 2016-12-21 | 2016-12-21 | A kind of Chinese and Western medicine combination for treating hylactic pneumonia and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611189082.4A CN106728287A (en) | 2016-12-21 | 2016-12-21 | A kind of Chinese and Western medicine combination for treating hylactic pneumonia and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
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| CN106728287A true CN106728287A (en) | 2017-05-31 |
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| CN201611189082.4A Withdrawn CN106728287A (en) | 2016-12-21 | 2016-12-21 | A kind of Chinese and Western medicine combination for treating hylactic pneumonia and preparation method thereof |
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| Country | Link |
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| CN (1) | CN106728287A (en) |
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2016
- 2016-12-21 CN CN201611189082.4A patent/CN106728287A/en not_active Withdrawn
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Application publication date: 20170531 |
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