CN106728052A - A kind of monkshood essential oil extraction method - Google Patents
A kind of monkshood essential oil extraction method Download PDFInfo
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- CN106728052A CN106728052A CN201611206778.3A CN201611206778A CN106728052A CN 106728052 A CN106728052 A CN 106728052A CN 201611206778 A CN201611206778 A CN 201611206778A CN 106728052 A CN106728052 A CN 106728052A
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- Prior art keywords
- monkshood
- ether
- extraction
- essential oil
- distillation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D3/00—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
- B01D3/34—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping with one or more auxiliary substances
- B01D3/40—Extractive distillation
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D3/00—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
- B01D3/42—Regulation; Control
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Abstract
The invention discloses a kind of monkshood essential oil extraction method, comprise the following steps：（1）Monkshood raw material is taken, is cleaned up, air-dried or dry；（2）By monkshood slicing treatment, the thin slice that thickness is 1 5mm is obtained, above-mentioned monkshood thin slice is quickly transferred in extraction vessel；（3）To in extraction vessel, the mixed solution of water and ether is added, soaked 5 72 hours, then heating distillation is extracted 14 hours, collects distillation；（4）Distillation carries out extraction 24 times with 13 times of ether of volume, and concentration obtains final product monkshood volatile oil after ether extraction liquid merges.Monkshood is carried out steam distillation treatment by the inventive method, by distilling the volatile oil compositions extracted in monkshood, the extraction solution of selection is the mixed solution of water and ether, and extraction effect is preferable, volatile oil oil yield is high, and the quality control for monkshood volatile oil is better.
Description
Technical field
The present invention relates to a kind of monkshood finishing treatment technology, more particularly to a kind of extractive technique of monkshood volatile oil, category
In traditional medicine state-of-the-art technology Upgrading.
Background technology
The scientific research of Chinese medicine is New World huge engineering improved for the technology upgrading of conventional hospital, is directed to
The finishing treatment of thousands of Chinese medicine compositions, traditional Chinese medicine route of administration needs further improvement, with raising
Value of the medicinal material in modern medicine.
Monkshood, also known as the rhizome of Chinese monkshood or tag, alias：Radix aconiti agrestis, the salt rhizome of Chinese monkshood, E Erhua, the ornamental work of iron, the five poisonous creatures: scorpion, viper, centipede, house lizard, toad, Latin literary fame：
Aconitum carmichaeli Debx. Ranunculaceaes, the processed goods of the sub- root of aconitum plant.Main product is in Sichuan, Hunan etc.
Ground, is the wide variety of valuable Chinese medicine composition in In Southwest China.It is mainly concentration when traditional medicine application monkshood
Technical force is in the simple application research of monkshood, such as basis such as " salted aconite root ", " mud monkshood ", " Radix Aconiti Lateralis Preparata " concocting method, institute
The monkshood application value for obtaining is only limited to the application process of traditional chinese medicine, and the Chinese patent drug of modernization studies the pass applied
It is less.So that the application value of monkshood is difficult to play good effect in modern medicine system.
The effects such as monkshood has recuperating depleted yang, mends fire supporing yang, eliminating cold to stop pain.Control exessive yin refusing yang, loss of YANG due to profuse perspiration, tell profit faint it is inverse,
Trusted subordinate's crymodynia, Spleen diarrhea cold dysentery, tinea pedis oedema children shy slowly, wind-cold-dampness arthralgia, Wei lame contractions, impotence Gong Leng, and cloudy subcutaneous ulcer sore is leaked and all
The disease of chronic diseases.How the natural molecule composition in the effect of monkshood and monkshood accurately to be carried out into Separation Research is present urgency
The problem that need to be solved.
The content of the invention
It is an object of the invention to overcome the shortcomings of to study insufficient for monkshood in the prior art, there is provided a kind of monkshood is waved
The extracting method of hair oil.Monkshood essential oil extraction method of the invention can be accurately controlled the extraction effect of the volatile oil in monkshood
Really, it is ensured that the abundant extraction of monkshood volatile oil, it is the follow-up study of monkshood volatile oil, and prepare the Chinese patent drugs such as tablet, capsule
Application provide basic material composition.
In order to realize foregoing invention purpose, the invention provides following technical scheme：
A kind of monkshood essential oil extraction method, comprises the following steps：
（1）Monkshood raw material is taken, is cleaned up, air-dried or dry；
（2）By monkshood slicing treatment, the thin slice that thickness is 1-5mm is obtained, above-mentioned monkshood thin slice is quick（Within 5 minutes）Turn
In moving on to extraction vessel.
（3）To in extraction vessel, the mixed solution of water and ether is added, soak 5-72 hours, preferably 5-36 hours, so
Heating distillation afterwards is extracted 1-4 hours, collects distillation.
（4）Distillation carries out extraction 2-4 times with the 1-3 times of ether of volume, and concentration obtains final product monkshood after ether extraction liquid merges
Volatile oil.
Further, after monkshood is cleaned up, the monkshood medicinal material from single volume more than 10ml.
Further, during monkshood slicing treatment, the thickness control of gained monkshood sheet material keeps certain shape between 2-4mm
State stability.
Further, in step 3, the mixed solution reclaimed water of water and ether and the volume feed of ether are 3:1-1:1.
Further, step 3 monkshood carries out aid in treatment using ultrasonic unit during soaking for soaking solution.It is super
The power 200w-5kw of acoustic wave device.
Preferably, the time of ultrasonic unit treatment is 30 minutes to 4 hours.
Further, when steam distillation, the separation control of ether is noted.
Compared with prior art, beneficial effects of the present invention：
Monkshood is carried out steam distillation treatment by the inventive method, by distilling the volatile oil compositions extracted in monkshood, selection
The mixed solution that solution is water and ether is extracted, preferably, the quality control for monkshood volatile oil is better for extraction effect.
The extracting method of monkshood volatile oil of the invention, for the control of temperature, particularly water and the mixed solution of ether
Mixing ratio relation so that it can be good at realizing corresponding miscible, regulation distillation temperature that extraction effect is good, volatilization
Oily oil yield is high.
Specific embodiment
With reference to test example and specific embodiment, the present invention is described in further detail.But this should not be understood
For the scope of above-mentioned theme of the invention is only limitted to following embodiment, all technologies realized based on present invention belong to this
The scope of invention.Not specified percentage is weight percentage in the present invention, and Solution percentages are usually volume basis
Than.
Embodiment 1
Monkshood raw material is taken, is cleaned up, air-dried or dry；Section obtains the thin slice that thickness is 4-5mm, and above-mentioned monkshood thin slice is fast
Speed（Within 5 minutes）It is transferred in extraction vessel.The mixed solution of 2L water and 1L ether is added, is soaked 10 hours, Ran Houjia
Thermal distillation is extracted 3 hours, collects distillation.Distillation carries out extraction 4 times with 2 times of ether of volume, after ether extraction liquid merges
Concentration obtains final product monkshood volatile oil, and volatile oil extracting rate reaches 43.6%.
Embodiment 2
Monkshood raw material 5kg is taken, is cleaned up, air-dried or dry；Section obtains the thin slice that thickness is 2-3mm, and above-mentioned monkshood is thin
Piece is quickly transferred in extraction vessel.The mixed solution of 3L water and 1L ether is added, is soaked 6 hours, then heated distillation and carry
Take 3 hours, collect distillation.Distillation carries out extraction 3 times with 3 times of ether of volume, and ether extraction liquid is concentrated after merging and obtained final product
Monkshood volatile oil, volatile oil extracting rate reaches 31.9%.
Embodiment 3
Monkshood raw material is taken, is cleaned up, air-dried or dry；Section obtains the thin slice that thickness is 1-5mm, and above-mentioned monkshood thin slice is fast
Speed（Within 5 minutes）It is transferred in extraction vessel.The mixed solution of 2L water and 1L ether is added, is soaked 10 hours, Ran Houjia
Thermal distillation is extracted 3 hours, collects distillation.Distillation carries out extraction 4 times with 2 times of ether of volume, after ether extraction liquid merges
Concentration obtains final product monkshood volatile oil, and volatile oil extracting rate reaches 23.5%.
Embodiment 4
Monkshood raw material is taken, is cleaned up, air-dried or dry；Section obtains the thin slice that thickness is 1-2mm, and above-mentioned monkshood thin slice is fast
Speed（Within 5 minutes）It is transferred in extraction vessel.The mixed solution of 1L water and 1L ether is added, is soaked 5 hours, then heated
Distillation is extracted 2 hours, collects distillation.Distillation carries out extraction 3 times with 3 times of ether of volume, and ether extraction liquid is dense after merging
Contracting obtains final product monkshood volatile oil, and volatile oil extracting rate reaches 38.7%.
Embodiment 5
Monkshood raw material is taken, is cleaned up, air-dried or dry；Section obtains the thin slice that thickness is 3-5mm, and above-mentioned monkshood thin slice is fast
Speed（Within 5 minutes）It is transferred in extraction vessel.The mixed solution of 2L water and 1L ether is added, is soaked 10 hours, Ran Houjia
Thermal distillation is extracted 3 hours, collects distillation.Distillation carries out extraction 2 times with 3 times of ether of volume, after ether extraction liquid merges
Concentration obtains final product monkshood volatile oil, and volatile oil extracting rate reaches 41.1%.
Claims (7)
1. a kind of monkshood essential oil extraction method, comprises the following steps：
（1）Monkshood raw material is taken, is cleaned up, air-dried or dry；
（2）By monkshood slicing treatment, the thin slice that thickness is 1-5mm is obtained, above-mentioned monkshood thin slice is quickly transferred into extraction holds
In device；
（3）To in extraction vessel, the mixed solution of water and ether is added, soaked 5-72 hours, then heating distillation extraction 1-4 is small
When, collect distillation；
（4）Distillation carries out extraction 2-4 times with the 1-3 times of ether of volume, and concentration obtains final product monkshood volatilization after ether extraction liquid merges
Oil.
2. monkshood essential oil extraction method as claimed in claim 1, it is characterised in that after monkshood is cleaned up, from single body
Monkshood medicinal material of the product more than 10ml.
3. monkshood essential oil extraction method as claimed in claim 1, it is characterised in that during monkshood slicing treatment, gained monkshood piece
The thickness control of material is between 2-4mm.
4. monkshood essential oil extraction method as claimed in claim 1, it is characterised in that in step 3, the mixed solution of water and ether
The volume feed of reclaimed water and ether is 3:1-1:1.
5. monkshood essential oil extraction method as claimed in claim 1, it is characterised in that step 3 monkshood is used during soaking
Ultrasonic unit carries out aid in treatment for soaking solution.
6. monkshood essential oil extraction method as claimed in claim 5, it is characterised in that the power 200w-5kw of ultrasonic unit.
7. monkshood essential oil extraction method as claimed in claim 5, it is characterised in that the time of ultrasonic unit treatment is 30 points
Clock was by 4 hours.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611206778.3A CN106728052A (en) | 2016-12-23 | 2016-12-23 | A kind of monkshood essential oil extraction method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611206778.3A CN106728052A (en) | 2016-12-23 | 2016-12-23 | A kind of monkshood essential oil extraction method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106728052A true CN106728052A (en) | 2017-05-31 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611206778.3A Pending CN106728052A (en) | 2016-12-23 | 2016-12-23 | A kind of monkshood essential oil extraction method |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101745089A (en) * | 2009-12-16 | 2010-06-23 | 陈正华 | Medicament for treating stomach cancer and preparation method thereof |
-
2016
- 2016-12-23 CN CN201611206778.3A patent/CN106728052A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101745089A (en) * | 2009-12-16 | 2010-06-23 | 陈正华 | Medicament for treating stomach cancer and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 孔令义: "《中药制药化学》", 30 April 2007 * |
| 张晶等: "中药附子的化学成分", 《中国实验方剂学杂志》 * |
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Application publication date: 20170531 |