CN106727713A - A kind of micron order salmon oil capsule - Google Patents
A kind of micron order salmon oil capsule Download PDFInfo
- Publication number
- CN106727713A CN106727713A CN201611125715.5A CN201611125715A CN106727713A CN 106727713 A CN106727713 A CN 106727713A CN 201611125715 A CN201611125715 A CN 201611125715A CN 106727713 A CN106727713 A CN 106727713A
- Authority
- CN
- China
- Prior art keywords
- oil
- weight portions
- salmon oil
- phase
- salmon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229940119224 salmon oil Drugs 0.000 title claims abstract description 18
- 239000002775 capsule Substances 0.000 title claims abstract description 10
- 238000002360 preparation method Methods 0.000 claims abstract description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 7
- 108010010803 Gelatin Proteins 0.000 claims abstract description 6
- 229920000159 gelatin Polymers 0.000 claims abstract description 6
- 239000008273 gelatin Substances 0.000 claims abstract description 6
- 235000019322 gelatine Nutrition 0.000 claims abstract description 6
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 6
- 239000007764 o/w emulsion Substances 0.000 claims abstract description 6
- 239000007901 soft capsule Substances 0.000 claims abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 4
- 238000003756 stirring Methods 0.000 claims description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- -1 sucrose ester Chemical class 0.000 claims description 4
- 235000011187 glycerol Nutrition 0.000 claims description 3
- 239000002002 slurry Substances 0.000 claims description 3
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- 229930003427 Vitamin E Natural products 0.000 claims description 2
- 238000004821 distillation Methods 0.000 claims description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 2
- 238000002347 injection Methods 0.000 claims description 2
- 239000007924 injection Substances 0.000 claims description 2
- 239000008213 purified water Substances 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- 229940046009 vitamin E Drugs 0.000 claims description 2
- 235000019165 vitamin E Nutrition 0.000 claims description 2
- 239000011709 vitamin E Substances 0.000 claims description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
- 229920000053 polysorbate 80 Polymers 0.000 claims 1
- 206010028813 Nausea Diseases 0.000 abstract description 6
- 230000008693 nausea Effects 0.000 abstract description 6
- 239000003995 emulsifying agent Substances 0.000 abstract description 4
- 238000000034 method Methods 0.000 abstract description 4
- 206010012735 Diarrhoea Diseases 0.000 abstract description 3
- 208000012895 Gastric disease Diseases 0.000 abstract description 3
- 208000031361 Hiccup Diseases 0.000 abstract description 3
- 238000010521 absorption reaction Methods 0.000 abstract description 2
- 241000972773 Aulopiformes Species 0.000 description 7
- 235000019515 salmon Nutrition 0.000 description 7
- 241000277331 Salmonidae Species 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 235000019197 fats Nutrition 0.000 description 4
- 239000002253 acid Substances 0.000 description 2
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 description 2
- 229960005135 eicosapentaenoic acid Drugs 0.000 description 2
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 description 2
- 235000020673 eicosapentaenoic acid Nutrition 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 206010008111 Cerebral haemorrhage Diseases 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 241001417105 Clupea pallasii Species 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 201000001429 Intracranial Thrombosis Diseases 0.000 description 1
- 241001275898 Mylopharyngodon piceus Species 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 206010039966 Senile dementia Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 229940112822 chewing gum Drugs 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 235000021323 fish oil Nutrition 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/60—Fish, e.g. seahorses; Fish eggs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Marine Sciences & Fisheries (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention discloses a kind of salmon oil capsule, by emulsifying agent will be added to form a phase in salmon oil, adds emulsifying agent to form two-phase in water, and a phase and two-phase form micron order oil-in-water emulsion by secondary homogenate technique；It is subsequently adding edible gelatin and glycerine forms dense body of paste, finally by the preparation method preparation of general soft capsule.Compared with prior art, the present invention uses secondary homogenate technique so that salmon oil turns into micron-sized oil droplet outer layer covers moisture film, is conducive to absorption of human body, and improve mouthfeel, it is to avoid gastric disorder causing nausea nausea is had the hiccups and suffered from diarrhoea.
Description
Technical field
The present invention relates to health food, and in particular to a kind of micron order salmon oil chewing-gum capsule.
Background technology
Salmon is the general designation of all salmon (Salmon), trout (Trout) and salmon (Char) three major types.Additionally, northern
Extremely grey trout, the oily Pacific herring in the Atlantic Ocean, the cold trout of North America black carp and the arctic etc. also belong to salmon section.Salmon oil is refined from salmon, is most
Authentic fish oil.Contain precious Omega unrighted acids essential in health diet, including eicosapentaenoic acid
(EPA), DHA (DHA), has regulation blood fat, triglyceride reducing, dilute blood etc. to act on.Be suitable for hypertension,
High fat of blood, hyperglycemia population；Cerebral hemorrhage, cerebral thrombus, apoplexy, patients of senile dementia；Vision degeneration, forgetful and decrease of memory
Person.
The salmon fat capsule that is made generally in, is 100% salmon oil in capsule at present, due to salmon oil after all it is most of into
It is fat to divide, and some crowds such as dyshepatia person may not tolerate, and causes the hiccup of gastric disorder causing nausea nausea and suffers from diarrhoea.Especially take blood
The people of liquid diluent is more because both material reciprocations can cause serious side effects.
The content of the invention
The purpose of the present invention is to overcome the shortcomings of that existing salmon oil capsule is present, there is provided a kind of micron order salmon oil is oral
Liquid, the technical solution adopted by the present invention is：
A kind of salmon oil capsule, by emulsifying agent will be added to form a phase in salmon oil, adds emulsifying agent to be formed in water
Two-phase, a phase and two-phase form micron order oil-in-water emulsion by secondary homogenate technique；It is subsequently adding edible gelatin and glycerine shape
Into dense body of paste, finally by the preparation method preparation of general soft capsule.
Compared with prior art, the present invention uses secondary homogenate technique so that salmon oil turns into micron-sized oil droplet outer layer
Parcel moisture film, is conducive to absorption of human body, and improve mouthfeel, it is to avoid the hiccup of gastric disorder causing nausea nausea and diarrhoea.
Specific embodiment
A kind of salmon oil capsule, it is characterised in that：It is made by the steps：
1) vitamin E of 2 weight portions is added to stir the wild salmon oil of 998 weight portions in container one；Then
The distillation monoglyceride of the sucrose ester of 0.5 weight portion, 0.6 weight portion is added to be well mixed；
2) the polyoxyethylene sorbitol acid anhydride list oil of 4.2 total amounts part will be added in the purified water of 300 weight portions in container two
Acid esters stirs；
3) by the mixture in the mixture in container one and container two according to 3:It is even that 1 flow-rate ratio injects high shear together
Slurry device carries out first time homogenate；
4) by step 3) slurries injection high pressure homogenizer carry out second homogenate, form micron order oil-in-water emulsion；
5) glycerine, the edible gelatin of 250 weight portions of 100 weight portions will be added in oil-in-water emulsion, is stirred and is made
Edible gelatin forms dense body of paste after all dissolving；
6) by the body of paste of step 5 according to general soft capsule preparation method preparation.
Claims (1)
1. a kind of salmon oil capsule, it is characterised in that：It is made by the steps：
1) vitamin E of 2 weight portions is added to stir the wild salmon oil of 998 weight portions in container one；It is subsequently adding
The sucrose ester of 0.5 weight portion, the distillation monoglyceride of 0.6 weight portion is well mixed；
2) Tween-80 of 4.2 total amounts part will be added in the purified water of 300 weight portions in container two
Stir；
3) by the mixture in the mixture in container one and container two according to 3:1 flow-rate ratio injects high-shear homogenate device together
Carry out first time homogenate；
4) by step 3) slurries injection high pressure homogenizer carry out second homogenate, form micron order oil-in-water emulsion；
5) glycerine, the edible gelatin of 250 weight portions of 100 weight portions will be added in oil-in-water emulsion, stirs and make to eat
Gelatin forms dense body of paste after all dissolving；
6) by the body of paste of step 5 according to general soft capsule preparation method preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611125715.5A CN106727713A (en) | 2016-12-09 | 2016-12-09 | A kind of micron order salmon oil capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611125715.5A CN106727713A (en) | 2016-12-09 | 2016-12-09 | A kind of micron order salmon oil capsule |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106727713A true CN106727713A (en) | 2017-05-31 |
Family
ID=58882046
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611125715.5A Withdrawn CN106727713A (en) | 2016-12-09 | 2016-12-09 | A kind of micron order salmon oil capsule |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106727713A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107897466A (en) * | 2017-11-09 | 2018-04-13 | 山东天地健生物工程有限公司 | A kind of antarctic krill oil interlayer type gel candy and preparation method thereof |
| CN112956682A (en) * | 2021-03-30 | 2021-06-15 | 江南大学 | Preparation method of peanut-derived emulsion stabilizer |
| CN114916606A (en) * | 2022-03-30 | 2022-08-19 | 中国医科大学 | High-efficiency practical spicy candy |
-
2016
- 2016-12-09 CN CN201611125715.5A patent/CN106727713A/en not_active Withdrawn
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107897466A (en) * | 2017-11-09 | 2018-04-13 | 山东天地健生物工程有限公司 | A kind of antarctic krill oil interlayer type gel candy and preparation method thereof |
| CN112956682A (en) * | 2021-03-30 | 2021-06-15 | 江南大学 | Preparation method of peanut-derived emulsion stabilizer |
| CN112956682B (en) * | 2021-03-30 | 2023-04-28 | 江南大学 | Preparation method of peanut-derived emulsion stabilizer |
| CN114916606A (en) * | 2022-03-30 | 2022-08-19 | 中国医科大学 | High-efficiency practical spicy candy |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20170531 |